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| 1 | Tumor initiation and progression in hepatocellular carcinoma: risk factors, classification, and therapeutic targets显示文摘Hepatocellular 癌(HCC ) 每年是为 500 000 死亡负责的世界范围的一个主要健康问题。很多个风险因素与也被联系疾病或它的前进的正式就职;这些与肝炎 B 或 C 病毒,白酒消费,非酒精的 steatohepatitis 和某些先天的混乱包括感染。在约 80% 盒子, HCC 与肝硬化或先进纤维变性并且与发炎和氧化应力被联系。在这评论,我们为 HCC 第一集中于不同风险因素并且总结由哪个各被认为贡献 HCC 的机制。在第二部分,我们看涉及癌症前进的分子的过程。HCC 开发作为 multistep 进程被认出通常在许多年发展。在几个变化在房间和那积累的这个时期上刺激诽谤转变,生长,和变形行为。在最近的年,不仅肿瘤房间本身而且肿瘤 microenviroment 在一个肿瘤的发展起一个主要作用,变得明显。与这 microenviroment 在发炎和肝硬化的角色之间有一个直接连接。在 vitro 并且在 vivo,它被看了那肿瘤形成,变形性质被连接到上皮间充质的转变(EMT ) ,由 facillitates,肿瘤房间是尝试移居到更赞成的 microenviroment 的一个过程。几个组由 microarray 在 HCC 和它的包围织物分析了基因表示,这导致了分子的分类进班的一个不同数字。这里,我们也发现为组织缺氧的一个角色导致了基因表示导致一临床上在 HCC 的更好攻击的基因表示。分子的分析也帮助识别重要细胞的小径和可能的治疗学的目标。这样为肝癌症显示出临床的申请的第一个分子是 multikinase 禁止者 sorafenib,其它当前在象 mTOR 禁止者 everolimus 一样的临床的研究的不同阶段。 | Tamara SEVERI Hannah van MALENSTEIN Chris VERSLYPE Jos F van PELT | 2010 | Acta Pharmacologica Sinica2010，31，11： | 23 |
| 2 | Gastrointestinal neuromuscular apparatus: An underestimated target of gut microbiota显示文摘Over the last few years, the importance of the resident intestinal microbiota in the pathogenesis of several gastrointestinal diseases has been largely investigated. Growing evidence suggest that microbiota can influence gastrointestinal motility. The current working hypothesis is that dysbiosis-driven mucosal alterations induce the production of several inflammatory/immune mediators which affect gut neuro-muscular functions. Besides these indirect mucosal-mediated effects, the present review highlights that recent evidence suggests that microbiota can directly affect enteric nerves and smooth muscle cells functions through its metabolic products or bacterial molecular components translocated from the intestinal lumen. Tolllike receptors, the bacterial recognition receptors, are expressed both on enteric nerves and smooth muscle and are emerging as potential mediators between microbiota and the enteric neuromuscular apparatus. Furthermore, the ongoing studies on probiotics support the hypothesis that the neuromuscular apparatus may represent a target of intervention, thus opening new physiopathological and therapeutic scenarios. | Michele Pier Luca Guarino Michele Cicala Lorenza Putignani Carola Severi | 2016 | World Journal of Gastroenterology2016，22，45： | 8 |
| 3 | Common features between neoplastic and preneoplastic lesions of the biliary tract and the pancreas显示文摘the bile duct system and pancreas show many similarities due to their anatomical proximity and common embryological origin.Consequently,preneoplastic and neoplastic lesions of the bile duct and pancreas share analogies in terms of molecular,histological and pathophysiological features.Intraepithelial neoplasms are reported in biliary tract,as biliary intraepithelial neoplasm(BilIN),and in pancreas,as pancreatic intraepithelial neoplasm(PanIN).Both can evolve to invasive carcinomas,respectively cholangiocarcinoma(CCA)and pancreatic ductal adenocarcinoma(PDAC).Intraductal papillary neoplasms arise in biliary tract and pancreas.Intraductal papillary neoplasm of the biliary tract(IPNB)share common histologic and phenotypic features such as pancreatobiliary,gastric,intestinal and oncocytic types,and biological behavior with the pancreatic counterpart,the intraductal papillary mucinous neoplasm of the pancreas(IPMN).All these neoplastic lesions exhibit similar immunohistochemical phenotypes,suggesting a common carcinogenic process.Indeed,CCA and PDAC display similar clinic-pathological features as growth pattern,poor response to conventional chemotherapy and radiotherapy and,as a consequence,an unfavorable prognosis.The objective of this review is to discuss similarities and differences between the neoplastic lesions of the pancreas and biliary tract with potential implications on a common origin from similar stem/progenitor cells. | Piera Zaccari Vincenzo Cardinale Carola Severi Federica Pedica Guido Carpino Eugenio Gaudio Claudio Doglioni Maria Chiara Petrone Domenico Alvaro Paolo Giorgio Arcidiacono Gabriele Capurso | 2019 | World Journal of Gastroenterology2019，25，31： | 6 |
| 4 | Proton pump inhibitors and dysbiosis: Current knowledge and aspects to be clarified显示文摘Proton pump inhibitors (PPIs) are common medications within the practice of gastroenterology. These drugs, which act through the irreversible inhibition of the hydrogen/potassium pump (H+/K+-ATPase pump) in the gastric parietal cells, are used in the treatment of several acid-related disorders. PPIs are generally well tolerated but, through the long-term reduction of gastric acid secretion, can increase the risk of an imbalance in gut microbiota composition (i.e., dysbiosis). The gut microbiota is a complex ecosystem in which microbes coexist and interact with the human host. Indeed, the resident gut bacteria are needed for multiple vital functions, such as nutrient and drug metabolism, the production of energy, defense against pathogens, the modulation of the immune system and support of the integrity of the gut mucosal barrier. The bacteria are collected in communities that vary in density and composition within each segment of the gastrointestinal (GI) tract. Therefore, every change in the gut ecosystem has been connected to an increased susceptibility or exacerbation of various GI disorders. The aim of this review is to summarize the recently available data on PPI-related microbiota alterations in each segment of the GI tract and to analyze the possible involvement of PPIs in the pathogenesis of several specific GI diseases. | Giovanni Bruno Piera Zaccari Giulia Rocco Giulia Scalese Cristina Panetta Barbara Porowska Stefano Pontone Carola Severi | 2019 | World Journal of Gastroenterology2019，25，22： | 4 |
