|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Kinesin-4 Functions in Vesicular Transport on Cortical Microtubules and Regulates Cell Wall Mechanics during Cell Elongation in Plants显示文摘在植物,各向异性的房间扩大取决于作为轨道服务哪个大分子和泡被未知身份的马达 kinesins 搬运的外皮的微导管。我们使用了经历了柔韧的延伸发现涉及房间延伸并且发现 Gh KINESIN-4A 的 kinesins 的纤维富有地表示了的棉花(Gossypium hirsutum ) 。马达被 immunofluorescence 在与外皮的微导管被联系的像泡的结构上检测。在 Arabidopsis thaliana,在 KINESIN-4A/FRA1 的 orthologous 马达,以前在纤维细胞在第二等的生长期间在纤维素免职含有,被实时房间的成像在表示荧光灯地标注的功能的蛋白质的细胞检验。马达装饰了与 0.89m/min 的平均速度沿着外皮的微导管展出一个线性运动的像泡的粒子,它与连接到纤维素生合成的那些显著地不同。我们也在 KINESIN-4A/FRA1 发现了那并且在细胞墙力学,细胞延伸,和各种各样的植物、繁殖的器官的轴的生长在 KINESIN-4C 玩联系了冗余的角色,,损失在极大地提高的 KINESIN-4C,缺点在 KINESIN-4A/FRA1 地点由一个空变化引起了。双异种显示了房间墙在快速的房间延伸的正常阶段弄软的缺乏。而且,提高了包含 arabinose 的免职糖类在 kinesin-4 异种被检测。我们的调查结果建立了在在 flowering 植物沿着外皮的微导管和房间墙力学和房间延伸包含非有纤维质的部件的货物的 Kinesin-4-based 运输之间的一个连接。 | Zhaosheng Kong Motohide Ioki Siobhan Braybrook Shundai Li Zheng-Hua Ye Yuh-Ru Julie Lee Takashi Hotta Anny Chang Juan Tian Guangda Wang Bo Liu | 2015 | Molecular Plant2015，8，7： | 8 |
| 2 | One Stone Four Birds:A Novel Liposomal Delivery System Multi-functionalized with Ginsenoside Rh2 for Tumor Targeting Therapy显示文摘Liposomes hold great potential in anti-cancer drug delivery and the targeting treatment of tumors.However,the clinical therapeutic efficacy of liposomes is still limited by the complexity of tumor microenvironment(TME)and the insufficient accumulation in tumor sites.Meanwhile,the application of cholesterol and polyethylene glycol(PEG),which are usually used to prolong the blood circulation and stabilize the structure of liposomes respectively,has been questioned due to various disadvantages.Herein,we developed a ginsenoside Rh2-based multifunctional liposome system(Rh2-lipo)to effectively address these challenges once for all.Different with the conventional’wooden’liposomes,Rh2-lipo is a much more brilliant carrier with multiple functions.In Rh2-lipo,both cholesterol and PEG were substituted by Rh2,which works as membrane stabilizer,long-circulating stealther,active targeting ligand,and chemotherapy adjuvant at the same time.Firstly,Rh2 could keep the stability of liposomes and avoid the shortcomings caused by cholesterol.Secondly,Rh2-lipo showed a specifically prolonged circulation behavior in the blood.Thirdly,the accumulation of the liposomes in the tumor was significantly enhanced by the interaction of glucose transporter of tumor cells with Rh2.Fourth,Rh2-lipo could remodel the structure and reverse the immunosuppressive environment in TME.When tested in a 4T1 breast carcinoma xenograft model,the paclitaxel-loaded Rh2-lipo realized high efficient tumor growth suppression.Therefore,Rh2-lipo not only innovatively challenges the position of cholesterol as a liposome component,but also provides another innovative potential system with multiple functions for anti-cancer drug delivery. | Chao Hong Jianming Liang Jiaxuan Xia Ying Zhu Yizhen Guo Anni Wang Chunyi Lu Hongwei Ren Chen Chen Shiyi Li Dan Wang Huaxing Zhan Jianxin Wang | 2020 | Nano-Micro Letters2020，12，10： | 8 |
