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| 1 | Is rectal indomethacin effective in preventing of post-endoscopic retrograde cholangiopancreatography pancreatitis?显示文摘AIM:To investigate the effectiveness of rectally administered indomethacin in the prophylaxis of post-endoscopic retrograde cholangiopancreatography(ERCP)pancreatitis and hyperamylasaemia in a multicentre study.METHODS:A prospective,randomised,placebocontrolled multicentre study in five endoscopic units was conducted on 686 patients randomised to receive a suppository containing 100 mg indomethacin,or an inert placebo,10-15 min before ERCP.Post-ERCP pancreatitis and hyperamylasaemia were evaluated 24 h following the procedure on the basis of clinical signs and laboratory parameters,and computed tomography/magnetic resonance imaging findings if required.RESULTS:Twenty-one patients were excluded because of incompleteness of their data or because of protocol violation.The results of 665 investigations were evaluated:347 in the indomethacin group and 318 in the placebo group.The distributions of the risk factors in the two groups did not differ significantly.Pancreatitis developed in 42 patients(6.3%):it was mild in34(5.1%)and severe in eight(1.2%)cases.Hyperamylaesemia occurred in 160 patients(24.1%).There was no significant difference between the indomethacin and placebo groups in the incidence of either postERCP pancreatitis(5.8%vs 6.9%)or hyperamylasaemia(23.3%vs 24.8%).Similarly,subgroup analysis did not reveal any significant differences between the two groups.CONCLUSION:100 mg rectal indomethacin administered before ERCP did not prove effective in preventing post-ERCP pancreatitis. | Zoltán Dbrnte Zoltán Szepes Ferenc Izbéki Judit Gervain László Lakatos Gyula Pécsi Miklós Ihász Lilla Lakner Erzsébet Toldy László Czakó | 2014 | World Journal of Gastroenterology2014，20，29： | 16 |
| 2 | Compared efficacy of preservation solutions on the outcome of liver transplantation:Meta-analysis显示文摘AIM To compare the effects of the four most commonly used preservation solutions on the outcome of liver transplantations.METHODS A systematic literature search was performed using MEDLINE, Scopus, EMBASE and the Cochrane Library databases up to January 31^(st), 2017. The inclusion criteria were comparative, randomized controlled trials(RCTs) for deceased donor liver(DDL) allografts with adult and pediatric donors using the gold standard University of Wisconsin(UW) solution or histidinetryptophan-ketoglutarate(HTK), Celsior(CS) and Institut Georges Lopez(IGL-1) solutions. Fifteen RCTs(1830 livers) were included; the primary outcomes were primary non-function(PNF) and one-year posttransplant graft survival(OGS-1). RESULTS All trials were homogenous with respect to donor and recipient characteristics. There was no statistical difference in the incidence of PNF with the use of UW, HTK, CS and IGL-1(RR = 0.02, 95%CI: 0.01-0.03, P = 0.356). Comparing OGS-1 also failed to reveal any difference between UW, HTK, CS and IGL-1(RR = 0.80, 95%CI: 0.80-0.80, P = 0.369). Two trials demonstrated higher PNF levels for UW in comparison with the HTK group, and individual studies described higher rates of biliary complications where HTK and CS were used compared to the UW and IGL-1 solutions. However, the meta-analysis of the data did not prove a statistically significant difference: the UW, CS, HTK and IGL-1 solutions were associated with nearly equivalent outcomes.CONCLUSION Alternative solutions for UW yield the same degree of safety and effectiveness for the preservation of DDLs, but further well-designed clinical trials are warranted. | Agnes Lilla Szilágyi Péter Mátrai Péter Hegyi Eszter Tuboly Daniella Pécz András Garami Margit Solymár Erika Pétervári Márta Balaskó Gábor Veres László Czopf Bastian Wobbe Dorottya Szabó Juliane Wagner Petra Hartmann | 2018 | World Journal of Gastroenterology2018，24，16： | 5 |
