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| 1 | Microbiota transplantation: concept, methodology and strategy for its modernization显示文摘烘便的 microbiota 移植(FMT ) 在最近的年里成为了 biomedicine 和临床的药的一个研究焦点。从为不同疾病的 FMT 的临床的反应为与各种各样的混乱联系的 microbiota 主人相互作用提供了证据,包括 Clostridium 顽固感染,煽动性的肠疾病,糖尿病 mellitus,癌症,肝肝硬化, gutbrain 疾病和其它。为了讨论使用微生物从古老的中国治疗人的疾病到电流的经验,时代应该在向前移动标准化 FMT 并且完成更好的未来是重要的。这里,我们基于文学和州的专家观点从 FMT 考察 microbiota 移植的变化概念到选择 microbiota 移植, FMT 的方法论发展和 stepup FMT 策略。 | Faming Zhang Bota Cui Xingxiang He Yuqiang Nie Kaichun Wu Daiming Fan | 2018 | Protein & Cell2018，9，5： | 79 |
| 2 | Biological properties and clinical applications of berberine显示文摘Berberine,an isoquinoline alkaloid isolated from the Chinese herb Coptis chinens is and other Berber is plants,has a wide range of pharmacological properties.Berberine can be used to treat many diseases,such as cancer and digestive,metabolic,cardiovascular,and neurological diseases.Berberine has protective capacities in digestive diseases.It can inhibit toxins and bacteria,including Helicobac terpylo riprotect the intestinal epithelial barrier from injury,and ameliorate liver injury.Berberine also inhibits the proliferation of various types of cancer cells and impedes invasion and metastasis.Recent evidence has confirmed that berberine improves the efficacy and safety of chemoradiotherapies.In addition,berberine regulates glycometabolism and lipid metabolism,improves energy expenditure,reduces body weight,and alleviates nonalcoholic fatty liver disease.Berberine also improves cardiovascular hemodynamics,suppresses ischemic arrhythmias,attenuates the development of atherosclerosis,and reduces hypertension.Berberine shows potent neuroprotective effects,including antioxidative,antiapoptotic,and anti-ischemic.Furthermore,berberine exerts protective effects against other diseases.The mechanisms of its functions have been extensively explored,but much remains to be clarified.This article summarizes the main pharmacological actions of berberine and its mechanisms in cancer and digestive,metabolic,cardiovascular,and neurological diseases. | Danyang Song Jianyu Hao Daiming Fan | 2020 | Frontiers of Medicine2020，14，5： | 30 |
| 3 | Holistic integrative medicine: toward a new era of medical advancement显示文摘药遇到了为幸存,长寿,和健康在自然,社会,和环境与变化,以及与新人的探索联系的崭新的问题。同时,药的发展正在面对源于学科和医药知识的破碎的在部门上和专门化的挑战。构造对人的健康和疾病治疗更合适的一个新医药系统,整体的综合的药(他),它认为人的身体是一个整体的实体,有机性地在各种各样的临床的特长在每块医药地和最有效的惯例里集成最先进的知识和理论根据社会、环境、心理的条件修订并且调整。他是为药的未来发展的不可避免、必要的方向。在这篇文章,我们说明了他的涵义,他之间的差别和另外的医药概念,和最近的年里的他的实践。 | Daiming Fan | 2017 | Frontiers of Medicine2017，11，1： | 25 |
| 4 | DDIT4 promotes gastric cancer proliferation and tumorigenesis through the p53 and MAPK pathways显示文摘Background:Gastric cancer(GC)is one of the most common malignancies worldwide,particularly in China.DNA damage-inducible transcript 4(DDIT4)is a mammalian target of rapamycin inhibitor and is induced by various cellular stresses;however,its critical role in GC remains poorly understood.The present study aimed to investigate the poten-tial relationship and the underlying mechanism between DDIT4 and GC development.Methods:We used western blotting,real-time polymerase chain reaction,and immunohistochemical or immunoflu-orescence to determine DDIT4 expression in GC cells and tissues.High-content screening,cell counting kit-8 assays,colony formation,and in vivo tumorigenesis