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| 1 | 应用中国商环包皮环切手术标准化方案对328例成年男性包皮环切的临床报告显示文摘目的:成年男性包皮环切手术标准化和培训可显著降低因手术引起的并发症发生率。由于目前国内外尚无可供参考的成年男性包皮环切手术标准化方案和培训制度,使得临床医生开展成年男性包皮环切手术的质量无法保证。为了建立成年男性包皮环切手术标准化和培训制度,便于临床医生和相关医护人员学习和掌握包皮环切器的临床应用技巧,以中国商环(简称'商环,ShangRing')包皮环切技术为例,根据商环的技术特点和临床实践经验,特别制订了商环包皮环切手术标准化方案,并将其标准化操作运用于临床。方法:采用商环包皮环切手术标准化方案对328例受术者(年龄18~58岁,平均27.8岁;已婚134例,未婚194例;包茎25例,包皮过长303例)进行包皮环切手术。对手术时间、疼痛评分(视觉模拟评分法,VAS)、术后并发症、包皮创口愈合时间、术后外观满意情况进行观察和随访。结果:手术时间为(4.70±1.31)min。手术时受术者疼痛(VAS)评分为(0.24±0.59)分,术后24h疼痛评分为(1.59±0.95)分,去环前24h内疼痛评分(1.72±1.11)分,去环时疼痛评分为(2.72±1.37)分。主要并发症发生率为术后感染0.6%(2/328)、出血0.6%(2/328)、伤口裂开0.6%(2/328)和水肿4.89%(16/328)。在发生出血和伤口裂开的受术者中无1例需要缝合。术后包皮创口完全愈合时间为(20.30±6.69)d。受术者对术后外观满意率99.7%(327/328)。结论:商环包皮环切术具有手术方式易于标准化、手术时间短、术中疼痛轻、术后无须特殊护理、容易完整保留系带,并完全暴露冠状沟、术后外观满意度高、受术者易于接受等优点。初步证明了中国商环包皮环切手术标准化方案的可接受性,严格按照此方案实施手术和随访护理,能最大化地实现商环包皮环切技术的诸多临床优势,将并发症发生率控制在可接受的范围内。 | 程跃 彭弋峰 刘毅东 田龙 吕年青 苏新军 严泽军 胡嘉盛 Richard LEE Howard KIM David C. SOKAL 李石华 | 2009 | 中华男科学杂志2009，15，7： | 155 |
| 2 | 中国建立男性包皮环切手术标准化和培训的重要性显示文摘尽管HIV在非洲的大流行仍然是一个严重的问题,而在其他地区,如亚洲和南美洲,HIV感染率也正在迅速上升。国际健康组织已经认识到有必要制定有效的策略来检测和控制全球HIV的传播。研究表明,男性包皮环切能显著降低HIV、人乳头状瘤病毒(HPV)、单纯疱疹病毒2型(HSV-2)和其他性传播疾病(STD)的感染率。虽然男性包皮环切技术有许多,但是没有标准化的手术方案和培训计划。研究表明,男性包皮环切技术的标准化与培训计划的实施可以大大降低并发症发生率。并发症发生率高是实施男性包皮环切服务的一个主要障碍。我们建议,在推广男性包皮环切之前应建立手术标准和培训计划。 | 李石华 吕年青 程跃 彭弋峰 田龙 刘毅东 贲昆龙 徐建春 Richard LEE Howard KIM David C.SOKAL | 2009 | 中华男科学杂志2009，15，5： | 56 |
| 3 | 中药及其活性成分对绝经后骨质疏松症的治疗及其作用机制显示文摘绝经后骨质疏松症是更年期妇女的常见全身性骨代谢疾病,体内雌激素水平下降是其重要病因。激素替代疗法(HRT)虽然在多年的临床实践中有着良好和肯定的疗效,但其在提高妇科肿瘤发生率等方面具有明显的副作用。临床实践已经证明,多种妇科中药方剂、单味中药及中药植物雌激素样活性成分对骨质疏松症有确凿疗效且副作用小。其主要通过作用于靶组织、靶细胞的雌激素受体并进而影响其下游信号传导通路中骨代谢相关调节蛋白和因子的表达情况,达到对骨质疏松症的防治效果。同时,近年来雌激素相关受体的研究也为全面揭示中药及其活性成分抗骨质疏松症的作用机制提供了新的可能角度和途径。 | 赵丕文 牛建昭 David Yue-Wei Lee 王继峰 孙艳玲 李亚东 | 2012 | 中国中药杂志2012，37，12： | 25 |
| 4 | 泽泻提取物Alisol Monoacetate A和B对HepG2细胞株胆固醇代谢的影响显示文摘目的:考察泽泻有效成分Alisol Monoacetate A和B对人类肝癌细胞株(HepG2)胆固醇合成与代谢的影响。方法:以HepG2细胞为模型,Lipitor为阳性对照,加入不同浓度的Alisol Monoacetate A和B,培养24h后分别收集与测定培养液及细胞内的胆固醇含量。结果:Alisol Monoacetate A和B在10μM、20μM浓度时开始出现10%左右的细胞毒性,但线粒体代谢活性却增强约50%。而当浓度超过50μM时细胞毒性显著增强达70%以上。随着Alisol Monoacetate A和B浓度的增加(0、3、10、20μM),细胞内胆固醇含量也显著升高,分别为24.4、26.7、32.3、38.3μg/mg蛋白质,存在正量效关系;但培养液内的胆固醇含量无明显不同。结论:Alisol Monoac-etate A和B可能具有增强细胞的线粒体代谢活性而促进HepG2合成胆固醇的作用,其机制有待进一步研究。 | 吴水生 郭改革 施红 王宏 David Lee | 2007 | 中华中医药杂志2007，22，7： | 21 |
