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| 1 | Epigallocatechin-3-gallate (EGCG) attenuates nflammation in MRL/Ipr mouse mesangial cells显示文摘 | Abigail Peairs Rujuan Dai Lu Gan Samuel Shimp M Nichole Rylander Liwu Li Christopher M Reilly | 2010 | Cellular & Molecular Immunology2010，7，2： | 12 |
| 2 | Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma显示文摘Although genome-wide association studies have identified more than eighty genetic variants associated with non-small cell lung cancer(NSCLC)risk,biological mechanisms of these variants remain largely unknown.By integrating a large-scale genotype data of 15581 lung adenocarcinoma(AD)cases,8350 squamous cell carcinoma(SqCC)cases,and 27355 controls,as well as multiple transcriptome and epigenomic databases,we conducted histology-specific meta-analyses and functional annotations of both reported and novel susceptibility variants.We identified 3064 credible risk variants for NSCLC,which were overrepresented in enhancer-like and promoter-like histone modification peaks as well as DNase I hypersensitive sites.Transcription factor enrichment analysis revealed that USF1 was AD-specific while CREB1 was SqCC-specific.Functional annotation and genebased analysis implicated 894 target genes,including 274 specifics for AD and 123 for SqCC,which were overrepresented in somatic driver genes(ER=1.95,P=0.005).Pathway enrichment analysis and Gene-Set Enrichment Analysis revealed that AD genes were primarily involved in immune-related pathways,while SqCC genes were homologous recombination deficiency related.Our results illustrate the molecular basis of both wellstudied and new susceptibility loci of NSCLC,providing not only novel insights into the genetic heterogeneity between AD and SqCC but also a set of plausible gene targets for post-GWAS functional experiments. | Na Qin Yuancheng Li Cheng Wang Meng Zhu Juncheng Dai Tongtong Hong Demetrius Albanes Stephen Lam Adonina Tardon Chu Chen Gary Goodman Stig EBojesen Maria Teresa Landi Mattias Johansson Angela Risch H-Erich Wichmann Heike Bickeboller Gadi Rennert Susanne Arnold Paul Brennan John KField Sanjay Shete Loic Le Marchand Olle Melander Hans Brunnstrom Geoffrey Liu Rayjean JHung Angeline Andrew Lambertus AKiemeney Shan Zienolddiny Kjell Grankvist Mikael Johansson Neil Caporaso Penella Woll Philip Lazarus Matthew BSchabath Melinda CAldrich Victoria LStevens Guangfu Jin David CChristiani Zhibin Hu Christopher IAmos Hongxia Ma Hongbing Shen | 2021 | Frontiers of Medicine2021，15，2： | 3 |
| 3 | Inhibiting Cxcr2 disrupts tumor-stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma显示文摘 | Ijichi Hideaki Chytil Anna Gorska Agnieszka E Aakre Mary E Bierie Brian Tada Motohisa Mohri Dai Miyabayashi Koji Asaoka Yoshinari Maeda Shin Ikenoue Tsuneo Tateishi Keisuke Wright Christopher V E Koike Kazuhiko Omata Masao Moses Harold L | 2011 | Journal of Clinical Investigation2011，，10： | 3 |
| 4 | Tumor-Derived Jagged1 Promotes Osteolytic Bone Metastasis of Breast Cancer by Engaging Notch Signaling in Bone Cells显示文摘 | Nilay Sethi Xudong Dai Christopher G. Winter Yibin Kang | 2011 | Cancer Cell2011，，2： | 2 |
| 5 | The Msi1-mTOR pathway drives the pathogenesis of mammary and extramammary Paget’s disease显示文摘Mammary and extramammary Paget’s Diseases(PD)are a malignant skin cancer characterized by the appearance of Paget cells.Although easily diagnosed,its pathogenesis remains unknown.Here,single-cell RNA-sequencing identified distinct cellular states,novel biomarkers,and signaling pathways—including mTOR,associated with extramammary PD.Interestingly,we identified MSI1 ectopic overexpression in basal epithelial cells of human PD skin,and show that Msi1 overexpression in the epidermal basal layer of mice phenocopies human PD at histopathological,single-cell and molecular levels.Using this mouse model,we identified novel biomarkers of Paget-like cells that translated to human Paget cells.Furthermore,single-cell trajectory,RNA velocity and lineage-tracing analyses revealed a putative keratinocyte-to-Paget-like cell conversion,supporting the in situ transformation theory of disease pathogenesis.Mechanistically,the Msi1-mTOR pathway drives keratinocyte-Paget-like cell conversion,and suppression of mTOR signaling with Rapamycin significantly rescued the Paget-like phenotype in Msi1-overexpressing transgenic mice.Topical Rapamycin treatment improved extramammary PD-associated symptoms in humans,suggesting mTOR inhibition as a novel therapeutic treatment in PD. | Yongli Song Christian F.Guerrero-Juarez Zhongjian Chen Yichen Tang Xianghui Ma Cong Lv Xueyun Bi Min Deng Lina Bu Yuhua Tian Ruiqi Liu Ran Zhao Jiuzhi Xu Xiaole Sheng Sujuan Du Yeqiang Liu Yunlu Zhu Shi-jun Shan Hong-duo Chen Yiqiang Zhao Guangbiao Zhou Jianwei Shuai Fazheng Ren Lixiang Xue Zhaoxia Ying Xing Dai Christopher J.Lengner Bogi Andersen Maksim V.Plikus Qing Nie Zhengquan Yu-Show | 2020 | Cell Research2020，30，10： | 2 |
