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| 1 | Combined carriership of TLR9 -1237C and CD14 -260T alleles enhances the risk of developing chronic relapsing pouchitis显示文摘AIM: To investigate the single nucleotide polymorphisms (SNPs) in genes involved in bacterial recognition and the susceptibility to pouchitis or pouchitis severity.METHODS: Analyses of CD14 -260C>T, CARD15/NOD2 3020insC, Toll-like receptor (TLR)4 +896A>G,TLR9 -1237T>C, TLR9+ 2848G>A, and IRAKM +22148G>A SNPs were performed in 157 ileal-pouch anal anastomosis (IPAA) patients (79 patients who did not develop pouchitis, 43 infrequent pouchitis patients,35 chronic relapsing pouchitis patients) and 224 Italian Caucasian healthy controls.RESULTS: No significant differences were found in SNP frequencies between controls and IPAA patients.However, a significant difference in carriership frequency of the TLR9-1237C allele was found between the infrequent pouchitis and chronic relapsing pouchitis groups [P = 0.028, odd's ratio (OR) = 3.2, 95%CI = 1.2-8.6].This allele uniquely represented a 4-locus TLR9 haplotype comprising both studied TLR9 SNPs in Caucasians.Carrier trait analysis revealed an enhanced combined carriership of the alleles TLR9 -1237C and CD14 -260T in the chronic relapsing pouchitis and infrequent pouchitis group (P = 0.018, OR = 4.1, 95%CI = 1.4 -12.3).CONCLUSION: There is no evidence that the SNPs predispose to the need for IPAA surgery. The significant increase of the combined carriership of the CD14 -260T and TLR9 -1237C alleles in the chronic relapsing pouchitis group suggests that these markers identify a subgroup of IPAA patients with a risk of developing chronic or refractory pouchitis. | KM Lammers S Ouburg SA Morré JBA Crusius P Gionchetti F Rizzello C Morselli E Caramelli R Conte G Poggioli M Campieri AS Pea | 2005 | World Journal of Gastroenterology2005，11，46： | 7 |
| 2 | Immunotherapy of metas tatic kidney cancer显示文摘 | De Vinci C Lo Conte G | 2001 | Int J Cancer2001，94，1： | 1 |
| 3 | Perfluoroalkanesulfonylimides and their lithium salts: synthesis and characterisation of intermediates and target compounds显示文摘 | Conte L Gambaretto G Caporiccio G | 2004 | J Fluorine Chemistry2004，125，2： | 1 |
| 4 | Cystatin C is associated with an increased coronary atherosclerotic burden and a stable plaque pheno- type in patients with ischemic heart disease and normal glomerular filtra- tion rate显示文摘 | Niccoli G Conte M Della Bona R | 2008 | Atherosclerosis2008，198，2： | 1 |
| 5 | Differential gene expression induced by insulin and IGF-Ⅱ through the insulin receptor isoform A显示文摘 | Pandini G Medico E Conte E | 2003 | J Biol Chem2003，278，42： | 1 |
| 6 | Hydrochlorination of acetylene using supported bimetallic Au-based cata- lysts显示文摘 | Conte M Carley A Attard G | 2008 | Journal of Catalysis2008，257，1： | 1 |
| 7 | GLRT-Based Adaptive Detection Algorithms for Range-Spread Targets显示文摘 | Conte E De Maio A Ricci G | 2001 | IEEE Trans on Signal Processing2001，49，7： | 1 |
| 8 | GLRT-based adaptive detection algorithms for range-spread targets 显示文摘 | CONTE E DE MAIO A RICCI G | 2001 | IEEE Trans on Signal Processing2001，49，7： | 1 |
| 9 | Adaptive detection schemes in cornpound-Gaussian clutter 显示文摘 | E Conte M Lops G Ricci | 1998 | IEEE Transactions on Aerospace and ElecllOnic Systems1998，34，4： | 1 |
| 10 | Accuracy of three electronic apex locators in anterior and posterior teeth:an ex vivo study显示文摘 | Mancini M Felici R Conte G | | 0，，05： | 1 |
| 11 | Controlled release of thymol from zein based film显示文摘 | Mastromatteo M Barbuzzi G Conte A | 2009 | Innov Food Sci Emerg2009，10，2： | 1 |
| 12 | Analysis of circulating tumor DNA in plasma at diagnosis and during follow-up of hmg cancer patients显示文摘 | Sozzi G Conte D Mariani L | 2001 | Cancer Res2001，61，12： | 1 |
| 13 | GLRT-based adaptive detection algorithms for range-spread targets显示文摘 | Conte E De Maio A and Ricei G | 2001 | IEEE Transactions on Signal Processing2001，49，7： | 1 |
| 14 | Vascular access complications after cardiac catheterisation:a nurse-led quelity assurance program显示文摘 | Steffennino G Dutto S Conte L | 2006 | Eur J Cardiovasc Nurs2006，5，1： | 1 |
| 15 | Analysis of circulating tumor DNA in plasma at diagnosis and during follow-up of lung cancer patients 显示文摘 | Sozzi G Conte D Mariani L | 2001 | Cancer Res2001，61，12： | 1 |
| 16 | CFAR detection of distributed target in non-Gaussian disturbance显示文摘 | Conte E De Maio A and Ricci G | 2002 | IEEE Transactions on Aerospace and Electronic Systems2002，38，2： | 1 |
| 17 | Effects of prolonged storage of whole plasma or isolated plasma DNA on the results of irculating DNA quantification assays 显示文摘 | Sozzi G Roz L Conte D | 2005 | J Natl Cancer Inst2005，97，24： | 1 |
| 18 | Polarization'diversity detection in compound Gaussian clutter 显示文摘 | De Maio A Alfano G Conte E | 2004 | IEEE Transactions on Aerospace and Electronic Systems2004，40，1： | 1 |
| 19 | Acute cardiovascular diseases and re- spiratory sleep disorders显示文摘 | Conte G Rigon N Perrone A | 1999 | Minnerva Cardioangiol1999，47，6： | 1 |
| 20 | Synthesis and application of perfluoroalkyl quaternary ammonium salts in protein-based fire-fight ing foam concentrates显示文摘 | Zaggia A Conte L Padoan G | | Journal of Surfactants and Detergents0，13，1： | 1 |
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