assays were performed to evaluate cell proliferation.Flow cytometry was used to investigate cell apoptosis and cell cycle distribution.Results:DDIT4 was upregulated in GC cells and tissue.Furthermore,downregulating DDIT4 in GC cells inhibited proliferation both in vitro and in vivo and increased 5-fluorouracil-induced apoptosis and cell cycle arrest.In contrast,ectopic expression of DDIT4 in normal gastric epithelial cells promoted proliferation and attenuated chemosensitivity.Further analysis indicated that the mitogen-activated protein kinase and p53 signaling pathways were involved in the suppression of proliferation,and increased chemosensitivity upon DDIT4 downregulation.Conclusion:DDIT4 promotes GC proliferation and tumorigenesis,providing new insights into the role of DDIT4 in the tumorigenesis of human GC. | Feng Du Lina Sun Yi Chu Tingyu Li Chao Lei Xin Wang Mingzuo Jiang Yali Min Yuanyuan Lu Xiaodi Zhao Yongzhan Nie Daiming Fan | 2018 | Cancer Communications2018，38，1： | 10 |
| 5 | Transjugular intrahepatic portosystemic shunt for portal vein thrombosis with symptomatic portal hypertension in liver cirrhosis显示文摘 | Guohong Han Xingshun Qi Chuangye He Zhanxin Yin Jianhong Wang Jielai Xia Zhiping Yang Ming Bai Xiangjie Meng Jing Niu Kaichun Wu Daiming Fan | 2010 | Journal of Hepatology2010，，： | 5 |
| 6 | Barriers and countermeasures in developing traditional Chinese medicine in Europe显示文摘繁体中文药(TCM ) 是汉语的唯一的文化财富之一;它在中国代表一个重要特征和保健原因的突出的优点。在这份报纸的数据是 fromWorld 健康组织,统计的中国局,中国知识基础结构,和 PubMed。在最近的年里, TCM 在欧洲建立了一个稳固的基础,它在立法,教育,研究,和国际交换做了大迈进,并且在大陆享受了一个广阔发展空格。现在, TCM 在欧洲正在拥抱崭新的发展机会。同时,生硬国际比赛形成严重威胁到瓷器 TCM 工业。与以方法的多重文化、法律、机构的挑战,以及才能缺乏, TCM 现在在欧洲正在面对许多困难。充分准备并且制定抓住机会的活跃、精力旺盛的步,我们应该关于在欧洲妨碍 TCM 开发的严肃的挑战有一幅清楚的图画。在海外市场的 TCM 发展从一项自发的贸易活动变了进政府领导并且由多重股东参予了的国家策略。我们应该在象 TCM 治疗,保健,教育,研究,文化,和工业开发那样的领域里做系统、全面、持续的推。最终的目标是把 TCM 带到全球市场并且允许他们在与现代医学一起保卫公共健康起一个作用。 | Yunfang Liu Zhiping Yang Jing Cheng Daiming Fan | 2016 | Frontiers of Medicine2016，10，3： | 4 |
| 7 | Transjugular intrahepatic portosystemic shunt in the treatment of Budd–Chiari syndrome: a critical review of literatures显示文摘 | Xingshun Qi Man Yang Daiming Fan Guohong Han | 2013 | Scandinavian Journal of Gastroenterology2013，，7： | 3 |
| 8 | The Prognostic and Chemotherapeutic Value of miR-296 in Esophageal Squamous Cell Carcinoma显示文摘 | Liu Hong Yu Han Hongwei Zhang Mengbin Li Taiqian Gong Li Sun Kaichun Wu Qingchuan Zhao Daiming Fan | 2010 | Annals of Surgery2010，，6： | 3 |
| 9 | Fecal microbiota transplantation through mid‐gut for refractory C rohn’s disease: Safety, feasibility, and efficacy trial results显示文摘 | Bota Cui Qiang Feng Honggang Wang Min Wang Zhaoyuan Peng Pan Li Guangming Huang Zheng Liu Ping Wu Zhining Fan Guozhong Ji Xin Wang Kaichun Wu Daiming Fan Faming Zhang | 2015 | J Gastroenterol Hepatol2015，，1： | 3 |
| 10 | Regulation of drug sensitivity of gastric cancer cells by human calcyclin-binding protein (CacyBP)显示文摘 | Yongquan Shi Wenhua Hu Fang Yin Li Sun Changjiang Liu Mei Lan Daiming Fan | 2004 | Gastric Cancer2004，，3： | 3 |
| 11 | Fish Consumption and Colorectal Cancer Risk in Humans: A Systematic Review and Meta-analysis显示文摘 | Shengjun Wu Bin Feng Kai Li Xia Zhu Shuhui Liang Xufeng Liu Shuang Han Biaoluo Wang Kaichun Wu Danmin Miao Jie Liang Daiming Fan | 2012 | The American Journal of Medicine2012，，6： | 2 |
