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| 1 | Gastroenterologist perceptions of faecal microbiota transplantation显示文摘AIM: To explore gastroenterologist perceptions towards and experience with faecal microbiota transplantation(FMT).METHODS: A questionnaire survey consisting of 17 questions was created to assess gastroenterologists' attitude towards and experience with FMT. This was anonymously distributed in hard copy format amongst attendees at gastroenterology meetings in Australia between October 2013 and April 2014. Basic descriptive statistical analyses were performed.RESULTS: Fifty-two clinicians participated. Twenty one percent had previously referred patients for FMT,8% more than once. Ninety percent would refer patients with Clostridium difficile infection(CDI) for FMT if easily available,37% for ulcerative colitis,13% for Crohn's disease and 6% for irritable bowel syndrome. Six percent would not refer any indication,including recurrent CDI. Eighty-six percent would enroll patients in FMT clinical trials. Thirty-seven percent considered the optimal mode of FMT administration transcolonoscopic,17% nasoduodenal,13% enema and 8% oral capsule. The greatest concerns regarding FMT were: 42% lack of evidence,12% infection risk,10% non infectious adverse effects/lack of safety data,10% aesthetic,10% lack of efficacy,4% disease exacerbation,and 2% inappropriate use; 6% had no concerns. Seventy seven percent believed there is a lack of accessibility while 52% had an interest in learning how to provide FMT. Only 6% offered FMT at their institution.CONCLUSION: Despite general enthusiasm,most gastroenterologists have limited experience with,or access to,FMT. The greatest concerns were lack of supportive evidence and safety issues. However a significant proportion would refer indications other than CDI for FMT despite insufficient evidence. These data provide guidance on where education and training are required. | Sudarshan Paramsothy Alissa J Walsh Thomas Borody Douglas Samuel Johan van den Bogaerde Rupert WL Leong Susan Connor Watson Ng Hazel M Mitchell Nadeem O Kaakoush Michael A Kamm | 2015 | World Journal of Gastroenterology2015，21，38： | 5 |
| 2 | Mental and physical symptoms associated with lower social support for patients with hepatitis C显示文摘AIM: To systematically examine the impact of the hepatitis C virus (HCV) diagnosis on patients' level of social support in a large-scale study. METHODS: Patients evaluated and treated for HCV in a tertiary referral center were enrolled in a cross-sectional study. Demographic data, functional and emotional status as measured by the Hospital Anxiety and Depression Scale (HAD) and the Sickness Impact Profile (SIP), severity of liver disease, mode of acquisition, and physical and psychiatric comorbidities were collected from patients or abstracted from the medical record. All participants completed a semi-structured interview, addressing questions of social support. RESULTS: A total of 342 patients (mean age 45.2 years; 37% women) were enrolled. Ninety-two (27%) patients described lower levels of support by family and friends. Nearly half of the participants (45%) noted the loss of at least one relationship due to the disease. Fears related to transmitting the disease (25%) were common and often associated with ignorance or even discrimination by others (19%). Nearly one fifth of the patients did not share information about their disease with others to avoid being stigmatized. Lower levels of social support were significantly associated with living alone, being unemployed, being excluded from antiviral therapy, having psychiatric comorbidities, contracting HCV through intravenous drug use, having high levels of anxiety and depression as measured by the HAD and negative mood state as measured by the SIP. Patients reporting lower levels of social support also noted more physical symptoms as measured by the SIP. CONCLUSION: Patients with hepatitis C often face significant social problems, ranging from social isolation to familial stress. The most common concerns reflect a limited insight of patients and their relatives and friends about the disease, the risk factors for its spread, and about potential consequences. Our data suggest that educational interventions targeting support persons and the stressors identified in our findings may lessen or alleviate the social strains patients with hepatitis C experience. | Julie A Blasiole Laura Shinkunas Douglas R LaBrecque Robert M Arnold Susan L Zickmund | 2006 | World Journal of Gastroenterology2006，12，29： | 5 |