| 3 | Anxiety,depression,and quality of life in Parkinson's disease:the implications of multidisciplinary treatment显示文摘Anxiety and depression in Parkinson's disease(PD)reduce well-being of the patients.Emotional alterations influence motor skills and cognitive performance;moreover,they contribute significantly and independently to worsen rehabilitative treatment response.We investigated anxiety,depression,and quality of life in PD patients subjected to multidisciplinary rehabilitative training.The self-controlled study included 100 PD patients(49 males and 51 females with the mean age of 64.66 years)admitted to 60 days hospitalization rehabilitative program,between January 2017 and December 2018.Motor,cognitive,linguistic abilities,and functional independence were evaluated at admission(T0 baseline visit)and 60 days after(T1)the multidisciplinary rehabilitation including motor exercises,speech therapies,and cognitive intervention.The multidisciplinary rehabilitation improved functional status in PD patients and exerted its positive effects on mood,motor abilities,autonomy in the activities of daily life,perception of quality of life,cognitive performance and speech skills.Non-motor symptoms may worsen severe disability and reduce quality of life.They are often poorly recognized and inadequately treated.Nonetheless,multidisciplinary rehabilitative training represents an optimal strategy to improve disease management.The study was approved by Istituito di Ricovero e Cura a Carattere Scientifico(IRCCS)Centro Neurolesi'Bonino-Pulejo'Ethical Committee(approval No.6/2016)in June 2016. | Viviana Lo Buono Rosanna Palmeri Simona De Salvo Matteo Berenati Agata Greco Rosella Ciurleo Chiara Sorbera Vincenzo Cimino Francesco Corallo Placido Bramanti Silvia Marino Giuseppe Di Lorenzo Lilla Bonanno | 2021 | Neural Regeneration Research2021，16，3： | 5 |
| 4 | 德国柏林亚洲艺术博物馆藏克孜尔石窟壁画显示文摘20世纪初,德国考察队从克孜尔石窟揭取了大量壁画,其中的大部分现藏于德国柏林亚洲艺术博物馆。然而,考察队对这些壁画所出洞窟的记录存在一定错漏。近年,新疆龟兹研究院与德国柏林亚洲艺术博物馆合作,对该馆所藏克孜尔石窟壁画进行了深入调查,并通过实地考察与逐一核对,确认了大部分德藏克孜尔壁画所属的洞窟及原来所在的位置,为相关研究提供了便利。 | 赵莉 Lilla Russell-Smith Caren Dreyer Ines Buschmann 祁梅香 | 2015 | 文物2015，，6： | 4 |
| 5 | Collaboration for success:the value of strategic collaborations for precision medicine and biomarker discovery显示文摘Precision medicine aims to provide the precise treatment for the patient with the right dose at the right point of time.Biomarkers(BM)are vital for the identification of patients who would benefit the most from individualized treatment.In addition,they help to enable the prediction of prognosis,the detection of early therapeutic and adverse effects,and may serve as surrogate endpoints in clinical trials.BM are becoming essential tools to increase productivity in drug discovery and impressively enhance the way medicine is practiced.However,the identification,sufficient validation and implementation of such BM are challenging.This process requires expertise from different areas and high resource investments.Collaborations of different partners may be helpful to overcome these challenges.In the past decade,collaborations between diagnostics and pharmaceutical companies as well as industrial–academic collaborations have been increasingly pursued.Moreover,public funding may offer support and open new opportunities to form such consortia.Herein we give an overview of the different types of collaborations,their opportunities and challenges,and describe experiences in forming strategic partnerships with other companies. | Lilla Landeck Monika Lessl Joachim Reischl Andreas Busch Patricia Carrigan Matthias Gottwald Petra Reinke Khusru Asadullah | 2016 | Advances in Precision Medicine2016，1，1： | 3 |
