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| 1 | Combined carriership of TLR9 -1237C and CD14 -260T alleles enhances the risk of developing chronic relapsing pouchitis显示文摘AIM: To investigate the single nucleotide polymorphisms (SNPs) in genes involved in bacterial recognition and the susceptibility to pouchitis or pouchitis severity.METHODS: Analyses of CD14 -260C>T, CARD15/NOD2 3020insC, Toll-like receptor (TLR)4 +896A>G,TLR9 -1237T>C, TLR9+ 2848G>A, and IRAKM +22148G>A SNPs were performed in 157 ileal-pouch anal anastomosis (IPAA) patients (79 patients who did not develop pouchitis, 43 infrequent pouchitis patients,35 chronic relapsing pouchitis patients) and 224 Italian Caucasian healthy controls.RESULTS: No significant differences were found in SNP frequencies between controls and IPAA patients.However, a significant difference in carriership frequency of the TLR9-1237C allele was found between the infrequent pouchitis and chronic relapsing pouchitis groups [P = 0.028, odd's ratio (OR) = 3.2, 95%CI = 1.2-8.6].This allele uniquely represented a 4-locus TLR9 haplotype comprising both studied TLR9 SNPs in Caucasians.Carrier trait analysis revealed an enhanced combined carriership of the alleles TLR9 -1237C and CD14 -260T in the chronic relapsing pouchitis and infrequent pouchitis group (P = 0.018, OR = 4.1, 95%CI = 1.4 -12.3).CONCLUSION: There is no evidence that the SNPs predispose to the need for IPAA surgery. The significant increase of the combined carriership of the CD14 -260T and TLR9 -1237C alleles in the chronic relapsing pouchitis group suggests that these markers identify a subgroup of IPAA patients with a risk of developing chronic or refractory pouchitis. | KM Lammers S Ouburg SA Morré JBA Crusius P Gionchetti F Rizzello C Morselli E Caramelli R Conte G Poggioli M Campieri AS Pea | 2005 | World Journal of Gastroenterology2005，11，46： | 7 |
| 2 | Influence of diabetes and perivascular allogeneic endothelial cell im plants on arteriovenous fistula remodeling 显示文摘 | Conte M S Nugent H M Gaecione P | 2011 | J Vasc Surg2011，54，5： | 1 |
| 3 | Remotely Operated Vehicle Depth Control 显示文摘 | Zanoli S M Conte G | 2003 | Control Engineering Practice2003，，11： | 1 |
| 4 | Efficient repopulation of denuded rabbit arteries with autologous genetically modified endothelial cells显示文摘 | CONTE M S BIRINYI L K MIYATA T | 1994 | Circulation1994，89，5： | 1 |
| 5 | Attach- ment of single-wall carbon nanotubes on platinum surfaces by self-as- sembling techniques显示文摘 | ROSARIO-CASTRO B CONT S E P REZ-DAVIS M | 2005 | Rev Adv Mater Sei2005，10，： | 1 |
| 6 | Long-term follow-up of neuroblastoma-associated op-soclonus-myoclonus-ataxia syndrome显示文摘 | De Grandis E Parodi S Conte M Angelini P Battaglia F Gan-dolfo C | 2009 | Neuropediatrics2009，40，3： | 1 |
| 7 | Diacylglyeerol acyltransferase 1, stearoyl-CoA desaturase 1, and sterol regulatory element binding protein 1 gene polymorphisms and milk fatty acid composition in Italian Brown cattle显示文摘 | Conte G Mele M Chessa S | 2010 | J Dairy Sci2010，93，2： | 1 |
| 8 | Indications to Upper Gastrointestinal Endoscopy in Children With Dyspepsia显示文摘 | G Guariso A Meneghel L Visonà Dalla Pozza C Romano L Dall?Oglio G Lombardi S Conte M Calacoci A Campanozzi C Nichetti S Piovan L Zancan P Facchin | 2010 | Journal of Pediatric Gastroenterology and Nutrition2010，，5： | 1 |
| 9 | Early diagenesis of lipid biomarker compounds in North Atlantic Sediments显示文摘 | Madureim L A S CONTE M H EGIJNTONg G | 1995 | Paleoceanogra-phy1995，10，3： | 1 |
| 10 | Endothelial cell seeding influence lesion development following arterial injury in the cholesterol-fed rabbit显示文摘 | Conte M S VanMeter G A Akst L M | 2002 | Cardiovasc Res2002，53，2： | 1 |
| 11 | Overview of energy/hydrogen storage:state-of the-art of the technologies and prospects for nanomaterials显示文摘 | Conte M Prosini P Passerini S | 2004 | Materials Science and Engineering B-solid State Materials Advanced Technology2004，108，2： | 1 |
| 12 | Gut-associated bacterial microbiota in paediatric patients with inflammatory bowel disease显示文摘 | Conte M P Schippa S Zamboni I | 2006 | Gut2006，55，12： | 1 |
| 13 | Pan-histone demethylase inhibitors simultaneously targeting jumonji C and lysine-specific demethylases display high antieancer activities显示文摘 | Rotili D Tomassi S Conte M | 2014 | J Med Chem2014，57，1： | 1 |
| 14 | From opportunistic net- works to opportunistic computing显示文摘 | CONT! M G1ORDANO S MAY M | 2010 | Communications Magazine IEEE2010，48，9： | 1 |
| 15 | Molecular engineering of wein bypass grafts显示文摘 | Conte M S | 2007 | J Vas Surg2007，45，9： | 1 |
| 16 | Thymol and modified atmosphere packaging to control microbiological spoilage in packed fresh cod hamburgers 显示文摘 | Corbo M R Giulio S D Conte A | 2009 | International Journal of Food Science and Technology2009，44，8： | 1 |
| 17 | Clinical results of carotid artery stenting compared with carotid endarectomy显示文摘 | BRAHAMANDAM S DING E L CONTE M S | 2008 | J Vasc Surg2008，47，2： | 1 |
| 18 | The Ideal Small Arterial Substitute: A Search for the Holy Grail? 显示文摘 | Conte M S | 1998 | FASEBJ1998，12，1： | 1 |
| 19 | Association between n-3 polyunsaturated fatty acid content of red blood cells and inflammatory biomarkers in patients with peripheral artery disease显示文摘 | Grenon S M Conte M S Nosova E | | 0，，： | 1 |
| 20 | Synthesis of S-gly cosyl amino acids and S-glycopeptides via photoinducedclick thiol-ene coupling显示文摘 | Fiore M Lo Conte M Pacifico S | 2011 | Tetrahedron Letters2011，52，3： | 1 |
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