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| 1 | Drug-targeting methodologies with applications: A review显示文摘Targeted drug delivery to solid tumors is a very active research area, focusing mainly on improved drug formulation and associated best delivery methods/devices. Drug-targeting has the potential to greatly improve drug-delivery efficacy, reduce side effects, and lower the treatment costs. However, the vast majority of drug-targeting studies assume that the drug-particles are already at the target site or at least in its direct vicinity. In this review, drug-delivery methodologies, drug types and drug-delivery devices are discussed with examples in two major application areas:(1) inhaled drug-aerosol delivery into human lung-airways; and(2) intravascular drug-delivery for solid tumor targeting. The major problem addressed is how to deliver efficiently the drug-particles from the entry/infusion point to the target site. So far, most experimental results are based on animal studies. Concerning pulmonary drug delivery, the focus is on the pros and cons of three inhaler types, i.e., pressurized metered dose inhaler, dry powder inhaler and nebulizer, in addition to drug-aerosol formulations. Computational fluid-particle dynamics techniques and the underlying methodology for a smart inhaler system are discussed as well.Concerning intravascular drug-delivery for solid tumor targeting, passive and active targeting are reviewed as well as direct drug-targeting, using optimal delivery of radioactive microspheres to liver tumors as an example. The review concludes with suggestions for future work, considereing both pulmonary drug targeting and direct drug delivery to solid tumors in the vascular system. | Clement Kleinstreuer Yu Feng Emily Childress | 2014 | World Journal of Clinical Cases2014，2，12： | 4 |
| 2 | Experimental-computational study of fibrous particle transport and deposition in a bifurcating lung model显示文摘 | Xiaole Chen Wenqi Zhong Josin Tom Clement Kleinstreuer Yu Feng Xiaopu He | 2016 | Particuology2016，14，5： | 3 |
| 3 | Plant Cell Wall Proteomics: Mass Spectrometry Data, a Trove for Research on Protein Structure/Function Relationships显示文摘Proteomics 在整个有机体或在净化的细胞器允许蛋白质表示的大规模学习。特别地,分开胶化的蛋白质的集体 spectrometry (MS ) 分析不仅为蛋白质鉴定,而且为蛋白质结构生产数据,地点,并且也处理。深入的分析从 Arabidopsis thaliana 的变白的胚轴房间墙 proteomics 在 MS 数据上被执行。这些分析证明 multigene 家庭的高度相应的成员能被区分。介绍 93% 氨基酸身份的二 lectins 用采指纹的肽质量被识别。尽管象 extensins 那样的结构的蛋白质或 hydroxyproline/proline-rich 蛋白质(H/PRPs ) 的鉴定是艰巨的, MS 系列的不同类型被利用识别并且描绘 H/PRP。在几房间墙蛋白质(CWP ) 的成熟事件用地点印射被分析。氨基酸的 CWP 以及 hydroxylation 或氧化的 N-glycosylation 也被探索,增加信息改进我们 CWP 结构 / 功能关系的理解。一个生物信息的工具被开发借助于 MS 定位成熟分泌蛋白质和 N-glycosylation 的 N 终点。 | Cecile Albenne Herve Canut Georges Boudart Yu Zhang Helene San Clemente Rafael Pont-Lezica Elisabeth Jamet | 2009 | Molecular Plant2009，2，5： | 2 |
| 4 | Automatic integration of Web search interfaces with WISE-Integrator显示文摘 | Hai He Weiyi Meng Clement Yu Zonghuan Wu | 2004 | The VLDB Journal2004，，3： | 1 |
| 5 | Short-channel effect improved by lateral channel-engineering in deep-sub-micron meter MOSFET's显示文摘 | Yu B Clement H J Edward D | 1997 | IEEE Trans Electron Devices1997，44，4： | 1 |
| 6 | A statistical method for estimating the usefulness of text databases显示文摘 | Liu King-Lup Yu Clement Meng Weiyi | 2002 | IEEE Transactionson Knowledge and Data Engineering2002，14，6： | 1 |
| 7 | Nodal culture of buffalograss and its potential use for genetic transformation through particle bombardment显示文摘 | Yu T Clemente T Riordan T P | 2001 | Int Turfgrass Soc Res J2001，9，： | 1 |
| 8 | A hybrid Bilevel Image Decode Algorithm for Group 4 FAX 显示文摘 | Chengjie Luo Clement Yu | 1991 | ACM1991，89，7： | 1 |
| 9 | Personalized web search for improving retrieval effectiveness显示文摘 | Fang Liu Clement Yu and Weiyi Meng | 2004 | IEEE transactions on knowledge and data engineering2004，16，1： | 1 |
| 10 | Building Efficient and Effective Metasearch Engine显示文摘 | Meng Weiyi Yu Clement Liu Kinglup | 2002 | ACM Computing Surveys2002，34，1： | 1 |
| 11 | Association of Apolipoprotein E Polymorphisms With Normal Tension Glaucoma in a Chinese Population显示文摘 | Ching Yan Lam Bao Jian Fan Dan Yi Wang Pancy Oi Sin Tam Clement Chee Yung Tham Dexter Yu Lung Leung Dorothy Shu Ping Fan Dennis Shun Chiu Lam Chi Pui Pang | 2006 | Journal of Glaucoma2006，，3： | 1 |
| 12 | Towards Deeper Understanding of the Search Interfaces of the Deep Web显示文摘 | Hai He Weiyi Meng Yiyao Lu Clement Yu Zonghuan Wu | 2007 | World Wide Web2007，，2： | 1 |
| 13 | Building efficient and effective metasearch engines显示文摘 | Meng Weiyi Yu Clement Liu King-lup | 2002 | ACM Computing Surveys2002，34，1： | 1 |
| 14 | A statistical method for estimating the usefulness of text databases显示文摘 | Liu King-Lup Yu Clement Meng Weiyi | 2002 | IEEE Transactions on Knowledge and Data Engineering2002，14，6： | 1 |
| 15 | Building Efficient and Effective Metasearch Engines显示文摘 | Weiyi Meng Clement Yu and King-Lup Liu | 2002 | ACM Computing Surveys2002，34，1： | 1 |
| 16 | NaPhtali Rishe: A statistical method for estimating the usefulness of text databases显示文摘 | Liu King-Lup Yu Clement Meng Weiyi | 2002 | IEEE transactions on Knowledge and Data Engineering2002，，： | 1 |
| 17 | Techniques and systems for image and video retrieval显示文摘 | Clement Yu T | 1999 | IEEE trans on Knowledge and Data Engineering1999，11，1： | 1 |
| 18 | Personalized web search for improving retrieval effectiveness显示文摘 | Fang liu Clement Yu Weiyi Meng | 2004 | IEEE Transactions on Knowledge and Data Engineering2004，16，1： | 1 |
| 19 | Continuum-regime field charging in an electron swarm显示文摘 | Clements J C Yu K K | 1991 | IEEE Trans on Ind Appl1991，27，6： | 1 |
| 20 | Experimental and theoretical studies of nanofluid thermal conductivity enhance- ment:a review 显示文摘 | CLEMENT K YU F | 2011 | Nanoscale Res Lett2011，6，1： | 1 |
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