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| 1 | New genes emerging for colorectal cancer predisposition显示文摘Colorectal cancer(CRC)is one of the most frequent neoplasms and an important cause of mortality in the developed world.This cancer is caused by both genetic and environmental factors although 35%of the variation in CRC susceptibility involves inherited genetic differences.Mendelian syndromes account for about5%of the total burden of CRC,with Lynch syndrome and familial adenomatous polyposis the most common forms.Excluding hereditary forms,there is an important fraction of CRC cases that present familial aggregation for the disease with an unknown germline genetic cause.CRC can be also considered as a complex disease taking into account the common diseasecommom variant hypothesis with a polygenic model of inheritance where the genetic components of common complex diseases correspond mostly to variants of low/moderate effect.So far,30 common,low-penetrance susceptibility variants have been identified for CRC.Recently,new sequencing technologies including exomeand whole-genome sequencing have permitted to add a new approach to facilitate the identification of new genes responsible for human disease predisposition.By using whole-genome sequencing,germline mutations in the POLE and POLD1 genes have been found to be responsible for a new form of CRC genetic predisposition called polymerase proofreading-associated polyposis. | Clara Esteban-Jurado Pilar Garre Maria Vila Juan José Lozano Anna Pristoupilova Sergi Beltrán Anna Abulí Jenifer Muoz Francesc Balaguer Teresa Ocaa Antoni Castells Josep M Piqué Angel Carracedo Clara Ruiz-Ponte Xavier Bessa Montserrat Andreu Luis Bujanda Trinidad Caldés Sergi Castellví-Bel | 2014 | World Journal of Gastroenterology2014，20，8： | 3 |
| 2 | Nuclear PTEN Regulates the APC-CDH1 Tumor-Suppressive Complex in a Phosphatase-Independent Manner显示文摘 | Min Sup Song Arkaitz Carracedo Leonardo Salmena Su Jung Song Ainara Egia Marcos Malumbres Pier Paolo Pandolfi | 2011 | Cell2011，，2： | 3 |
| 3 | Tenets of PTEN Tumor Suppression显示文摘 | Leonardo Salmena Arkaitz Carracedo Pier Paolo Pandolfi | 2008 | Cell2008，，： | 3 |
| 4 | MicroRNAs in biliary diseases显示文摘Cholangiopathies are a group of diseases primarily or secondarily affecting bile duct cells, and result in cholangiocyte proliferation, regression, and/or transformation. Their etiopathogenesis may be associated with a broad variety of causes of different nature, which includes genetic, neoplastic, immune-associated, infectious, vascular, and drug-induced alterations, or being idiopathic. miRNAs, small non-coding endogenous RNAs that post-transcriptionally regulate gene expres sion, have been associated with pathophysiological processes in different organs and cell types, and are postulated as potential targets for diagnosis and therapy. In the current manuscript, knowledge regarding the role of miRNAs in the development and/or progression of cholangiopathies has been reviewed and the most relevant findings in this promising field of hepatology have been highlighted. | Patricia Munoz-Garrido Maite García-Fernández de Barrena Elizabeth Hijona Miguel Carracedo JoséJ G Marín Luis Bujanda Jesús M Banales | 2012 | World Journal of Gastroenterology2012，18，43： | 2 |
| 5 | Highlights of the 2nd International Symposium on Tribbles and Diseases: tribbles tremble in therapeutics for immunity, metabolism, fundamental cell biology and cancer显示文摘The Tribbles(TRIB) family of pseudokinase proteins has been shown to play key roles in cell cycle, metabolic diseases, chronic inflammatory disease, and cancer development. A better understanding of the mechanisms of TRIB pseudokinases could provide new insights for disease development and help promote TRIB proteins as novel therapeutic targets for drug discovery. At the 2 nd International Symposium on Tribbles and Diseases held on May 7–9, 2018 in Beijing, China, a group