| 3 | Towards single-molecule optoelectronic devices显示文摘Benefiting from the development of molecular electronics and molecular plasmonics, the interplay of light and electronic transport in molecular junctions has attracted growing interest among researchers in both fields, leading to a new research direction of 'single-molecule optoelectronics'. Here, we review the latest developments of photo-modulated charge transport,electroluminescence and Raman spectroscopy from single-molecule junctions, and suggest future directions for single-molecule optoelectronics. | Lijue Chen Anni Feng Maoning Wang Junyang Liu Wenjing Hong Xuefeng Guo Dong Xiang | 2018 | Science China Chemistry2018，61，11： | 7 |
| 4 | Applications of RNA interference highthroughput screening technology in cancer biology and virology显示文摘RNA 干扰(RNAi ) 是调整基因表示和房间功能的古老的细胞内机制。用 RNAi 的大规模基因 silencing (HTS ) 高产量的屏蔽打开了令人激动的边疆系统地在哺乳动物的房间学习基因功能。这条途径使研究人员能在给定的生物上下文和愿望识别基因功能提供可观的新奇卓见。这里,我们在癌症生物学和病毒学用案例研究考察 RNAi HTS 策略和应用。 | Shan Gao Chen Yang Shan Jiang Xiao-Ning Xu Xin Lu You-Wen He Annie Cheung Hui Wang | 2014 | Protein & Cell2014，5，11： | 4 |
| 5 | Effect of the structure of ginsenosides on the in vivo fate of their liposomes显示文摘To utilize themultiple functions and give full play of ginsenosides,a variety of ginsenosides with different structures were prepared into liposomes and evaluated for their effect on the stability,pharmacokinetics and tumor targeting capability of liposomes.The results showed that the position and number of glycosyl groups of ginsenosides have significant effect on the in vitro and in vivo properties of their liposomes.The pharmacokinetics of ginsenosides liposomes indicated that the C-3 sugar group of ginsenosides is beneficial to their liposomes for longer circulation in vivo.The C-3 and C-6 glycosyls can enhance the uptake of their liposomes by 4T1 cells,and the glycosyls at C-3 position can enhance the tumor active targeting ability significantly,based on the specific binding capacity to Glut 1 expressed on the surface of 4T1 cells.According to the results in the study,ginsenoside Rg3 and ginsenoside Rh2 are potential for exploiting novel liposomes because of their cholesterol substitution,long blood circulation and tumor targeting capabilities.The results provide a theoretical basis for further development of ginsenoside based liposome delivery systems. | Chen Chen Jiaxuan Xia Hongwei Ren Anni Wang Ying Zhu Ru Zhang Zicheng Gan Jianxin Wang | 2022 | Asian Journal of Pharmaceutical Sciences2022，17，2： | 4 |
| 6 | 抑郁症的非药物治疗:系统性综述与证据图显示文摘背景抑郁症非药物治疗的疗效比较目前仍然不清楚。方法我们对一些系统性综述作了概述,回顾了随机对照试验(RCT),比较抑郁症非药物治疗的有效性和认知行为治疗(CBT)。对多个电子数据库在2016年2月之前发表的所有文献进行了检索,不限制语言。成对的评阅人进行资料纳入、数据提炼并评估偏倚的风险。在适用的时候进行了荟萃分析。结果我们收录了367项RCT,纳入了约2000名患者,进行了11种治疗,导出17项独立的头对头比较。通过标准化的量表评估,发现CBT、自然疗法、行为干预与躯体活动干预可以降低抑郁的严重程度。然而,这些非药物干预的相对疗效仍然缺乏。这些干预对临床缓解和复发的效果不清楚。CBT的发生率比抗抑郁药物更低。局限性由于证据缺乏一致性、证据不清或偏倚风险高,导致证据的质量只是低到中等,限制了我们研究结果的可信度。结论抑郁症的非药物治疗能减少抑郁症状,在轻度到重度抑郁症患者中,应当合并抗抑郁药物治疗,一同进行。对于非药物治疗的选择,应当根据患者的价值观、偏好、临床和社会因素来与患者共同作出决定。 | Wigdan H Farah Mouaz Alsawas Maria Mainou Fares Alahdab Magdoleen H Farah Ahmed T Ahmed Essa A Mohamed Jehad Almasri Michael R Gionfriddo Ana Castaneda-Guarderas Khaled Mohammed Zhen Wang Noor Asi Craig N Sawchuk Mark D Williams Larry J Prokop M Hassan Murad Annie LeBlanc | 2017 | 英国医学杂志中文版2017，20，11： | 2 |