| 5 | Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics显示文摘交往受体的蛋白质 kinase-3 (RIP3 或 RIPK3 ) 是执行 “ 的细胞的机械的必要部分; programmed”或 “ regulated”坏死。这里,我们证明那规划坏死响应许多化学疗法的代理人被激活并且贡献导致化疗的房间死亡。然而,我们证明那 RIP3 表情经常在化学疗法的死亡期间由于它的 transcriptional 开始地点, MLKL 的这样 RIP3 依赖的激活和下游地规划的坏死附近的 genomic methylation 是在癌症房间的 silenced 大部分被镇压。不过,有 hypomethylating 代理人的治疗恢复 RIP3 表示,并且从而以一种 RIP3 依赖的方式把敏感提升到 chemotherapeutics。RIP3 表示在 85% 乳癌病人与正常织物相比在肿瘤被减少,建议那 RIP3 缺乏断然在肿瘤生长 / 发展期间被选择。因为 hypomethylating 代理人在病人是相当容忍得好的,我们建议病人们可以从收到 hypomethylating 代理人与常规 chemotherapeutics 在治疗以前导致 RIP3 表示有益于的那 RIP3 缺乏的癌症。 | Gi-Bang Koo Michael J Morgan Da-Gyum Lee Woo-Jung Kim Jung-Ho Yoon Ja Seung Koo Seung I1 Kim Soo Jung Kim Mi Kwon Son Soon Still Hong Jean M Mulcahy Levy Daniel A Pollyea Craig T Jordan Pearlly Yan David Frankhouser Deedra Nicolet Kati Maharry Guido Marcucci Kyeong Sook Choi Hyeseong Cho ndrew Thorbum You-Sun Kim | 2015 | Cell Research2015，25，6： | 20 |
| 6 | 氮化镓功率晶体管三电平驱动技术显示文摘作为第三代半导体材料的典型代表,宽禁带半导体氮化镓(GaN)材料具有许多硅材料所不具备的优异性能,是高频、高压、高温和大功率应用的优良半导体材料,无论在民用或是军事领域都具有广阔的应用前景。随着GaN技术的进步,大直径硅(Si)基GaN外延技术逐步成熟并向商用化方向发展。2010年以来,多家国际著名半导体厂商相继推出GaN功率晶体管器件。与硅半导体功率器件一样,合理的驱动方式也是GaN功率晶体管优越性能得以体现的重要保障。本文将以GaN功率器件在同步整流Buck变换器中的应用为例,提出一种三电平的驱动方式,以充分发挥GaN功率晶体管器件的优越性。实验结果表明,本文提出的三电平驱动方式可以有效提高变换器的效率。 | 任小永 David Reusch 季澍 穆明凯 Fred C Lee | 2013 | 电工技术学报2013，28，5： | 19 |
| 7 | Endoscopy and polyps-diagnostic and therapeutic advances in management显示文摘Despite multiple efforts aimed at early detection through screening, colon cancer remains the third leading cause of cancer-related deaths in the United States, with an estimated 51000 deaths during 2013 alone. The goal remains to identify and remove benign neoplastic polyps prior to becoming invasive cancers. Polypoid lesions of the colon vary widely from hyperplastic, hamartomatous and inflammatory to neoplastic adenomatous growths. Although these lesions are all benign, they are common, with up to one-quarter of patients over 60 years old will develop pre-malignant adenomatous polyps. Colonoscopy is the most effective screening tool to detect polyps and colon cancer, although several studies have demonstrated missed polyp rates from 6%-29%, largely due to variations in polyp size. This number can be as high as 40%, even with advanced (> 1 cm) adenomas. Other factors including sub-optimal bowel preparation, experience of the endoscopist, and patient anatomical variations all affect the detection rate. Additional challenges in decision-making exist when dealing with more advanced, and typically larger, polyps that have traditionally required formal resection. In this brief review, we will explore the recent advances in polyp detection and therapeutic options. | Scott R Steele Eric K Johnson Bradley Champagne Brad Davis Sang Lee David Rivadeneira Howard Ross Dana A Hayden Justin A Maykel | 2013 | World Journal of Gastroenterology2013，19，27： | 16 |
