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| 1 | Combined carriership of TLR9 -1237C and CD14 -260T alleles enhances the risk of developing chronic relapsing pouchitis显示文摘AIM: To investigate the single nucleotide polymorphisms (SNPs) in genes involved in bacterial recognition and the susceptibility to pouchitis or pouchitis severity.METHODS: Analyses of CD14 -260C>T, CARD15/NOD2 3020insC, Toll-like receptor (TLR)4 +896A>G,TLR9 -1237T>C, TLR9+ 2848G>A, and IRAKM +22148G>A SNPs were performed in 157 ileal-pouch anal anastomosis (IPAA) patients (79 patients who did not develop pouchitis, 43 infrequent pouchitis patients,35 chronic relapsing pouchitis patients) and 224 Italian Caucasian healthy controls.RESULTS: No significant differences were found in SNP frequencies between controls and IPAA patients.However, a significant difference in carriership frequency of the TLR9-1237C allele was found between the infrequent pouchitis and chronic relapsing pouchitis groups [P = 0.028, odd's ratio (OR) = 3.2, 95%CI = 1.2-8.6].This allele uniquely represented a 4-locus TLR9 haplotype comprising both studied TLR9 SNPs in Caucasians.Carrier trait analysis revealed an enhanced combined carriership of the alleles TLR9 -1237C and CD14 -260T in the chronic relapsing pouchitis and infrequent pouchitis group (P = 0.018, OR = 4.1, 95%CI = 1.4 -12.3).CONCLUSION: There is no evidence that the SNPs predispose to the need for IPAA surgery. The significant increase of the combined carriership of the CD14 -260T and TLR9 -1237C alleles in the chronic relapsing pouchitis group suggests that these markers identify a subgroup of IPAA patients with a risk of developing chronic or refractory pouchitis. | KM Lammers S Ouburg SA Morré JBA Crusius P Gionchetti F Rizzello C Morselli E Caramelli R Conte G Poggioli M Campieri AS Pea | 2005 | World Journal of Gastroenterology2005，11，46： | 7 |
| 2 | Minimally invasive,video2assisted parathyroid surgery for p rimary hyperparathyroidism显示文摘 | Miccoli P Cecchini O Conte M | 1997 | J Endocrinol Invest1997，20，： | 1 |
| 3 | Antiepileptic drugs and cortical excitability: a study with repetitive transcra- nial stimulation显示文摘 | M INGHILLERI A CONTE V FRASCA | 2004 | Exp Brain Res2004，154，48： | 1 |
| 4 | Circulating ghrelin levels in celiac patients 显示文摘 | Peracchi M Conte D Terrani C | 2003 | Am J Gastroenterol2003，98，11： | 1 |
| 5 | Planned gait termina- tion in cerebellar ataxias 显示文摘 | Conte C Serrao M Casali C | 2012 | Cerebellum2012，11，4： | 1 |
| 6 | Minimally invasive surgery for thyroid small nodules preliminary report显示文摘 | Miccoli P Berti P Conte M | | 0，，11： | 1 |
| 7 | Identification of novel RP2 mutations in a subset of X-linked retilfitis pigmentosa families and prediction of new domains 显示文摘 | Miano MG Testa F Filippini F Trujifio M Conte I Lanzara C | 2001 | Hum Murat2001，18，2： | 1 |
| 8 | P16^INK4A hypermethylation detected by fluorescent methylation-specific PCR in plasmas from non-small cell lung cancer 显示文摘 | Bearzatto A Conte D Frattini M | 2002 | Clin Cancer Res2002，8，12： | 1 |
| 9 | Genetic and physiological influences on the alkenone/alkenoate versus growth temperature relationship in Emiliania huxleyi and Gephyrocapsa oceanica 显示文摘 | Conte M H Thompson A Lesley D | 1998 | Geochimica et Cosmochimica Acta1998，62，1： | 1 |
| 10 | Potential availability of heavy metals to phytoextraction from contaminated soils induced by exogenous humic sub- stances 显示文摘 | HALIM M CONTE P PICCOLO A | 2003 | Chemosphere2003，52，： | 1 |
| 11 | The Effect of Individual Perceptions of Deadlines on Team Performance显示文摘 | WALI ER M J CONTE J M GIBSON C B | 2001 | The Academy of Management Review2001，26，4： | 1 |
| 12 | Animal transmissible spongiform encephalopathies and genetics 显示文摘 | AGRIMI U CONTE M MORELLI L | 2003 | Vet Res Commun2003，27，1： | 1 |
| 13 | Severe coronary artery disease after radiation therapy of the chest and mediastinum: clinical presentation and treatment 显示文摘 | ORZAN F BRUSCA A CONTE M R | 1993 | Br Heart J1993，69，6： | 1 |
| 14 | Finite element response sensitivity analysis: a comparison between force-based and displacementbased frame element models 显示文摘 | BARBATO M CONTE J P | 2005 | Compter Methods in Applied Mechanics Engineering2005，194，12： | 1 |
| 15 | Cystatin C is associated with an increased coronary atherosclerotic burden and a stable plaque pheno- type in patients with ischemic heart disease and normal glomerular filtra- tion rate显示文摘 | Niccoli G Conte M Della Bona R | 2008 | Atherosclerosis2008，198，2： | 1 |
| 16 | Experimental and analytical thermal study of PTFE composite sliding against high carbon steel as a function of the surface roughness,sliding velocity and applied load显示文摘 | TZANAKIS I CONTE M HADFIELD M | 2013 | Wear2013，303，1： | 1 |
| 17 | Successful phacoemulsification in vitrectomized eyes : technical considerations 显示文摘 | Rouhette H Conte M Guillemot F | 2014 | J Fr Ophtalmol2014，37，3： | 1 |
| 18 | Influence of diabetes and perivascular allogeneic endothelial cell im plants on arteriovenous fistula remodeling 显示文摘 | Conte M S Nugent H M Gaecione P | 2011 | J Vasc Surg2011，54，5： | 1 |
| 19 | Hydrochlorination of acetylene using supported bimetallic Au-based cata- lysts显示文摘 | Conte M Carley A Attard G | 2008 | Journal of Catalysis2008，257，1： | 1 |
| 20 | Adaptive detection schemes in cornpound-Gaussian clutter 显示文摘 | E Conte M Lops G Ricci | 1998 | IEEE Transactions on Aerospace and ElecllOnic Systems1998，34，4： | 1 |
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