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| 1 | Clinical impact of confocal laser endomicroscopy in the management of gastrointestinal lesions with an uncertain diagnosis显示文摘AIM To evaluate the clinical impact of confocal laser endomicroscopy(CLE) in the diagnosis and management of patients with an uncertain diagnosis.METHODS A retrospective chart review was performed.Patients who underwent CLE between November 2013 and October 2015 and exhibited a poor correlation between endoscopic and histological findings were included.Baseline characteristics,indications,previous diagnostic studies,findings at the time of CLE,clinical management and histological results were analyzed.Interventions based on CLE findings were also analyzed.We compared the diagnostic accuracy of CLE and target biopsies of surgical specimens.RESULTS A total of 144 patients were included.Of these,51%(74/144) were female.The mean age was 51 years old.In all,41/144(28.4%) lesions were neoplastic(13 bile duct,10 gastric,8 esophageal,6 colonic,1 duodenal,1 rectal,1 ampulloma and 1 pancreatic).The sensitivity,specificity,positive predictive value,negative predictive value,and observed agreement when CLE was used to detect N-lesions were 85.37%,87.38%,72.92%,93.75% and 86.81%,respectively.Cohen's Kappa was 69.20%,thus indicating good agreement.Changes in management were observed in 54% of the cases.CONCLUSION CLE is a new diagnostic tool that has a significant clinical impact on the diagnosis and treatment of patients with uncertain diagnosis. | Carlos Robles-Medranda Maria Vargas Jesenia Ospina Miguel Puga-Tejada Manuel Valero Miguel Soria Gladys Bravo Carlos Robles-Jara Hannah Pitanga Lukashok | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，8： | 6 |
| 2 | Endoscopic ultrasound in oncology:An update of clinical applications in the gastrointestinal tract显示文摘An accurate staging is necessary to select the best treatment and evaluate prognosis in oncology. Staging usually begins with noninvasive imaging such ascomputed tomography, magnetic resonance imaging or positron emission tomography. In the absence of distant metastases, endoscopic ultrasound plays an important role in the diagnosis and staging of gastrointestinal tumors, being the most accurate modality for localregional staging. Its use for tumor and nodal involvement in pre-surgical evaluation has proven to reduce unnecessary surgeries. The aim of this article is to review the current role of endoscopic ultrasound in the diagnosis and staging of esophageal, gastric and colorectal cancer. | Manuel Valero Carlos Robles-Medranda | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，6： | 6 |
| 3 | Contractile effect of tachykinins on rabbit sma intestine显示文摘 | Marta Sofia VALERO Diego Santos FAGUNDES Laura GRASA Maria Pilar ARRUEBO Miguel Angel PLAZA Maria Divina MURILLO | 2011 | Acta Pharmacologica Sinica2011，32，4： | 5 |
| 4 | Cost-effectiveness of endoscopic ultrasound-guided coils plus cyanoacrylate injection compared to endoscopic cyanoacrylate injection in the management of gastric varices显示文摘BACKGROUND Cyanoacrylate(CYA)injection can be performed using a standard upper endoscopy technique or under endoscopic ultrasound(EUS)guidance alone or in combination with coils.There is little information available on the economic impact of these treatment methods.AIM To compare the cost-effectiveness of treating gastric varices by CYA injection via upper endoscopy vs coils plus CYA guided by EUS.METHODS This was an observational,descriptive,and retrospective study.Patients were allocated into two groups:A CYA group and coils plus CYA group.The baseline characteristics were compared,and a cost analysis was performed.RESULTS Overall,36 patients were included(19 in the CYA group and 17 in the coils+CYA group).All patients in the CYA group had acute bleeding.They underwent a higher mean number of procedures(1.47 vs 1,P=0.025),and the mean volume of glue used was 2.15 vs 1.65 mL,P=0.133.The coils+CYA group showed a higher technical success rate(100%vs 84.2%),with a complication rate similar to the CYA group.The majority of CYA patients required hospitalization,and although the mean total per procedure cost was lower(United States$1350.29 vs United States$2978),the mean total treatment cost was significantly different(United States$11060.89 for CYA vs United States$3007.13 for coils+CYA,P=0.03).CONCLUSION The use of EUS-guided coils plus cyanoacrylate is more cost-effective than cyanoacrylate injection when the total costs are evaluated.Larger,randomized trials are needed to validate the cost-effectiveness of the EUS-guided approach to treat gastric varices. | Carlos Robles-Medranda Joao Autran Nebel Miguel Puga-Tejada Roberto Oleas Jorge Baquerizo-Burgos Jesenia Ospina-Arboleda Manuel Valero Hannah Pitanga-Lukashok | 2021 | World Journal of Gastrointestinal Endoscopy2021，13，1： | 4 |
