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| 1 | Current research on pharmacologic and regenerative therapies for osteoarthritis显示文摘Osteoarthritis(OA)is a degenerative joint disorder commonly encountered in clinical practice,and is the leading cause of disability in elderly people.Due to the poor self-healing capacity of articular cartilage and lack of specific diagnostic biomarkers,OA is a challenging disease with limited treatment options.Traditional pharmacologic therapies such as acetaminophen,non-steroidal anti-inflammatory drugs,and opioids are effective in relieving pain but are incapable of reversing cartilage damage and are frequently associated with adverse events.Current research focuses on the development of new OA drugs(such as sprifermin/recombinant human fibroblast growth factor-18,tanezumab/monoclonal antibody againstβ-nerve growth factor),which aims for more effectiveness and less incidence of adverse effects than the traditional ones.Furthermore,regenerative therapies(such as autologous chondrocyte implantation(ACI),new generation of matrix-induced ACI,cell-free scaffolds,induced pluripotent stem cells(iPS cells or iPSCs),and endogenous cell homing)are also emerging as promising alternatives as they have potential to enhance cartilage repair,and ultimately restore healthy tissue.However,despite currently available therapies and research advances,there remain unmet medical needs in the treatment of OA.This review highlights current research progress on pharmacologic and regenerative therapies for OA including key advances and potential limitations. | Wei Zhang Hongwei Ouyang Crispin R Dass Jiake Xu | 2015 | Bone Research2015，3，4： | 9 |
| 2 | AN INVESTIGATION OF TURBULENT RECTANGULAR JET DISCHARGED INTO A NARROW CHANNEL WEAK CROSSFLOW显示文摘A computational investigation of the mean flow field of turbulent rectangular jets issuing into a narrow channel crossflow is presented. The length of the jet slot spans more than 55% of the crossflow channel bed, leaving a small clearance between the jet edge and sidewalls. A finite volume code employing the standard k-ε model is used to predict the mean, three-dimensional flow field. The mean flow field is investigated for two velocity ratios (6 and 9). Important flow features, such as the formation of different vortical structures and their characteristics owing to different values of the velocity ratio, are discussed. Some predicted results are compared with the experimental data reported in the literature. The predicted mean and turbulent flow properties are shown to be in good agreement with the experimental data. | PATHAK Manabendra DASS Anoop K. DEWAN Anupam | 2008 | Journal of Hydrodynamics2008，20，2： | 5 |
| 3 | The Molecular Pathogenesis of Osteosarcoma: A Review显示文摘 | Matthew L. Broadhead Jonathan C. M. Clark Damian E. Myers Crispin R. Dass Peter F. M. Choong H. Kovar | 2011 | Sarcoma2011，，： | 4 |
| 4 | 4-1BB signaling beyond T cells显示文摘Originally discovered as a T cell-activating molecule,4-1BB(CD137)is now also recognized as an activator of non-T cells,thus imparting a new dimension to its potential in vivo effects.4-1BB expression is seen on a variety of non-T cells including activated dendritic cells(DCs),monocytes,neutrophils,B cells and natural killer(NK)cells,and promotes their individual effector functions.The T cell-and non-T cell-activating ability of 4-1BB may be the basis of its powerful anti-cancer,anti-autoimmune and anti-viral effects.Here we discuss the consequence and importance of 4-1BB signaling in non-T cells.We consider its effects on immune regulation,and the distinct and/or overlapping pathways involved in these responses,as well as possible therapeutic applications. | Dass S Vinay Byoung S Kwon | 2011 | Cellular & Molecular Immunology2011，8，4： | 4 |
