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| 1 | Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury显示文摘The outbreak of the 2019-nCoV infection began in December 2019 in Wuhan,Hubei province,and rapidly spread to many provinces in China as well as other countries.Here we report the epidemiological,clinical,laboratory,and radiological characteristics,as well as potential biomarkers for predicting disease severity in 2019-nCoV-infected patients in Shenzhen,China.All 12 cases of the 2019-nCoV-infected patients developed pneumonia and half of them developed acute respiratory distress syndrome (ARDS).The most common laboratory abnormalities were hypoalbuminemia,lymphopenia,decreased percentage of lymphocytes (LYM) and neutrophils (NEU),elevated C-reactive protein (CRP) and lactate dehydrogenase (LDH),and decreased CD8 count.The viral load of 2019-nCoV detected from patient respiratory tracts was positively linked to lung disease severity.ALB,LYM,LYM (%),LDH,NEU (%),and CRP were highly correlated to the acute lung injury.Age,viral load,lung injury score,and blood biochemistry indexes,albumin (ALB),CRP,LDH,LYM (%),LYM,and NEU (%),may be predictors of disease severity.Moreover,the Angiotensin Ⅱlevel in the plasma sample from 2019-nCoV infected patients was markedly elevated and linearly associated to viral load and lung injury.Our results suggest a number of potential diagnosis biomarkers and angiotensin receptor blocker (ARB) drugs for potential repurposing treatment of 2019-nCoV infection. | Yingxia Liu Yang Yang Cong Zhang Fengming Huang Fuxiang Wang Jing Yuan Zhaoqin Wang Jinxiu Li Jianming Li Cheng Feng Zheng Zhang Lifei Wang Ling Peng Li Chen Yuhao Qin Dandan Zhao Shuguang Tan Lu Yin Jun Xu Congzhao Zhou Chengyu Jiang Lei Liu | 2020 | Science China(Life Sciences)2020，63，3： | 157 |
| 2 | Clinical characteristics of 24 asymptomatic infections with COVID-19 screened among close contacts in Nanjing,China显示文摘Previous studies have showed clinical characteristics of patients with the 2019 novel coronavirus disease(COVID-19)and the evidence of person-to-person transmission.Limited data are available for asymptomatic infections.This study aims to present the clinical characteristics of 24 cases with asymptomatic infection screened from close contacts and to show the transmission potential of asymptomatic COVID-19 virus carriers.Epidemiological investigations were conducted among all close contacts of COVID-19 patients(or suspected patients)in Nanjing,Jiangsu Province,China,from Jan 28 to Feb 9,2020,both in clinic and in community.Asymptomatic carriers were laboratory-confirmed positive for the COVID-19 virus by testing the nucleic acid of the pharyngeal swab samples.Their clinical records,laboratory assessments,and chest CT scans were reviewed.As a result,none of the 24 asymptomatic cases presented any obvious symptoms while nucleic acid screening.Five cases(20.8%)developed symptoms(fever,cough,fatigue,etc.)during hospitalization.Twelve(50.0%)cases showed typical CT images of ground-glass chest and 5(20.8%)presented stripe shadowing in the lungs.The remaining 7(29.2%)cases showed normal CT image and had no symptoms during hospitalization.These 7 cases were younger(median age:14.0 years;P=0.012)than the rest.None of the 24 cases developed severe COVID-19 pneumonia or died.The median communicable period,defined as the interval from the first day of positive nucleic acid tests to the first day of continuous negative tests,was 9.5 days(up to 21 days among the 