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| 1 | Liver fat deposition and mitochondrial dysfunction in morbid obesity:An approach combining metabolomics with liver imaging and histology显示文摘AIM: To explore the usefulness of magnetic resonance imaging(MRI) and spectroscopy(MRS) for assessment of non-alcoholic fat liver disease(NAFLD) as compared with liver histological and metabolomics findings. METHODS: Patients undergoing bariatric surgery following procedures involved in laparoscopic sleeve gastrectomy were recruited as a model of obesityinduced NAFLD in an observational, prospective, singlesite, cross-sectional study with a pre-set duration of 1 year. Relevant data were obtained prospectively and surrogates for inflammation, oxidative stress and lipid and glucose metabolism were obtained through standard laboratory measurements. To provide reliable data from MRI and MRS, novel procedures were designed to limit sampling variability and other sources of error using a 1.5T Signa HDx scanner and protocols acquired from the 3D or 2D Fat SAT FIESTA prescription manager. We used our previously described 1H NMRbased metabolomics assays. Data were obtained immediately before surgery and after a 12-mo period including histology of the liver and measurement of metabolites. Values from 1H NMR spectra obtained after surgery were omitted due to technical limitations.RESULTS: MRI data showed excellent correlation with the concentration of liver triglycerides, other hepatic lipid components and the histological assessment, w h i c h e xc l u d e d t h e p r e s e n c e o f n o n-a l c o h o l i c steatohepatitis(NASH). MRI was sufficient to follow up NAFLD in obese patients undergoing bariatric surgery and data suggest usefulness in other clinical situations. The information provided by MRS replicated that obtained by MRI using the-CH3 peak(0.9 ppm), the-CH2- peak(1.3 ppm, mostly triglyceride) and the-CH=CH- peak(2.2 ppm). No patient depicted NASH. After surgery all patients significantly decreased their body weight and steatosis was virtually absent even in patients with previous severe disease. Improvement was also observed in the serum concentrations of selected variables. The most relevant findings using metabolomics indicate increased levels of triglyceride and monounsaturated fatty acids in severe steatosis but those results were accompanied by a significant depletion of diglycerides, polyunsaturated fatty acids, glucose-6-phosphate and the ATP/AMP ratio. Combined data indicated the coordinated action on mitochondrial fat oxidation and glucose transport activity and may support the consideration of NAFLD as a likely mitochondrial disease. This concept may helpto explain the dissociation between excess lipid storage in adipose tissue and NAFLD and may direct the search for plasma biomarkers and novel therapeutic strategies. A limitation of our study is that data were obtained in a relatively low number of patients.CONCLUSION: MRI is sufficient to stage NAFLD in obese patients and to assess the improvement after bariatric surgery. Other data were superfluous for this purpose. | Nahum Calvo Raúl Beltrán-Debón Esther Rodríguez-Gallego Anna Hernández-Aguilera Maria Guirro Roger Mariné-Casadó Lidón Millá Josep M Alegret Fàtima Sabench Daniel del Castillo María Vinaixa Miguelàngel Rodríguez Xavier Correig Roberto García-álvarez Javier A Menendez Jordi Camps Jorge Joven | 2015 | World Journal of Gastroenterology2015，21，24： | 2 |
| 2 | Effect of ethylene concentration on quality parameters of fresh tomatoes stored using a carbon-heat hybrid ethylene scrubber显示文摘 | Domingo Martínez-Romero Fabián Guillén Salvador Castillo Pedro Javier Zapata Daniel Valero María Serrano | 2008 | Postharvest Biology and Technology2008，，2： | 1 |
| 3 | Inspiratory Muscle Training in Patients With COPD显示文摘 | Hildegard Sánchez Riera Teodoro Montemayor Rubio Francisco Ortega Ruiz Pilar Cejudo Ramos Daniel Del Castillo Otero Teresa Elias Hernandez Jose Castillo Gomez | 2001 | Chest2001，，3： | 1 |
| 4 | Using Logarithmic Mean Divisia Index to Analyze Changes in Energy Use and Carbon Dioxide Emissions in Mexico' s Iron and Steel Industry显示文摘 | CLAUDIA SHEINBAUM LETICIA OZAWA DANIEL CASTILLO | 2010 | Energy Economics2010，，： | 1 |
| 5 | Gastric volvulus after sleeve gastrectomy for morbid obesity显示文摘 | Daniel Del Castillo Déjardin Fàtima Sabench Pereferrer Mercè Hernàndez Gonzàlez Santiago Blanco Blasco Arantxa Cabrera Vilanova | 2012 | Surgery2012，，： | 1 |
| 6 | The addition of essential oils to MAP as a tool to maintain the overall quality of fruits显示文摘 | María Serrano Domingo Martínez-Romero Fabián Guillén Juan Miguel Valverde Pedro Javier Zapata Salvador Castillo Daniel Valero | 2008 | Trends in Food Science & Technology2008，，9： | 1 |
