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| 1 | Comparative efficacy of various exercise interventions on cognitive function in patients with mild cognitive impairment or dementia:A systematic review and network meta-analysis显示文摘Background:Exercise is a promising nonpharmacological therapy for cognitive dysfunction,but it is unclear which type of exercise is most effective.The objective of this study was to compare and rank the effectiveness of various exercise interventions on cognitive function in patients with mild cognitive impairment(MCI)or dementia and to examine the effects of exercise on the symptoms relevant to cognitive impairment.Methods:We searched PubMed,Web of Science,Embase,Cochrane Central Register of Controlled Trials,SPORTDiscus,and PsycInfo through September 2019 and included randomized controlled trials that examined the effectiveness of exercise interventions in patients with MCI or dementia.Primary outcomes included global cognition,executive cognition,and memory cognition.Secondary outcomes included activities of daily living,neuropsychiatric symptoms,and quality of life.Pairwise analyses and network meta-analyses were performed using a random effects model.Results:A total of 73 articles from 71 trials with 5606 participants were included.All types of exercise were effective in increasing or maintaining global cognition,and resistance exercise had the highest probability of being the most effective intervention in slowing the decrease in global cognition(standard mean difference(SMD)=1.05,95%confidence interval(95%CI):0.56-1.54),executive function(SMD=0.85,95%CI:0.21-1.49),and memory function(SMD=0.32,95%CI:0.01-0.63)in patients with cognitive dysfunction.Subgroup analyses for patients with MCI revealed different effects,and multicomponent exercise was most likely to be the optimal exercise therapy for preventing the decline of global cognition(SMD=0.99,95%CI:0.44-1.54)and executive function(SMD=0.72,95%CI:0.06-1.38).However,only resistance exercise showed significant effects on memory function for patients with MCI(SMD=0.35,95%CI:0.01-0.69).Exercise interventions also showed various effects on the secondary outcomes.Conclusion:Resistance exercise has the highest probability of being the optimal exercise type for slowing cognitive declin e in patients withcognitive dysfunction,especially in patients with dementia.Multicomponent exercise tends to be most effective in protecting global cognition and executive function in patients with MCI. | Xiuxiu Huang Xiaoyan Zhao Bei Li Ying Cai Shifang Zhang Qiaoqin Wan Fang Yu | 2022 | Journal of Sport and Health Science2022，11，2： | 19 |
| 2 | Distribution of IgG galactosylation as a promising biomarker for cancer screening in multiple cancer types显示文摘 | Shifang Ren Zejian Zhang Congjian Xu Lin Guo Renquan Lu Yihong Sun Jianming Guo Ruihuan Qin Wenjun Qin Jianxin Gu | 2016 | Cell Research2016，26，8： | 8 |
| 3 | Biofilm-inspired adhesive and antibacterial hydrogel with tough tissue integration performance for sealing hemostasis and wound healing显示文摘Uncontrolled bleeding and infection can cause significant increases in mortalities.Hydrogel sealants have attracted extensive attention for their ability to control bleeding.However,because interfacial water is a formidable barrier to strong surface bonding,a challenge remains in finding a product that offers robust tissue adhesion combined with anti-infection properties.Inspired by the strong adhesive mechanism of biofilm and mussels,we report a novel dual bionic adhesive hydrogel(DBAH)based on chitosan grafted with methacrylate(CS-MA),dopamine(DA),and N-hydroxymethyl acrylamide(NMA)via a facile radical polymerization process.CS-MA and DA were simultaneously included in the adhesive polymer for imitating the two key adhesive components:polysaccharide intercellular adhesin(PIA)of