| 5 | Helicobacter pylori infection in obesity and its clinical outcome after bariatric surgery显示文摘The present review summarizes the prevalence and active clinical problems in obese patients with Helicobacter pylori(H.pylori)infection,as well as the outcomes after bariatric surgery in this patient population.The involvement of H.pylori in the pathophysiology of obesity is still debated.It may be that the infection is protective against obesity,because of the gastritis-induced decrease in production and secretion of the orexigenic hormone ghrelin.However,recent epidemiological studies have failed to show an association between H.pylori infection and reduced body mass index.H.pylori infection might represent a limiting factor in the access to bariatric bypass surgery,even if highquality evidence indicating the advantages of preoperative H.pylori screening and eradication is lacking.The clinical management of infection is complicated by the lower eradication rates with standard therapeutic regimens reported in obese patients than in the normalweight population.Prospective clinical studies to ameliorate both H.pylori eradication rates and control the clinical outcomes of H.pylori infection after different bariatric procedures are warranted. | Marilia Carabotti Chiara D'Ercole Angelo Iossa Enrico Corazziari Gianfranco Silecchia Carola Severi | 2014 | World Journal of Gastroenterology2014，20，3： | 3 |
| 6 | Synthesis and activity of a new series of chalcone as aldose reductase inhibitors 显示文摘 | Severi F Benvenuti S Costantino L | 1998 | Eur J Med Chem1998，33，11： | 1 |
| 7 | Modeling of Carrier Mobility Against Carrier Concentration in Arsenic Boron-doped Silicon显示文摘 | Masetti G Severi M Solmi S | 1983 | IEEE Transactions on Electronic Devices1983，30，7： | 1 |
| 8 | Both Ca2+-dependent and-independent pathways are involved in rat hepatic stellate cell contraction and intrahepatic hyperresponsiveness to methoxamine显示文摘 | Laleman W Van Landeghem L Severi T | 2007 | Physiol Gastrointest Liver Physiol2007，292，2： | 1 |
| 9 | Sialic acid utilization by bac- terial pathogens 显示文摘 | Severi E Hood DW Thomas GH | 2007 | Microbiology2007，153，： | 1 |
| 10 | Human cytomegalovirus morphogenesis : an ultrastructural study of the late cytoplasmic phases 显示文摘 | Severi B Landini MP Govoni E | 1988 | Arch Virol1988，98，12： | 1 |
| 11 | Analysis of possible factors affecting the specificity of the gamma interferon test in tuberculosis-free cattle herds显示文摘 | Cagiola M Feliziani F Severi G | 2004 | Clin Diagn Lab Immunol2004，11，5： | 1 |
| 12 | Endometrial expression and secretion of activin A, but not follistatin, increase in the secretory phase of the menstrual cycle显示文摘 | Florio P Severi F M Luisi S et at | 2003 | J Soc Gynecol Investig2003，10，4： | 1 |
| 13 | Reassessment of intrinsic factor and parietal cell autoantibodies in atrophic gastritis with respect to cobalamin deficiency显示文摘 | Lahner E Norman GL Severi C | | 0，，： | 1 |
| 14 | Intorno ai punti doppi impropri di una superficie generale dello spazio a quattro dimensioni, e a’ suoi punti tripli apparenti显示文摘 | Francesco Severi | | 0，1901，： | 1 |
| 15 | Uterine fibroids affect pregnancy out- come in women over 30 years old : role of other risk factors 显示文摘 | Conti N Tosti C Pinzauti S Tomaiuolo T Cevenini G Severi FM Di Tommaso M Petraglia F | 2013 | Matem Fetal Neonatal Med2013，26，6： | 1 |
| 16 | Alterations ofatrial electrophysiology related to hemodialysis ses-sion: insights from a multiscale computer model显示文摘 | Krueger M W Severi S Rhode K | 2011 | JElectrocardiol2011，44，2： | 1 |
| 17 | Umbilical cord serum activin A levels are increased in pre - eclampsia with impaired blood flow in the uteroplacental and fetal circulation 显示文摘 | Florio P Reis FM Severi FM | 2006 | Placenta2006，27，45： | 1 |
| 18 | The common variant rs1447295 on chromosome 8q24 and prostate cancer risk: results from an Australian population-based case-control study 显示文摘 | Severi G Hayes VM Padilla EJ | 2007 | Cancer Epidemiol Biomarkers Prev2007，16，3： | 1 |
| 19 | Early growth,adult body size and prostate cancer risk显示文摘 | GILES GG SEVERI G ENGLISH DR | 2003 | Int J Cancer2003，103，2： | 1 |
| 20 | Alterations ofatrial electrophysiology induced by electrolyte varia-tions :combined computational and P-wave analysis显示文摘 | Severi S Pogliani D Fantini G | 2010 | Europace2010，12，6： | 1 |
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