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| 1 | Association between fundamental motor skills and physical activity in the early years:A systematic review and meta-analysis显示文摘Background:Physical activity(PA)in the early years is associated with a range of positive health outcomes.Fundamental motor skill(FMS)competence is associated with PA and is theorized to be driven by PA in the early years and vice versa in mid to late childhood.However,to date,no studies have meta-analyzed the association between PA and FMS in the early years.Methods:Six electronic databases were searched for articles published up to April 2019.Cross-sectional and longitudinal studies were included if they targeted children(ages 3-6 year)as the population of the study and assessed the association between objectively measured PA and FMS.Total FMS,total physical activity(TPA),and moderate-to-vigorous physical activity(MVPA)data were meta-analyzed using a random effects model.Results:We identified 24,815 titles and abstracts.In total,19 studies met the inclusion criteria,including 14 cross-sectional and 4 longitudinal studies,as well as 1 study with cross-sectional and longitudinal analysis.There was a significant but small positive association between FMS and MVPA(r=0.20,95%confidence interval(CI):0.13-0.26)and TPA(r=0.20,95%CI:0.12-0.28).Findings from longitudinal studies revealed that PA drives FMS in early childhood.Mediation was explored in 1 study,which found that perceived motor competence did not mediate the association between FMS and PA.Conclusion:Using a meta-analysis,this study is the first to show a positive association between FMS,MVPA,and TPA in the early years of childhood,suggesting that the association begins at an early age.Limited evidence from longitudinal studies supports the theory that PA drives FMS in the early years of childhood.More evidence is needed from large studies to track PA and FMS until mid to late childhood and to explore the mediators of this association. | Dan Jones Alison Innerd Emma L.Giles Liane B.Azevedo | 2020 | Journal of Sport and Health Science2020，9，6： | 6 |
| 2 | Recent advances in the diagnostic evaluation of pancreatic cystic lesions显示文摘Pancreatic cystic lesions(PCLs)are becoming more prevalent due to more frequent abdominal imaging and the increasing age of the general population.It has become crucial to identify these PCLs and subsequently risk stratify them to guide management.Given the high morbidity associated with pancreatic surgery,only those PCLs at high risk for malignancy should undergo such treatment.However,current diagnostic testing is suboptimal at accurately diagnosing and risk stratifying PCLs.Therefore,research has focused on developing new techniques for differentiating mucinous from non-mucinous PCLs and identifying high risk lesions for malignancy.Cross sectional imaging radiomics can potentially improve the predictive accuracy of primary risk stratification of PCLs at the time of detection to guide invasive testing.While cyst fluid glucose has reemerged as a potential biomarker,cyst fluid molecular markers have improved accuracy for identifying specific types of PCLs.Endoscopic ultrasound guided approaches such as confocal laser endomicroscopy and through the needle microforceps biopsy have shown a good correlation with histopathological findings and are evolving techniques for identifying and risk stratifying PCLs.While most of these recent diagnostics are only practiced at selective tertiary care centers,they hold a promise that management of PCLs will only get better in the future. | Devarshi R Ardeshna Troy Cao Brandon Rodgers Chidiebere Onongaya Dan Jones Wei Chen Eugene J Koay Somashekar G Krishna | 2022 | World Journal of Gastroenterology2022，28，6： | 3 |