| 12 | Multi-Agent Modeling and Simulation in the AI Age显示文摘With the rapid development of artificial intelligence(AI)technology and its successful application in various fields,modeling and simulation technology,especially multi-agent modeling and simulation(MAMS),of complex systems has rapidly advanced.In this study,we first describe the concept,technical advantages,research steps,and research status of MAMS.Then we review the development status of the hybrid modeling and simulation combining multi-agent and system dynamics,the modeling and simulation of multi-agent reinforcement learning,and the modeling and simulation of large-scale multi-agent.Lastly,we introduce existing MAMS platforms and their comparative studies.This work summarizes the current research situation of MAMS,thus helping scholars understand the systematic technology development of MAMS in the AI era.It also paves the way for further research on MAMS technology. | Wenhui Fan Peiyu Chen Daiming Shi Xudong Guo Li Kou | 2021 | Tsinghua Science and Technology2021，26，5： | 2 |
| 13 | MicroRNA-501 promotes HBV replication by targeting HBXIP显示文摘 | Jiang Jin Shanhong Tang Lin Xia Rui Du Huahong Xie Jiugang Song Rui Fan Qian Bi Zheng Chen Guitao Yang Jie Liu Yongquan Shi Daiming Fan | 2013 | Biochemical and Biophysical Research Communications2013，，： | 2 |
| 14 | Association of systemic inflammation and body mass index with survival in patients with resectable gastric or gastroesophageal junction adenocarcinomas显示文摘Objective:The systemic inflammation index and body mass index(BMI)are easily accessible markers that can predict mortality.However,the prognostic value of the combined use of these two markers remains unclear.The goal of this study was therefore to evaluate the association of these markers with outcomes based on a large cohort of patients with gastric cancer.Methods:A total of 2,542 consecutive patients undergoing radical surgery for gastric or gastroesophageal junction adenocarcinoma between 2009 and 2014 were included.Systemic inflammation was quantified by the preoperative neutrophil-to-lymphocyte ratio(NLR).High systemic inflammation was defined as NLR≥3,and underweight was defined as BMI<18.5 kg/m2.Results:Among 2,542 patients,NLR≥3 and underweight were common[627(25%)and 349(14%),respectively].In the entire cohort,NLR≥3 or underweight independently predicted overall survival(OS)[hazard ratio(HR):1.236,95%confidence interval(95%CI):1.069–1.430;and HR:1.600,95%CI:1.350–1.897,respectively]and recurrence-free survival(RFS)(HR:1.230,95%CI:1.054–1.434;and HR:1.658,95%CI:1.389–1.979,respectively).Patients with both NLR≥3 and underweight(vs.neither)had much worse OS(HR:2.445,95%CI:1.853–3.225)and RFS(HR:2.405,95%CI:1.802–3.209).Furthermore,we observed similar results in subgroup analyses according to pathological stage,age,and postoperative chemotherapy.Conclusions:Our results showed that preoperative elevated NLR and decreased BMI had a significant negative effect on survival.Underweight combined with severe inflammation could enhance prognostication.Taking active therapeutic measures to reduce inflammation and increase nutrition may help improve outcomes. | Xianchun Gao Yanan Pan Weili Han Caie Hu Chenchen Wang Ling Chen Yong Guo Yupeng Shi Yan Pan Huahong Xie Liping Yao Jianjun Yang Jianyong Zheng Xiaohua Li Xiaonan Liu Liu Hong Jipeng Li Mengbin Li Gang Ji Zengshan Li Jielai Xia Qingchuan Zhao Daiming Fan Kaichun Wu Yongzhan Nie | 2021 | Cancer Biology & Medicine2021，18，1： | 2 |
