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| 1 | Combined carriership of TLR9 -1237C and CD14 -260T alleles enhances the risk of developing chronic relapsing pouchitis显示文摘AIM: To investigate the single nucleotide polymorphisms (SNPs) in genes involved in bacterial recognition and the susceptibility to pouchitis or pouchitis severity.METHODS: Analyses of CD14 -260C>T, CARD15/NOD2 3020insC, Toll-like receptor (TLR)4 +896A>G,TLR9 -1237T>C, TLR9+ 2848G>A, and IRAKM +22148G>A SNPs were performed in 157 ileal-pouch anal anastomosis (IPAA) patients (79 patients who did not develop pouchitis, 43 infrequent pouchitis patients,35 chronic relapsing pouchitis patients) and 224 Italian Caucasian healthy controls.RESULTS: No significant differences were found in SNP frequencies between controls and IPAA patients.However, a significant difference in carriership frequency of the TLR9-1237C allele was found between the infrequent pouchitis and chronic relapsing pouchitis groups [P = 0.028, odd's ratio (OR) = 3.2, 95%CI = 1.2-8.6].This allele uniquely represented a 4-locus TLR9 haplotype comprising both studied TLR9 SNPs in Caucasians.Carrier trait analysis revealed an enhanced combined carriership of the alleles TLR9 -1237C and CD14 -260T in the chronic relapsing pouchitis and infrequent pouchitis group (P = 0.018, OR = 4.1, 95%CI = 1.4 -12.3).CONCLUSION: There is no evidence that the SNPs predispose to the need for IPAA surgery. The significant increase of the combined carriership of the CD14 -260T and TLR9 -1237C alleles in the chronic relapsing pouchitis group suggests that these markers identify a subgroup of IPAA patients with a risk of developing chronic or refractory pouchitis. | KM Lammers S Ouburg SA Morré JBA Crusius P Gionchetti F Rizzello C Morselli E Caramelli R Conte G Poggioli M Campieri AS Pea | 2005 | World Journal of Gastroenterology2005，11，46： | 7 |
| 2 | The impact of patient age and aortic size on the results of aortobifemoral bypass grafting 1 1 Competition of interest: none. Published online Mar 6, 2003显示文摘 | Amy B Reed Michael S Conte Magruder C Donaldson John A Mannick Anthony D Whittemore Michael Belkin | 2003 | Journal of Vascular Surgery2003，，： | 2 |
| 3 | Antiepileptic drugs and cortical excitability: a study with repetitive transcra- nial stimulation显示文摘 | M INGHILLERI A CONTE V FRASCA | 2004 | Exp Brain Res2004，154，48： | 1 |
| 4 | Critical limb ischemia显示文摘 | Schanzer A Conte MS | 2010 | Curr Treat Options Cardiovasc Med2010，12，3： | 1 |
| 5 | A new ibuprofen pulsed release oral dosage form 显示文摘 | Conte U Colombo P Manna A La | 1989 | Drug Delivery Ind Pharm1989，15，1： | 1 |
| 6 | Nitric-oxide synthase activity in molluscan hemocytes显示文摘 | CONTE A OTTAVIANI E | 1995 | FEBS Lett1995，365，23： | 1 |
| 7 | P16^INK4A hypermethylation detected by fluorescent methylation-specific PCR in plasmas from non-small cell lung cancer 显示文摘 | Bearzatto A Conte D Frattini M | 2002 | Clin Cancer Res2002，8，12： | 1 |
| 8 | Genetic and physiological influences on the alkenone/alkenoate versus growth temperature relationship in Emiliania huxleyi and Gephyrocapsa oceanica 显示文摘 | Conte M H Thompson A Lesley D | 1998 | Geochimica et Cosmochimica Acta1998，62，1： | 1 |
| 9 | Potential availability of heavy metals to phytoextraction from contaminated soils induced by exogenous humic sub- stances 显示文摘 | HALIM M CONTE P PICCOLO A | 2003 | Chemosphere2003，52，： | 1 |
| 10 | Pediatric endocrinology update : an overview 显示文摘 | Mac Gillivray MH Morishima A Conte F | 1998 | Horm Res1998，49，1： | 1 |
| 11 | Severe coronary artery disease after radiation therapy of the chest and mediastinum: clinical presentation and treatment 显示文摘 | ORZAN F BRUSCA A CONTE M R | 1993 | Br Heart J1993，69，6： | 1 |
| 12 | Statistical analysis of real clutter at different range resolutions 显示文摘 | Conte E De Maio A Galdi C | 2004 | IEEE Transactions on Aerospace and Electronic Systems2004，40，3： | 1 |
| 13 | In vitro and in vivo antifungal activity of liposomal and free itraconazole against Candida albicans显示文摘 | Conte PL Faintreny A | 1994 | Med Parazitol (Mosk)1994，55，8： | 1 |
| 14 | Soil remediation:humic acids as natural surfactants in the washings of highly contaminated soils显示文摘 | CONTE P AGRETTO A SPACCINI R | 2005 | Environmental Pollution2005，135，： | 1 |
| 15 | Hydrochlorination of acetylene using supported bimetallic Au-based cata- lysts显示文摘 | Conte M Carley A Attard G | 2008 | Journal of Catalysis2008，257，1： | 1 |
| 16 | GLRT-Based Adaptive Detection Algorithms for Range-Spread Targets显示文摘 | Conte E De Maio A Ricci G | 2001 | IEEE Trans on Signal Processing2001，49，7： | 1 |
| 17 | GLRT-based adaptive detection algorithms for range-spread targets 显示文摘 | CONTE E DE MAIO A RICCI G | 2001 | IEEE Trans on Signal Processing2001，49，7： | 1 |
| 18 | Controlled release of thymol from zein based film显示文摘 | Mastromatteo M Barbuzzi G Conte A | 2009 | Innov Food Sci Emerg2009，10，2： | 1 |
| 19 | GLRT-based adaptive detection algorithms for range-spread targets显示文摘 | Conte E De Maio A and Ricei G | 2001 | IEEE Transactions on Signal Processing2001，49，7： | 1 |
| 20 | Intraperitoneal chemotherapy in the management of patients with ad-vanced epithelial ovarian cancer:a critical review of the literature显示文摘 | Gadducci A Conte PF | 2008 | Int J Gynecol Cancer2008，18，： | 1 |
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