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| 1 | 青年型开角型青光眼的中国家系的新型Myocilin基因突变显示文摘目的:探讨某中国家系青年型开角型青光眼(JOAG)的致病基因。
方法:在一个青光眼家系中,三代人中患JOAG或高眼压。我们筛查了6位家族成员Myocilin(MYOC)和 optineurin(OPTN)的突变和apolipoprotein E的多态性,2位患有JOAG,2位患有高眼压,2位无症状。正常对照组包括200位与本家系无关联的受试者。用编码野生型或变异性 MYOC 互补 DNA 的表达载体转染cos-7细胞系。细胞内或分泌的MYOC蛋白用Western法进行检测。 | Bao Jian Fan Dexter Y. L Leung Dan Yi Wang Stéphane Vincent Raymond Pancy O. S. Tam Dennis S. C. Lam Chi Pui Pang 王婷(译) | 2006 | 美国医学会眼科杂志(中文版)2006，18，4： | 5 |
| 2 | Genome-wide analysis identified 17 new loci influencing intraocular pressure in Chinese population显示文摘Intraocular pressure(IOP) is a major risk factor for glaucoma. Genetic determinants of intraocular pressure can provide critical insights into the genetic architecture of glaucoma and, as a result, open new avenues for therapeutic intervention. We performed a genome-wide association study and replication analysis of 8,552 Chinese participants. In the genome-wide association study, we identified 51 loci that surpassed the significance of P<9×10^(-7), and we formally replicated these loci. A combined discovery and replication meta-analysis identified 21 genome-wide loci that surpassed the genome-wide significance of P<5×10^(-8), including 4 previously reported loci: rs145063132(7 p21.2, ETV1/DGKB), rs548030386(7 q31.2, ST7 near CAV1/CAV2), rs7047871(9 p24.2, GLIS3), and rs2472494(9 q31.1, ABCA1/SLC44 A1). Of the 17 newly identified loci, five were reported to have ocular related phenotypes: PTCH2(rs7525308 in 1 p34.1), LRIF1/DRAM2(rs1282146 in 1 p13.3), COLEC11(rs201143466 in 2 p25.3),SPTBN1(rs4514918 in 2 p16.2), and CRK(rs11078446 in 17 p13.3). The genetic loci identified in this study not only increase our understanding of the genes involved in intraocular pressure but also provide important genetic markers to improve future genetic screening and drug discovery for intraocular pressure disorders. | Lulin Huang Yuhong Chen Ying Lin Pancy O.S.Tam Yilian Cheng Yi Shi Bo Gong Fang Lu Jialiang Yang Haixin Wang Yi Yin Yong Cao Dan Jiang Ling Zhong Bai Xue Jing Wang Fang Hao Dean-Yao Lee Chi-Pui Pang Xinghuai Sun Zhenglin Yang | 2019 | Science China(Life Sciences)2019，62，2： | 4 |
| 3 | Zona thinning with the use of laser:anew approach to assisted hatching in human embryos显示文摘 | ANTINORI S PANCI C SELMAN H A | 1996 | Hum Reprod1996，11，3： | 1 |
| 4 | Association of Apolipoprotein E Polymorphisms With Normal Tension Glaucoma in a Chinese Population显示文摘 | Ching Yan Lam Bao Jian Fan Dan Yi Wang Pancy Oi Sin Tam Clement Chee Yung Tham Dexter Yu Lung Leung Dorothy Shu Ping Fan Dennis Shun Chiu Lam Chi Pui Pang | 2006 | Journal of Glaucoma2006，，3： | 1 |
| 5 | Blind phase recovery for QAM communication systems 显示文摘 | CAMPISI P PANCI G COLONNESE S | 2005 | IEEE Transactions on Signal Processing2005，53，4： | 1 |
| 6 | There lation ship between coro- nary artery disease and abnormal glucose regulation in china : the china Heart are Heart Surey 显示文摘 | Hu DY PanCY Yu JM | 2006 | Eur HeatJ2006，27，21： | 1 |
| 7 | In-Control-Free Blind Carrier frequency Offset Acquisition for QAM Constellations 显示文摘 | STEFANIA COLONNESE STEFANO RINAURO GIANPIERO PANCI | 2010 | IEEE Transactions on Signal Processing2010，58，1： | 1 |
| 8 | 瑞格列奈一新型口服抗糖尿病药显示文摘 | PANCY(潘长玉) | 1999 | 中国糖尿病杂志1999，7，5： | 1 |