| 15 | Overexpressed CacyBP/SIP leads to the suppression of growth in renal cell carcinoma显示文摘 | Shiren Sun Xiaoxuan Ning Jie Liu Lili Liu Yu Chen Shuang Han Yanqi Zhang Jie Liang Kaichun Wu Daiming Fan | 2007 | Biochemical and Biophysical Research Communications2007，，4： | 2 |
| 16 | Transjugular intrahepatic portosystemic shunt in combination with or without variceal embolization for the prevention of variceal rebleeding: A meta‐analysis显示文摘 | Xingshun Qi Lei Liu Ming Bai Hui Chen Juan Wang Zhiping Yang Guohong Han Daiming Fan | 2014 | J Gastroenterol Hepatol2014，，4： | 2 |
| 17 | Occlusive portal vein thrombosis as a new marker of decompensated cirrhosis显示文摘 | Xingshun Qi Ming Bai Zhiping Yang Shanshan Yuan Cheng Zhang Guohong Han Daiming Fan | 2010 | Medical Hypotheses2010，，4： | 2 |
| 18 | MicroRNA-19a/b regulates multidrug resistance in human gastric cancer cells by targeting PTEN显示文摘 | Fang Wang Ting Li Bin Zhang Hong Li Qiong Wu Li Yang Yongzhan Nie Kaichun Wu Yongquan Shi Daiming Fan | 2013 | Biochemical and Biophysical Research Communications2013，，3： | 2 |
| 19 | Associations of Coagulation Factor V Leiden and Prothrombin G20210A Mutations With Budd–Chiari Syndrome and Portal Vein Thrombosis: A Systematic Review and Meta-analysis显示文摘 | Xingshun Qi Weirong Ren Valerio De Stefano Daiming Fan | 2014 | Clinical Gastroenterology and Hepatology2014，，： | 2 |
| 20 | Silencing of ER-resident oxidoreductase PDIA3 inhibits malignant biological behaviors of multidrug-resistant gastric cancer显示文摘Glycosylation is a common posttranslational modification of proteins,which plays a role in the malignant transformation,growth,progression,chemoresistance,and immune response of tumors.Disulfide isomerase family A3(PDIA3)specifically acts on newly synthesized glycoproteins to promote the correct folding of sugar chains.Studies have shown that PDIA3 participates in multidrug-resistant gastric cancer(MDR-GC).In this study,we performed western blot analysis and immunohistochemistry to identify PDIA3 expression.Cell proliferation was assessed by CCK-8 assay.Transwell assays were used to detect the migration and invasion abilities of cells.Immunoprecipitation coupled to mass spectrometry(IP-MS)analysis was employed to identify PDIA3-interacting proteins and the associated pathways in MDR-GC cells.Glycoprotein interactions and translocation were detected by immunofluorescence assay.The results showed that PDIA3 knockdown significantly inhibited the proliferation,invasion,and migration abilities of MDR-GC cells.Kyoto Encyclopedia of Genes and Genomes analysis of the IP-MS results showed that PDIA3 was closely associated with focal adhesion pathways in MDR-GC cells.Additionally,important components of focal adhesion pathways,including fibronectin-1(FN1)and integrinα5(ITGA5),were identified as pivotal PDIA3-binding glycoproteins.Knockdown of PDIA3 altered the cellular locations of FN1 and ITGA5,leading to abnormal accumulation.In conclusion,our results suggest that knockdown of PDIA3 inhibited the malignant behaviors of MDR-GC cells and influenced the translocation of FN1 and ITGA5. | Danyang Song Meng Guo Kaichu Wu Jianyu Hao Yongzhan Nie Daiming Fan | 2021 | Acta Biochimica et Biophysica Sinica2021，53，9： | 2 |
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