| 6 | No association of the cytotoxic T-lymphocyte associated gene CTLA4 +49A/G polymorphisms with Crohn's disease and ulcerative colitis in Hungarian population samples显示文摘瞄准:当前的工作的目标细胞毒素的 T 淋巴细胞抗原是分析 +49A/G 的流行变体的在有 Crohn 的匈牙利病人的 4 基因(CTLA4 )?ˉs 疾病(CD ) 和 ulcerative (UC ) 。方法:有 CD 的 130 个无关的题目的一个总数并且 150 与 UC,和 170 匹配的控制是为单个核苷酸多型性(SNP ) 的 genotyped。遗传型被使用 PCR/RFLP 测试决定。结果:G 等位基因频率和 GG 遗传型的流行在 CD 组,是 38.1% 和 12.3%40.6% 和 18.6% 在 UC 病人,并且 37.4% 和 15.9% 在控制组分别地。结论:当前的学习的结果显示出 +49G SNP 的那辆马车在异质接合或不在匈牙利人口为 CD 或为 UC 在同型结合的形式授与风险任何一个。 | Lili Magyari Bernadett Faragó Judit Bene Katalin Horvatovich Lilla Lakner Márta Varga Mária Figler Beáta Gasztonyi Gyula Mózsik Béla Melegh | 2007 | World Journal of Gastroenterology2007，13，15： | 3 |
| 7 | Antioxidant potential,tannin and polyphenol contents of seed and pericarp of three Coffea species显示文摘Objective:To investigate the antioxidant activity,total phenolic and total tannin content of the pericarp and the seed of Coffea benghalensis(C.benghalensis) and Coffea liberica compared to Coffea arabica(C.arabica).Methods:The antioxidant potential,total tannin and polyphenol contents of the immature and mature seed and pericarp of C.benghalensis and Coffea liberica were quantified and compared to C.arabica.Enhanced chemiluminescence(ECL).2,2-diphenyl-1-picrylhydruzyl(DPPH).oxygen radical absorbance capacity,Folin-Ciocaltcau method and total tannin content assays were used.Results:Trolox equivalent(TE/g plant material) values obtained by ECL and DPPH methods showed loose correlation(r^2=0.587)while those measured by oxygen radical absorbance capacity assay were higher without correlation in each plant.A closer correlation was detected between the ECL method and the percentage antioxidant activity of the DPPH technique(r^2=0.610 7) in each species,however the immature pericarp of C.benghalensis showed much higher DPPH scavenging potential than was seen in the ECL assay.The immature pericarp of C.benghalensis expressed the highest tannin and polyphenol content,and a high polyphenol level was also detected in the immature seed of C.arabica.The immature pericarp of Bengal and Liberian coffees showed the largest amount of phenolic contents.Conclusions:The obtained data highlight the potential role of C.benghalensis as a new source of natural antioxidants and polyphenols compared to C.arabica. | va Brigitta Patay Nikolett Sali Tams Kszegi Rita Csepregi Viktória Lilla Blaz Tibor Sebastian Németh Tibor Németh Nóra Papp | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，4： | 3 |
| 8 | Interaction of the major inflammatory bowel disease susceptibility alleles in Crohn’s disease patients显示文摘AIM:To investigate the interaction of interleukin-23 receptor(IL23R)(rs1004819 and rs2201841),autophagy-related 16-like 1(ATG16L1)(rs2241880), caspase recruitment domain-containing protein 15 (CARD15)genes,and IBD5 locus in Crohn's disease(CD) patients. METHODS:A total of 315 unrelated subjects with CD and 314 healthy controls were genotyped.Interactions and specific genotype combinations of a total of eight variants were tested.The variants of IBD5locus(IGR2198a_1 rs11739135 and IGR2096a_1 rs12521868),CARD15(R702W rs2066845 and L1007fs rs2066847),ATG16L1(rs2241880)and IL23R (rs1004819,rs2201841)genes were genotyped by PCR-RFLP,the G908R(rs2066844)in CARD15 was determined by direct sequencing. RESULTS:The association of ATG16L1 T300A with CD was confirmed[P=0.004,odds ratio(OR)=1.69, 95%CI:1.19-2.41],and both IL23R variants were found to represent significant