24 asymptomatic cases).Through epidemiological investigation,we observed a typical asymptomatic transmission to the cohabiting family members,which even caused severe COVID-19 pneumonia.Overall,the asymptomatic carriers identified from close contacts were prone to be mildly ill during hospitalization.However,the communicable period could be up to three weeks and the communicated patients could develop severe illness.These results highlighted the importance of close contact tracing and longitudinally surveillance via virus nucleic acid tests.Further isolation recommendation and continuous nucleic acid tests may also be recommended to the patients discharged. | Zhiliang Hu Ci Song Chuanjun Xu Guangfu Jin Yaling Chen Xin Xu Hongxia Ma Wei Chen Yuan Lin Yishan Zheng Jianming Wang Zhibin Hu Yongxiang Yi Hongbing Shen | 2020 | Science China(Life Sciences)2020，63，5： | 77 |
| 3 | Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial显示文摘 | Ann-Lii Cheng Yoon-Koo Kang Zhendong Chen Chao-Jung Tsao Shukui Qin Jun Suk Kim Rongcheng Luo Jifeng Feng Shenglong Ye Tsai-Sheng Yang Jianming Xu Yan Sun Houjie Liang Jiwei Liu Jiejun Wang Won Young Tak Hongming Pan Karin Burock Jessie Zou Dimitris Volio | 2009 | Lancet Oncology2009，，1： | 23 |
| 4 | Application of next-generation sequencing technology to precision medicine in cancer: joint consensus of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology显示文摘Next-generation sequencing(NGS) technology is capable of sequencing millions or billions of DNA molecules simultaneously.Therefore, it represents a promising tool for the analysis of molecular targets for the initial diagnosis of disease, monitoring of disease progression, and identifying the mechanism of drug resistance. On behalf of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology(CSCO) and the China Actionable Genome Consortium(CAGC), the present expert group hereby proposes advisory guidelines on clinical applications of NGS technology for the analysis of cancer driver genes for precision cancer therapy. This group comprises an assembly of laboratory cancer geneticists, clinical oncologists, bioinformaticians,pathologists, and other professionals. After multiple rounds of discussions and revisions, the expert group has reached a preliminary consensus on the need of NGS in clinical diagnosis, its regulation, and compliance standards in clinical sample collection. Moreover, it has prepared NGS criteria, the sequencing standard operation procedure(SOP), data analysis, report, and NGS platform certification and validation. | Xuchao Zhang Zhiyong Liang Shengyue Wang Shun Lu Yong Song Ying Cheng Jianming Ying Weiping Liu Yingyong Hou Yangqiu Li Yi Liu Jun Hou Xiufeng Liu Jianyong Shao Yanhong Tai Zheng Wang Li Fu Hui Li Xiaojun Zhou Hua Bai Mengzhao Wang You Lu Jinji Yang Wenzhao Zhong Qing Zhou Xuening Yang Jie Wang Cheng Huang Xiaoqing Liu Xiaoyan Zhou Shirong Zhang Hongxia Tian Yu Chen Ruibao Ren Ning Liao Chunyan Wu Zhongzheng Zhu Hongming Pan Yanhong Gu Liwei Wang Yunpeng Liu Suzhan Zhang Tianshu Liu Gong Chen Zhimin Shao Binghe Xu Qingyuan Zhang Ruihua Xu Lin Shen Yilong Wu | 2019 | Cancer Biology & Medicine2019，16，1： | 14 |