| 6 | Classification of Coronary Atherosclerotic Plaques Ex Vivo With T1, T2, and Ultrashort Echo Time CMR显示文摘 | Mihály Károlyi Harald Seifarth Gary Liew Christopher L. Schlett Pál Maurovich-Horvat Paul Stolzmann Guangping Dai Shuning Huang Craig J. Goergen Masataka Nakano Fumiyuki Otsuka Renu Virmani Udo Hoffmann David E. Sosnovik | 2013 | JACC: Cardiovascular Imaging2013，，4： | 1 |
| 7 | Lipid levels in patients hospitalized with coronary artery disease: An analysis of 136,905 hospitalizations in Get With The Guidelines显示文摘 | Amit Sachdeva Christopher P. Cannon Prakash C. Deedwania Kenneth A. LaBresh Sidney C. Smith David Dai Adrian Hernandez Gregg C. Fonarow | 2009 | American Heart Journal2009，，1： | 1 |
| 8 | An international Delphi consensus statement on metabolic dysfunction-associated fatty liver disease and risk of chronic kidney disease显示文摘Background:With the rising global prevalence of fatty liver disease related to metabolic dysfunction,the association of this common liver condition with chronic kidney disease(CKD)has become increasingly evident.In 2020,the more inclusive term metabolic dysfunction-associated fatty liver disease(MAFLD)was proposed to replace the term non-alcoholic fatty liver disease(NAFLD).The observed association between MAFLD and CKD and our understanding that CKD can be a consequence of underlying metabolic dysfunction support the notion that individuals with MAFLD are at higher risk of having and developing CKD compared with those without MAFLD.However,to date,there is no appropriate guidance on CKD in individuals with MAFLD.Furthermore,there has been little attention paid to the link between MAFLD and CKD in the Nephrology community.Methods and Results:Using a Delphi-based approach,a multidisciplinary panel of 50 international experts from 26 countries reached a consensus on some of the open research questions regarding the link between MAFLD and CKD.Conclusions:This Delphi-based consensus statement provided guidance on the epidemiology,mechanisms,management and treatment of MAFLD and CKD,as well as the relationship between the severity of MAFLD and risk of CKD,which establish a framework for the early prevention and management of these two common and interconnected diseases. | Dan-Qin Sun Giovanni Targher Christopher D.Byrne David C.Wheeler Vincent Wai-Sun Wong Jian-Gao Fan Herbert Tilg Wei-Jie Yuan Christoph Wanner Xin Gao Michelle T.Long Mehmet Kanbay Mindie H.Nguyen Sankar D.Navaneethan Yusuf Yilmaz Yuli Huang Rino A.Gani Pierluigi Marzuillo Jérôme Boursier Huijie Zhang Chan-Young Jung Jin Chai Luca Valenti George Papatheodoridis Giovanni Musso Yu-Jun Wong Mohamed El-Kassas Nahum Méndez-Sánchez Silvia Sookoian Michael Pavlides Ajay Duseja Adriaan G.Holleboom Junping Shi Wah-Kheong Chan Yasser Fouad Junwei Yang Sombat Treeprasertsuk Helena Cortez-Pinto Masahide Hamaguchi Manuel Romero-Gomez Mamun Al Mahtab Ponsiano Ocama Atsushi Nakajima Chunsun Dai Mohammed Eslam Lai Wei Jacob George Ming-Hua Zheng | 2023 | Hepatobiliary Surgery and Nutrition2023，12，3： | 1 |
| 9 | Multifunctional carbon nanotube yarns and transparent sheets: Fabrication, properties, and applications显示文摘 | Ken R. Atkinson Stephen C. Hawkins Chi Huynh Chris Skourtis Jane Dai Mei Zhang Shaoli Fang Anvar A. Zakhidov Sergey B. Lee Ali E. Aliev Christopher D. Williams Ray H. Baughman | 2007 | Physica B: Physics of Condensed Matter2007，，： | 1 |
| 10 | Design, synthesis and biological evaluation of cycloalkyl arylpyrimidines (CAPYs) as HIV-1 NNRTIs显示文摘 | Shuang-Xi Gu Shi-Qiong Yang Qiu-Qin He Xiao-Dong Ma Fen-Er Chen Hui-Fang Dai Erik De Clercq Jan Balzarini Christophe Pannecouque | 2011 | Bioorganic & Medicinal Chemistry2011，，23： | 1 |
| 11 | Genetic polymorphisms in IL10RA and TNF modify the association between blood transfusion and risk of non‐Hodgkin lymphoma显示文摘 | Xiaofeng Bi Tongzhang Zheng Qing Lan Zhijian Xu Yingtai Chen Gongjian Zhu Francine Foss Christopher Kim Min Dai Ping Zhao Theodore Holford Brian Leaderer Peter Boyle Qian Deng Stephen J. Chanock Nathaniel Rothman Yawei Zhang | 2012 | Am J Hematol2012，，8： | 1 |