| 3 | A Sustained Virologic Response Is Durable in Patients With Chronic Hepatitis C Treated With Peginterferon Alfa-2a and Ribavirin显示文摘 | Mark G. Swain Ming–Yang Lai Mitchell L. Shiffman W. Graham E. Cooksley Stefan Zeuzem Douglas T. Dieterich Armand Abergel Mário G. Pess?a Amy Lin Andreas Tietz Edward V. Connell Moisés Diago | 2010 | Gastroenterology2010，，5： | 3 |
| 4 | Quality in the technical performance of colonoscopy and the continuous quality improvement process for colonoscopy: recommendations of the U.S. Multi-Society Task Force on Colorectal Cancer显示文摘 | Douglas K Rex John H Bond Sidney Winawer Theodore R Levin Randall W Burt David A Johnson Lynne M Kirk Scott Litlin David A Lieberman Jerome D Waye James Church John B Marshall Robert H Riddell | 2002 | The American Journal of Gastroenterology2002，，6： | 3 |
| 5 | 14-day triple, 5-day concomitant, and 10-day sequential therapies for Helicobacter pylori infection in seven Latin American sites: a randomised trial显示文摘 | E Robert Greenberg Garnet L Anderson Douglas R Morgan Javier Torres William D Chey Luis Eduardo Bravo Ricardo L Dominguez Catterina Ferreccio Rolando Herrero Eduardo C Lazcano-Ponce María Mercedes Meza-Montenegro Rodolfo Pe?a Edgar M Pe?a Eduardo Salazar- | 2011 | The Lancet2011，，9790： | 2 |
| 6 | Potent vasodilator responses to human urotensin Ⅱ in human pulmonary and abdominal resistance arteries显示文摘 | Stirrat A Gallagher M Douglas S A | 2001 | Am J Physiol Heart Cire Physiol2001，280，2： | 2 |
| 7 | Label-retaining liver cancer cells are relatively resistant to sorafenib显示文摘 | Hong-Wu Xin Chenwi M Ambe Danielle M Hari Gordon W Wiegand Tyler C Miller Jin-Qiu Chen Andrew J Anderson Satyajit Ray John E Mullinax Tomotake Koizumi Russell C Langan Douglas Burka Michelle A Herrmann Paul K Goldsmith Alexander Stojadinovic Udo Rudloff S | 2013 | Gut2013，，12： | 2 |
| 8 | An equivalent linear finite element approach for the estimation of pile foundation stiffnesses 显示文摘 | Maragakis E A Douglas B M Abdel-Ghaffr S M | 1994 | Earthquake Eng Struct Dyn1994，23，： | 2 |
| 9 | Determination of extractable and bound condensed tannin concentrations in forage plants, protein concentrate meals and cereal grains显示文摘 | Terrill T H Rowan A M Douglas G B | 1992 | Journal of the Science of Food and Agriculture1992，58，3： | 1 |
| 10 | On the generation of trajectories for multiple UAVs in environments with obstacles显示文摘 | Armando A N Douglas G M Mado F M | 2010 | J of Intelligent and Robotic Systems Archive2010，57，4： | 1 |
| 11 | Combustion characteristics of coal in a mixture of oxygen and recycled flue gas显示文摘 | TAN Y CROISET E DOUGLAS M A THAMBIMUTHU K V | 2006 | Fuel2006，85，4： | 1 |
| 12 | Radiation-induced epigenetic DNA methylation modification of radiation-response pathways显示文摘 | Deborah A Antwih Kristina M Gabbara Wayne D Lancaster Douglas M Ruden Steven P Zielske | 2013 | Epigenetics2013，，8： | 1 |
| 13 | A role for endogenous endothelin-1 in neointima formation following rat carotid artery balloon angioplasty: antiproliferative effects of the non-peptide endothelin receptor antagonist 显示文摘 | VICKERY-CLARK L M STORER B L | 1994 | Circ Res1994，75，： | 1 |
| 14 | Selective ETA receptor antagonism with BQ-123 is insufficient to inhibit angioplasty induced neointima formation in the rat 显示文摘 | Douglas S A Vickery-Clark L M Louden C | 1995 | Cardiovasc Res1995，29，5： | 1 |
| 15 | A New Set of Type Curves Simplifies Well Test Analysis 显示文摘 | Bourdet D Whittle T M Douglas A A | 1983 | World Oil1983，5，： | 1 |
| 16 | Crown profile models based on branch attributes in coastal Douglas-fir显示文摘 | RANDY L R DOUGLAS A M | 1997 | For Ecol and Manage1997，96，： | 1 |
| 17 | Prevalence and sta-bility of social skill deficits schizophrenia 显示文摘 | Mueser K T Bellack A S Douglas M S | 1991 | Schizophr Res1991，5，2： | 1 |
| 18 | Laser desorption ionization ofpolycyclic aromatic hydrocarbons from glass surfaces with ion mobility spectrometry analysis显示文摘 | Young D Douglas K M Eiceman G A | | 0，，： | 1 |
| 19 | New venture survival: Ignorance,external shocks, and risk reduction strategies显示文摘 | Shepherd D A Douglas E J Shanley M | 2000 | Journal of Business Venturing2000，，： | 1 |
| 20 | Developing and Implementing Supply Partnerships 显示文摘 | Douglas M L Margaret A E John T G | 1996 | The International Journal of Logistics Management1996，7，2： | 1 |
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