risk for the disease(P= 0.008,OR=2.05,95%CI:1.20-3.50 for rs1004819 AA;P<0.001,OR=2.97,95%CI:1.65-5.33 for rs2201841 CC).Logistic regression analysis of pairwise interaction of the inflammatory bowel disease (IBD)loci indicated that IL23R,ATG16L1,CARD15 and IBD5(IGR2198a_1)contribute independently to disease risk.We also analysed the specific combina- tions by pair of individual ATG16L1,IL23R rs1004819, rs2201841,IGR2198a_1,IGR2096a_1 and CARD15 genotypes for disease risk influence.In almost all cases,the combined risk of susceptibility pairs was higher in patients carrying two different risk-associated gene variants together than individuals with just one polymorphism.The highest OR was found for IL23R rs2201841 homozygous genotype with combination of positive CARD15 status(P<0.001,OR=9.15,95% CI:2.05-40.74). CONCLUSION:The present study suggests a cumulative effect of individual IBD susceptibility loci. | Veronika Csngei Luca Járomi EnikSáfrány Csilla Sipeky Lili Magyari Bernadett Faragó Judit Bene Noémi Polgár Lilla Lakner Patrícia Sarlós Márta Varga Béla Melegh | 2010 | World Journal of Gastroenterology2010，16，2： | 2 |
| 9 | Inflammation and oxidative stress caused might lead to left ventricular diastolic and hypertension by nitric oxide synthase uncoupling systolic dysfunction in patients with显示文摘 | Zsuzsanna Szelenyi Adam Fazakas Gabor Szenasi Melinda KiSS Narcis Tegze Bertalan CsabaFekete Eszter Nagy Imre Bodo Balint Nagy Attila Molvarec Attila Patocs Lilla Pepo Zoltan Prohatszka Andras Vereckei | 2015 | Journal of Geriatric Cardiology2015，12，1： | 2 |
| 10 | Genetic polymorphisms in DNA repair anddamage response genes and late normal tissue complications of radiotherapy for breast cancer显示文摘 | Chang-Claude J Ambrosone CB Lilla C | 2009 | BrJ Cancer2009，100，： | 1 |
| 11 | HeartWare third-generation implantable continuous flow pump as biventricular support: mid-term follow-up 显示文摘 | Antonio Loforte Paola Lilla Delia Monica Andrea Montalto | 2011 | Interactive CardioVascular and Thoracic Surgery2011，12，： | 1 |
| 12 | Exposure to environmen- tal tobacco smoke and the risk of colorectal cancer in a case-control study from Germany显示文摘 | Verla-Tebit E Lilla C Hoffmeister M | 2009 | Eur J Cancer Prey2009，18，1： | 1 |
| 13 | Determination of 'net carbohydrates' using high-performance anion exchange chromatography显示文摘 | LILLA Z SULLIVAN D ELLEFSON W | 2005 | Journal of AOAC International2005，88，3： | 1 |
| 14 | Formation of polycyclic aromatic hydrocarbons by ionizing radiations显示文摘 | Perez G Lilla E Cristalli A | 1986 | Chemosphere1986，15，： | 1 |
| 15 | Cryst Eng Comm 显示文摘 | Cahill C L Lilla D T Friseh M | 2007 | (9) :15-262007，，9： | 1 |
| 16 | Evaluation of transforming growth factor-betal (TGF- 1 )in type II diabetic patients with diabetic nephropathy 显示文摘 | Salwa I Lilla R | 2003 | Nephrol Dial Transplant2003，18，4： | 1 |
| 17 | Effects of galactomannan as carbon source on production of α-galactosidase by Thermomyces lanuginosus:fermentation,purification and partial characterization显示文摘 | LILLA S D NGUYEN Q D DOMINIKA D L | 2009 | Enzyme and Microbial Technology2009，45，5： | 1 |
| 18 | Ra- diation-induced crosslinking of collagen gelatin into a stable hydrogel显示文摘 | CATALDO F URSINI O LILLA E | 2008 | Journal of Radioana- lyrical and Nuclear Chemistry2008，275，1： | 1 |
| 19 | Homo- and heterometallic coordination polymers from the f elements 显示文摘 | Cahill CL de Lilla DT Frisch M | 2007 | CrystEngComm [ISSN 1466-8033]2007，9，1： | 1 |
| 20 | Endovascular stent graft treatment of thoracic aortic disease显示文摘 | GONZALO GARZON MARIA FERNANDEZ-VE LILLA MILAGROS MARTI | 2005 | Radio Graphics2005，25，： | 1 |
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