staphylococci biofilm and 3,4-dihydroxy-L-phenylalanine(Dopa)of mussel foot protein,respectively.DBAH presented strong adhesion at 34 kPa even upon three cycles of full immersion in water and was able to withstand up to 168 mm Hg blood pressure,which is significantly higher than the 60–160 mm Hg measured in most clinical settings.Most importantly,these hydrogels presented outstanding hemostatic capability under wet and dynamic in vivo movements while displaying excellent antibacterial properties and biocompatibility.Therefore,DBAH represents a promising class of biomaterials for high-efficiency hemostasis and wound healing. | Wei Han Bo Zhou Kai Yang Xin Xiong Shifang Luan Yu Wang Zheng Xu Peng Lei Zhengshan Luo Jian Gao Yijing Zhan Guopu Chen Lei Liang Rui Wang Sha Li Hong Xu | 2020 | Bioactive Materials2020，5，4： | 6 |
| 4 | Obtained transgenic wheat expressing pac1 mediated by Agrobacterium is resistant against Barley yellow dwarf virus-GPV显示文摘In fission yeast (Schizosaccharomyces pombe), pac1 gene was cloned with 99.3% nucleo- tide sequence similarity with published pac1 in GenBank. In pET-5α expression system, the expres- sion product of cloned pac1 in E. coli showed activity to degrade the double-strand RNA. Harboring the binary vector pBI121, which contains pac1 gene, Agrobacterium tumefaciens strain LBA4404 was used to transform the wheat immature embryos pre- cultured 7―10 d. After preregeneration, regeneration and selection culture stage, totally 41 G418 resistant plants were obtained, in which 25 lines were proved to integrate with transgene and express transgene normally by PCR, Dot blot, RT-PCR and ELISA de- tection. Antivirus test carried out on 25 positive lines with high dose of Barley yellow dwarf virus-GPV re- vealed that 12 lines had resistance to BVDV-GPV in low level, another 12 lines had resistance to BVDV- GPV in middle level, and 1 line showed resistance to BVDV-GPV in high level. However, both low and middle level of resistance plants showed no symp- toms when infected by viruses at low dose, which suggested the dose-dependent effect of the resis- tance mediated by pac1 to BYDV-GPV. | YAN Fei ZHENG Yinying ZHANG Wenwei XIAO Hong LI Shifang CHENG Zhuomin | 2006 | Chinese Science Bulletin2006，51，19： | 5 |
| 5 | Efficacy and Economic Evaluation of Nonbiological Artificial Liver Therapy in Acute-on-chronic Hepatitis B Liver Failure显示文摘Background and Aims:Nonbiological artificial liver(NBAL)is frequently used as a first-line treatment for hepatitis B virus-associated acute-on-chronic liver failure(HBV-ACLF).This study aimed to compare the therapeutic efficacy and cost-effectiveness ratio(CER)of comprehensive medical treatment,plasma exchange(PE),and double plasma molecular adsorption system(DPMAS)plus half-dose PE(DPMAS+PE)in patients with HBV-ACLF.Methods:A total of 186 patients with HBV-ACLF randomly received comprehensive medical treatment,PE,or DPMAS+PE and were prospectively evaluated.Patients were divided into four subgroups based on the pretreatment prothrombin activity(PTA):Group I(PTA>40%),group II(PTA 30–40%),group III(PTA 20–30%),and group IV(PTA<20%).The main outcome measures were 28 day effectiveness;90 day liver transplantation-free survival;change of biochemical parameters;and CER.Results:DPMAS+PE treatment was associated with significantly higher 28 day effectiveness and 90 day liver transplantation-free survival compared with PE treatment in patients with group I liver failure.Clearance of serum total bilirubin(TBIL),AST,and creatinine(Cr)were significantly higher in the DPMAS+PE group than in the PE group.For subjects with group I liver failure,DPMAS+PE treatment had advantages of lower CER values and better cost-effectiveness.Conclusions:Compared with comprehensive medical treatment and PE alone,DPMAS with halfdose sequential PE treatment more effectively improved TBIL,AST,and Cr in HBV-ACLF patients,improved 28 day effectiveness and 90 day survival rates in patients with group I liver failure,and was more cost effective.DPMAS+PE is a viable NBAL approach for treatment of HBV-ACLF. | Cichun Wu Wenting Peng Da Cheng Huimin Gu Fei Liu Shifang Peng Lei Fu | 2023 | Journal of Clinical and Translational Hepatology2023，11，2： | 5 |
