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| 1 | Anti-inflammatory mechanisms of the novel cytokine interleukin-38 in allergic asthma显示文摘We elucidated the anti-inflammatory mechanisms of IL-38 in allergic asthma.Human bronchial epithelial cells and eosinophils were cocultured upon stimulation with the viral RLR ligand poly(I:C)/LyoVec or infection-related cytokine TNF-αto induce expression of cytokines/chemokines/adhesion molecules.House dust mite(HDM)-induced allergic asthma and humanized allergic asthma NOD/SCID murine models were established to assess anti-inflammatory mechanisms in vivo.IL-38 significantly inhibited induced proinflammatory IL-6,IL-1β,CCL5,and CXCL10 production,and antiviral interferon-βand intercellular adhesion molecule-1 expression in the coculture system.Mass cytometry and RNA-sequencing analysis revealed that IL-38 could antagonize the activation of the intracellular STAT1,STAT3,p38 MAPK,ERK1/2,and NF-κB pathways,and upregulate the expression of the host defense-related gene POU2AF1 and anti-allergic response gene RGS13.Intraperitoneal injection of IL-38 into HDM-induced allergic asthma mice could ameliorate airway hyperreactivity by decreasing the accumulation of eosinophils in the lungs and inhibiting the expression of the Th2-related cytokines IL-4,IL-5,and IL-13 in the bronchoalveolar lavage fluid(BALF)and lung homogenates.Histological examination indicated lung inflammation was alleviated by reductions in cell infiltration and goblet cell hyperplasia,together with reduced Th2,Th17,and innate lymphoid type 2 cell numbers but increased proportions of regulatory T cells in the lungs,spleen,and lymph nodes.IL-38 administration suppressed airway hyperreactivity and asthma-related IL-4 and IL-5 expression in humanized mice,together with significantly decreased CCR3^(+) eosinophil numbers in the BALF and lungs,and a reduced percentage of human CD4^(+)CRTH2^(+)Th2 cells in the lungs and mediastinal lymph nodes.Together,our results demonstrated the anti-inflammatory mechanisms of IL-38 and provided a basis for the development of a regulatory cytokine-based treatment for allergic asthma. | Xiaoyu Sun Tianheng Hou Edwin Cheung Tiffany Nga-Teng Iu Victor Wai-Hou Tam Ida Miu-Ting Chu Miranda Sin-Man Tsang Paul Kay-Sheung Chan Christopher Wai-Kei Lam Chun-Kwok Wong | 2020 | Cellular & Molecular Immunology2020，17，6： | 22 |
| 2 | Would integrated Western and traditional Chinese medicine have more benefits for stroke rehabilitation? A systematic review and meta-analysis显示文摘Background Stroke is a major cause of death or long-term disability worldwide.Many patients with stroke receive integrative therapy consisting of Western medicine(WM)and routine rehabilitation in conjunction with Chinese medicine(CM),such as acupuncture and Chinese herbal medicine.However,there is no available evidence on the effectiveness of the combined use of WM and CM interventions in stroke rehabilitation.Aims The purpose of this meta-analysis is to evaluate the results of all individual studies to assess the combined use of CM and WM in stroke rehabilitation compared with WM only.Methods The Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines were followed.MEDLINE,EMBASE,Cochrane and China National Knowledge Infrastructure(CNKI)were searched.The included outcomes were dependency,motor function,depression and swallowing function.Subgroup analysis was performed,and publication bias was assessed using funnel plots.Summary of review 58 studies and 6339 patients were included in the meta-analysis.Subgroup analysis revealed that combined therapy comprising both acupuncture and WM had a superior effect on improving dependency and swallowing function compared with standard WM therapy alone.Potential superiority of combined therapy comprising CM and WM in improving depression compared with standard WM therapy was also found.Conclusions Our results indicate that the combined use of CM and WM could be more efficacious in stroke rehabilitation compared with the use of WM therapy alone.However,most studies were short in duration(2 to 4 weeks)and prone to different types of biases,which prevents making any conclusion regarding the long-term effects and raises concerns regarding true efficacy in context of high likelihood of Hawthorn bias.So,more randomised controlled trials with more rigorous design and longer duration of treatment and follow-up need to be conducted to compare WM alone versus WM and CM combined. | Linda LD Zhong Ya Zheng Alexander Y Lau Norman Wong Liang Yao Xingyao Wu Tengteng Shao Zhenxing Lu Huijuan Li Chun Sum Yuen Jianwen Guo Suzanne Lo Janita Chau Kam Wa Chan Bacon Fung Leung Ng Zhaoxiang Bian Edwin Chau-leung Yu | 2022 | Stroke & Vascular Neurology2022，7，1： | 7 |
