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| 1 | Unraveling a genetic roadmap for improved taste in the domesticated apple显示文摘Although taste is an important aspect of fruit quality, an understanding of its genetic control remains elusive in apple and other fruit crops. In this study, we conducted genomic sequence analysis of 497 Malus accessions and revealed erosion of genetic diversity caused by apple breeding and possible independent domestication events of dessert and cider apples. Signatures of selection for fruit acidity and size, but not for fruit sugar content, were detected during the processes of both domestication and improvement. Furthermore, we found that single mutations in major genes affecting fruit taste, including Ma1, MdTDT, and MdSOT2, dramatically decrease malate, citrate, and sorbitol accumulation, respectively, and correspond to important domestication events. Interestingly, Ma1 was identified to have pleiotropic effects on both organic acid content and sugar:acid ratio, suggesting that it plays a vital role in determining fruit taste. Fruit taste is unlikely to have been negatively affected by linkage drag associated with selection for larger fruit that resulted from the pyramiding of multiple genes with minor effects on fruit size. Collectively, our study provides new insights into the genetic basis of fruit quality and its evolutionary roadmap during apple domestication, pinpointing several candidate genes for genetic manipulation of fruit taste in apple. | Liao Liao Weihan Zhang Bo Zhang Ting Fang Xiao-Fei Wang Yarning Cai Collins Ogutu Lei Gao Gang Chen Xiaoqing Nie Jinsheng Xu Quanyan Zhang Yiran Ren Jianqiang Yu Chukun Wang Cecilia H.Deng Baiquan Ma Beibei Zheng Chun-Xiang You Da-Gang Hu Richard Espley Kui Lin-Wang Jia-Long Yao Andrew C.Allan Awais Khan Schuyler S.Korban Zhangjun Fei Ray Ming Yu-Jin Hao Li Li Yuepeng Han | 2021 | Molecular Plant2021，14，9： | 5 |
| 2 | Transcriptional regulation of endothelial cell adhesion molecules: NF-kappa B and cytokine-inducible enhancers显示文摘 | Read MA Neish AS | 1995 | FASEB J1995，9，： | 1 |
| 3 | Onocogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice 显示文摘 | Collins MA Bednar F Zhang Y ct al | 2012 | J Clin Invest2012，122，2： | 1 |
| 4 | The path to personalized medicine显示文摘 | HAMBURG MA COLLINS FS | 2010 | N Engl JMed2010，363，4： | 1 |
| 5 | Physiological improvement with moderate exercise in type IT diabetic neuropathy显示文摘 | Fisher MA Langbein WE Collins EG | 2007 | J Electromyogr Clin Neurophysiol2007，47，1： | 1 |
| 6 | Quality of life is impaired in men with chronic prostatitis: the Chronic Prostatitis Collaborative Research Network显示文摘 | McNaughton Collins M Pontari MA | 2001 | J Gen Intern Med2001，16，10： | 1 |
| 7 | The kinetics of repair of oxidative DNA damage(strand breaks and oxidized pyrimidines)in human cells显示文摘 | Andrew R Collins Ma Ai-guo Susan J | 1995 | Mut Res1995，338，： | 1 |
| 8 | Evolution of nano-fingers in epitaxial Mn-doped Ba(Zr,Ti)O3 thin films driven by {110} twin boundaries显示文摘 | J. He J.C. Jiang E.I. Meletis M. Liu J. Liu G. Collins C.R. Ma C.L. Chen A. Bhalla | 2011 | Philosophical Magazine Letters2011，，5： | 1 |
| 9 | Egr-2 and Egr-3 are negative regulators of T cell activation 显示文摘 | Safford M Collins S Lutz MA | 2005 | Nat Immunol2005，6，5： | 1 |
| 10 | Transcription regulation of endothelial cells adhesion molecules: NF-kappa B cytokineinducible enhances显示文摘 | Collins T Read MA Neish AS | 1995 | FASEB J1995，9，10： | 1 |
| 11 | The kinetics of repair of oxidative DNA damage in human cells显示文摘 | Collins AR Ma AG Duthie SJ | 1995 | Mutat Res1995，336，1： | 1 |
| 12 | Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)显示文摘 | Bentley SD Chater KF Cerdeno-Tarraga AM Challis GL Thomson NR James KD Harris DE Quail MA Kieser H Harper D Bateman A Brown S Chandra G Chen CW Collins M Cronin A Fraser A Goble A Hidalgo J Hornsby T Howarth S Huang CH Kieser T Larke L Murphy L Oliver K O | | 0，，： | 1 |
| 13 | The kinetics of repair of oxidative DNA damage( strand breaks and oxidized pyrimidines) in human cells显示文摘 | Collins A R Ma A G Duthie S J | 1995 | Mutat Res1995，336，1： | 1 |
| 14 | The path Io personalized medicine显示文摘 | Hamburg MA Collins FS | 2010 | N Engl J Med2010，363，4： | 1 |
| 15 | Novel pyrrolecontaining progesterone receptor modulators 显示文摘 | COLLINS MA HUDAK V BENDER R | 2004 | Bioorg Med Chem Lett2004，14，9： | 1 |
| 16 | Transcriptional regulation of endothelial cell adhesion molecules:NF-κB and cytokine inducible enhancers显示文摘 | Collins T Read MA Neish AS | 1995 | FASEB J1995，9，10： | 1 |
| 17 | Complement activation in acute humoral renal allograft rejection: diagnostic significance of C4d deposits in peritubular capillaries显示文摘 | Collins AB Schneeberger EE Pascual MA | 1999 | J Am Soc Nephrol1999，10，10： | 1 |
| 18 | How antibiotics kill bacteria:from targets to networks 显示文摘 | Kohanski MA Dwyer DJ Collins JJ | 2010 | Nat Rev Microbiol2010，8，6： | 1 |
| 19 | Kras as a key oncogene and therapeutic target in pancreatic cancer显示文摘 | Collins MA Pasca di Magliano M | 2014 | Front Physiol2014，4，： | 1 |
| 20 | The path to personalized medicine 显示文摘 | Hamburg MA Collins FS | 2010 | N Engl J Med2010，363，4： | 1 |
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