| 6 | Phase Ⅱ open-label study of recombinant circularly permuted TRAIL as a single-agent treatment for relapsed or refractory multiple myeloma显示文摘Background: Despite the recent development of new therapies, multiple myeloma(MM) remains an incurable disease. Thus, new, efective treatments are urgently needed, particularly for relapsed or refractory MM(RRMM). In an earlier phase I study, a novel form of recombinant human Apo2L/tumor necrosis factor-related apoptosis-inducing ligand(TRAIL) that is currently in clinical development for the treatment of hematologic malignancies, i.e., circularly permuted TRAIL(CPT), was well tolerated at a dose of 2.5 mg/kg per day and showed promising preliminary activity in patients with RRMM. This phase II, open-label, multicenter study further investigated the eicacy and safety of 2.5-mg/kg per day CPT as single-agent therapy for patients with RRMM.Methods: Patients with RRMM were treated once daily with CPT(2.5 mg/kg, intravenously) for 14 consecutive days for each 21-day cycle. Clinical response and toxicity were assessed after each treatment cycle.Results: Twenty-seven patients received CPT. Using the European Group for Blood and Marrow Transplantation criteria, we calculated the overall response rate of 33.3% with 1 near-complete response(n CR) and 8 partial responses(PRs). The clinical beneit rate(48.1%) included 1 nCR, 8 PRs, and 4 minimal responses. The most common treatmentrelated adverse events(TRAEs) were fever, aspartate aminotransferase elevation, alanine aminotransferase elevation, leucopenia, rash, neutropenia, and thrombocytopenia. We graded toxicity using the Common Toxicity Criteria for Adverse Events, version 3.0, and determined that 37.0% of patients had at least 1 grade 3–4 TRAE.Conclusions: CPT as a single agent can elicit a response in patients with RRMM and is well tolerated. Further clinical investigation is warranted. | Yun Leng Lugui Qiu Jian Hou Yaozhong Zhao Xuejun Zhang Shifang Yang Hao Xi Zhongxia Huang Ling Pan Wenming Chen | 2016 | Chinese Journal of Cancer2016，35，12： | 4 |
| 7 | A Positive Correlation between Elevated Altitude and Frequency of Mutant Alleles at the EPAS1 and HBB Loci in Chinese Indigenous Dogs显示文摘Hypoxia represents one of the most extreme environmental conditions for both human beings and animals living at high altitudes(Zhao et al.,2009).Over the past few years,great attention has been focused on the genetic bases of adaption to high-altitude environments(Bigham et al.,2010;Simonson et al.,2010).The domestic dog(Canis familiaris)is the first animal that | Ruoxi Fan Fei Liu Hong Wu Shifang Wu Chunling Zhu Yan Li Guodong Wang Yaping Zhang | 2015 | Journal of Genetics and Genomics2015，42，4： | 4 |
| 8 | Bimetal-organic frameworks derived Co/N-doped carbons for lithium-sulfur batteries显示文摘Lithium-sulfur(Li-S) batteries have received extensive attention due to their high theoretical specific energy density.However,the utilization of sulfur is seriously reduced by the shuttle effect of lithium polysulfides and the low conductivity of sulfur and lithium sulfide(Li2S).Herein,we introduced bimetalorganic frameworks(Co/Zn-ZIF) derived cobalt and nitrogen-doped carbons(Co/N-C) into Li-S batteries through host design and sepa rator modification.The Co/N-C in Li-S batteries effectively limits the shuttle effect through simultaneously serving as polysulfide traps and chemical catalyst.As a result,the Li-S batteries deliver a high reversible capacity of 1614.5 mAh/g and superior long-term cycling stability with a negligible capacity decay of only 0.04% per cycle after 1000 cycles.Furthermore,they have a high area capacity of 5.5 mAh/cm2. | Shifang Jiang Shuo Huang Minjie Yao Jiacai Zhu Lili Liu Zhiqiang Niu | 2020 | Chinese Chemical Letters2020，31，9： | 4 |