| 8 | 急性心肌梗死医疗保险患者介入治疗与药物治疗强度区域变化对远期预后的影响显示文摘背景:与药物治疗比较,急性心肌梗死(acute myocardial infarction,AMI)患者介入治疗强度存在显著的地区差异,这种差异在卫生及政策方面的意义还不清楚。目标:评价接受积极治疗患者的相关临床特征;评估居住于积极采取介入治疗策略地区的AMI患者与居住于积极采取药物治疗策略地区的患者相比,是否具有更好的远期生存率。设计、地点及患者:在158831例老年医疗保险患者中进行该项全国性队列研究。患者于1994~1995年因首次发生并确诊AMI而入院,随访7年(平均随访3.6年)。根据居住地区介入治疗(30天内接受心导管手术)与药物治疗(出院时对适宜的患者应用β-阻滞剂)强度进行分析。基线资料来自心血管协作项目,并与医疗保险管理资料联合。主要观察指标:7年随访期间的远期生存率。结果:各地区AMI基线严重程度相似。在所有地区,较年轻、较健康的患者与年老的高危患者相比,更可能接受介入治疗和药物治疗。更多实施介入治疗的地区具备更多的心脏导管室条件;这些地区的患者无论年龄、临床指征还是危险特点如何,均更多接受介入治疗。介入和药物治疗策略采用率最高的地区与介入和药物治疗采用率最低的地区,两者未经校正的7年绝对生存率差异为6.2%。对于ST抬高和非ST抬高AMI患者,其生存率随着地区介入治疗和药物治疗强度的增高而升高。在药物治疗比例较高的地区,随着介入治疗的增加,相应的生存率提高很少甚或没有提高。结论:老年医疗保险AMI患者接受较为积极的药物治疗对改善人群的生存有益。 | Therese A. Stukel F. Lee Lucas David E. Wennberg 王淑敏(译) 胡大一(校) | 2005 | 美国医学会杂志(中文版)2005，24，4： | 15 |
| 9 | Portal hypertension: Imaging of portosystemic collateral pathways and associated image-guided therapy显示文摘Portal hypertension is a common clinical syndrome, defined by a pathologic increase in the portal venous pressure. Increased resistance to portal blood flow, the primary factor in the pathophysiology of portal hypertension, is in part due to morphological changes occurring in chronic liver diseases. This results in rerouting of blood flow away from the liver through collateral pathways to low-pressure systemic veins. Through a variety of computed tomographic, sonographic, magnetic resonance imaging and angiographic examples, this article discusses the appearances and prevalence of both common and less common portosystemic collateral channels in the thorax and abdomen. A brief overview of established interventional radiologic techniques for treatment of portal hypertension will also be provided. Awareness of the various imaging manifestations of portal hypertension can be helpful for assessing overall prognosis and planning proper management. | Murad Feroz Bandali Anirudh Mirakhur Edward Wolfgang Lee Mollie Clarke Ferris David James Sadler Robin Ritchie Gray Jason Kam Wong | 2017 | World Journal of Gastroenterology2017，23，10： | 14 |
| 10 | A view of cloud computing显示文摘 | Michael Armbrust Armando Fox Rean Griffith Anthony D. Joseph Randy Katz Andy Konwinski Gunho Lee David Patterson Ariel Rabkin Ion Stoica Matei Zaharia | 2010 | Communications of the ACM2010，，4： | 13 |
| 11 | Suppressing the liquid product crossover in electrochemical CO_(2)reduction显示文摘Coupling electrochemical CO_(2)reduction(CO_(2)R)with a renewable energy source to create high‐value fuels and chemicals is a promising strategy in moving toward a sustainable global energy economy.CO_(2)R liquid products,such as formate,acetate,ethanol,and propanol,offer high volumetric energy density and are more easily stored and transported than their gaseous coun-terparts.However,a significant amount(~30%)of liquid products from electrochemical CO_(2)R in a flow cell reactor cross the ion exchange membrane,leading to