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| 1 | Increased secretion of pro-inflammatory cytokines by circulating polymorphonuclear neutrophills and regulation by interleukin 10 during intestinal inflammation显示文摘Increasedsecretionofproinflammatorycytokinesbycirculatingpolymorphonuclearneutrophilsandregulationbyinterleukin10duringintes... | S Nikolaus 1, J Bauditz 1, P Gionchetti 2, C Witt 3, H Lochs 1 and S Schreiber 1 1Charité University Hospital, 4th Medical Department, Humboldt University, Berlin, Germany 2Clinica Media I, Policlinico S. Orsola, University of Bolog | 1998 | World Journal of Gastroenterology1998，4，3： | 17 |
| 2 | Combined carriership of TLR9 -1237C and CD14 -260T alleles enhances the risk of developing chronic relapsing pouchitis显示文摘AIM: To investigate the single nucleotide polymorphisms (SNPs) in genes involved in bacterial recognition and the susceptibility to pouchitis or pouchitis severity.METHODS: Analyses of CD14 -260C>T, CARD15/NOD2 3020insC, Toll-like receptor (TLR)4 +896A>G,TLR9 -1237T>C, TLR9+ 2848G>A, and IRAKM +22148G>A SNPs were performed in 157 ileal-pouch anal anastomosis (IPAA) patients (79 patients who did not develop pouchitis, 43 infrequent pouchitis patients,35 chronic relapsing pouchitis patients) and 224 Italian Caucasian healthy controls.RESULTS: No significant differences were found in SNP frequencies between controls and IPAA patients.However, a significant difference in carriership frequency of the TLR9-1237C allele was found between the infrequent pouchitis and chronic relapsing pouchitis groups [P = 0.028, odd's ratio (OR) = 3.2, 95%CI = 1.2-8.6].This allele uniquely represented a 4-locus TLR9 haplotype comprising both studied TLR9 SNPs in Caucasians.Carrier trait analysis revealed an enhanced combined carriership of the alleles TLR9 -1237C and CD14 -260T in the chronic relapsing pouchitis and infrequent pouchitis group (P = 0.018, OR = 4.1, 95%CI = 1.4 -12.3).CONCLUSION: There is no evidence that the SNPs predispose to the need for IPAA surgery. The significant increase of the combined carriership of the CD14 -260T and TLR9 -1237C alleles in the chronic relapsing pouchitis group suggests that these markers identify a subgroup of IPAA patients with a risk of developing chronic or refractory pouchitis. | KM Lammers S Ouburg SA Morré JBA Crusius P Gionchetti F Rizzello C Morselli E Caramelli R Conte G Poggioli M Campieri AS Pea | 2005 | World Journal of Gastroenterology2005，11，46： | 7 |
| 3 | Oral bacteriotherapy as maintenance treatment in patients with chronic pouchitis : a double-blind, placebo-controlled trial 显示文摘 | Gionchetti P Rizzello F Venturi A | 2000 | Gastroenterology2000，119，： | 1 |
| 4 | Prophylaxis of pouchitis onset with probiotic therapy : a double-blind, placebo-controlled trial 显示文摘 | GIONCHETTI P RIZZELLO F HELWlG U | 2003 | Gastroenter- ology2003，124，5： | 1 |
| 5 | Oral bacteriotherapy as maintenance treatment in patients with chronic pouchitis:a double-blind,placebo-controlled trial显示文摘 | GIONCHETTI P RIZZELLO F VENTURI A | 2000 | Gastroenterology2000，119，2： | 1 |
| 6 | Bacteria as the cause of ulcerativecolitis显示文摘 | Gionchetti P | 2001 | Gut2001，48，： | 1 |
| 7 | Oral beclomethasone dipropionate in patients with mild to moderate ulcerative colitis:a dose-finding study显示文摘 | RIZZELLO F GIONCHETTI P GALEAZZI R | 2001 | Adv Ther2001，18，6： | 1 |
| 8 | Impact on the composition of the faecal flora by a new probiotic preparation: preliminary data on maintenance treatment of patients with ulcerative colitis 显示文摘 | Venturi A Gionchetti P Rizzello F | 1999 | Aliment Pharmacol Ther1999，13，8： | 1 |
| 9 | Comparison of oral with rectal mesalazine in the treatment of ulcerative proctitis显示文摘 | Gionchetti P Rizzello F Venturi A | 1998 | Dis Colon Rectum1998，41，1： | 1 |
| 10 | Prophylaxis of pouchitis onset with Probiotic therapy:a double-hlind,placebo-controlled trial显示文摘 | Gionchetti P Rizzello F Helwig U | 2003 | Gastroenterology2003，124，5： | 1 |
| 11 | Prophylaxis of pouchitis onset with probiotic therapy: a double-blind, placebo-controlled trial显示文摘 | GIONCHETTI P RIZZELLO F HELWIG U | 2003 | Gastroenterology2003，124，5： | 1 |
| 12 | Obscure gastrointestinal bleeding: single centre experience of capsule endoscopy 显示文摘 | Calabrese C Liguori G Gionchetti P | 2013 | Intern Emerg Med2013，8，8： | 1 |
| 13 | Rectal dialysate and fecal concentra- tion of neutrophil gelatinase associated li- pocalin, inter leukin-8, and tumor necrosis factor-alpha in ulcerative colitis显示文摘 | Nielsen OH Gionchetti P Ainsworth M | 1999 | Am J Gastroenterol1999，94，10： | 1 |
| 14 | Impact on the composition of the faecal flora by a new probiotic preparation: preliminary data on maintenance treatment of patients with ulcerative colitis 显示文摘 | Venturi A Gionchetti P Rizzello F | 1999 | Aliment Pharmacol Ther1999，13，8： | 1 |
| 15 | Rifaximin systemic absorption in patients with ulcerative colitis显示文摘 | Rizzello F Gionchetti P Venturi A | 1998 | Eur J Clin Pharmacol1998，54，： | 1 |
| 16 | Rifaximin systemic absorption in patients with ulcerative colitis 显示文摘 | Rizzello F Gionchetti P VENTURI A | 1998 | Eur J Clin Pharmacol1998，54，1： | 1 |
| 17 | Standard treatment of ulcerativecolitis显示文摘 | Gionchetti P RizzeUo F Habal F | 2003 | Dig Dis2003，21，2： | 1 |
| 18 | Oral bacteriotherapy as maintenance treatment in patients with chronic pouchitis: A double-blind, placebo-controlled trial显示文摘 | Gionchetti P Rizzello F Venturi A | 2000 | Gastroenterology2000，119，： | 1 |
| 19 | Rectal dialysate and fecal concentration of neutrophil gelati- nase-associated lipocalin,interleukin-8, and tumor ne- crosis factor-alpha in ulcerative colitis显示文摘 | Nielsen 0 H Gionchetti P Ainsworth M | 1999 | Am J Gastr- oenterol1999，94，10： | 1 |
| 20 | Medical treatment of severe ulcerative colitis显示文摘 | Rizzello F Gionchetti P Venturi A | | 0，，2： | 1 |
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