| 5 | Low temperature fabrication of high performance and transparent Pt counter electrodes for use in flexible dye-sensitized solar cells显示文摘High performance Pt counter electrode is prepared by using vacuum thermal decomposition at a relatively low (120℃) temperature on a flexible polyethylene naphthalate substrate coated with indium-doped tin oxide for use in flexible dye-sensitized solar cells.The obtained Pt counter electrode shows a good chemical stability,high light transmittance,and high electrocatalytic activity for the I3-/I-redox reaction.The energy conversion efficiency of a flexible dye-sensitized solar cell based on the prepared Pt counter electrode and a TiO 2 /Ti photoanode reaches 5.14% under a simulated solar light irradiation with intensity of 100 mW cm-2. | XIAO YaoMing,WU JiHuai,CHENG CunXi,CHEN Yuan,YUE GenTian,LIN JianMing,HUANG MiaoLiang,FAN LeQing & LAN Zhang Engineering Research Center of Environment-Friendly Functional Materials,Ministry of Education,Institute of Materials Physical Chemistry,Huaqiao University,Quanzhou 362021,China | 2012 | Chinese Science Bulletin2012，57，18： | 10 |
| 6 | Optimizing protein and lipid levels in practical diet for juvenile northern snakehead fish(Channa argus)显示文摘A 3×3 factorial feeding trial was conducted to evaluate the production response of juvenile northern snakehead fish(Channa argus). Nine diets containing 3 protein levels(45%, 48% and 51%) and 3 lipid levels(9%,12% and 15%) were formulated and fed to triplicate groups of juvenile northern snakehead(15.78 ± 0.09 g/fish) for 8 weeks. The formulated diets were named as P45 L9, P45 L12, P45 L15, P48 L9,P48 L12, P48 L15, P51 L9, P51 L12 and P51 L15(P-Protein, L-Lipid), respectively. Fish fed diets with the lowest protein and lipid combination(P45 L9) had the lowest growth performance. Weight gains(WG) of fish fed the 4 diets P48 L12, P48 L15, P51 L9, and P51 L12 were not significantly different(P> 0.05), but significantly higher(P < 0.05) than those of fish fed the other diets. Fish fed diets P48 L12 and P48 L15 had significantly lower(P < 0.05) feed conversion ratios(FCR) than the rest of the treatments. Protein retentions(PR) among fish fed the diets P45 L12, P45 L15, P48 L12, P48 L15, P51 L9, and P51 L12 were similar and significantly higher(P < 0.05) than those of fish fed the remaining diets. Protein sparing effect was observed in the treatments when fish was fed diets containing 45% or 48% dietary protein levels with dietary lipid increased from 9% to12%. Fish fed diets with 9% lipid tended to have lower viscerosomatic index(VSI), hepatosomatic index(HSI),and whole-body lipid. Increasing dietary protein level significantly increased(P < 0.05) liver moisture and lipid while dietary lipid level increased liver lipid. Intestinal lipase activity increased significantly(P < 0.05)with increasing dietary lipid and protein levels while intestinal a-amylase and protease activities were not significantly influenced(P > 0.05) by dietary treatments. Based on these results, the diet containing 48%protein with either 12% or 15% lipid is the optimal for supporting growth and feed utilization of juvenile northern snakehead under the current testing conditions. | Gladstone Sagada Jianming Chen Binqian Shen Aixia Huang Lihui Sun Jianhu Jiang Chunhua Jin | 2017 | Animal Nutrition2017，，2： | 10 |
