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| 1 | Combined carriership of TLR9 -1237C and CD14 -260T alleles enhances the risk of developing chronic relapsing pouchitis显示文摘AIM: To investigate the single nucleotide polymorphisms (SNPs) in genes involved in bacterial recognition and the susceptibility to pouchitis or pouchitis severity.METHODS: Analyses of CD14 -260C>T, CARD15/NOD2 3020insC, Toll-like receptor (TLR)4 +896A>G,TLR9 -1237T>C, TLR9+ 2848G>A, and IRAKM +22148G>A SNPs were performed in 157 ileal-pouch anal anastomosis (IPAA) patients (79 patients who did not develop pouchitis, 43 infrequent pouchitis patients,35 chronic relapsing pouchitis patients) and 224 Italian Caucasian healthy controls.RESULTS: No significant differences were found in SNP frequencies between controls and IPAA patients.However, a significant difference in carriership frequency of the TLR9-1237C allele was found between the infrequent pouchitis and chronic relapsing pouchitis groups [P = 0.028, odd's ratio (OR) = 3.2, 95%CI = 1.2-8.6].This allele uniquely represented a 4-locus TLR9 haplotype comprising both studied TLR9 SNPs in Caucasians.Carrier trait analysis revealed an enhanced combined carriership of the alleles TLR9 -1237C and CD14 -260T in the chronic relapsing pouchitis and infrequent pouchitis group (P = 0.018, OR = 4.1, 95%CI = 1.4 -12.3).CONCLUSION: There is no evidence that the SNPs predispose to the need for IPAA surgery. The significant increase of the combined carriership of the CD14 -260T and TLR9 -1237C alleles in the chronic relapsing pouchitis group suggests that these markers identify a subgroup of IPAA patients with a risk of developing chronic or refractory pouchitis. | KM Lammers S Ouburg SA Morré JBA Crusius P Gionchetti F Rizzello C Morselli E Caramelli R Conte G Poggioli M Campieri AS Pea | 2005 | World Journal of Gastroenterology2005，11，46： | 7 |
| 2 | Minimally invasive,video2assisted parathyroid surgery for p rimary hyperparathyroidism显示文摘 | Miccoli P Cecchini O Conte M | 1997 | J Endocrinol Invest1997，20，： | 1 |
| 3 | Minimally invasive surgery for thyroid small nodules preliminary report显示文摘 | Miccoli P Berti P Conte M | | 0，，11： | 1 |
| 4 | Potential availability of heavy metals to phytoextraction from contaminated soils induced by exogenous humic sub- stances 显示文摘 | HALIM M CONTE P PICCOLO A | 2003 | Chemosphere2003，52，： | 1 |
| 5 | Finite element response sensitivity analysis: a comparison between force-based and displacementbased frame element models 显示文摘 | BARBATO M CONTE J P | 2005 | Compter Methods in Applied Mechanics Engineering2005，194，12： | 1 |
| 6 | Influence of diabetes and perivascular allogeneic endothelial cell im plants on arteriovenous fistula remodeling 显示文摘 | Conte M S Nugent H M Gaecione P | 2011 | J Vasc Surg2011，54，5： | 1 |
| 7 | Modal identification study of vincent thomas bridge using simulated wind-induced ambient vibration data 显示文摘 | He X F Babak M Conte J P | 2008 | Computer-Aided Civil and Infrastructure Engineering2008，23，： | 1 |
| 8 | Lactoferrin inhibits herpes simplex virus type 1 adsorption to Vero cells显示文摘 | Marchetti M C Longhi M P Conte | 1996 | Antiviral Res1996，29，： | 1 |
| 9 | Influence of lactoferrin on the entry process of Escherichia coli I-IB 101 (pRI203) in HeLa cells显示文摘 | LONGHI C CONTE M P SEGANTI L | 1993 | Med Microbiol Immunol1993，182，1： | 1 |
| 10 | Polycyclic aromatic hydrocarbons in farmed rainbow trout (Oncorhynchus mykiss) processed by traditional flue gas smoking and by liquid smoke flavorings显示文摘 | VISCIANO P PERUGINI M CONTE F | 2008 | Food and Chemical Toxicology2008，46，5： | 1 |
| 11 | Potential availability of heavy metals to phytoext raction from contaminated soils induced by exogenous humic substances显示文摘 | Halim M Conte P Piccolo A | 2003 | Chemosphere2003，52，1： | 1 |
| 12 | Minimally invasive surgery for small thyroid nodules:preliminary report显示文摘 | Miccoli P Berti P Conte M | 1999 | J Endocrinol Invest1999，22，： | 1 |
| 13 | Attach- ment of single-wall carbon nanotubes on platinum surfaces by self-as- sembling techniques显示文摘 | ROSARIO-CASTRO B CONT S E P REZ-DAVIS M | 2005 | Rev Adv Mater Sei2005，10，： | 1 |
| 14 | Minimally invasive surgery for thyroid small nodules:preliminary report显示文摘 | MICCOLI P BERTI P CONTE M | 1999 | J Endocr Invest1999，22，11： | 1 |
| 15 | As- sociation between a polymorphism at the stearoyl CoA desaturase locus and milk production traits in Italian Hol- steins显示文摘 | MACCIOTTA N P P MELM M CONTE G | 2008 | J Dairy Sci2008，91，： | 1 |
| 16 | Acid tolerance in Listeria monocytogenes influences invasiveness of enterocyte -like cells and macrophage-like cells显示文摘 | Conte M P Petrone G Di Biase A M | 2000 | Microb Pathog2000，29，： | 1 |
| 17 | A Re- cursive Bayesian Approach for Fatigue Damage Prog- nosis: An Experimental Validation at the Reliability Component Level显示文摘 | GOBBATO M KSOMATKA J B CONTE J P | 2014 | Mechanical Systems and Signal Processing2014，45，2： | 1 |
| 18 | Nonlinear seismic response analysis of steel-concrete composite frames 显示文摘 | Zona A Barbato M Conte J P | 2008 | Journal of Structural Engineering ASCE2008，134，6： | 1 |
| 19 | Long-term follow-up of neuroblastoma-associated op-soclonus-myoclonus-ataxia syndrome显示文摘 | De Grandis E Parodi S Conte M Angelini P Battaglia F Gan-dolfo C | 2009 | Neuropediatrics2009，40，3： | 1 |
| 20 | Minimally invasive, videoassisted parathyroid surgery for primary hyperparathyroidism显示文摘 | Miccoli P Cecchini G Conte M | 1997 | J Endocrinol Invest1997，20，： | 1 |
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