| 9 | Evaluation of the association of C5 with neovascular age-related macular degeneration and polypoidal choroidal vasculopathy显示文摘Background:Neovascular age-related macular degeneration(AMD)and polypoidal choroidal vasculopathy(PCV)are sight-threatening maculopathies with both environmental and genetic risk factors.We have previously shown relative risks posed by genes of the complement pathways to neovascular AMD and PCV.Methods:In this study,we investigated the haplotype-tagging single nucleotide polymorphisms(SNPs)in the complement component 5(C5)gene in 708 unrelated Chinese individuals:200 neovascular AMD patients,233 PCV patients and 275 controls.Six tagging SNPs in C5 were genotyped.Univariate single SNP association analysis,haplotype-based association analysis and gene-gene interaction analysis between C5 and other AMD-associated genes were performed.Results:The results revealed none of the six tagging SNPs of the C5 gene had a significant association with neovascular AMD or PCV(P>0.05).We also found insignificant haplotype-based association,and no significant SNPSNP interaction between C5 and other genes(including C2-CFB-RDBP-SKIV2L,SERPING1,CETP,ABCG1,PGF,ANGPT2,CFH and HTRA1)for neovascular AMD and PCV.Conclusions:This study showed no statistical significance in the genetic association of C5 with neovascular AMD or PCV in a Hong Kong Chinese population.Further studies in large samples from different populations are warranted to elucidate the role of C5 in the genetic susceptibility of AMD and PCV. | Ke Liu Li Ma Timothy Y.Y.Lai Marten E.Brelen Pancy O.S.Tam Clement C.Tham Chi Pui Pang Li Jia Chen | 2019 | Eye and Vision2019，6，1： | 1 |
| 10 | Associations of the C2-CFB-RDBP-SKIV2L Locus with Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy显示文摘 | Ke Liu Li Jia Chen Pancy O.S. Tam Yi Shi Timothy Y.Y. Lai David T.L. Liu Sylvia W.Y. Chiang Mingming Yang Zhenglin Yang Chi Pui Pang | 2012 | Ophthalmology2012，，： | 1 |
| 11 | Multichannel blind image deconvolution using the Bussgang algorithm: Spatial and multiresolution approaches 显示文摘 | Panci G Campisi P Colonnese S | 2003 | IEEE Transactions on Image Processing2003，12，11： | 1 |
| 12 | Management of Chinese patientswith type 2 diabetes,1998~2006: the Diabcare - China sueveys 显示文摘 | PanCY Yang WY Jia WP | 2009 | Curr Med Res Opin2009，25，1： | 1 |
| 13 | Chapter 5 Dark Matter and New Physics Beyond the Standard Model with LHAASO显示文摘In order to reveal the nature of dark matter,it is crucial to detect its non-gravitational interactions with the standard model particles.The traditional dark matter searches focused on the so-called weakly interacting massive particles.However,this paradigm is strongly constrained by the null results of current experiments with high precision.Therefore there is a renewed interest of searches for heavy dark matter particles above TeV scale.The Large High Altitude Air Shower Observatory(LHAASO)with large effective area and strong background rejection power is very suitable to investigate the gamma-ray signals induced by dark matter annihilation or decay above TeV scale.In this document,we review the theoretical motivations and background of heavy dark matter.We review the prospects of searching for the gamma-ray signals resulted from dark matter in the dwarf spheroidal satellites and Galactic halo for LHAASO,and present the projected sensitivities.We also review the prospects of searching for the axion-like particles,which are a kind of well motivated light pseudo-scalars,through the LHAASO measurement of the very high energy gamma-ray spectra of astrophysical sources. | 毕效军 Andrea Addazi Konstantin Belotsky Vitaly Beylin Marco Cirelli Arman Esmaili Nicolao Fornengo 甘庆余 Michael Kachekriess Maxim Khlopov Vladimir Korchagin Alexander Korochkin Vladimir Kuksa Antonino Marciano Andrei Neronov Paolo Panci Roman Pasechnick Alexander Sakharov Filippo Sala Giuseppe Di Sciascio Dimiri Semikoz Pasquale Dario Serpico Nikolay Volchanskiy 殷鹏飞 | 2022 | Chinese Physics C2022，46，3： | 0 |
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