| 7 | Simultaneous determination of six alkaloids and one monoterpene in rat plasma by liquid chromatography–tandem mass spectrometry and pharmacokinetic study after oral administration of a Chinese medicine Wuji Pill显示文摘 | Jin Yuan Ying Wang Rui An Shuang Wang Shui-Jun Li Jing-Ying Jia S.W. Annie Bligh Xin-Hong Wang Yue-ming Ma | 2012 | Journal of Chromatography B2012，，： | 1 |
| 8 | Paper-Based Planar Reaction Arrays for Printed Diagnostics 显示文摘 | Anni M Daniela F Wang S X | 2011 | Sensors and Actuators B: Chemical2011，16，1： | 1 |
| 9 | Nanotheranostics – a review of recent publications显示文摘 | Ja-an Annie Ho Min-Chieh Chuang Li-Sheng Wang | 2012 | 2012 (defa)2012，，： | 1 |
| 10 | Pharmacokinetics and bioavailability of gentiopicroside from decoctions of Gentianae and Longdan Xiegan Tang after oral administration in rats-Comparison with gentiopicroside alone显示文摘 | WANG CH CHENGXM ANNIE BLIGHD SW | 2007 | J Pharm Biomed Anal2007，44，5： | 1 |
| 11 | Design of Wide - Bandwidth Envelope- Tracking Power Amplifiers for OFDM Applications显示文摘 | Feipeng Wang Annie Hueiching Yang | 2005 | IEEE Transactions on microwave theory and techniques April2005，53，4： | 1 |
| 12 | Pharmacokinetic behavior of gentiopicroside from decoction of radix gentianae, gentiana macrophylla after oral administration in rats: A pharmacokinetic comaprison with gentiopicroside after oral and intravenous administration alone显示文摘 | Chang- hong Wang Xue- mei Cheng Yu-qi He Kenneth N. White S. W. Annie Bligh Christopher J. Branford-White Zheng-tao Wang | 2007 | Archives of Pharmacal Research2007，，9： | 1 |
| 13 | Long noncoding RNA(lncRNA)H19:An essential developmental regulator with expanding roles in cancer,stem cell differentiation,and metabolic diseases显示文摘Recent advances in deep sequencing technologies have revealed that,while less than 2%of the human genome is transcribed into mRNA for protein synthesis,over 80%of the genome is transcribed,leading to the production of large amounts of noncoding RNAs(ncRNAs).It has been shown that ncRNAs,especially long non-coding RNAs(lncRNAs),may play crucial regulatory roles in gene expression.As one of the first isolated and reported lncRNAs,H19 has gained much attention due to its essential roles in regulating many physiological and/or pathological processes including embryogenesis,development,tumorigenesis,osteogen-esis,and metabolism.Mechanistically,H19 mediates diverse regulatory functions by serving as competing endogenous RNAs(CeRNAs),Igf2/H19 imprinted tandem gene,modular scaffold,cooperating with H19 antisense,and acting directly with other mRNAs or lncRNAs.Here,we summarized the current understanding of H19 in embryogenesis and development,cancer development and progression,mesenchymal stem cell lineage-specific differentiation,and metabolic diseases.We discussed the potential regulatory mechanisms underlying H19’s func-tions in those processes although more in-depth studies are warranted to delineate the exact molecular,cellular,epigenetic,and genomic regulatory mechanisms underlying the physiolog-ical and pathological roles of H19.Ultimately,these lines of investigation may lead to the development of novel therapeutics for human diseases by exploiting H19 functions. | Junyi Liao Bowen Chen Zhenglin Zhu Chengcheng Du Shengqiang Gao Guozhi Zhao Piao Zhao Yonghui Wang Annie Wang Zander Schwartz Lily Song Jeffrey Hong William Wagstaff Rex CHaydon Hue HLuu Jiaming Fan Russell RReid Tong-Chuan He Lewis Shi Ning Hu Wei Huang | 2023 | Genes & Diseases2023，10，4： | 1 |