the substantial loss of system‐level Faradaic efficiency.This severe crossover of the liquid product has—until now—received limited attention.Here,we review promising methods to suppress liquid product crossover,including the use of bipolar membranes,solid‐state electrolytes,and cation‐exchange membranes‐based acidic CO_(2)R systems.We then outline the re-maining challenges and future prospects for the production of concentrated liquid products from CO_(2). | Ning Wang Rui Kai Miao Geonhui Lee Alberto Vomiero David Sinton Alexander H.Ip Hongyan Liang Edward H.Sargent | 2021 | SmartMat2021，2，1： | 13 |
| 12 | 雌激素、雌激素受体与心血管疾病显示文摘雌激素是一种参与机体多个器官系统功能调节的重要的固醇类激素。其水平的下降与女性绝经后心血管疾病发病率的增高存在着密切的关系。雌激素或雌激素样物质可以通过经典的雌激素受体(ER)α、ERβ或膜G蛋白偶联受体(GPR)30等介导的基因和非基因传导通路发挥心血管系统的调节功能;靶细胞受体亚型的特异性分布和状况是影响雌激素或雌激素样物质最终效应的主要因素。同时,雌激素对心血管系统作用机制的阐明对激素替代治疗(HRT)或植物雌激素的临床应用将具有重要指导意义。 | 赵丕文 牛建昭 David Yue-Wei Lee 孙丽萍 陈梦 陶仕英 | 2012 | 时珍国医国药2012，23，11： | 11 |
| 13 | G蛋白偶联雌激素受体在雌激素相关肿瘤发生中的作用显示文摘在经典的雌激素核受体α和β之外,雌激素或雌激素样物质也可以经过膜受体,即G蛋白偶联雌激素受体(GPER)发挥功能。G蛋白偶联雌激素受体是雌激素非基因通路信号转导过程的重要介导因子,在雌激素相关肿瘤细胞的发生和治疗中具有重要的意义。现针对G蛋白偶联雌激素受体在雌激素相关肿瘤细胞中介导的效应及有关机制的研究进展进行综述。 | 赵丕文 David Yue-Wei Lee 陶仕英 陈梦 牛建昭 | 2014 | 中国药理学通报2014，30，8： | 10 |
| 14 | 鼠尾草酚抗乳腺癌细胞增殖活性及其雌激素受体亚型介导和调节机制的研究显示文摘既往研究已经表明,鼠尾草酚(carnoso1)具有一定的抗乳腺癌效应,但其ER亚型特异性调节和介导机制与该物质抑制细胞增殖效应的相关性尚不清楚。该研究利用雌激素受体(ER)阳性乳腺癌T47D细胞观察鼠尾草酚对细胞增殖活性的影响及其雌激素受体α,卢亚型特异性介导和调节机制。以ERα和ERβ特异性拮抗剂MPP,PHTPP为工具药,采用MTT细胞增殖实验观察鼠尾草酚对T47D细胞增殖的影响;检测T47D细胞增殖周期的变化。利用Western blot方法检测鼠尾草酚对T47D细胞ERα和ERβ表达情况的影响。研究发现,1×10^(-5)~1×10^(-7)mol·L^(-1)鼠尾草酚能够显著抑制T47D细胞增殖,该抑制作用可被ERα拮抗剂MPP增强、被ERβ拮抗剂PHTPP减弱;1×10^(-1),1×10^(-6)mol·L^(-1)鼠尾草酚可使T47D细胞增殖指数显著下降。Western blot检测结果显示1×10^(-5),1×10^(-6)mol·L^(-1)鼠尾草酚可使T47D细胞ERα和ERβ蛋白表达显著增加,并可明显提高ERα/ERβ。结果表明鼠尾草酚具有抑制ER阳性乳腺癌细胞增殖的作用,其效应是通过靶细胞雌激素受体,特别是ERβ途径实现的;同时,鼠尾草酚对靶细胞雌激素受体ERα和ERβ亚型的表达及其比例具有调节功能。 | 赵丕文 David Yue-Wei LEE Zhongze Ma 孙艳玲 陶仕英 臧金凤 牛建昭 | 2014 | 中国中药杂志2014，39，17： | 10 |
| 15 | Classification of Subtype of Acute Ischemic Stroke: Definitions for Use in a Multicenter Clinical Trial显示文摘 | Harold P. Adams Birgitte H. Bendixen L. Jaap Kappelle José Biller Betsy B. Love David Lee Gordon E. Eugene Marsh | 1993 | Stroke1993，，1： | 9 |
| 16 | Applications of Pueraria lobata in treating diabetics and reducing alcohol drinking显示文摘Pueraria lobata is one of the most important medicinal herbs used traditionally in China. According to Shanghan Lun(Treatise on Exogenous Febrile Disease), it has been used traditionally to relieve body heat,eye soring, dry mouth, headache associated with high blood pressure, and stiff neck problems. Modern studies in the 1970 s revealed that isoflavonoids extracted from P. lobata were the bioactive components of an herbal remedy namely Yufeng Ningxin Tablets for the treatment of patients after stroke. This article reviews recent application of P. lobota in the treatment of diabetics and in reducing alcohol drinking. In view of its low toxicity profile, P. lobota stands an excellent chance to be developed as a phytomedicine for treating human diseases. | Jing Liu Yeu-Ching Shi David Yue-Wei Lee | 2019 | Chinese Herbal Medicines2019，11，2： | 8 |