| 7 | Us- ing logarithmic mean divisia index to analyze changes in energy use and carbon dioxide emission in Mexico's iron and steel in- dustry显示文摘 | Claudia Sheinbaum Leticia Ozawa Daniel Castillo | 2010 | Energy Economics2010，32，6： | 1 |
| 8 | In vitro antifungal activity of plant extracts obtained with alternative organic solvents against Rhizoctonia solani Kühn显示文摘 | Francisco Castillo Daniel Hernández Gabriel Gallegos Martha Mendez Raúl Rodríguez Alfonso Reyes Cristóbal N. Aguilar | 2010 | Industrial Crops & Products2010，，3： | 1 |
| 9 | Long-term Changes in Leptin, Chemerin and Ghrelin Levels Following Different Bariatric Surgery Procedures: Roux-en-Y Gastric Bypass and Sleeve Gastrectomy显示文摘 | Ximena Terra Teresa Auguet Esther Guiu-Jurado Alba Berlanga Josep Maria Orellana-Gavaldà Mercè Hernández Fàtima Sabench Jose Antonio Porras Jordi Llutart Salomé Martinez Carmen Aguilar Daniel Castillo Cristóbal Richart | 2013 | Obesity Surgery2013，，11： | 1 |
| 10 | Using logarithmic mean Divisia index to analyze changes in energy use and carbon dioxide emissions in Mexico’s iron and steel industry显示文摘 | Claudia Sheinbaum Leticia Ozawa Daniel Castillo | 2010 | Energy Economics2010，，6： | 1 |
| 11 | Product Competence Exploitation and Ex- ploration Strategies: The Impact on New Product Performance Through Quality and Innovativeness显示文摘 | Francisco - jose Molina - castillo Daniel Jimenez - Jimenez Jose - Luis Munuera- Aleman | 2011 | Industrial Marketing Man- agement2011，40，7： | 1 |
| 12 | Complications during multiorgan retrieval and pancreas preservation显示文摘In pancreas transplantation, complications can arise at each step of the process,from the initial selection of donors and recipients through the surgical techniqueitself and the post-operative period, when lifelong immunosuppression isrequired. In the early steps, careful retrieval and preservation of the pancreas arecrucial for the viability of the organ and ultimate success of the transplant. Thepancreas is a low-flow gland, making it highly sensitive to transplantationconditions and presenting risk of pancreatitis due to periods of ischemia. The twogroups of donors - after brain death (DBD) or after cardiac arrest (DCD) - requiredifferent strategies of retrieval and preservation to avoid or reduce the risk ofcomplications developing during and after the transplantation. For DBD donortransplantation, multiorgan retrieval and cold preservation is the conventionaltechnique. Asystole donor (DCD) transplantation, in contrast, can benefit from thenewest technologies, such as hypothermic and especially normothermicpreservation machines (referred to as NECMO), to optimize organ preservation.The latter has led to an increase in the pool of donors by facilitating recuperationof organs for transplantation that would have been discarded otherwise. | Daniel Casanova Gonzalo Gutierrez Monica Gonzalez Noriega Federico Castillo | 2020 | World Journal of Transplantation2020，10，12： | 0 |
| 13 | Multiorgan retrieval and preservation of the thoracic and abdominal organs in Maastricht III donors显示文摘This editorial describes the indications and technical aspects of the simultaneous retrieval of thoracic and abdominal organs in Maastricht III donors as well as the preservation of such organs until their implantation. | Daniel Casanova Federico Castillo Eduardo Miñambres | 2022 | World Journal of Transplantation2022，12，5： | 0 |
| 14 | Pathological response to neoadjuvant therapy with chemotherapy vs chemoradiotherapy in stage III NSCLC-contribution of IASLC recommendations显示文摘BACKGROUND Neoadjuvant treatment(NT)with chemotherapy(Ch)is a standard option for resectable stage III(N2)NSCLC.Several studies have suggested benefits with the addition of radiotherapy(RT)to NT Ch.The International Association for the Study of Lung Cancer(IASLC)published recommendations for the pathological response(PHR)of NSCLC resection specimens after NT.AIM To contribute to the IASLC recommendations showing our results of PHR to NT Ch vs NT chemoradiotherapy(ChRT).METHODS We analyzed 67 consecutive patients with resectable stage III NSCLC with positive mediastinal nodes treated with surgery after NT Ch or NT ChRT between 2013 and 2020.After NT,all patients were evaluated for radiological response(RR)according to Response Evaluation Criteria in Solid Tumours criteria and evaluated for surgery by a specialized group of thoracic surgeons.All histological samples were examined by the same two pathologists.PHR was evaluated by the