| 3 | The world’s ten most feared fungi显示文摘An account is provided of the world’s ten most feared fungi.Within areas of interest,we have organized the entries in the order of concern.We put four human pathogens first as this is of concern to most people.This is followed by fungi producing mycotoxins that are highly harmful for humans;Aspergillus flavus,the main producer of aflatoxins,was used as an example.Problems due to indoor air fungi may also directly affect our health and we use Stachybotrys chartarum as an example.Not everyone collects and eats edible mushrooms.However,fatalities caused by mushroom intoxications often make news headlines and therefore we include one of the most poisonous of all mushrooms,Amanita phalloides,as an example.We then move on to the fungi that damage our dwellings causing serious anxiety by rotting our timber structures and flooring.Serpula lacrymans,which causes dry rot is an excellent example.The next example serves to represent all plant and forest pathogens.Here we chose Austropuccinia psidii as it is causing devastating effects in Australia and will probably do likewise in New Zealand.Finally,we chose an important amphibian pathogen which is causing serious declines in the numbers of frogs and other amphibians worldwide.Although we target the top ten most feared fungi,numerous others are causing serious concern to human health,plant production,forestry,other animals and our factories and dwellings.By highlighting ten feared fungi as an example,we aim to promote public awareness of the cost and importance of fungi. | Kevin D.Hyde Abdullah M.S.Al-Hatmi Birgitte Andersen Teun Boekhout Walter Buzina Thomas L.Dawson Jr. Dan C.Eastwood E.B.Gareth Jones Sybren de Hoog Yingqian Kang Joyce E.Longcore Eric H.C.McKenzie Jacques F.Meis Laetitia Pinson-Gadais Achala R.Rathnayaka Florence Richard-Forget Marc Stadler Bart Theelen Benjarong Thongbai Clement K.M.Tsui | 2018 | Fungal Diversity2018，，6： | 2 |
| 4 | Keeping vigilant about drug safety显示文摘 | Dan Jones | 2007 | Nature Reviews Drug Discovery2007，6，： | 1 |
| 5 | Exhaustion of the Frank–Starling mechanism in conscious dogs with heart failure induced by chronic coronary microembolization显示文摘 | Robert M. Gill Bonita D. Jones Angela K. Corbly Dan G. Ohad Gerald D. Smith George E. Sandusky Michael E. Christe Jie Wang Weiqun Shen | 2006 | Life Sciences2006，，6： | 1 |
| 6 | Wegener’s granulomatosis masquerading as pancreatic carcinoma显示文摘 | Kevin M. O’Neil Dan M. Jones J. Mark Lawson | 1992 | Digestive Diseases and Sciences1992，，5： | 1 |
| 7 | Mechanism of Activation of the RAF-ERK Signaling Pathway by Oncogenic Mutations of B-RAF显示文摘 | Paul T.C Wan Mathew J Garnett S.Mark Roe Sharlene Lee Dan Niculescu-Duvaz Valerie M Good Cancer Genome Project C.Michael Jones Christopher J Marshall Caroline J Springer David Barford Richard Marais | 2004 | Cell2004，，6： | 1 |
| 8 | Nature Reviews 显示文摘 | Dan Jones | 2007 | Drug Discover2007，，6： | 1 |
| 9 | CD4 +/CD56 + Hematodermic Tumor The Features of an Evolving Entity and Its Relationship to Dendritic Cells显示文摘 | Marco Herling Dan Jones | 2007 | American Society for Clinical Pathology2007，127，： | 1 |
| 10 | Clinical Characteristics and Outcome of Candida Keratitis显示文摘 | Regina L. Sun Dan B. Jones Kirk R. Wilhelmus | 2007 | American Journal of Ophthalmology2007，，6： | 1 |
| 11 | Mega events where business, sport and politics meet 显示文摘 | Jones Dan | 2003 | Sport business International2003，，79： | 1 |
| 12 | Epidermal growth factor receptor expression in follicular dendritic cells: a shared feature of follicular dendritic cell sarcoma and Castleman’s disease显示文摘 | Xiaoping Sun Kong-Chao Chang Lynne V Abruzzo Raymond Lai Anas Younes Dan Jones | 2003 | Human Pathology2003，，9： | 1 |
| 13 | Development of diagnostic markers for use in breeding potatoes resistant to Globodera pallida pathotype Pa2/3 using germplasm derived from Solanum tuberosum ssp. andigena CPC 2802显示文摘 | Claire Moloney Denis Griffin Peter W. Jones Glenn J. Bryan Karen McLean John E. Bradshaw Dan Milbourne | | 0，，： | 1 |
