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| 1 | Great flood in the middle-lower Yellow River reaches at 4000 a BP inferred from accurately-dated stalagmite records显示文摘Recently,Wu et al.[1]suggested an earthquake-induced landslide dam outburst flood on the eastern Tibetan Plateau at 1920BCE(3870 a BP,BP denotes year before 1950 CE)caused the Great Flood in the middle-lower Yellow River reaches,and resulted in the founding of Xia Dynasty at 3850 a BP.This age is$150–300younger than the previously estimated age of the Xia Dynasty[2].While the geological evidence of the outburst flood。 | Liangcheng Tan Chuan-Chou Shen Yanjun Cai Hai Cheng R.Lawrence Edwards | 2018 | Science Bulletin2018，63，4： | 16 |
| 2 | The Homo sapiens Cave hominin site of Mulan Mountain,Jiangzhou District,Chongzuo,Guangxi with emphasis on its age显示文摘One of the most hotly debated and frontal issues in paleoanthropology focuses on the origins of modern humans. Recently, an incomplete hominin mandible with a distinctly weaker mental protuberance than modern human and a great variety of coexisting fossil mammals were unearthed from the Homo sapiens Cave of Mulan Mountain, Chongzuo, Guangxi. The mammalian fauna from the Homo sapiens Cave characterized by the combination of Elephas kiangnanensis, first occurring Elephas maixmus, and Megatapirus augustus, and strikingly different from the Early Pleistocene Gigantopithecus fauna and the Middle Pleistocene Ailuropoda-Stogodon fauna of South China could be regarded as an early representive of the typical Asian elephant fauna. Faunal analysis, biostratigraphic correlation, and, most importantly, U-series dating all consistently support an estimate of ca. 110 ka for the age of the fossil Homo sapiens and coexisting mammalian fauna, that is, the early Late Pleistocene. The fauna is mainly made up of tropical-subtropical elements, but grassland elements have a much greater variety than forest elements, which probably indicates a drier climate at that time. This discovery of early Homo sapiens at the Mulan Mountain will play a significant role in the study of the origin and its environmental background of modern humans. | JIN ChangZhu PAN WenShi ZHANG YingQi CAI YanJun XU QinQi TANG ZhiLu WANG Wei WANG Yuan LIU JinYi QIN DaGong R. Lawrence Edwards CHENG Hai | 2009 | Chinese Science Bulletin2009，54，21： | 13 |
| 3 | Twa1/Gid8 is a β-catenin nuclear retention factor in Wnt signaling and colorectal tumorigenesis显示文摘 | Yi Lu Shanshan Xie Wen Zhang Cheng Zhang Cheng Gao Qiang Sun Yuqi Cai Zhangqi Xu Min Xiao Yanjun Xu Xiao Huang Ximei Wu Wei Liu Fudi Wang Yibin Kang Tianhua Zhou | 2017 | Cell Research2017，27，12： | 9 |
| 4 | Application of Avaatech X-ray fluorescence core-scanning in Sr/Ca analysis of speleothems显示文摘Application of X-ray fluorescence core-scanning(XRF-CS) on both marine and lake sediments has achieved remarkable results. However, its application has not been widely extended to the research on speleothems. In this study, we measure the Sr abundance and the Sr/Ca ratios of three stalagmites(two aragonite stalagmites, one calcite stalagmite) using the state-of-the-art fourth-generation Avaatech high-resolution XRF core scanner. Through comparisons among different scan paths and among different scan resolutions, as well as comparisons with inductively coupled plasma optical emission spectrometer(ICP-OES), Itrax XRF, and Artax XRF results, we confirm that the Avaatech XRF core scanner could precisely, quickly, and nondestructively analyze the high-resolution Sr abundance of speleothems. Furthermore, we combine the stalagmite δ^(18)O records to explore the paleoclimatic significance of the measured stalagmite Sr/Ca. | Dong LI Liangcheng TAN Fei GUO Yanjun CAI Youbin SUN Gang XUE Xing CHENG Hong YAN Hai CHENG R.Lawrence EDWARDS Yongli GAO Jessica KELLEY | 2019 | Science China Earth Sciences2019，62，6： | 7 |
| 5 | Empirical analysis of airport network and critical airports显示文摘Air transport network, or airport network, is a complex network involving numerous airports. Effective management of the air transport system requires an in-depth understanding of the roles of airports in the network. Whereas knowledge on air transport network properties has been improved greatly, methods to find critical airports in the network are still lacking. In this paper, we present methods to investigate network properties and to identify critical airports in the network. A novel network model is proposed with airports as nodes and the correlations between traffic flow of airports as edges. Spectral clustering algorithm is developed to classify airports. Spatial distribution characteristics and intraclass correlation of different categories of airports are carefully analyzed. The analyses based on the fluctuation trend of distance-correlation and power spectrum of time series are performed to examine the self-organized criticality of the network. The results indicate that there is one category of airports which dominates the self-organized critical state of the network. Six airports in this category are found to be the most important ones in the Chinese air transport network. The flights delay occurred in these six airports can propagate to the other airports, having huge impact on the operation characteristics of the entire network. The methods proposed here taking traffic dynamics into account are capable of identifying critical airports in the whole air transport network. | Cong Wei Hu Minghua Dong Bin Wang Yanjun Feng Cheng | 2016 | Chinese Journal of Aeronautics2016，29，2： | 7 |