| 5 | Aerobic bacterial flora of the normal conjunctiva at high altitude area of Shimla Hills in India:a hospital based study显示文摘AIM:To study the normal aerobic conjunctival flora in lower to mid Himalayan region of Shimla Hills.METHODS:Samples from normal conjunctiva of 200 individuals above the age of 13 years who visited Indira Gandhi Medical College Hospital Shimla for refraction or cataract surgery were taken by anaesthetising the conjunctival sac with sterile 4% Xylocaine solution.Samples were obtained by gently rubbing lower fornix with a sterile cotton wool swab moistened with normal saline and keeping the eye lids wide apart to avoid contamination from lid margins.It was immediately inoculated in Brain Heart infusion and subjected to standard aerobic culture and identification techniques.RESULTS:Totally,72 eyes(36%) conjunctival sacs were sterile.Predominant aerobes isolated were Staphylococcus spp.in 120(60%) followed by Haemophilus in 16(8%),diphtheroids in 10(5%),and Escherichia coli(E.coli) in 4(2%).A single aerobe was isolated from 98 eyes(49%) while 30 eyes(15%) yielded more than 1 aerobe.Staphylococcus epidermidis(S.epidermidis) was the most common bacterium,found alone in 58 eyes(29%) and in combination with another aerobe in 30 eyes(15%),followed by Staphylococcus aureus(S.aureus) in 18(9%) and 10 eyes(5%) respectively.CONCLUSION:S.epidermidis is the most common commensal organism followed by Haemophilus species.diphtheroids occupied the third position which otherwise are found more abundantly in literature.Pathogens like S.aureus,Staphylococcus citreus and E.coli were also found.Therefore,preoperative administration of topical broad spectrum antibiotics is extremely important in prophylaxis against ocular infection.The variation in microflora of normal conjunctiva in this part of world can be attributed to geographical,climatic and ethnic characteristics of the population under study. | Sharma Parmeshri Dass Sharma Neelam Gupta Ravinder Kumar Singh Parul | 2013 | International Journal of Ophthalmology(English edition)2013，6，5： | 4 |
| 6 | Increased plasma malondialdehyde and fructosamine in anemic H pylori infected patients:Effect of treatment显示文摘AIM: To unravel the possible association of malon-dialdehyde (MDA) and fructosamine in anemic H pylori infected patients and to observe the alteration in MDA and fructosamine levels in these patients after treatment for one month.METHODS: Fructosamine, MDA and glucose were estimated in 22 anemic H pylori infected patients and 16 healthy controls. Hematological parameters were also evaluated in both the groups using Sysmex-K-100 automated cell counter. The H pylori infected patients were randomly divided into two groups. H pylori infected patients in GroupⅠreceived both iron supplementation and anti-H pylori therapy, while patients in Group Ⅱ received only iron supplementation. All the biochemical and hematological parameters were estimated after one month of treatment. RESULTS: In anemic H pylori infected patients, while MDA (5.41 ± 2.16 vs 2.26 ± 0.50; P < 0.05) and fructosamine (2.64 ± 0.93 vs 1.60 ± 0.35; P < 0.05) were significantly increased, iron (32.72 ± 14.93 vs 110.25 ± 26.58; P < 0.05), hemoglobin (6.9 ± 2.6 vs 12.66 ± 0.74; P < 0.05) and ferritin (28.82 ± 16.27 vs 140.43 ± 30.72; P < 0.05) levels were significantly decreased compared with the controls. With partial correlation analysis, fructosamine was found to have a significant positive correlation with MDA. In GroupⅠ, while MDA level decreased significantly (3.11 ± 1.73 vs 5.50 ± 2.46; P < 0.05), there was a significant increase in iron (84.09 ± 29.51 vs 36.09 ± 17.81; P < 0.05), hemoglobin (10.40 ± 1.11 vs 7.42 ± 1.90; P < 0.05) and ferritin (116.91 ± 63.34 vs 30.46 ± 17.81; P < 0.05) levels after one month. There was no significant change in the levels of fructosamine in groupⅠafter treatment. Similarly, no significant alterations were noted in the levels of MDA, fructosamine, hemoglobin or ferritin in Group Ⅱ patients after one month of treatment.CONCLUSION: An increased level of fructosamine and MDA was found in anemic H pylori infected patients. Present data supports the premise that lipid peroxides per se do play a role in the glycation of plasma proteins. Furthermore, the findings from this study indicate that treatment for both anemia and H pylori infections is required for lowering the levels of lipid peroxides in these patients. | G Vijayan RC Sundaram Zachariah Bobby Abdoul Hamide N Selvaraj N Rattina Dasse | 2007 | World Journal of Gastroenterology2007，13，5： | 4 |
| 7 | 频率医学睡眠对慢性失眠症的治疗作用显示文摘目的:探讨'频率医学睡眠'治疗慢性失眠症的疗效.方法:选取2019 年5-7 月在原乡奥伦达医学博物馆高端医学门诊就诊的慢性失眠症患者15 例作为研究对象,应用'频率医学睡眠',包括Healy微电刺激、睡眠扑满SleepBank、Tim-eWaver时光波量子仪多维干预及精油芳香疗愈.治疗1 周,治疗前后采用匹兹堡睡眠质量指数量表(PSQI)评定临床疗效.结果:PSQI睡眠质量分别为(2.17 ±0.58)和(1.33 ±0.65);睡眠时间分别为(1.58 ±0.90)和(0.67 ±0.49);匹兹堡问卷总分分别为(9.92 ±1.56)和(7.17 ±2.48),以上差异均具有统计学意义(P均<0.05).结论:频率医学睡眠能够改善慢性失眠症患者的睡眠质量、增加睡眠时间. | 曹彬彬 刘宇航 梁正贤 Durga Dass 王春梅 陈同欣 | 2020 | 世界睡眠医学杂志2020，7，1： | 3 |
| 8 | 两种草蛉对取食棉花的扶桑绵粉蚧的嗅觉反应(英文)显示文摘捕食性的普通草蛉Chrysoperla sp.(carnea group)和安平草蛉Mallada desjardinsi(Navas)(脉翅目:草蛉科)的寄主-生境定位取决于其觅食行为以及对各阶段释放的植物气味的行为反应。本研究调查了这两种交配的草蛉成虫以及取食棉花的扶桑绵粉蚧Phenacoccus solenopsis的反应,以便了解它们之间的三重营养关系。结果表明:草蛉雄虫和雌虫均能感受到棉花植株释放的绿叶挥发物;植株的各个阶段均可使捕食性昆虫和绵粉蚧定位。在受绵粉蚧为害的棉叶上饱和烃含量高,说明草蛉成虫的反应更为强烈;在植株受为害期和开花期释放捕食性昆虫,可提高田间捕食性昆虫的作用。这些结果提示有效的生物防治取决于捕食性昆虫在植株上的天然定殖能力以及对害虫的吞食能力。 | Sudhida GAUTAM Ashok Kumar SINGH Ram Dass GAUTAM | 2010 | 昆虫学报2010，53，5： | 3 |
| 9 | Absolute copy number differences of Y chromosomal genes between crossbred (Bos taurus×Bos indicus) and Indicine bulls显示文摘Background: The Y chromosome in mammal is paternally inherited and harbors genes related to male fertility and spermatogenesis. The unique intra-chromosomal recombination pattern of Y chromosome and morphological difference of this chromosome between Bos taurus and Bos indicus make it an ideal model for studying structural variation, especially in crossbred(Bos taurus × Bos indicus) bulls. Copy Number Variation(CNV) is a type of genomic structural variation that gives information complementary to SNP data. The purpose of this study was to find out copy number differences of four Y chromosomal spermatogenesis-related candidate genes in genomic DNA of crossbred and purebred Indicine bulls. Result: Four Y chromosomal candidate genes of spermatogenesis namely, sex determining gene on Y chromosome(SRY), DEAD box polypeptide 3-Y chromosome(DDX3Y), Ubiquitin specific peptidase 9, Y-linked(USP9Y), testis-specific protein on Y chromosome(TSPY) were evaluated. Absolute copy numbers of Y chromosomal genes were determined by standard curve-based quantitative real time PCR. Copy numbers of SRY and TSPY genes per unit amount of genomic DNA are higher in crossbred than Indicine bulls. However, no difference was observed in DDX3Y and USP9Y gene copy numbers between two groups. Conclusion: The present study demonstrates that the structural organization of Y chromosomes differs between crossbred and Indicine bulls which are reproductively healthy as observed from analysis of semen attributes. The absolute copy numbers of SRY and TSPY genes in unit mass of genomic DNA of crossbred bulls are significantly higher than Indicine bulls. No alteration in absolute copies of DDX3Y and USP9Y gene was found between the genome of crossbred and Indicine bulls. This study suggests that the DDX3Y and USP9Y are likely to be single copy genes in the genome of crossbred and Indicine bulls and variation in Y chromosome length between crossbred and Indicine bulls may be due to the copy number variation of SRY gene and TSPY array. | Ayan Mukherjee Gulshan Dass Jagan Mohanarao G Moloya Gohain Biswajit Brahma Tirtha Kumar Datta Sachinandan De | 2013 | Journal of Animal Science and Biotechnology2013，4，4： | 3 |
