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| 1 | Noninvasive detection and evaluation of atherosclerotic coronary plaques with multislice computed tomography 1 1 This study was performed without additional financial support.显示文摘 | Stephen Schroeder Andreas F Kopp Andreas Baumbach Christoph Meisner Axel Kuettner Christian Georg Bernd Ohnesorge Christian Herdeg Claus D Claussen Karl R Karsch | 2001 | Journal of the American College of Cardiology2001，，5： | 3 |
| 2 | Strong prognostic value of nodal and bone marrow micro-involvement in patients with pancreatic ductal carcinoma receiving no adjuvant chemotherapy显示文摘AIM: To study the prognostic value of adjuvant chemo-therapy in patients with pancreatic, ductal adenocar-cinoma.METHODS: Lymph nodes from 106 patients with resectable pancreatic ductal adenocarcinoma were systematically sampled. A total of 318 lymph nodes classified histopathologically as tumor-free were examined using sensitive immunohistochemical assays. Forty-three (41%) of the 106 patients were staged as pT1/2, 63 (59%) as pT3/4, 51 (48%) as pN0, and 55 (52%) as pN1. The study population included 59 (56%) patients exhibiting G1/2, and 47 (44%) patients with G3 tumors. Patients received no adjuvant chemo- or radiation therapy and were followed up for a median of 12 (range: 3.5 to 139) mo.RESULTS: Immunostaining with Ber-EP4 revealed nodal microinvolvement in lymph nodes classified as “tumor free” by conventional histopathology in 73 (69%) out of the 106 patients. Twenty-nine (57%)of 51 patients staged histopathologically as pN0 had nodal microinvolvement. The five-year survival probability for pN0-patients was 54% for those without nodal microinvolvement and 0% for those with nodal microinvolvement. Cox-regression modeling revealed the independent prognostic effect of nodal microinvolvement on recurrence-free (relative risk 2.92, P = 0.005) and overall (relative risk 2.49, P = 0.009) survival.CONCLUSION: The study reveals strong and independent prognostic significance of nodal microinvolvement in patients with pancreatic ductal adenocarcinoma who have received no adjuvant therapy. The addition of immunohistochemical findings to histopathology reports may help to improve risk stratification of patients with pancreatic cancer. | Emre F Yekebas Dean Bogoevski Michael Bubenheim Bjrn-Christian Link Jussuf T Kaifi Robin Wachowiak Oliver Mann Asad Kutup Guellue Cataldegirmen Lars Wolfram Andreas Erbersdobler Christoph Klein Klaus Pantel Jakob R Izbicki | 2006 | World Journal of Gastroenterology2006，12，40： | 3 |
| 3 | A multibit E A modulator in floating-body SOS/SOI CMOS for extreme radiation environments显示文摘 | CHRISTOPHER F E WILLIAM R W MARK B | 1999 | IEEE J of Solid State Circuits1999，34，7： | 1 |
| 4 | Vasopressin: a new target for the treatment of heart failure显示文摘 | Craig R Lee Michael L Watkins J.Herbert Patterson Wendy Gattis Christopher M O'Connor Mihai Gheorghiade Kirkwood F Adams | 2003 | American Heart Journal2003，，1： | 1 |
| 5 | The Incidence and Effects of Coherence of Marked Themes in Inteflanguage Texts : A Corpus-based Enquiry 显示文摘 | Green C F Christopher E R | 2000 | English for Specific Purpose2000，，19： | 1 |
| 6 | The effect of body contact series resistance on SOI CMOS amplifier stages显示文摘 | CHRISTOPHER F E WILLIAM R W BERNARD M T | 1997 | IEEE Trans Electron Devices1997，44，12： | 1 |
| 7 | Assessing the risks of exposures to multiple chemicals with a common mechanism of toxicity: how to cumulate? 显示文摘 | Wilkinson C F Christoph G R Julien E | 2000 | Regulatory Toxicology and Pharmacology2000，31，1： | 1 |
| 8 | Comparison of electrom agnetic absorber used in anechoic and semianechoic chambers for emission and immunity testing of digital devices显示文摘 | HOLLOWAY Christopher L DELYSER Ronald R GGE-RMAN Robert F | 1997 | EMC IEEE Trans on1997，39，1： | 1 |
| 9 | Cardiac troponin T in chest pain unit patients without ischemic electrocardiographic changes: angiographic correlates and long-term clinical outcomes显示文摘 | Christopher R deFilippi Monica Tocchi Rohit J Parmar Salvatore Rosanio Gerard Abreo Marjorie A Potter Marschall S Runge Barry F Uretsky | 2000 | Journal of the American College of Cardiology2000，，7： | 1 |
| 10 | Comparison of Electromagnetic Absorber Used in Anechoic and Semi-Anechoic Chambers for Emissions and Immunity Testing of Digital Devices 显示文摘 | CHRISTOPHER L RONALD R ROBERT F | 1997 | IEEE Transactions On Electronic magnetic Compatibility1997，39，： | 1 |
| 11 | SCR deactiva- tion in a full-scale confired utility boiler显示文摘 | Oshua R S Christopher J Z Bruce C F | 2008 | Fuel2008，87，： | 1 |
| 12 | Erosion and Surface Structure Development of Metal-Diamond Particulate Composites显示文摘 | Brian E M Christopher D R Paul F | 2010 | Wear2010，269，： | 1 |
| 13 | Clinical features,pathogenesis,and computed tomographic characteristics of internal watershed infarction显示文摘 | Christopher F Brian R | 1993 | Stroke1993，24，12： | 1 |
| 14 | Enhancement of Latent Heat Energy Storage Using Embedded Heat Pipes 显示文摘 | Christopher W R Theodore L B Amir F | 2011 | International Journal of Heat and Mass Transfer2011，，54： | 1 |
| 15 | Sequence architecture within a low-accommodation setting : An example from the Permian of the Galilee and Bowen basins, Queensland, Australia 显示文摘 | Jonathan P A Christopher R F | 2007 | AAPG Bul- letin2007，91，11： | 1 |
| 16 | Mutations in filamin 1 Prevent Migration of Cerebral Cortical Neurons in Human Periventricular Heterotopia显示文摘 | Jeremy W Fox Edward D Lamperti Yaman Z Ek?io?lu Susan E Hong Yuanyi Feng Donna A Graham Ingrid E Scheffer William B Dobyns Betsy A Hirsch Rodney A Radtke Samuel F Berkovic Peter R Huttenlocher Christopher A Walsh | 1998 | Neuron1998，，6： | 1 |
| 17 | The effect of aromatization on the isotopic composition of hydrocarbons during early diagenesis 显示文摘 | Katherine H F Christopher J Boreham R E S | 1994 | Organic Geochemistry1994，21，1011： | 1 |
| 18 | The neural basis of loss aversion in decision-making under risk显示文摘 | SABRINA M T GRAIG R F CHRISTOPHER T | 2007 | Science2007，315，： | 1 |
| 19 | Background to Framenet显示文摘 | Charles J F Christopher R J Miriam R L | | International Journal of Lexicography0，16，3： | 1 |
| 20 | The kinefics of bmding to p38 MAP kinaseby anflogues of BIRB796显示文摘 | JOHN R CHRISTOPHER A P PIER F C etal | 2003 | BioorgMed ChemLett2003，13，18： | 1 |
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