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| 1 | Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage显示文摘Asparaginyl endopeptidase (AEP ) 是有为在 P1 地点的天门冬素残余的偏爱的 endo/lysosomal 半胱氨酸 endopeptidase 并且在像使用费的受体 3/7/9 的成熟起一个重要作用。AEP 被知道为催化激活在酸的 pH 经历 autoproteolytic 成熟。这里,我们描述 AEP 酶原的水晶结构和 AEP 的成熟形式。在 AEP 和 caspases 之间的结构的比较在关键残余的作文并且在催化机制揭示了类似。Mutagenesis 研究作为为肽底层的劈开是必要的残余识别了 N44, R46, H150, E189, C191, S217/S218 和 D233。在成熟期间, AEP 的帽子领域的 autoproteolytic 劈开在核心领域上开创存取到活跃地点。出人意料地,一个中间的 autoproteolytic 成熟阶段被发现在近似 pH 4.5 在哪个部分激活的 AEP 能被颠倒回到它的酶原形式。这个唯一的特征被 AEP pH4.5 (AEP 在 pH 被成熟 4.5 并且在 pH 结晶 8.5 ) ,在哪个破肽契约被重新绑扎,结构被转变回到它的酶原形式。另外, AEP 禁止者 cystatin C 能被充分激活的 AEP 消化,但是不能被激活的组织蛋白酶消化。因此,我们第一次证明 cystatins 可以为活跃地点通过底层竞争调整 AEP 的活动。 | Lixia Zhao Tian Hua Christopher Crowley Heng Ru Xiangmin Ni Neil Shaw Lianying Jiao Wei Ding Lu Qu Li-Wei Hung Wei Huang Lei Liu Keqiang Ye Songying Ouyang Genhong Cheng Zhi-Jie Liu | 2014 | Cell Research2014，24，3： | 6 |
| 2 | 基于实物的博物馆里的家庭学习——共同注意的作用显示文摘共同注意是从小开始亲子沟通的一个基础。此项研究透过54个家庭在自然历史博物馆里对实景模型馆的探索体验,探讨了加强共同注意将会如何引起学习的强化。本文作者使用2×2的析因设计,检验了两种旨在增进父母跟孩子(5-8岁)对实景模型里的实物的共同注意的干预措施。在一种干预里,家庭使用手电筒去探索昏暗的实景模型,由此限制其视野;在另一种干预里,研究者给家庭提供引导标示提示,使其将注意力集中在特定的实景模型的特征上。结果显示,相较于控制器,用手电筒去探究实景模型馆的家庭明显更可能形成共同注意;而且,这些家庭一旦建立对某物的共同注意,他们就更可能参与到对此物的学习谈论中,由此表明在基于实物的学习环境里,比如在自然历史博物馆,相对简单地操作共同注意是一种支持家庭学习的有效手段。 | Kaleen Tison Povis Kevin Crowley 张莉 | 2016 | 中国博物馆2016，，2： | 4 |
| 3 | Crystal structure and nucleotide selectivity of human IFIT5/ISG58显示文摘 | Feng Feng LingminYuan Yao E Wang Christopher Crowley Zongyang Lv Jingjing Li Yingfang Liu Genhong Cheng Su Zeng Huanhuan Liang | 2013 | Cell Research2013，23，8： | 4 |
| 4 | Effect of biochar amendment on yield and methane and nitrous oxide emissions from a rice paddy from Tai Lake plain, China显示文摘 | Afeng Zhang Liqiang Cui Gengxing Pan Lianqing Li Qaiser Hussain Xuhui Zhang Jinwei Zheng David Crowley | 2010 | Agriculture Ecosystems and Environment2010，，4： | 3 |
| 5 | Biochar effects on soil biota – A review显示文摘 | Johannes Lehmann Matthias C. Rillig Janice Thies Caroline A. Masiello William C. Hockaday David Crowley | 2011 | Soil Biology and Biochemistry2011，，9： | 3 |
| 6 | Effect of biochar amendment on yield and methane and nitrous oxide emissions from a rice paddy from Tai Lake plain, China显示文摘 | Afeng Zhang Liqiang Cui Gengxing Pan Lianqing Li Qaiser Hussain Xuhui Zhang Jinwei Zheng David Crowley | 2010 | Agriculture Ecosystems and Environment2010，，4： | 3 |
| 7 | A Probabilistic Displacement-based Vulnerability Assessment Procedure for Earthquake Loss Estimation显示文摘 | Helen Crowley Rui Pinho Julian J. Bommer | 2004 | Bulletin of Earthquake Engineering2004，，2： | 2 |
| 8 | The IASLC Lung Cancer Staging Project: Proposals for the Revision of the TNM Stage Groupings in the Forthcoming (Seventh) Edition of the TNM Classification of Malignant Tumours显示文摘 | Peter Goldstraw John Crowley Kari Chansky Dorothy J. Giroux Patti A. Groome Ramon Rami-Porta Pieter E. Postmus Valerie Rusch Leslie Sobin | 2007 | Journal of Thoracic Oncology2007，，8： | 2 |
| 9 | Evolution of endovascular mechanical thrombectomy for acute ischemic stroke显示文摘Acute ischemic stroke(AIS) is a common medical problem associated with significant morbidity and mortality worldwide. A small proportion of AIS patients meet eligibility criteria for intravenous thrombolysis(IVT) with recombinant tissue plasminogen activator, and its efficacy for large vessel occlusion is poor. Therefore, an increasing number of patients with AIS are being treated with endovascular mechanical thrombectomy when IVT is ineffective or contraindicated. Rapid advancement in catheter-based and endovascular device technology has led to significant improvements in rates of cerebral reperfusion with