percentage of viable cells in the tumor and the resected lymph nodes.RESULTS Forty patients underwent NT ChRT and 27 NT Ch.Fifty-six(83.6%)patients underwent surgery(35 ChRT and 21 Ch).The median time from ChRT to surgery was 6 wk(3-19)and 8 wk(3-21)for Ch patients.We observed significant differences in RR,with disease progression in 2.5%and 14.8%of patients with ChRT and Ch,respectively,and partial response in 62.5%ChRT vs 29.6%Ch(P=0.025).In PHR we observed≤10%viable cells in the tumor in 19(54.4%)and 2 cases(9.5%),and in the resected lymph nodes(RLN)30(85.7%)and 7(33.3%)in ChRT and Ch,respectively(P=0.001).Downstaging was greater in the ChRT compared to the Ch group(80%vs 33.3%;P=0.002).In the univariate analysis,NT ChRT had a significant impact on partial RR[odds ratio(OR)12.5;95%confidence interval(CI):1.21-128.61;P=0.034],a decreased risk of persistence of cancer cells in the tumor and RLN and an 87.5%increased probability for achieving downstaging(OR 8;95%CI:2.34-27.32;P=0.001).CONCLUSION We found significant benefits in RR and PHR by adding RT to Ch as NT.A longer follow-up is necessary to assess the impact on clinical outcomes. | Diego Muñoz-Guglielmetti David Sanchez-Lorente Roxana Reyes Daniel Martinez Carmen Lucena Marc Boada Pilar Paredes Marta Parera-Roig Ivan Vollmer Joel Mases Roberto Martin-Deleon Sergi Castillo Mariana Benegas Silvia Muñoz Maria Mayoral Carla Cases Meritxell Mollà Francesc Casas | 2021 | World Journal of Clinical Oncology2021，12，11： | 0 |
| 15 | Pregnancy-related psychopathology:A comparison between pre-COVID-19 and COVID-19–related social restriction periods显示文摘BACKGROUND The coronavirus disease 2019(COVID-19)pandemic impacted in a still undefined way pregnant women’s mental health.There are reports of mood and affect changes in the general population and the suggestion that similar changes occur also in the pregnant population.The greater vulnerability of women during the COVID-19 restriction period may translate into a greater risk for mental disorders in the gestational period.We hypothesised that pregnant women in the prepandemic period would have less psychopathology and more psychological support than pregnant women during the pandemic restriction period.AIM To compare pregnant women for anxiety,prenatal depression,psychopathology,and social support before and after the awareness of the pandemic.METHODSWe administered to women willing to participate in their 2nd-3rd trimesters of pregnancy theEdinburgh Postnatal Depression Scale(EPDS),the State-Trait Anxiety Inventory Form Y(STAI-Y),and the Symptom CheckList-90-Revised(SCL-90R);we further collected sociodemographicvariables and explored women’s social support.The comparison was cross-sectional.The firstsample was termed nonCOVID-19 because data were gathered before the COVID-19 outbreak(January 2020-February 2020)was declared,and the second sample termed COVID-19 becauseparticipants were already subjected to the COVID-19-related restrictive measures(January 2021-February 2021).Since normal distribution was not met(Shapiro-Wilk test applied),we appliednonparametric Mann-Whitney’s U-test to compare psychometric tests.Ethical standards were met.RESULTSThe nonCOVID-19 group reported higher support from partners only,while the COVID-19 groupreported multiple support(χ^(2)=9.7181;P=0.021);the nonCOVID-19 group scored higher than theCOVID-19 group only on state anxiety among psychometric scales[STAI-Y1,nonCOVID-19median=39(95%CI:39.19-51.10)vs COVID-19 median=32(95%CI:30.83-38.90);Mann-Whitney’sU=117.5,P=0.00596].Other measures did not differ meaningfully between the two groups.Scoreson the EPDS,the state and trait subscales of the STAI-Y,and most SCL-90R subscales intercorrelatedwith one another.The anxiety component of the EPDS,EPDS-3A,correlated poorlywith other measures,while it was the Global Symptom Index of the SCL-90-R that correlated moststrongly with most measures.Our results are at odds with most literature and do not confirmincreased depression and anxiety rates in pregnant women during the pandemic.CONCLUSIONThe ability of pregnant women to deal with novel generalised threats involves mobilization ofinner resources.Increasing sources of social support may have produced anxiolysis in the COVID-19 sample. | Daniela Chieffo Carla Avallone Annamaria Serio Georgios Demetrios Kotzalidis Marta Balocchi Ilaria De Luca Daniele Hirsch Angela Gonsalez del Castillo Pierluigi Lanzotti Giuseppe Marano Lucio Rinaldi Antonio Lanzone Eugenio Mercuri Marianna Mazza Gabriele Sani | 2022 | World Journal of Clinical Cases2022，10，19： | 0 |
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