| 7 | Transdifferentiation of tumor infiltrating innate lymphoid cells during progression of colorectal cancer显示文摘Innate lymphoid cells(ILCs)reside in mucosal surfaces to potentiate immune responses,sustain mucosal integrity and maintain tissue homeostasis.However,how tumor infiltrating ILCs modulate tumor development and progression is unclear.Here we profiled tumor infiltrating ILCs during colorectal cancer(CRC)progression by single-cell RNA sequencing.We identified six clusters of tumor infiltrating ILCs with unique features.ILC1s expressed inhibitory receptors and underwent inhibitory functional conversion at the late stage of CRC.ILC2s were classified into three subsets(called ILC2-A,-B,-C),of which ILC2-C subset could facilitate tumor progression.HS3ST1 and PD1 were highly expressed in ILC2s of late stage CRC tumors and deficiency of HS3ST1 or PD1 in ILC2s suppressed tumor growth.Moreover,ILC3s transdifferentiated into ILCregs during CRC progression and ILCregs promoted tumor growth.Of note,TGF-βsignaling initiated the conversion of ILC3s to ILCregs and blockade of TGF-βsignaling could disrupt the ILCreg transdifferentiation and inhibited tumor growth.Thus,intervention of ILC conversions might be a potential strategy for CRC immunotherapy. | Shuo Wang Yuan Qu Pengyan Xia Yi Chen Xiaoxiao Zhu Jing Zhang Guan Wang Yong Tian Jianming Ying Zusen Fan | 2020 | Cell Research2020，30，7： | 9 |
| 8 | Measuring the resilience of an airport network显示文摘Resilience is the ability of a system to withstand and stay operational in the face of an unexpected disturbance or unpredicted changes. Recent studies on air transport system resilience focus on topology characteristics after the disturbance and measure the robustness of the network with respect to connectivity. The dynamic processes occurring at the node and link levels are often ignored. Here we analyze airport network resilience by considering both structural and dynamical aspects. We develop a simulation model to study the operational performance of the air transport system when airports operate at degraded capacity rather than completely shutting down. Our analyses show that the system deteriorates soon after disruptive events occur but returns to an acceptable level after a period of time. Static resilience of the airport network is captured by a phase transition in which a small change to airport capacity will result in a sharp change in system punctuality. After the phase transition point, decreasing airport capacity has little impact on system performance. Critical airports which have significant influence on the performance of whole system are identified, and we find that some of these cannot be detected based on the analysis of network structural indicators alone. Our work shows that air transport system’s resilience can be well understood by combining network science and operational dynamics. | Yanjun WANG Jianming ZHAN Xinhua XU Lishuai LI Ping CHEN Mark HANSEN | 2019 | Chinese Journal of Aeronautics2019，32，12： | 8 |
| 9 | One Stone Four Birds:A Novel Liposomal Delivery System Multi-functionalized with Ginsenoside Rh2 for Tumor Targeting Therapy显示文摘Liposomes hold great potential in anti-cancer drug delivery and the targeting treatment of tumors.However,the clinical therapeutic efficacy of liposomes is still limited by the complexity of tumor microenvironment(TME)and the insufficient accumulation in tumor sites.Meanwhile,the application of cholesterol and polyethylene glycol(PEG),which are usually used to prolong the blood circulation and stabilize the structure of liposomes respectively,has been questioned due to various disadvantages.Herein,we developed a ginsenoside Rh2-based multifunctional liposome system(Rh2-lipo)to effectively address these challenges once for all.Different with the conventional’wooden’liposomes,Rh2-lipo is a much more brilliant carrier with multiple functions.In Rh2-lipo,both cholesterol and PEG were substituted by Rh2,which works as membrane stabilizer,long-circulating stealther,active