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| 1 | Combined carriership of TLR9 -1237C and CD14 -260T alleles enhances the risk of developing chronic relapsing pouchitis显示文摘AIM: To investigate the single nucleotide polymorphisms (SNPs) in genes involved in bacterial recognition and the susceptibility to pouchitis or pouchitis severity.METHODS: Analyses of CD14 -260C>T, CARD15/NOD2 3020insC, Toll-like receptor (TLR)4 +896A>G,TLR9 -1237T>C, TLR9+ 2848G>A, and IRAKM +22148G>A SNPs were performed in 157 ileal-pouch anal anastomosis (IPAA) patients (79 patients who did not develop pouchitis, 43 infrequent pouchitis patients,35 chronic relapsing pouchitis patients) and 224 Italian Caucasian healthy controls.RESULTS: No significant differences were found in SNP frequencies between controls and IPAA patients.However, a significant difference in carriership frequency of the TLR9-1237C allele was found between the infrequent pouchitis and chronic relapsing pouchitis groups [P = 0.028, odd's ratio (OR) = 3.2, 95%CI = 1.2-8.6].This allele uniquely represented a 4-locus TLR9 haplotype comprising both studied TLR9 SNPs in Caucasians.Carrier trait analysis revealed an enhanced combined carriership of the alleles TLR9 -1237C and CD14 -260T in the chronic relapsing pouchitis and infrequent pouchitis group (P = 0.018, OR = 4.1, 95%CI = 1.4 -12.3).CONCLUSION: There is no evidence that the SNPs predispose to the need for IPAA surgery. The significant increase of the combined carriership of the CD14 -260T and TLR9 -1237C alleles in the chronic relapsing pouchitis group suggests that these markers identify a subgroup of IPAA patients with a risk of developing chronic or refractory pouchitis. | KM Lammers S Ouburg SA Morré JBA Crusius P Gionchetti F Rizzello C Morselli E Caramelli R Conte G Poggioli M Campieri AS Pea | 2005 | World Journal of Gastroenterology2005,11,46: | 7 |
| 2 | Oral bacteriotherapy as maintenance treatment in patients with chronic pouchitis : a double-blind, placebo-controlled trial 显示文摘 | Gionchetti P Rizzello F Venturi A | 2000 | Gastroenterology2000,119,: | 1 |
| 3 | Prophylaxis of pouchitis onset with probiotic therapy : a double-blind, placebo-controlled trial 显示文摘 | GIONCHETTI P RIZZELLO F HELWlG U | 2003 | Gastroenter- ology2003,124,5: | 1 |
| 4 | Endometriosis and infertility Surgery and ART : An integrated approach for successful management 显示文摘 | Coccia ME Rizzello F Cammilli F | 2008 | Eur J Obstet Gynecol Reprod Biol2008,138,1: | 1 |
| 5 | Oral bacteriotherapy as maintenance treatment in patients with chronic pouchitis:a double-blind,placebo-controlled trial显示文摘 | GIONCHETTI P RIZZELLO F VENTURI A | 2000 | Gastroenterology2000,119,2: | 1 |
| 6 | Endometriosis and in- fertility surgery and ART an integrated approach for successful management 显示文摘 | Elisabetta MC Rizzello F Cammilli F | 2008 | European Journal of Obstetrics and Gynecology and Reproductive Biology2008,138,1: | 1 |
| 7 | Long-term effects of laparoscopic sleeve gastrectomy, gastric bypass, and adjustable gastric banding on type 2 diabetes 显示文摘 | Abbatini F Rizzello M Casella G | 2010 | Surg Endosc2010,24,5: | 1 |
| 8 | Ovarian surgery for bilateral endometriomas influences age at menopause显示文摘 | Coccia ME Rizzello F Mariani G | 2011 | Hum Reprod2011,26,11: | 1 |
| 9 | Does controlledovarian hypers-timulation in women with a history of endometriosis influence recur-rence rate 显示文摘 | Coccia ME Rizzello F Gianfranco S | 2010 | Womens Health ( Larchmt)2010,19,11: | 1 |
| 10 | Design of Pd-based membrane reactor for gas detritation 显示文摘 | Tosyi S Rizzello C Borgognoni F | 2011 | FusionEngineering and Design2011,86,: | 1 |
| 11 | Oral beclomethasone dipropionate in patients with mild to moderate ulcerative colitis:a dose-finding study显示文摘 | RIZZELLO F GIONCHETTI P GALEAZZI R | 2001 | Adv Ther2001,18,6: | 1 |
| 12 | Endom- etriosis and infertility-Surgery and ART: An integrated ap- proach for successful management 显示文摘 | COCCIA M E RIZZELLO F CAMMILLI F | 2012 | Eur J Obstet Gyneeol Reprod Biol2012,138,1: | 1 |
| 13 | Long-term follow-up after laparoscopic treatment for endometriosis:multivariate analysis of predictive factors for recurrence of endometriotic lesions and pain显示文摘 | Coccia ME Rizzello F Palagiano A | 2011 | Eur J Obstet Gynecol Reprod Biol2011,157,1: | 1 |
| 14 | Impact on the composition of the faecal flora by a new probiotic preparation: preliminary data on maintenance treatment of patients with ulcerative colitis 显示文摘 | Venturi A Gionchetti P Rizzello F | 1999 | Aliment Pharmacol Ther1999,13,8: | 1 |
| 15 | AngiotensinIConverting-Enzyme-Inhibitory and Antibacterial Peptides from Lactobacillus helveticus PR4 Proteinase-Hydrolyzed Caseins of Milk from Six Species显示文摘 | F Minervini F Algaron C G Rizzello | 2003 | Applied and Environmental Microbiology2003,69,9: | 1 |
| 16 | Does controlled ovarian hyperstlmulation inwomen with a history of endometriosis in- fluence recurrence rate? 显示文摘 | Coeeia ME Rizzello F Gianfranco S | 2010 | Womens Health (Larchmt)2010,19,11: | 1 |
| 17 | Comparison of oral with rectal mesalazine in the treatment of ulcerative proctitis显示文摘 | Gionchetti P Rizzello F Venturi A | 1998 | Dis Colon Rectum1998,41,1: | 1 |
| 18 | Prophylaxis of pouchitis onset with Probiotic therapy:a double-hlind,placebo-controlled trial显示文摘 | Gionchetti P Rizzello F Helwig U | 2003 | Gastroenterology2003,124,5: | 1 |
| 19 | Once daily high dose probiotic therapy(VSL#3)for maintaining remission in recurrent or refractory pouchitis显示文摘 | Mimura T Rizzello F Helwig U | 2004 | Gut2004,53,1: | 1 |
| 20 | Angiotensin I-converting-enzyme-inhibitory and antimicrobial bioactive peptides显示文摘 | Gobbetti M Minervini F Rizzello C G | 2004 | Int J Dairy Technol2004,57,: | 1 |