| 5 | Drag reduction via turbulent boundary layer flow control显示文摘Turbulent boundary layer control(TBLC) for skin-friction drag reduction is a relatively new technology made possible through the advances in computational-simulation capabilities,which have improved the understanding of the flow structures of turbulence.Advances in micro-electronic technology have enabled the fabrication of active device systems able to manipulating these structures.The combination of simulation,understanding and micro-actuation technologies offers new opportunities to significantly decrease drag,and by doing so,to increase fuel efficiency of future aircraft.The literature review that follows shows that the application of active control turbulent skin-friction drag reduction is considered of prime importance by industry,even though it is still at a low technology readiness level(TRL).This review presents the state of the art of different technologies oriented to the active and passive control for turbulent skin-friction drag reduction and contributes to the improvement of these technologies. | ABBAS Adel BUGEDA Gabriel FERRER Esteban FU Song PERIAUX Jacques PONS-PRATS Jordi VALERO Eusebio ZHENG Yao | 2017 | Science China(Technological Sciences)2017，60，9： | 4 |
| 6 | Laparoscopic versus open surgery for rectal cancer: results of a prospective multicentre analysis of 4,970 patients显示文摘 | J. Lujan G. Valero S. Biondo E. Espin P. Parrilla H. Ortiz | 2013 | Surgical Endoscopy2013，，1： | 3 |
| 7 | Natural products:Perspectives in the pharmacological treatment of gastrointestinal anisakiasis显示文摘Objective: To evaluate the activity of different natural products against L3 larvae of Anisakis type I. Methods: Information on investigations into the activity of natural products against the L3 larvae of Anisakis simplex was collected from scientific journals, books, theses and reports via a library and electronic search(using Pubmed, Scopus, Medline, Web of Science and Science Direct). The search terms included: natural products, medicinal plants, essential oils, terpenic derivatives, Anisakis, antinematodal activity. Results: In the literature reviewed numerous papers were found concerning the in vitro and in vivo activity against Anisakis type I of various natural products(plant extracts, essential oils and their major components). Analysis of the results showed that in vitro tests the Melaleuca alternifolia essential oil and the ar-turmerone isolated from Curcuma longa displayed the greatest activity. In vivo, the most active compound was perillaldehyde, the main component of Perilla frutescens essential oil. Conclusions: This study shows that some natural products exhibited promising antianisakis properties. | Valero A Romero MC Gómez-Mateos M Hierro I Navarro MC | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，8： | 2 |
| 8 | Modelling the growth boundaries of Staphylococcus aureus : Effect of temperature, pH and water activity显示文摘 | A. Valero F. Pérez-Rodríguez E. Carrasco J.M. Fuentes-Alventosa R.M. García-Gimeno G. Zurera | 2009 | International Journal of Food Microbiology2009，，1： | 2 |
| 9 | Quality improvement and extension of shelf life by 1 -methylcyclopropene in plum as affected by ripening stage at harvest显示文摘 | VALERO D MARTINEZ-ROMERO D VALVERDE J M | 2003 | Innovative Food Science and Emerging Technologies2003，4，： | 1 |
| 10 | Structural theory and thermoeconomic diagnosis:Part I on malfunction and dysfunction analysis显示文摘 | CESAR Torres ANTONIO Valero LUIS Serra | 2002 | Energy Conversion and Mana-gement2002，43，912： | 1 |
| 11 | A petri net approach for the design and analysis of Web Services Choreographies 显示文摘 | Valero V | 2009 | The Journal of Logic and Algebric Programming2009，78，： | 1 |
| 12 | Analysis of volatile components of manchego cheese by dynamic head-space followed by automatic thermal desorption GC-MS 显示文摘 | Villasenor M J L Valero E Sanz J | 2000 | Milchwissenschaft2000，55，7： | 1 |
| 13 | Primary chemotherapy with docetaxel for the management of breast cancer显示文摘 | Valero V | 2002 | Oncology (Huntingt)2002，16，66： | 1 |
| 14 | Software Trace Cache显示文摘 | Alex Ramirez Josep L Larriba-Pey Mato Valero | 2005 | IEEE Transaction on Computers2005，54，1： | 1 |
| 15 | Structural theory and thermoeconomic diagnosis显示文摘 | Cesar Tones Antonio Valero Luis Serra Javier Royo | 2002 | Energy Conversion and management2002，，： | 1 |
| 16 | The role of polyamines in the improvement of shelf life of fruits 显示文摘 | Valero D Martinez-romero D Serrano M | 2002 | Trends Food Sci Teehnol2002，13，： | 1 |
| 17 | Normo- thermic recirculation reduces primary graft dysfunction of kidneys obtained from non-heart-beating donors显示文摘 | Valero R Cabrer C Oppenheimer F | 2000 | Transpl Int2000，13，4： | 1 |
| 18 | Geotechnical properties of municipalsolid waste显示文摘 | Gabr MA Valero SN | | 0，，： | 1 |
| 19 | Randomized clinical trial comparing laparoseopie and open suegery in patients with rectal cancer 显示文摘 | Lujan J Valero G Hemandez Q | 2009 | Br J Surg2009，96，9： | 1 |
| 20 | Software Trace Cache显示文摘 | Alex Ramirez Josep L Larriba-Pey Mato Valero | 2005 | IEEE Transaction on Computers2005，54，1： | 1 |
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