targeting ligand,and chemotherapy adjuvant at the same time.Firstly,Rh2 could keep the stability of liposomes and avoid the shortcomings caused by cholesterol.Secondly,Rh2-lipo showed a specifically prolonged circulation behavior in the blood.Thirdly,the accumulation of the liposomes in the tumor was significantly enhanced by the interaction of glucose transporter of tumor cells with Rh2.Fourth,Rh2-lipo could remodel the structure and reverse the immunosuppressive environment in TME.When tested in a 4T1 breast carcinoma xenograft model,the paclitaxel-loaded Rh2-lipo realized high efficient tumor growth suppression.Therefore,Rh2-lipo not only innovatively challenges the position of cholesterol as a liposome component,but also provides another innovative potential system with multiple functions for anti-cancer drug delivery. | Chao Hong Jianming Liang Jiaxuan Xia Ying Zhu Yizhen Guo Anni Wang Chunyi Lu Hongwei Ren Chen Chen Shiyi Li Dan Wang Huaxing Zhan Jianxin Wang | 2020 | Nano-Micro Letters2020，12，10： | 8 |
| 10 | Bevacizumab plus capecitabine and cisplatin in Chinese patients with inoperable locally advanced or metastatic gastric or gastroesophageal junction cancer: randomized, double-blind, phase III study (AVATAR study)显示文摘 | Lin Shen Jin Li Jianming Xu Hongming Pan Guanghai Dai Shukui Qin Liwei Wang Jinwan Wang Zhenzhou Yang Yongqian Shu Ruihua Xu Lei Chen Yunpeng Liu Shiying Yu Lilian Bu Yongzhe Piao | 2015 | Gastric Cancer2015，，1： | 7 |
| 11 | MicroRNA expression profile of gastric cancer stem cells in the MKN-45 cancer cell line显示文摘MicroRNAs (miRNAs ) 玩在目标送信人 RNA 的 post-transcriptional 基因 silencing 的重要角色,它几乎涉及所有生物过程。以前,我们证明了从 MKN-45 癌症房间的形成身体的房间衬里的球状体拥有了胃的癌症干细胞(CSC ) 性质。在这研究,我们试图决定胃的 CSC 的 miRNA 侧面并且在胃的 CSC 探索 miRNAs 的角色。人的 miRNA microarrays,它包含为 1887 人的 miRNAs 特定的探针被用来决定胃的 CSC 的表示侧面。有一个超过 2 褶层变化的 182 miRNAs 的一个总数被识别是在球状体之间表示的差别形成身体的房间和父母房间。这些 miRNAs, 9 miRNAs 在球状体是过去表示的形成身体的房间当另外的 173 miRNAs 都是下面表示的时,显示在人的胃的 CSC 的大多数 miRNAs 的角色可以是肿瘤 suppressors。microarray 分析的结果被量的即时聚合酶链反应验证,并且坚固性率是 70%(7 从 10 ) 。为验证 miRNAs 的目标基因被使用三个联机软件程序预言,人权保护, PicTar,和 TargetScan。大多数 miRNAs 的潜在的目标与在癌症的肌动朊细胞骨架,焦点的粘附,细胞外的 matrixreceptor 相互作用,和小径的规定相关。特别,几基因与干细胞基因的一些枢轴的发信号小径被联系。评估胃的 CSC 的典型 miRNAs 可以是为学习胃的癌症并且开发治疗学的策略的一个新方法,它在胃的癌症在根除瞄准了 CSC 的 subpopulation。 | Jianming Liu Lilin Ma Zhiwei Wang Lei Wang Chun Liu Ruixin Chen Jianguo Zhang | 2014 | Acta Biochimica et Biophysica Sinica2014，46，2： | 6 |
| 12 | Elevated plasma levels of selective cytokines in COVID-19 patients reflect viral load and lung injury显示文摘A recent outbreak of pneumonia in Wuhan,China was found to be caused by a 2019 novel coronavirus(2019-nCoV or SARS-CoV-2 or HCoV-19).We previously reported the clinical features of 12 patients with2019-n Co V infections in Shenzhen,China.To further understand the pathogenesis of COVID-19 and find better ways to monitor and treat the disease caused by 2019-n Co V,we measured the levels of 48 cytokines in the blood plasma of those 12 COVID-19 patients.Thirty-eight out of the 48 measured cytokines in the plasma of 2019-n Co V-infected patients were significantly elevated compared to healthy individuals.Seventeen cytokines were linked to 2019-nCoV loads.Fifteen cytokines,namely M-CSF,IL-10,IFN-α2,IL-17,IL-4,IP-10,IL-7,IL-1 ra,G-CSF,IL-12,IFN-γ,IL-1α,IL-2,HGF and PDGF-BB,were strongly associated with the lung-injury Murray score and could be used to predict the disease severity of2019-n Co V infections by calculating the area under the curve of the receiver-operating characteristics.Our