| 14 | Prolactin receptor maps to pig Chromosome 16显示文摘 | Amy L. Vincent Lizben Wang Christopher K. Tuggle Annie Robic Max F. Rothschild | 1997 | Mammalian Genome1997，，10： | 1 |
| 15 | Pharmacokinetics and tissue distribution of gentiopicroside following oral and intravenous administration in mice 显示文摘 | WANG C H WANG Z T ANNIE B | 2004 | Eur J Drug Metab Pharmacokin2004，29，3： | 1 |
| 16 | Optical Trapping of a Single Molecule of Length Sub-1 nm in Solution显示文摘Plasmonic optical manipulation has emerged as an affordable alternative to manipulate single chemical and biological molecules in nanoscience.Although the theoretical models of sub-5 nm single-molecule trapping have been considered promising,the experimental strategies remain a challenge due to the Brownian motions and weak optical gradient forces with significantly reduced molecular polarizability.Herein,we address direct trapping and in situ sensing of single molecules with unprecedented size,down to∼5Åin solution,by employing an adjustable plasmonic optical nanogap and single-molecule conductance measurement.The theoretical simulations demonstrate that local fields with a high enhancement factor,over 103,were generated at such small nanogaps,resulting in optical forces as large as several piconewtons to suppress the Brownian motion and trap a molecule of length sub-1 nm.This work demonstrates a strategy for directly manipulating the small molecule units,promising a vast multitude of applications in chemical,biological,and materials sciences at the single-molecule level. | Biao-Feng Zeng Ran Deng Yu-Ling Zou Chun-An Huo Jing-Yu Wang Wei-Ming Yang Qing-Man Liang Sheng-Jie Qiu Anni Feng Jia Shi Wenjing Hong Zhilin Yang Zhong-Qun Tian Yang Yang | 2023 | CCS Chemistry2023，5，4： | 1 |
| 17 | Pharmacokinetics and tissue distribution of gentiopi- croside following oral and intravenous administration in mice显示文摘 | Chang-hong Wang Zheng-tao Wang SW Annie Bligh | 2004 | European Drug Metabol Pharmacokinet2004，29，3： | 1 |
| 18 | Biological fingerprinting analysis of the traditional Chinese prescription Longdan Xiegan Decoction by on/off-line comprehensive two-dimensional biochromatography显示文摘 | Yun Wang Liang Kong Lianghai Hu Xiaoyuan Lei Li Yang Guixin Chou Hanfa Zou Changhong Wang S.W. Annie Bligh Zhengtao Wang | 2007 | Journal of Chromatography B2007，，2： | 1 |
| 19 | The increase of mitochondrial DNA content in endometrial adenocarcinoma cells: A quantitative study using laser-captured microdissected tissues显示文摘 | Yue Wang Vincent W.S. Liu Wei-Cheng Xue Percy C.K. Tsang Annie N.Y. Cheung Hextan Y.S. Ngan | 2005 | Gynecologic Oncology2005，，1： | 1 |
| 20 | Intra-annual stem radial increment response of Qilian juniper to temperature and precipitation along an altitudinal gradient in northwestern China显示文摘 | Zhangyong Wang Bao Yang Annie Deslauriers Achim Br?uning | 2015 | Trees2015，，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员