| 9 | Energy conservation and emissions reduction strategies in foundry industry显示文摘Current energy conservation and emissions reduction strategies in iron and steel industry were reviewed. Since foundry industry is one of the major source of energy consumption and pollution emission (especially CO 2 ), issues concerning energy-saving and emission-reduction have been raised by governments and the industry. Specialists from around the world carried out multidimensional analyses and evaluation on the potentials in energy conservation and emissions reduction in iron and steel industry, and proposed various kinds of analyzing models. The primary measures mainly focus on the targeted policies formulation and also on clean and highefficient technologies development. The differences and similarities in energy conservation and emission reduction in foundry industry between China and other countries were discussed, while, the future development trend was also pointed out. | Li Yuanyuan Chen Weiping Huang Dan Luo Jie Liu Zhe Chen Yongcheng Liu Qiping Su Shifang | 2010 | China Foundry2010，7，4： | 4 |
| 10 | Three dysregulated microRNAs in serum as novel biomarkers for gastric cancer screening显示文摘 | Hui Wang Lei Wang Zheng Wu Rong Sun Haifeng Jin Jifeng Ma Lili Liu Rui Ling Jun Yi Ling Wang Jiefang Bian Jianghao Chen Nanlin Li Shifang Yuan Jun Yun | 2014 | Medical Oncology2014，，12： | 4 |
| 11 | Repression of interferon-γ expression in T cells by Prosperorelated Homeobox protein显示文摘 | Linfang Wang Jianmei Zhu Shifang Shan Yi Qin Yuying Kong Jing Liu Yuan Wang Youhua Xie | 2008 | Cell Research2008，18，9： | 3 |
| 12 | Recent advances in polymeric biomaterials-based gene delivery for cartilage repair显示文摘Untreated articular cartilage damage normally results in osteoarthritis and even disability that affects millions of people.However,both the existing surgical treatment and tissue engineering approaches are unable to regenerate the original structures of articular cartilage durably,and new strategies for integrative cartilage repair are needed.Gene therapy provides local production of therapeutic factors,especially guided by biomaterials can minimize the diffusion and loss of the genes or gene complexes,achieve accurate spatiotemporally release of gene products,thus provideing long-term treatment for cartilage repair.The widespread application of gene therapy requires the development of safe and effective gene delivery vectors and supportive gene-activated matrices.Among them,polymeric biomaterials are particularly attractive due to their tunable physiochemical properties,as well as excellent adaptive performance.This paper reviews the recent advances in polymeric biomaterial-guided gene delivery for cartilage repair,with an emphasis on the important role of polymeric biomaterials in delivery systems. | Ran Yang Fei Chen Jinshan Guo Dongfang Zhou Shifang Luan | 2020 | Bioactive Materials2020，5，4： | 3 |
| 13 | An unsymmetric constitutive equation for anisotropic viscoelastic fluid显示文摘连续统 corotational 衍生物类型的组成的理论为各向异性的粘弹性的液体液体被开发水晶(LC ) 聚合物。各向异性的粘弹性的简单液体的一个概念被介绍。压力张肌被第一 Rivlin Ericksen 张肌 A 和关于一个 co 旋转的坐标系统测量的旋转张肌 W 描述而不是在经典莱斯莉·埃里克森理论的速度坡度张肌 D。这个理论上的模型 LCP-H 被建议, shear 压力的典型 unsymmetric 行为为 LC 聚合物液体被预言。二砍从而强调在砍聚合物液体导致的 LC 的流动内部旋涡流动和旋转流动。结论能为现代液体的理论意味着是水晶的显示技术。由使用方程,挤出前液体的紧张的流动被学习因为纤维旋转 LC 聚合物融化,有变化的 elongational 粘性对延期率砍率在图被给。当主任向量的 orientational 运动被考虑时, elongational 粘性和分叉行为的可观的增加被观察。聚合物融化的 LC 的 extrudate 的收缩被高 elongational 粘性引起。为各向异性的粘弹性的液体,重要进展根据一系列新各向异性的非牛顿的液体问题能根据哪个被处理在组成的方程上在调查被做了。 | Shifang Han | 2007 | Acta Mechanica Sinica2007，23，2： | 2 |