results suggest that 2019-nCoV infections trigger extensive changes in a wide array of cytokines,some of which could be potential biomarkers of disease severity of 2019-n Co V infections.These findings will likely improve our understanding of the immunopathologic mechanisms of this emerging disease.Our results also suggest that modulators of cytokine responses may play a therapeutic role in combating the disease once the functions of these elevated cytokines have been characterized. | Yingxia Liu Cong Zhang Fengming Huang Yang Yang Fuxiang Wang Jing Yuan Zheng Zhang Yuhao Qin Xiaoyun Li Dandan Zhao Shunwang Li Shuguang Tan Zhaoqin Wang Jinxiu Li Chenguang Shen Jianming Li Ling Peng Weibo Wu Mengli Cao Li Xing Zhixiang Xu Li Chen Congzhao Zhou William J Liu Lei Liu Chengyu Jiang | 2020 | National Science Review2020，7，6： | 6 |
| 13 | Design and simulation of self-powered radio frequency identification (RFID) tags for mobile temperature monitoring显示文摘This paper presents a design for a self-powered radio frequency identification (RFID) tag with a thin film bulk acoustic reso- nating piezoelectric power supply (PPS), which can be used for portable remote temperature monitoring. We call this system a PPS-RFID for short. The RFID systems have been found to have many applications in the internet of things (IOT) in the past decade. But semi-active RFID tags require an onboard battery which limits their applications in many fields. For these reasons, our research focuses on power sources for the RFID tags. This paper emphasizes the circuit design and simulation of PPS. In our tests, 0.283 mW was generated by PPS at 1 Hz vibration by a 650 N impact force. The results showed that the integrated PPS could supply sufficient power for the designed PPS-RFID tag. The PPS-RFID tag can be widely used for temperature monitoring during mobile transport of perishable items such as medicines or food. | CHU HeQun WU GuangMin CHEN JianMing FEI Fei MAI John D LI Wen J | 2013 | Science China(Technological Sciences)2013，56，1： | 6 |
| 14 | Treatment of epilepsy in China Formal or informal?显示文摘Antiepileptic drugs are the preferred treatment approach for epileptic patients.However,informal treatment is important for intractable epilepsy.In this study,500 epileptic patients were recruited from the General Hospital of Beijing Military Area Command of Chinese PLA during the period of October 2009 to January 2012.These involved patients that had been medically treated for at least1 year.Information on the initial treatment and changes to treatment regimens for each patient was collected through questionnaires.The survey results showed that 52.3%of the epileptic patients searched for treatment after the first seizure,and the mean numbers of seizures was 12.8;59.8%of the epileptic patients were diagnosed at the first visit,and the mean onset time was 17 months after the first seizure.After diagnosis,patients were treated for an average of 20 days,and the median time was 1 day.Formal anti-epileptic drugs were selected as the first treatment regimen by 67.8%of patients,and 77.5%of these drugs were monotherapies.The mean and median numbers of seizure were respectively 36.9 and 3.0 times before the first regimen was changed.The regimen was changed within the first 6 months by 46.6%of patients,and after the first and second years of treatment,the proportions increased to 54.0%and 71.8%,respectively.In total,78.5%of the regimens were changed to informal treatments.The informal treatment of epilepsy in China is common,being initiated by either patients or physicians.Enhancing epileptic treatment services in hospital,improving physicians’professional quality,and strengthening health propaganda may promote the normalization of drug treatment of epilepsy in China. | Jianming Liu Zhiliang Liu Tao Chen Ruxiang Xu | 2013 | Neural Regeneration Research2013，8，35： | 5 |