these devices. Stentrievers and modern aspiration catheters have now surpassed earlier generation devices in the degree and rapidity of revascularization. This progress has been achieved with no concurrent increase in risk of major complications or mortality, both when used alone or in combination with IVT. The initial randomized controlled trials comparing endovascular therapy to IVT for AIS failed to show superior outcomes with endovascular treatment, butkey limitations of each trial may limit the significance of these results to current practice. While endovascular devices and operator experience continue to evolve, we are optimistic that this will be accompanied by improvements in patient outcomes. This review highlights the major endovascular devices used in current practice and the trials which have investigated their efficacy. | Colin J Przybylowski Dale Ding Robert M Starke Christopher R Durst R Webster Crowley Kenneth C Liu | 2014 | World Journal of Clinical Cases2014，2，11： | 2 |
| 10 | The IASLC Lung Cancer Staging Project: Proposals for the Revision of the N Descriptors in the Forthcoming Seventh Edition of the TNM Classification for Lung Cancer显示文摘 | Valerie W. Rusch John Crowley Dorothy J. Giroux Peter Goldstraw Jung-Gi Im Masahiro Tsuboi Ryosuke Tsuchiya Johan Vansteenkiste | 2007 | Journal of Thoracic Oncology2007，，7： | 2 |
| 11 | Effect of biochar amendment on yield and methane and nitrous oxide emissions from a rice paddy from Tai Lake plain, China显示文摘 | Afeng Zhang Liqiang Cui Gengxing Pan Lianqing Li Qaiser Hussain Xuhui Zhang Jinwei Zheng David Crowley | 2010 | Agriculture, Ecosystems and Environment2010，，4： | 2 |
| 12 | Targeted Deletion Reveals Essential and Overlapping Functions of the miR-17~92 Family of miRNA Clusters显示文摘 | Andrea Ventura Amanda G. Young Monte M. Winslow Laura Lintault Alex Meissner Stefan J. Erkeland Jamie Newman Roderick T. Bronson Denise Crowley James R. Stone Rudolf Jaenisch Phillip A. Sharp Tyler Jacks | 2008 | Cell2008，，5： | 2 |
| 13 | Biochar effects on soil biota – A review显示文摘 | Johannes Lehmann Matthias C. Rillig Janice Thies Caroline A. Masiello William C. Hockaday David Crowley | 2011 | Soil Biology and Biochemistry2011，，9： | 2 |
| 14 | First detection of a class 2 integron among clinical isolates of Serratia marcescens 显示文摘 | Crowley D Cryan B Lucey B | 2008 | Br J Biomed Sci2008，65，2： | 1 |
| 15 | p63 and p73 are required for p53-dependent apoptosis in response to DNA damage显示文摘 | Tsai KY Crowley D | 2002 | Nature2002，416，6880： | 1 |
| 16 | Evaluation of landfarm remediation of hydrocarbon-contaminated soil at the inveresk railyard,Launceston,Australia显示文摘 | Line MA Garlandh CD and Crowley M | 1996 | Waste Management1996，16，7： | 1 |
| 17 | Ice age terrestrial carbon changes revisited显示文摘 | CROWLEY T J | 1995 | Global Biogeochemical Cycles1995，9，： | 1 |
| 18 | Validation of a onedimensional wave model for the stratified-to-slug flow regime transition, with consequences for wave growth and slug frequency 显示文摘 | Crowley C J Wallis G B Barry J J | 1992 | Int J Multiphase Flow1992，18，2： | 1 |
| 19 | Randomized trial comparing cisplatin with cisplatin plus vinorelbine in the treatment of advanced non-small-cell lung cancer:a Southwest oncology group study显示文摘 | Wozniak AJ Crowley JJ Balcerzak SP | 1998 | J Clin Oncol1998，16，7： | 1 |
| 20 | The international Association for the Study of Lung Cancer lung cancer staging project: proposals regarding the clinical staging of small cell lung cancer in the forthcoming (seventh) edition of the tumor, node, metastasis classification for lung cancer显示文摘 | SHEPHERD FA CROWLEY J van HOUTI'E P | 2007 | J Thorac Oncol2007，2，12： | 1 |
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