| 10 | 闭孔粉煤灰泡沫铝的应变速率敏感性(英文)显示文摘随着金属泡沫在工程应用中的增加,对它们在不同应变速率下的动态行为进行研究是有必要的。采用熔体发泡法制备闭孔粉煤灰泡沫铝,并对其在应变速率从700 s^(-1)增加到1950 s^(-1)时的应力—应变行为进行研究。使用商用有限元软件Abaqus/Explicit对分离式霍普金森压杆(SHPB)的数学模型进行模拟。实验和模拟结果证实了数学模型是可用的。研究了应变速率对抗压强度和能量吸收的影响,得到了多种应变率下的应力—应变曲线。结果表明,闭孔粉煤灰泡沫铝对应变速率是敏感的。 | Manmohan DASS GOEL VASANT A.MATSAGAR Anil K.GUPTA Steffen MARBURG | 2013 | Transactions of Nonferrous Metals Society of China2013，23，4： | 2 |
| 11 | Vitamin D enzymes (CYP27A1, CYP27B1, and CYP24A1) and receptor expression in non-melanoma skin cancer显示文摘The relationship between vitamin D metabolic enzymes (CYP27A1, CYP27B1, and CYP24A1) and vitamin D receptor (VDR) in nonmelanoma skin cancer (NMSC) development and progression is not entirely clear. However, several clinical studies and in vitro reports indicate a connection between vitamin D metabolic key players and NMSCs by demonstrating inhibitory effects on tumor cells and positive effects in skin cancer prevention of higher circulatory 25-hydroxyvitamin D [1]. Vitamin D synthesis is mediated via mitochondrial cytochrome P450 family hydroxylase enzymatic reactions: anabolic and catabolic hydroxylases (CYP27A1, CYP27B1, and CYP24A1). | Natalie Nemazannikova Gregory L. Blatch Crispin R. Dass Rodney Sinclair Vasso Apostolopoulos | 2019 | Acta Biochimica et Biophysica Sinica2019，51，4： | 2 |
| 12 | Investigating CH 4 and N 2 O emissions from eco-engineering wastewater treatment processes using constructed wetland microcosms显示文摘 | R. Inamori P. Gui P. Dass M. Matsumura K.-Q. Xu T. Kondo Y. Ebie Y. Inamori | 2006 | Process Biochemistry2006，，3： | 2 |
| 13 | Cellular uptake,distribution,and stability of 10-23 deoxyribozymes显示文摘 | Dass CR Saravolac EG Li Y Sun LQ | 2002 | Antisense Nucleic Acid Drug Dev2002，12，5： | 1 |
| 14 | Genome-wide transcriptomic analysis of cotton under drought stress reveal significant down-regulation of genes and pathways involved in fibre elongation and up-regulation of defense responsive genes显示文摘 | Kethireddy Venkata Padmalatha Gurusamy Dhandapani Mogilicherla Kanakachari Saravanan Kumar Abhishek Dass Deepak Prabhakar Patil Vijayalakshmi Rajamani Krishan Kumar Ranjana Pathak Bhupendra Rawat Sadhu Leelavathi Palakolanu Sudhakar Reddy Neha Jain Kasu N | 2012 | Plant Molecular Biology2012，，3： | 1 |
| 15 | Empyema thoracis: analysis of 150 cases from a teriatry care centre in North East India显示文摘 | Dass R Deak NM Barman H | 2011 | Indian J Pediatr2011，78，11： | 1 |
| 16 | Double Perovskites as Anode Materials for Solid-Oxide Fuel Cells显示文摘 | Huang Y H Dass R I Xing Z L | 2006 | Science2006，312，5771： | 1 |
| 17 | E-cadherin downregnlation at the infiltrating tumour front is associated with histological grade and stage in colorectal carcinoma of Malaysians显示文摘 | Dass SD Cheah PL Ong DB | 2015 | Malays J Pathol2015，37，1： | 1 |
| 18 | Growth hormone secretagogue receptors in rat and human gastrointestinal tract and the effects of ghrelin显示文摘 | DASS N B MUNONYARA M BASSIL A K | 2003 | Neuroscience2003，120，2： | 1 |
| 19 | Surgical treatment of canine transmissible venereal tumor-a retrospective study显示文摘 | Dass LL Sahay PN | 1989 | Indian Vet J1989，66，： | 1 |
| 20 | Osteosarcoma treatment:stateof the art显示文摘 | Ta HT Dass CR Choong PFM | 2009 | Cancer Metastasis Reviews2009，28，1： | 1 |
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