| 15 | Study on the sedimentation capability of bauxite flotation concentrate显示文摘The sedimentation behaviors of bauxite flotation concentrates were investigated at different pH values and flocculant dosages. The effects of three types of flocculants (cationic,anionic and non-ionic polyacrylamide flocculants) as well as the molecular weight of anionic flocculants on the sedimentation of concentrate were studied. It is shown from the experimental results that at the pH 7.0,best sedimentation capability is reached when anionic polyacrylamide flocculant (molecular weight 14 million) is added and the optimal dosage is 30 g/t. | Chen Jianming Liu Sanjun Qin Wenqing Chen Zhiyou Hu Yuehua | 2008 | Engineering Sciences2008，6，4： | 5 |
| 16 | 早搏性心律失常的多重危险因素及病理特征临床研究显示文摘目的:探讨心律失常的高危因素、中医证候特点和物理检查特征表现。方法:将北京中医药大学国医堂门诊随诊164例心律失常患者和随机抽查的164例病人分为观察组和对照组,通过化验血糖、血脂,检查血压值、超声心动检查左室收缩内径、左室舒张内径的宽度和室间隔厚、左室后壁的厚度、射血分数;24 h动态心电图的SDNN、SDANN和RMSSD;心电图检查测量P波离散度、QT离散度,两组结果通过SPSS 17.0软件包进行统计分析。同时记录本病中医常见证候频次频率。结果:164例心律失常患者高脂血症患者71例(43.29%),高血压病74例(45.12%),糖尿病67例(40.85%),3种危险因素在观察组中的发生率要高于正常组人员(P<0.01)。中医常见证候类型出现频率由高到低为:心脾两虚证42例(25.61%)、心虚胆怯证33例(20.12%)、阴虚火旺证28例(17.07%)、心血瘀阻证24例(14.63%)、痰热扰心证15例(9.15%)、心肾阳虚证13(7.92%)、气虚证9例(5.49%)。超声心动检查观察组的左室收缩内径、左室舒张内径的宽度和室间隔厚、左室后壁的厚度均高于对照组人员(P<0.05)观察组射血分数要低于正常组人员(P<0.05)。24 h动态心电图检查观察组中SDNN低于对照组(P<0.05),而SDANN和RMSSD在观察组中要高于对照组(P<0.05或0.01)。心电图检查测量观察组P波离散度、QT离散度要高于对照组人员(P<0.05或0.01)。结论:高血压、高血脂、高血糖是心律失常发病的危险因素,结合中医病机特点,解释了中医理论'久病伤络'在心律失常发病机制的含义和物理检查对本病的诊断和预后的指导。 | 齐欣 郭书文 黄琨 张璐 陈曦 CHEN Jianming | 2017 | 中华中医药学刊2017，35，1： | 5 |
| 17 | Wang-Bi tablet, a patented Chinese medicine, maintains the balance of Th1/Th2 in mice with collagen-induced arthritis显示文摘OBJECTIVE: To investigate the pharmacological mechanism of Wang-Bi tablets(WBTs), a Chinese patented medicine, in rheumatoid arthritis(RA) using mice with collagen-induced arthritis(CIA).METHODS: A mouse model of CIA was induced using bovine type Ⅱ collagen. WBT treatment was administered and efficacy was evaluated. The levels of interferon-γ(IFN-γ), interleukin-2(IL-2), and interleukin-4(IL-4) were examined using an enzyme-linked immunosorbent assay, and the proportions of Th1 and Th2 were detected using flow cytometry. T-bet and GATA-binding protein 3(GATA3)expression were demonstrated using Western blot analysis.RESULTS: Paw swelling and the arthritis index decreased significantly following WBT treatment. Histopathological analysis revealed markedly alleviated damage to synovium tissue in the WBT and methotrexate treatment groups. WBT regulated the production of IFN-γ, IL-2, and IL-4 and modulated Th1 and Th2 cell populations, which might have been induced by the attenuation of Th1 and Th2 cell differentiation through a decrease in the expression of T-bet and an increase in the expression of GATA3 in the synovial tissue in CIA mice.CONCLUSION: These results indicate that WBT may produce a therapeutic effect on CIA through maintaining the balance of Th1/Th2 cells, which could result in a decrease in the autoinflammatory disorder observed in RA. | Wang Jianming Luo Jing Xu Yuan Yan Zeran Qu Xiangke Chen Mengxue Tao Qingwen | 2020 | Journal of Traditional Chinese Medicine2020，40，3： | 5 |
