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| 1 | Constitutive renal Rel/nuclear factor-κB expression in Lewis polycystic kidney disease rats显示文摘AIM:To determine the temporal expression and pattern of Rel/nuclear factor(NF)-κB proteins in renal tissue in polycystic kidney disease(PKD). METHODS: The renal expression of Rel/NF-κB proteins was determined by immunohistochemistry, immunofluorescence and immunoblot analysis in Lewis polycystic kidney rats(LPK, a genetic ortholog of human nephronopthsis-9) from postnatal weeks 3 to 20. At each timepoint, renal disease progression and the mR NA expression of NF-κB-dependent genes(TNFa and CCL2) were determined. NF-κB was also histologicaly assessed in human PKD tissue.RESULTS: Progressive kidney enlargement in LPK rats was accompanied by increased renal cell proliferation and interstitial monocyte accumulation(peaking at weeks 3 and 10 respectively), and progressive interstitial fibrosis(with a smooth muscle actin and Sirius Red deposition significantly increased compared to Lewis kidneys from weeks 3 to 6 onwards). Rel/NF-κB proteins(phosphorylated-p105, p65, p50, c-Rel and RelB) were expressed in cystic epithelial cells(CECs) of LPK kidneys as early as postnatal week 3 and sustained until latestage disease at week 20. From weeks 10 to 20, nuclear p65, p50, Rel B and cytoplasmic IκBa protein levels, and TNFa and CCL2 expression, were upregulated in LPK compared to Lewis kidneys. NF-κB proteins were consistently expressed in CECs of human PKD. The DNA damage marker γ-H2AX was also identified in the CECs of LPK and human polycystic kidneys. CONCLUSION: Several NF-κB proteins are consistently expressed in CECs in human and experimental PKD. These data suggest that the upregulation of both the canonical and non-canonical pathways of NF-κB signaling may be a constitutive and early pathological feature of cystic renal diseases. | Michelle HT Ta Kristina G Schwensen David Liuwantara David L Huso Terry Watnick Gopala K Rangan | 2016 | World Journal of Nephrology2016，5，4： | 2 |
| 2 | Osteosarcoma treatment:stateof the art显示文摘 | Ta HT Dass CR Choong PFM | 2009 | Cancer Metastasis Reviews2009，28，1： | 1 |
| 3 | Osteosarcoma treatment: state of the art显示文摘 | Ta HT Dass CR Choong PF | 2009 | Cancer Metastasis Rev2009，28，12： | 1 |
| 4 | Micronutrients and pregnancy; effect of Sup- plementation on pregnancy and pregnancy outcomes : a Systematic review 显示文摘 | Zerfu TA Ayele HT | 2013 | Nutr J2013，12，： | 1 |
| 5 | Associated injuries in traumatic sternal fractures: a review of the National Trauma DataBank 显示文摘 | Oyetunji TA Jackson HT Obirieze AC | 2013 | Am Surg2013，79，7： | 1 |
| 6 | Micronutrients and pregnancy; effect of supplementation on pregnancy and pregnancy outcomes: a systematic review 显示文摘 | Zerfu TA Ayele HT | 2013 | Nutr J2013，31，12： | 1 |
| 7 | Injectable chitosan hydrogels for lo- calised cancer therapy 显示文摘 | Ta HT Dass CR Dunstan DE | 2008 | Journal of Controlled Release2008，126，： | 1 |
| 8 | Osteosarcoma treatment: state of the art 显示文摘 | Ta HT Dass CR Choong PF | 2009 | Cancer Metastasis Rev2009，28，12： | 1 |
| 9 | First-in-human phase I trial of two schedules of OSI-930, a novel multikinase inhibitor, incorporating translational proof-of-mechanism studies 显示文摘 | Yap TA Arkenau HT Camidge DR | 2013 | Clin Cancer Res2013，19，4： | 1 |
| 10 | A fatal case of propyl- thiouracil-induced ANCA-associated vasculitis resulting in rapidly progressive glomerulonephritis, acute hepatic failure, and cerebral angiitis显示文摘 | Khan TA Yin Luk FC Uqdah HT | 2015 | Clin Nephrol2015，83，5： | 1 |
| 11 | Osteosa'coma tr atmcm: state of the art显示文摘 | Ta HT Dass CR Choong PFM | 2009 | Cancer Metastasis Rev2009，28，12： | 1 |
| 12 | Osteosarcoma treatment:state of the art显示文摘 | Ta HT Dass CR Choong PF | | 0，，01： | 1 |
| 13 | Osteosarcoma treatment: state of the art 显示文摘 | Ta HT Dass CR Choong PF | 2009 | Cancer Metastasis Rev2009，28，12： | 1 |
| 14 | Osteosarcoma treatment:state of the art显示文摘 | Ta HT Dass CR Choong PFM | | 0，，01： | 1 |
| 15 | Multicenter trial of L-carnitine in maintenance hemodialysis patients显示文摘 | Ahmad S Robertson HT Golper TA | | 0，，： | 1 |
| 16 | Trial of earnitine in maintenance hemodialysis patients II clinicel and biochemical effect 显示文摘 | Ahmad S Robertson HT Gloper TA | 1990 | Kidney Int1990，38，： | 1 |
| 17 | Osteosarcoma treatment:state of the art显示文摘 | Ta HT Dass CR Choong PFM | | 0，，01： | 1 |
| 18 | Osteosarco- ma treatment: state of the art显示文摘 | Ta HT Dass CR Choong PF | 2009 | Cancer Metas- tasis Rev2009，28，12： | 1 |
| 19 | Prevalence and risk factors associated with HIV infection among men having sex with men in Ho Chi Minh City, Vietnam显示文摘 | Nguyen TA Nguyen HT Le GT | 2007 | AIDS Behav2007，12，3： | 1 |
| 20 | Associated in- juries in traumatic sternal fractures : a review of the Nation- al Trauma Data Bank 显示文摘 | Oyetunji TA Jackson HT Obirieze AC | 2013 | Am Surg2013，79，7： | 1 |
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