| 14 | Loss of CREST leads to neuroinflammatory responses and ALS-like motor defects in mice显示文摘Background:Amyotrophic lateral sclerosis(ALS)is a late onset neurodegenerative disease with fast progression.ALS has heavy genetic components in which a series of genetic mutations have been identified.In 2013,Mutations of the CREST gene(also known as SS18L1),which functions as a calcium-regulated transcriptional activator,were found in sporadic ALS patients.However,the pathogenic causality and mechanisms of ALS-associated mutations of CREST remain to be determined.Methods:In this study,we constructed CREST knockout and Q394X knock-in mice with CRISPR/Cas9 system.Using biochemical and imaging tools,we illustrated core pathological phenotypes in CREST mutant mice and claimed the possible pathogenic mechanisms.Furthermore,we also observed locomotion defects in CREST mutant mice with behavioural tests.Results:We demonstrate that ALS-related CREST-Q388X mutation exhibits loss-of-function effects.Importantly,the microglial activation was prevalent in CREST haploinsufficiency mice and Q394X mice mimicking the human CREST Q388X mutation.Furthermore,we showed that both CREST haploinsufficiency and Q394X mice displayed deficits in motor coordination.Finally,we identified the critical role of CREST-BRG1 complex in repressing the expression of immune-related cytokines including Ccl2 and Cxcl10 in neurons,via histone deacetylation,providing the molecular mechanisms underlying inflammatory responses within mice lack of CREST.Conclusion:Our findings indicate that elevated inflammatory responses in a subset of ALS may be caused by neuron-derived factors,suggesting potential therapeutic methods through inflammation pathways. | Cheng Cheng Kan Yang Xinwei Wu Yuefang Zhang Shifang Shan Aaron Gitler Anirvan Ghosh Zilong Qiu | 2019 | Translational Neurodegeneration2019，8，1： | 2 |
| 15 | Dislocation-Induced Precipitation and Its Strengthening of Al–Cu–Li–Mg Alloys with High Mg显示文摘Generally, the good combination of pre-deformation and aging can improve the mechanical strength of the Al–Cu–Li–Mg alloys. However, the effects of pre-deformation on competitive precipitation relationship and precipitation strengthening have not been clarified in detail in Al–Cu–Li–Mg alloys with high Mg. In the present study, the effects of pre-deformation level on the microstructure and mechanical properties of an Al–2.95 Cu–1.55 Li–0.57 Mg–0.18 Zr alloy have been investigated. It is found that the introduction of dislocation by 5% pre-deformation can facilitate the precipitation of new successive composite precipitates and T _1 precipitates along the sub-grain boundaries or dislocations and inhibit the precipitation of dispersive GPB zones which is the main precipitates of the alloys without pre-deformation. The introduction of 5% pre-deformation can enhance the mechanical properties considerably. When the pre-deformation level increases from 5 to 15%, the number density of the successive composite precipitates and T _1 precipitates increases, and the aspect ratio of T _1 precipitates decreases. The decrease in T _1 precipitate aspect ratio and the increment of the successive composite precipitates result in the reduction in precipitation strengthening. Therefore, the increase in pre-deformation level from 5 to 15% does not further improve the mechanical properties of the alloys, although the dislocation strengthening increases continuously. | Xiangpeng Gong Shifang Luo Shiyong Li Cuilan Wu | 2021 | Acta Metallurgica Sinica(English Letters)2021，34，5： | 2 |