| 17 | Impact of disease severity on gastric residual volume in critical patients显示文摘AIM: To investigate whether illness severity has an impact on gastric residual volume (GRV) in medical critically ill patients. METHODS: Medical intensive care unit (ICU) patients requiring nasogastric feeding were enrolled. Sequential Organ Failure Assessment (SOFA) score was assessed immediately preceding the start of the study. Acute Physiology and Chronic Health Evaluation (APACHE) Ⅱ scores were recorded on the first, fourth, seventh, and fourteenth day of the study period. GRV was measured every 4 h during enteral feeding. The relationship be-tween mean daily GRV and SOFA scores and the correlation between mean daily GRV and mean APACHE Ⅱ score of all patients were evaluated and compared. RESULTS: Of the 61 patients, 43 patients were survivors and 18 patients were non-survivors. The mean daily GRV increased as SOFA scores increased (P < 0.001, analysis of variance). Mean APACHE Ⅱ scores of all patients correlated with mean daily GRV (P = 0.011, Pearson correlation) during the study period. Patients with decreasing GRV in the first 2 d had better survival than patients without decreasing GRV (P = 0.017, log rank test). CONCLUSION: GRV is higher in more severely ill medical ICU patients. Patients with decreasing GRV had lower ICU mortality than patients without decreasing GRV. | Chien-Wei Hsu Shu-Fen Sun David Lin Lee Shoa-Lin Lin Kam-Fai Wong Hsiu-Hua Huang Hung-Ju Li | 2011 | World Journal of Gastroenterology2011，17，15： | 8 |
| 18 | Neuronal failure in Alzheimer's disease: a view through the oxidative stress looking-glass显示文摘Considerable debate and controversy surround the cause(s) of Alzheimer's disease(AD). To date, several theories have gained notoriety, however none is universally accepted. In this review, we provide evidence for the oxidative stress-induced AD cascade that posits aged mitochondria as the critical origin of neurodegeneration in AD. | David J. Bonda Xinglong Wang Hyoung-Gon Lee Mark A. Smith George Perry Xiongwei Zhu | 2014 | Neuroscience Bulletin2014，30，2： | 7 |