| 12 | Establishing a model spinal cord injury in the African green monkey for the preclinical evaluation of biodegradable polymer scaffolds seeded with human neural stem cells显示文摘 | Christopher D. Pritchard Jonathan R. Slotkin Dou Yu Haining Dai Matthew S. Lawrence Roderick T. Bronson Francis M. Reynolds Yang D. Teng Eric J. Woodard Robert S. Langer | 2010 | Journal of Neuroscience Methods2010，，： | 1 |
| 13 | Photon polarization effects in polarized electron–positron pair production in a strong laser field显示文摘Deep understanding of the impact of photon polarization on pair production is essential for the efficient generation of laser-driven polarized positron beams and demands a complete description of polarization effects in strong-field QED processes.Employing fully polarization-resolved Monte Carlo simulations,we investigate correlated photon and electron(positron)polarization effects in the multiphoton Breit–Wheeler pair production process during the interaction of an ultrarelativistic electron beam with a counterpropagating elliptically polarized laser pulse.We show that the polarization of e−e+pairs is degraded by 35%when the polarization of the intermediate photon is resolved,accompanied by an∼13%decrease in the pair yield.Moreover,in this case,the polarization direction of energetic positrons at small deflection angles can even be reversed when high-energy photons with polarization parallel to the laser electric field are involved. | Ya-Nan Dai Bai-Fei Shen Jian-Xing Li Rashid Shaisultanov Karen Z.Hatsagortsyan Christoph H.Keitel Yue-Yue Chen | 2022 | Matter and Radiation at Extremes2022，7，1： | 0 |
| 14 | Encapsulating maytansinoid in pH-sensitive nanocarriers:The importance of using extremely potent cytotoxic agents and fast release for nanomedicine to achieve tumor elimination显示文摘The clinical translation of nanomedicine is hindered by the low delivery efficiency, and consequently drug concentration in tumor sites falls short of the therapeutic effective range which leads to poor clinical outcomes. One important lesson learned from the development of antibody-drug-conjugates (ADCs) is that to achieve significant clinical benefits, extremely potent cytotoxic agents and cleavable linkers should be used. By encapsulating maytansinoid, AP3, which is 100-1,000 times more potent than most conventional small molecule anticancer drugs, in pH-sensitive acetalated dextran-polyethylene glycol (PEG)(ADP) nanocarriers, even with only 1% drug loading, we were able to eradicate tumors in 50% of tested animals with negligible side effects, while free AP3 only showed marginal efficacy and severe liver damages. This study suggests that besides improving the low efficiency of nano-delivery systems, the potency of drug to be delivered is also critical to the clinical outcomes of nanomedicine. Our results also showed that ADP nanoparticles (NPs) were able to expand the narrow therapeutic window of maytansinoids in a similar manner to the ADCs. | Bo Dai Xingyu Wu Christopher J. Butch Jianquan Wang Ziyang Wang Yisheng Wang Shuming Nie Qian Lu Yiqing Wang Yitao Ding | 2019 | Nano Research2019，12，8： | 0 |
| 15 | Wide-field three-photon excitation in biological samples显示文摘Three-photon wide-field depth-resolved excitation is used to overcome some of the limitations in conventional point-scanning two-and three-photon microscopy.Excitation of chromophores as diverse as channelrhodopsins and quantum dots is shown,and a penetration depth of more than 700μm into fixed scattering brain tissue is achieved,approximately twice as deep as that achieved using two-photon wide-field excitation.Compatibility with live animal experiments is confirmed by imaging the cerebral vasculature of an anesthetized mouse;a complete focal stack was obtained without any evidence of photodamage.As an additional validation of the utility of wide-field three-photon excitation,functional excitation is demonstrated by performing threephoton optogenetic stimulation of cultured mouse hippocampal neurons expressing a channelrhodopsin;action potentials could reliably be excited without causing photodamage. | Christopher J Rowlands Demian Park Oliver T Bruns Kiryl D Piatkevich Dai Fukumura Rakesh K Jain Moungi G Bawendi Edward S Boyden Peter TC So | 2016 | Light(Science & Applications)2016，5，1： | 0 |
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