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| 1 | Combined carriership of TLR9 -1237C and CD14 -260T alleles enhances the risk of developing chronic relapsing pouchitis显示文摘AIM: To investigate the single nucleotide polymorphisms (SNPs) in genes involved in bacterial recognition and the susceptibility to pouchitis or pouchitis severity.METHODS: Analyses of CD14 -260C>T, CARD15/NOD2 3020insC, Toll-like receptor (TLR)4 +896A>G,TLR9 -1237T>C, TLR9+ 2848G>A, and IRAKM +22148G>A SNPs were performed in 157 ileal-pouch anal anastomosis (IPAA) patients (79 patients who did not develop pouchitis, 43 infrequent pouchitis patients,35 chronic relapsing pouchitis patients) and 224 Italian Caucasian healthy controls.RESULTS: No significant differences were found in SNP frequencies between controls and IPAA patients.However, a significant difference in carriership frequency of the TLR9-1237C allele was found between the infrequent pouchitis and chronic relapsing pouchitis groups [P = 0.028, odd's ratio (OR) = 3.2, 95%CI = 1.2-8.6].This allele uniquely represented a 4-locus TLR9 haplotype comprising both studied TLR9 SNPs in Caucasians.Carrier trait analysis revealed an enhanced combined carriership of the alleles TLR9 -1237C and CD14 -260T in the chronic relapsing pouchitis and infrequent pouchitis group (P = 0.018, OR = 4.1, 95%CI = 1.4 -12.3).CONCLUSION: There is no evidence that the SNPs predispose to the need for IPAA surgery. The significant increase of the combined carriership of the CD14 -260T and TLR9 -1237C alleles in the chronic relapsing pouchitis group suggests that these markers identify a subgroup of IPAA patients with a risk of developing chronic or refractory pouchitis. | KM Lammers S Ouburg SA Morré JBA Crusius P Gionchetti F Rizzello C Morselli E Caramelli R Conte G Poggioli M Campieri AS Pea | 2005 | World Journal of Gastroenterology2005，11，46： | 7 |
| 2 | Empirical properties of asset returns: Stylized facts and statistical issues显示文摘 | Cont R | 2001 | Quantitative Finance2001，1，： | 1 |
| 3 | Empirical Properties of Asset Returns: Stylized Facts and Statistical Issues显示文摘 | Cont R | 2001 | Quantitative Finance2001，1，2： | 1 |
| 4 | Severe coronary artery disease after radiation therapy of the chest and mediastinum: clinical presentation and treatment 显示文摘 | ORZAN F BRUSCA A CONTE M R | 1993 | Br Heart J1993，69，6： | 1 |
| 5 | Cystatin C is associated with an increased coronary atherosclerotic burden and a stable plaque pheno- type in patients with ischemic heart disease and normal glomerular filtra- tion rate显示文摘 | Niccoli G Conte M Della Bona R | 2008 | Atherosclerosis2008，198，2： | 1 |
| 6 | Empirical properties of asset returns:Stylized faets and statistical issues显示文摘 | | 2001 | Quantitative Finance2001，，1： | 1 |
| 7 | Soil remediation:humic acids as natural surfactants in the washings of highly contaminated soils显示文摘 | CONTE P AGRETTO A SPACCINI R | 2005 | Environmental Pollution2005，135，： | 1 |
| 8 | Empirical properties of asset returns:stylized facts and statistical issues显示文摘 | Cont R | 2001 | QUANTITATIVE FINANCE2001，1，： | 1 |
| 9 | Accuracy of three electronic apex locators in anterior and posterior teeth:an ex vivo study显示文摘 | Mancini M Felici R Conte G | | 0，，05： | 1 |
| 10 | Frequent sequence variation in the human myostatin(GDFS) gene as a marker for analysis of muscle-related phenotypes 显示文摘 | Ferrell R E conte V Lawrence E C | 1999 | Genomic1999，62，2： | 1 |
| 11 | High molecular weight polyethylene oxides (PEOs) as an alternative to HPMC in controlled release dosage forms 显示文摘 | Maggi L Bruni R and Conte U | 2000 | lnt J Pharm2000，195，1： | 1 |
| 12 | A langevin approach to stock market fluctuations and crashes 显示文摘 | Bouchaud J P Cont R | 1998 | The European Physical Journal B1998，6，2： | 1 |
| 13 | Robustness and sensitivity analysis of risk measurement procedures显示文摘 | Cont R Deguest R Scandolo R | 2010 | Quantitative Finance2010，10，6： | 1 |
| 14 | A graph-based, multi- resolution algorithm for tracking objects in presence of occlusions显示文摘 | CONTE D FOGGIA R JOLION J M | 2006 | Pattern Recognition2006，39，4： | 1 |
| 15 | Comparison between accelerated solvent extraction and traditional extraction methods for the analysis of the herbicide diflufenican in soil显示文摘 | Conte E Milani R Morali G | 1997 | J Chromatogr A1997，765，1： | 1 |
| 16 | Herd behavior and aggregate fluctuation in financial markets显示文摘 | Cont R Bouchaud J P | 2000 | Macroeconomics Dynamics2000，4，： | 1 |
| 17 | Hermite expansions of compact support waveforms: Applications to myoelectrie signals显示文摘 | LO CONTE L R MERLETTI R SANDRI G V | 1994 | IEEE Transactions on Biomedical Engineering1994，41，12： | 1 |
| 18 | Link between solitary waves and projective Riecati equations显示文摘 | CONTE R MUSETFE M | 1992 | Phys A: Math Gen1992，25，21： | 1 |
| 19 | Model uncertainty and its impact on the pricing of derivative instruments 显示文摘 | Cont R | 2006 | Mathematical Finance2006，16，3： | 1 |
| 20 | Cooling kinetics experiments on different Stromboli lavas:effects on crystal morphologies and phase composition显示文摘 | Conte A M Perinelli C Trigila R | 2006 | Journal of Volcanology and Geothermal Research2006，155，： | 1 |
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