| 14 | Needle-free Biojector injection of a dengue virus type 1 DNA vaccine with human immunostimulatory sequences and the GM-CSF gene increases immunogenicity and protection from virus challenge in Aotus monkeys显示文摘 | Kanakatte Raviprakash Dan Ewing Monika Simmons Kevin R Porter Trevor R Jones Curtis G Hayes Richard Stout Gerald S Murphy | 2003 | Virology2003，，： | 1 |
| 15 | 新型减肥药蓄势待发显示文摘随着三种药物临床试验数据的公布,近几个月来肥胖治疗研究领域一片欣欣向荣。分别是Arena开发的lorcaserin,Virus开发的Qnexa(芬特明加托比酯)和Orexigen开发的Contrave(丁氨苯丙酮和纳曲酮)。三种药物都是通过影响食欲和饱腹感来减少食物摄入,但是机制不同(见表1)。 | Dan Jones Creaty | 2009 | 中国处方药2009，8，11： | 1 |
| 16 | Loss of SHP-1 tyrosine phosphatase expression correlates with the advanced stages of cutaneous T-cell lymphoma.显示文摘 | Agnieszka Witkiewicz Puthiyaveettil Raghunath Agnieszka Wasik Jacqueline M. Junkins-Hopkins Dan Jones Qian Zhang Niels Odum Mariusz A. Wasik | 2007 | Human Pathology2007，，3： | 1 |
| 17 | The Chemokine Receptor CXCR4 Is Required for the Retention of B Lineage and Granulocytic Precursors within the Bone Marrow Microenvironment显示文摘 | Qing Ma Dan Jones Timothy A Springer | 1999 | Immunity1999，，4： | 1 |
| 18 | The Chemokine Receptor CXCR4 Is Required for the Retention of B Lineage and Granulocytic Precursors within the Bone Marrow Microenvironment显示文摘 | Qing Ma Dan Jones Timothy A Springer | 1999 | Immunity1999，，4： | 1 |
| 19 | Boceprevir early-access for advanced-fibrosis/cirrhosis in Asia-pacific hepatitis C virus genotype 1 non-responders/relapsers显示文摘AIM:To examined the efficacy and safety of treatment with boceprevir,PEGylated-interferon and ribavirin(PR)in hepatitis C virus genotype 1(HCVGT1) PR treatmentfailures in Asia.METHODS:The Boceprevir Named-Patient Program provided boceprevir to HCVGT1 PR treatment-failures.Participating physicians were invited to contribute data from their patients:baseline characteristics,ontreatment responses,sustained virological response at week 12(SVR12),and safety were collected and analysed.Multivariate analysis was performed to determine predictors of response.RESULTS:150 patients were enrolled from Australia,Malaysia,Singapore and Thailand(Asians = 86,Caucasians = 63).Overall SVR12 was 61%(Asians= 59.3%,Caucasians = 63.5%).SVR12 was higher in relapsers(78%) compared with non-responders(34%).On-treatment responses predicted SVR,with undetectable HCVRNA at week 4,8 and 12 leading to SVR12 s of 100%,87%,and 82%respectively,and detectable HCVRNA at week 4,8 and 12,leading to SVR12 s of 58%,22%and 6%respectively.Asian patients were similar to Caucasian patients with regards to on-treatment responses.Patients with cirrhosis(n= 69) also behaved in the same manner with regards to on-treatment responses.Those with the IL28 B CC genotype(80%) had higher SVRs than those with the CT/TT(56%) genotype(P = 0.010).Multivariate analysis showed that TW8 and TW12 responses were independent predictors of SVR.Serious adverse events occurred in 18.6%:sepsis(2%),decompensation(2.7%) and blood transfusion(14%).Discontinuations occurred in 30.7%,with 18.6%fulfilling stopping rules.CONCLUSION:Boceprevir can be used successfully in PR treatment failures with a SVR12 > 80%if they have good on-treatment responses;however,discontinuations occurred in 30%because of virological failure or adverse events. | Wattana Sukeepaisarnjaroen Tri Pham Tewesak Tanwandee Saroja Nazareth Sam Galhenage Lindsay Mollison Leanne Totten Alan Wigg Rosalie Altus Anton Colman Brenda Morales Sue Mason Tracey Jones Nadine Leembruggen Vince Fragomelli Cheryl Sendall Richard Guan Dede Sutedja Soek Siam Tan Yock Young Dan Yin Mei Lee Widjaja Luman Eng Kiong Teo Yin Min Than Teerha Piratvisuth Seng Gee Lim | 2015 | World Journal of Gastroenterology2015，21，28： | 0 |
| 20 | CB1R类减肥药物研发受挫显示文摘以大麻素受体1阻滞剂作为减肥药物的计划被终止了,这类曾被寄予厚望的药物带着遗憾止步于此。如何汲取其中的教训,促进此后同类药物的开发,需要业界思考。 | Dan Jones 黄艳 | 2008 | 中国处方药2008，7，12： | 0 |
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