| 16 | 调强适形放疗在乳腺癌保乳术后应用的系统评价(英文)显示文摘Objective:The aim of this study was to assess the long-term effect of breast conservation with breast intensitymodulated radiotherapy (IMRT) for early-stage breast cancers.Methods:Pub Med,EMBASE,Cochrane Library,Chinese Biomedical Literature Database were searched to identify relevant original published trails,and the references of eligible studies were manually screened.Randomized controlled trails reported in any language,comparing breast IMRT with conventional radiotherapy (RT) in patients with early-stage breast cancer were eligible for inclusion.Two investigators independently assessed the quality of included trials and extracted data.The RevMan 5.0 software was used for statistical analysis.Results:Four trials involving 1440 patients were included.The results showed that in the IMRT group,the occurrence of acute moist dermatitis,the edema of the mammary gland and the occurrence of hyperpigmentation were lower than those of RT group,the pooled risk ratio value and 95% confidence interval were 0.28 (0.17-0.48),0.03 (0.00-0.21) and 0.06 (0.02-0.15) respectively.The use of IMRT did not correlate with pain and quality of life,but the presence of moist desquamation did significantly correlate with pain and reduced quality of life.Conclusion:The currently available evidence showed that IMRT significantly reduces the occurrence of moist acute dermatitis anywhere in the breast and alleviates the suffering of patients and improves the quality of life of patients.Future large-scale,high-quality,double-blind trials are needed. | Xiupeng Ye Ling Su Xiaohu Wang Kehu Yang inhui Tian Qiuning Zhang Qiang Wang Xiaojun Li Yuqing Kang Liyun Guo Ruifeng Liu Shifang Feng | 2010 | The Chinese-German Journal of Clinical Oncology2010，9，12： | 2 |
| 17 | Opportunities and challenges for the development of polymer-based biomaterials and medical devices显示文摘Biomaterials and medical devices are broadly used in the diagnosis,treatment,repair,replacement or enhancing functions of human tissues or organs.Although the living conditions of human beings have been steadily improved in most parts of the world,the incidence of major human’s diseases is still rapidly growing mainly because of the growth and aging of population.The compound annual growth rate of biomaterials and medical devices is projected to maintain around 10%in the next 10 years;and the global market sale of biomaterials and medical devices is estimated to reach$400 billion in 2020.In particular,the annual consumption of polymeric biomaterials is tremendous,more than 8000 kilotons.The compound annual growth rate of polymeric biomaterials and medical devices will be up to 15-30%.As a result,it is critical to address some widespread concerns that are associated with the biosafety of the polymer-based biomaterials and medical devices.Our group has been actively worked in this direction for the past two decades.In this review,some key research results will be highlighted. | Jinghua Yin Shifang Luan | 2016 | Regenerative Biomaterials2016，3，2： | 2 |
| 18 | Effects of ovarian hormone loss on neuritic plaques and autophagic flux in the brains of adult female APP/PS1 double-transgenic mice显示文摘流行病的研究证明了女人们说明疾病(广告) 案例,在传播 gonadal 荷尔蒙的衰落为被认为是专业之一冒险的三分之二 Alzheimers 因素。另外,卵巢的荷尔蒙缺乏可以影响淀粉的(A) 免职,它与 autophagic 流动有一种靠近的关系。在这研究,我们在二个老鼠模型,上调查了短期或长期的卵巢的荷尔蒙剥夺的影响非转基因(野类型) 并且 APP/PS1 双 transgenic | Qiuhui Yao Min Feng Bo Yang Zhimin Long Shifang Luo Min Luo Guiqiong He Kejian Wang | 2018 | Acta Biochimica et Biophysica Sinica2018，50，5： | 2 |
| 19 | Changes in soil properties and vegetation following exclosure and grazing in degraded Alxa desert steppe of Inner Mongolia, China显示文摘 | Shifang Pei Hua Fu Changgui Wan | 2007 | Agriculture Ecosystems and Environment2007，，1： | 1 |
| 20 | The Role of Carotid Plaque Vulnerability and Inflammation in the Pathogenesis of Acute Ischemic Stroke显示文摘 | SHIFANG DING MEI ZHANG YUXIA ZHAO WENQIANG CHEN GUIHUA YAO CHENG ZHANG PENGFEI ZHANG YUN ZHANG | 2008 | The American Journal of the Medical Sciences2008，，1： | 1 |
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