| 19 | Advances in adjuvant systemic therapy for non-small-cell lung cancer显示文摘Non-small-cell lung cancer remains a leading cause of death around the world. For most cases, the only chance of cure comes from resection for localised disease, however relapse rates remain high following surgery. Data has emerged over recent years regarding the utility of adjuvant chemotherapy for improving disease-free and overall survival of patients following curative resection. This paper reviews the clinical trials that have been conducted in this area along with the studies integrating radiation therapy in the adjuvant setting. The role of prognostic gene signatures are reviewed as well as ongoing clinical trials including those incorporating biological or targeted therapies. | David Leong Rajat Rai Brandon Nguyen Andrew Lee Desmond Yip | 2014 | World Journal of Clinical Oncology2014，5，4： | 7 |
| 20 | A comparison of three methods of decellularization of pig corneas to reduce immunogenicity显示文摘·AIM: To investigate whether decellularization using different techniques can reduce immunogenicity of the cornea, and to explore the decellularized cornea as a scaffold for cultured corneal endothelial cells(CECs).Transplantation of decellularized porcine corneas increases graft transparency and survival for longer periods compared with fresh grafts.·METHODS: Six-month-old wild-type pig corneas were cut into 100-200 μm thickness, and then decellularized by three different methods: 1) 0.1% sodium dodecyl sulfate(SDS); 2) hypoxic nitrogen(N2); and 3) hypertonic NaCl. Thickness and transparency were assessed visually. Fresh and decellularized corneas were stained with hematoxylin/eosin(H&E), and for the presence of galactose-α1,3-galactose(Gal) and N-glycolylneuraminic acid(NeuGc, a nonGal antigen). Also, a human IgM/IgG binding assay was performed. Cultured porcine CECs were seeded on the surface of the decellularized cornea and examined after H&E staining.· RESULTS: All three methods of decellularization reduced the number of keratocytes in the stromal tissue by >80% while the collagen structure remained preserved. No remaining nuclei stained positive for Gal or NeuGc, and expression of these oligosaccharides on collagen was also greatly decreased compared to expression on fresh corneas. Human IgM/IgG binding to decellularized corneal tissue was considerably reduced compared to fresh corneal tissue. The cultured CECs formed a confluent monolayer on the surface of decellularized tissue.· CONCLUSION: Though incomplete, the significant reduction in the cellular component of the decellularized cornea should be associated with a significantly reduced in vivo immune response compared to fresh corneas. | Whayoung Lee Yuko Miyagawa Cassandra Long David K.C.Cooper Hidetaka Hara | 2014 | International Journal of Ophthalmology(English edition)2014，7，4： | 7 |
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