of leading Tribbles scientists reported their findings and ongoing studies about the effects of the different TRIB proteins in the areas of immunity, metabolism, fundamental cell biology and cancer. Here, we summarize important and insightful overviews from 4 keynote lectures, 13 plenary lectures and 8 short talks that took place during this meeting. These findings may offer new insights for the understanding of the roles of TRIB pseudokinases in the development of various diseases. | Bing Cui Patrick A. Eyers Leonard L. Dobens Nguan Soon Tan Peter D. Mace Wolfgang A. Link Endre Kiss-Toth Karen Keeshan Takuro Nakamura Warren S. Pear Yodit Feseha Jessica Johnston Arkatiz Carracedo Marcel Scheideler Zabran llyas Robert C. Bauer Jorge D. Erusalimsky Dominika Grzesik Juan Salamanca-Viloria Xiaoxi Lv Yishi Jin Ke Li Guillermo Velasco Shuang Shang Jose M. Lizcano Xiaowei Zhang Jichao Zhou Jiaojiao Yu Fang Hua Feng Wang Shanshan Liu Jinmei Yu Zhuowei Hu | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 2 |
| 6 | Massive telomere loss is an early event of DNA damage-induced apoptosis显示文摘 | Ramirez R Carracedo J Jimenez R | 2003 | Biol Chem2003，278，2： | 1 |
| 7 | SNPs in forensic genetics:a review on SNP typing methodologies显示文摘 | Sobrino B Brión M Carracedo A | 2005 | Forensic Sci Int2005，154，： | 1 |
| 8 | Artificial bowel sphincter in severe anal incontinence 显示文摘 | Casal E Ildefonso AS Carracedo R | 2004 | Colorectal Dis2004，6，： | 1 |
| 9 | Naturalistic pharmacogenetic study of treatment resistance to typical neuroleptics in European–Brazilian schizophrenics显示文摘 | Fabiana B. Kohlrausch Clarissa S. Gama Maria Inês Lobato Paulo Belmonte-de-Abreu Sidia M. Callegari-Jacques Alejandro Gesteira Francisco Barros ángel Carracedo Mara H. Hutz | 2008 | Pharmacogenetics and Genomics2008，，7： | 1 |
| 10 | Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells显示文摘 | Salazar M Carracedo A Salanueva IJ | 2009 | J Clin Invest2009，119，5： | 1 |
| 11 | Cytometric bead array (CBA) for the measurement of cytokines in urine and plasma of patients undergoing renal rejection 显示文摘 | Jimrnez R Ramlrez R Carracedo J Agllera M Navarro D Santamafla R et 81 | 2005 | Cytokine2005，32，： | 1 |
| 12 | SNPs in forensic genetics:a review on SNP typing methodologies显示文摘 | Sobrino B Brin M Carracedo A | 2005 | Forensic Sci Int2005，154，23： | 1 |
| 13 | SIRT3 opposes reprogramming of cancer cell metabolism through HIF1 alpha destabilization 显示文摘 | Finley LW Carracedo A Lee J | 2011 | Cancer Cell2011，19，3： | 1 |
| 14 | Lym-phocyte subpopulations of regional lymph nodes in human colon and gas- tric adenocarcinomas 显示文摘 | Lores Vazquez B Pacheeo Carracedo M Oliver Morales J | 1996 | Cancer Immunol Immunother1996，42，6： | 1 |
| 15 | DNA Commission of the International Society of Forensic Genet- ics(ISFG) : an update of the recommendations on the use of Y-STRs in forensic analysis 显示文摘 | GUSMAO L BUTLER JM CARRACEDO A | 2006 | Forensic Sci Int2006，157，23： | 1 |
| 16 | SNPs in forensic genetics: a review on SNP typing methodologies显示文摘 | Sobrino B Brion M Carracedo A | 2005 | Forensic Sci Int2005，154，23： | 1 |
| 17 | Results of a collaborative study of the EDNAP group regarding the reproducibility and robustness of the Y-chromosome STRs DYSI9, DYS389 I and II, DYS390 and DYS393 in a PCR pentaplex format 显示文摘 | Carracedo A Beckmann A Bengs A | 2001 | Forensic Sei Int2001，119，1： | 1 |
| 18 | Monitoring photooxidation of the Prestige's oil spill by attenuated total reflectance infrared spectroscopy 显示文摘 | Varela R F Carracedo M P G Rivera P F | 2006 | Talanta2006，69，： | 1 |
| 19 | Behavior of an Aeromonas hydrophila aroA live vaccine in water microcosms显示文摘 | Vivas J Carracedo B Riafto J | 2004 | ApplEnviron Microbiol2004，70，5： | 1 |
| 20 | The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network显示文摘 | Song MS Salmena L Carracedo A | 2008 | Nature2008，455，7214： | 1 |
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