| 3 | Clinicopathological survey of 23 patients with lacrimal fossa lesions in Hong Kong显示文摘AIM: To survey the clinicopathological correlations of lacrimal fossa lesions in the Hong Kong population.METHODS: A total of 23 patients with lacrimal fossa lesions were identified radiologically.The mean age at the time of diagnosis was 52 year-old.The medical records of patients diagnosed with lacrimal fossa lesions and subsequently underwent radiological investigations were collected and reviewed retrospectively throughout a six years period from 2000 to 2006 from three regional hospitals (Tung Wah Eastern Hospital,Pamela Youde Nethersole Eastern Hospital and Queen Mary Hospital) belonging to the Hong Kong Mega Cluster.Patient demographics,presenting signs and symptoms,imaging modalities,pathological reports and subsequent management were recorded.RESULTS: The most common initial presenting symptom was upper lid swelling (83%) followed by proptosis (13%).19 patients (83%) had benign lacrimal fossa lesion and 4 patients (17%) had malignancy.Three of the malignancies were lymphomas and one was adenoid cystic carcinoma.CONCLUSION: Age is an important factor in considering the differential diagnosis of lacrimal fossa lesion.Lymphoproliferative diseases have the highest incidence in patients over 60 years of age while inflammatory lesions are more common in younger patients in Hong Kong. | Danny Siu-Chun Ng Edwin Chan Kin Yau Clement Wai-Nang Chan | 2011 | International Journal of Ophthalmology(English edition)2011，4，3： | 3 |
| 4 | Cystic meconium peritonitis with jejunoileal atresia:Is it associated with unfavorable outcome?显示文摘AIM To compare the outcome between patients with jejunoileal atresia(JIA) associated with cystic meconium peritonitis(CMP) and patients with isolated JIA(JIA without CMP).METHODS A retrospective study was conducted for all neonates with JIA operated in our institute from January 2005 to January 2016.Demographics including the gestation age,sex,birth weight,age at operation,the presence of associated syndrome was recorded.Clinical outcome including the type of operation performed,operative time,the need for reoperation and mortality were studied.The demographics and the outcome between the 2 groups were compared.RESULTS During the study period,53 neonates had JIA underwent operation in our institute.Seventeen neonates(32%) were associated with CMP.There was no statistical difference on the demographics in the two groups.Patients with CMP had earlier operation than patients with isolated JIA(mean 1.4 d vs 3 d,P = 0.038).Primaryanastomosis was performed in 16 patients(94%) with CMP and 30 patients(83%) with isolated JIA(P = 0.269).Patients with CMP had longer operation(mean 190 min vs 154 min,P = 0.004).There were no statistical difference the need for reoperation(3 vs 6,P = 0.606) and mortality(2 vs 1,P = 0.269) between the two groups.CONCLUSION Primary intestinal anastomosis can be performed in94% of patients with JIA associated with CMP.Although patients with CMP had longer operative time,the mortality and reoperation rates were low and were comparable to patients with isolated JIA. | Kin Wai Edwin Chan Kim Hung Lee Hei Yi Vicky Wong Siu Yan Bess Tsui Yuen Shan Wong Kit Yi Kristine Pang Jennifer Wai Cheung Mou Yuk Him Tam | 2017 | World Journal of Clinical Pediatrics2017，6，1： | 3 |
| 5 | Laparoscopic excision of Meckel's diverticulum in children:What is the current evidence?显示文摘Complications aroused from Meckel's diverticulum tend to developed in children.Children presented with abdominal pain,intestinal obstruction,intussusception or gastrointestinal bleeding may actually suffered from complicated Meckel's diverticulum.With the advancement of minimally invasive surgery(MIS) in children,the use of laparoscopy in the diagnosis and subsequent laparoscopic excision of Meckel's diverticulum has gained popularity.Recently,single incision laparoscopic surgery(SILS) has emerged as a new technique in minimally invasive surgery.This review offers the overview in the development of MIS in the management of children suffered from Meckel's diverticulum.The current evidence in different laparoscopic techniques,including conventional laparoscopy,SILS,the use of special laparoscopic instruments,intracorporeal diverticulectomy and extracorporeal diverticulectomy in the management of Meckel's diverticulum in children were revealed. | Kin Wai Edwin Chan Kim Hung Lee Hei Yi Vicky Wong Siu Yan Bess Tsui Yuen Shan Wong Kit Yi Kristine Pang Jennifer Wai Cheung Mou Yuk Him Tam | 2014 | World Journal of Gastroenterology2014，20，41： | 2 |
| 6 | A study of circulating interleukin 10 in prognostication of unresectable hepatocellular carcinoma显示文摘 | Stephen L. Chan Frankie K. F. Mo Cesar S. C. Wong Charles M. L. Chan Linda K. S. Leung Edwin P. Hui Brigette B. Ma Anthony T. C. Chan Tony S. K. Mok Winnie Yeo | 2011 | Cancer2011，，16： | 2 |