| 18 | Architecture of Power Internet of Things显示文摘In a smart grid system, utilizing Internet of Things technologies is an important approach to speed up the level of informatization of the system, and it is beneficial for effective management of the power grid infrastructure. Based on the construction and development features of the smart grid in China, this paper introduces the architecture of Power Internet of Things (PIoT), advanced technologies of PIoT, and the applications of PIoT in power generation, transmission, transformation, distribution and consumption in the smart grid. | Zhen Yan, Zeng Lingkang, Chen Xi, Li Xiangzhen and Liu Jianming State Grid Information & Telecommunication Company Ltd., | 2011 | Electricity2011，22，5： | 4 |
| 19 | Efficacy and safety of sorafenib in patients with advanced hepatocellular carcinoma according to baseline status: Subset analyses of the phase III Sorafenib Asia–Pacific trial显示文摘 | Ann-Lii Cheng Zhongzhen Guan Zhendong Chen Chao-Jung Tsao Shukui Qin Jun Suk Kim Tsai-Sheng Yang Won Young Tak Hongming Pan Shiying Yu Jianming Xu Fang Fang Jessie Zou Giuseppe Lentini Dimitris Voliotis Yoon-Koo Kang | 2011 | European Journal of Cancer2011，，10： | 4 |
| 20 | PhaseⅠdose-escalation and expansion study of PARP inhibitor,fluzoparib(SHR3162),in patients with advanced solid tumors显示文摘Objective:Fluzoparib(SHR3162)is a novel,potent poly(ADP-ribose)polymerases(PARP)1,2 inhibitor that showed anti-tumor activity in xenograft models.We conducted a phaseⅠ,first-in-human,dose-escalation and expansion(D-Esc and D-Ex)trial in patients with advanced solid cancer.Methods:This was a 3+3 phaseⅠD-Esc trial with a 3-level D-Ex at 5 hospitals in China.Eligible patients for DEsc had advanced solid tumors refractory to standard therapies,and D-Ex enrolled patients with ovarian cancer(OC).Fluzoparib was administered orally once or twice daily(bid)at 11 dose levels from 10 to 400 mg/d.Endpoints included dose-finding,safety,pharmacokinetics,and antitumor activity.Results:Seventy-nine patients were enrolled from March,2015 to January,2018[OC(47,59.5%);breast cancer(BC)(16,20.3%);colorectal cancer(8,10.1%),other tumors(8,10.1%)];48 patients were treated in the D-Esc arm and 31 in the D-Ex arm.The maximum tolerated dose(MTD)was 150 mg bid,with a half-life of 9.14 h.Grade 3/4 adverse events included anemia(7.6%)and neutropenia(5.1%).The objective response rate(ORR)was 30%(3/10)in patients with platinum-sensitive OC and 7.7%(1/13)in patients with BC.Among patients treated with fluzoparib≥120 mg/d,median progression-free survival(m PFS)was 7.2[95%confidence interval(95%CI),1.8-9.3]months in OC,9.3(95%CI,7.2-9.3)months in platinum-sensitive OC,and 3.5(range,2.0-28.0)months in BC.In patients with germline BC susceptibility gene mutation(g BRCAMut)(11/43 OC;2/16 BC),m PFS was 8.9 months for OC(range,1.0-23.2;95%CI,1.0-16.8)and 14 and 28 months for BC(those two patients both also had somatic BRCAMut).Conclusions:The MTD of fluzoparib was 150 mg bid in advanced solid malignancies.Fluzoparib demonstrated single-agent antitumor activity in BC and OC,particularly in BRCAMut and platinum-sensitive OC. | Huiping Li Rongrui Liu Bin Shao Ran Ran Guohong Song Ke Wang Yehui Shi Jihong Liu Wenjing Hu Fu Chen Xiaoran Liu Gairong Zhang Chuanhua Zhao Ru Jia Quanren Wang Hope S.Rugo Yifan Zhang Guangze Li Jianming Xu | 2020 | Chinese Journal of Cancer Research2020，32，3： | 4 |
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