| 7 | Use of laparoscopy as the initial surgical approach of impalpable testes:10-year experience显示文摘AIM: To review the experience in the management of impalpable testes using laparoscopy as the initial approach and the need for inguinal exploration.METHODS: From January 2004 to June 2014, 339 patients with undescended testes underwent operation in our institute. Fifty patients(15%) had impalpable testes. All children with impalpable testes underwent initial laparoscopy. A retrospective review was conducted on this group of patients and the outcome was analyzed.RESULTS: Forty children had unilateral impalpable testis. Ten children had bilateral impalpable testes. Thirty-one children(78%) in the unilateral group underwent subsequent inguinal exploration while 4 children(40%) in the bilateral group underwent inguinal exploration(P < 0.05). Orchidopexy was performed in 16 children(40%) in the unilateral group and 9 children(90%) in the bilateral group(P < 0.05). Regarding the 24 children with unilateral impalpable testis and underwent orchidectomy for testicular nubbin(n = 19) or atrophic testes(n = 2) or has vanishing testes(n = 3); contralateral testicular hypertrophy was noticed in 10(41%). No intra-operative complication was encountered. Two children after staged Fowler-Stephensprocedure and 1 child after inguinal orchidopexy had atrophic testes.CONCLUSION: The use of laparoscopy in children with impalpable testes is a safe procedure and can guide the need for subsequent inguinal exploration. Children with unilateral impalpable testis were associated with an increased need for inguinal exploration after laparoscopy. Orchidopexies could be performed successfully in 90% of children with bilateral impalpable testes. | Kin Wai Edwin Chan Kim Hung Lee Hei Yi Vicky Wong Siu Yan Bess Tsui Yuen Shan Wong Kit Yi Kristine Pang Jennifer Wai Cheung Mou Yuk Him Tam | 2015 | World Journal of Clinical Pediatrics2015，4，4： | 2 |
| 8 | MAUT-Based dispute resolution selection model prototype for international construction projects显示文摘 | Edwin H W Chan Henry C H Suen Charles K L Chan | 2006 | Journal of Construction Engineering and Management2006，132，5： | 1 |
| 9 | Predicting Performance of Design - Build and Design - Bid - Build Projects 显示文摘 | LING FLORENCE YEAN YNG SWEE LEAN CHAN EDWIN CHONG | 2004 | Journal of construction engineering and management2004，7583，： | 1 |
| 10 | Prognostic significance of the total dose of cisplatin administered during concurrent chemoradiotherapy in patients with locoregionally advanced nasopharyngeal carcinoma显示文摘 | Herbert H. Loong Brigette B.Y. Ma Sing-Fai Leung Frankie Mo Edwin P. Hui Michael K. Kam Stephen L. Chan Brian K.H. Yu Anthony T.C. Chan | 2012 | Radiotherapy and Oncology2012，，3： | 1 |
| 11 | Green tea cattechins and broccoli reduce fat-induced mortality in Drosophila melanogaster显示文摘 | Yuk ManLi Ho Yin Edwin Chan Xiao QIang Yao etal | 2008 | Journal of nutritional biochemistry2008，19，6： | 1 |
| 12 | Pre dicting Performanee of Design-Build and Design-Bid-Build Projeers 显示文摘 | Florence Yean Yng Ling Swee Lean Chan Edwin Chong | 2004 | Journal of Construction Engineering and Management2004，，2： | 1 |
| 13 | Blueberry extract prolongs lifespan of Drosophila melanogaster显示文摘 | Cheng Peng Yuanyuan Zuo Kin Ming Kwan Yintong Liang Ka Ying Ma Ho Yin Edwin Chan Yu Huang Hongjian Yu Zhen-Yu Chen | 2011 | Experimental Gerontology2011，，2： | 1 |
| 14 | The Analytic Hierarchy Process (AHP) Approach for Assessment of Urban Renewal Pro- posal 显示文摘 | Grace K L Lee Edwin H W Chan | 2008 | Soc Indic Res2008，，89： | 1 |
| 15 | Is the Development Control Legal Framework Conducive to a Sustainable Dense Urban Development in Hong Kong?显示文摘 | Chan Edwin H W Yung Esther H K | 2004 | Habitat International2004，28，3： | 1 |
| 16 | Factors affecting buildability of building fesigns显示文摘 | PatrickT I Lain Edwin H W Chan Franky W H Wong | | 0，，07： | 1 |
| 17 | Coexpression of hypoxia - inducible factors 1 α and 2α, carbonic anhydrase IX, and vascular endothelial growth factor in nasopharyngeal carcinoma and relationship to survival 显示文摘 | Edwin P Hui Anthony TC Chan Franeesco Pezzella | 2002 | Clin Cancer Res2002，8，8： | 1 |
| 18 | Success factors of energy performance contracting (EPC) for sustainable building energy efficiency retrofit (BEER) of hotel buildings in China显示文摘 | Pengpeng Xu Edwin Hon-Wan Chan Queena Kun Qian | | 0，，39： | 1 |
| 19 | Syringe Siliconization Process Investigation and Optimization 显示文摘 | Edwin Chan Aaron Hubbard Samir Sane | 2012 | PDA J Pharm Sci Tech2012，，66： | 1 |
| 20 | The analytic hierarchy process (AHP) approach for assessment of urban renewalproposals 显示文摘 | Grace K L Lee Edwin H W Chan | 2008 | Social Indicators Research2008，，89： | 1 |
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