| 6 | Synthesis of CaCO_3 crystals using hydroxypropylmethyl cellulose hydrogel as template显示文摘Calcium carbonate crystallization was performed in hydrogel of hydroxypropylmethyl cellulose (HPMC). Results showed that the polyhydroxy functionalities in HPMC gel network facilitated the nucleation of aragonite which was not found in experiment without HPMC hydrogel and in experiment using methylcellulose (MC) hydrogel as template. On the other hand, due to the unique assembly of the macromolecules in HPMC hydrogel network, which was different from other hydrogels used in some previous reports, particular crystal morphology, corncob-like CaCO_3, was obtained for the first time. | ZHAO Jin LI YanJun CHENG GuoXiang | 2007 | Chinese Science Bulletin2007，52，13： | 6 |
| 7 | Orbital-scale Asian summer monsoon variations:Paradox and exploration显示文摘The Asian summer monsoon(ASM) is a vast climate system, whose variability is critical to the livelihoods of billions of people across the Asian continent. During the past half-century, much progress has been made in understanding variations on a wide range of timescales, yet several significant issues remain unresolved. Of note are two long-standing problems concerning orbital-scale variations of the ASM.(1) Chinese loess magnetic susceptibility records show a persistent glacial-interglacial dominated ~100 kyr(thousand years) periodicity, while the cave oxygen-isotope(δ18 O) records reveal periodicity in an almost pure precession band(~20 kyr periodicity)—the 'Chinese 100 kyr problem'.(2) ASM records from the Arabian Sea and other oceans surrounding the Asian continent show a significant lag of 8–10 kyr to Northern Hemisphere summer insolation(NHSI), whereas the Asian cave δ18 O records follow NHSI without a significant lag—a discrepancy termed the 'sea-land precession-phase paradox'. How can we reconcile these differences? Recent and more refined model simulations now provide spatial patterns of rainfall and wind across the precession cycle, revealing distinct regional divergences in the ASM domain, which can well explain a large portion of the disparities between the loess, marine, and cave proxy records. Overall, we also find that the loess, marine, and cave records are indeed complementary rather than incompatible, with each record preferentially describing a certain aspect of ASM dynamics. Our study provides new insight into the understanding of different hydroclimatic proxies and largely reconciles the 'Chinese 100 kyr problem' and 'sea-land precession-phase paradox'. | Hai CHENG Haiwei ZHANG Yanjun CAI Zhengguo SHI Liang YI Chenglong DENG Qingzhen HAO Youbing PENG Ashish SINHA Hanying LI Jingyao ZHAO Ye TIAN Jonathan BAKER Carlos PEREZ-MEJIAS | 2021 | Science China Earth Sciences2021，64，4： | 6 |
| 8 | Present Situation of the Anti-Fatigue Processing of High-Strength Steel Internal Thread Based on Cold Extrusion Technology:A Review显示文摘The adoption of cold-extrusion forming for internal thread net forming becomes an important component of anti-fatigue processing with the development of internal thread processing towards high performance, low cost and low energy consumption. It has vast application foreground in the field of aviation, spaceflight, high speed train and etc. The internal thread processing and anti-fatigue manufacture technology are summarized. In terms of the perspective of processing quality and fatigue serving life, the advantages and disadvantages of the processing methods from are compared. The internal thread cold-extrusion processing technology is investigated for the purpose of improving the anti-fatigue serving life of internal thread. The superiorities of the plastic deformation law and surface integrity of the metal layer in the course of cold extrusion for improving its stability and economy are summed up. The proposed research forecasts the development tendency of the internal thread anti-fatigue manufacturing technology. | Hong MIAO Cheng JIANG Sixing LIU Shanwen ZHANG Yanjun ZHANG | 2017 | Chinese Journal of Mechanical Engineering2017，30，2： | 5 |
| 9 | Patient-derived non-small cell lung cancer xenograft mirrors complex tumor heterogeneity显示文摘Objective:Patient-derived xenograft(PDX)models have shown great promise in preclinical and translational applications,but their consistency with primary tumors in phenotypic,genetic,and pharmacodynamic heterogeneity has not been well-studied.This study aimed to establish a PDX repository for non-small cell lung cancer(NSCLC)and to further elucidate whether it could preserve the heterogeneity within and between tumors in patients.Methods:A total of 75 surgically resected NSCLC specimens were implanted into immunodeficient NOD/SCID mice.Based on the successful establishment of the NSCLC PDX model,we compared the expressions of vimentin,Ki67,EGFR,and PD-L1 proteins between cancer tissues and PDX models using hematoxylin and eosin staining and immunohistochemical staining.In addition,we detected whole gene expression profiling between primary tumors and PDX generations.We also performed whole exome sequencing(WES)analysis in 17 first generation xenografts to further assess whether PDXs retained the patient heterogeneities.Finally,paclitaxel,cisplatin,doxorubicin,atezolizumab,afatininb,and AZD4547 were used to evaluate the responses of PDX models to the standard-of-care agents.Results:A large collection of serially transplantable PDX models for NSCLC were successfully developed.The histology and pathological immunohistochemistry of PDX xenografts were consistent with the patients’tumor samples.WES and RNA-seq further confirmed that PDX accurately replicated the molecular heterogeneities of primary tumors.Similar to clinical patients,PDX models responded differentially to the standard-of-care treatment,including chemo-,targeted-and immuno-therapeutics.Conclusions:Our established PDX models of NSCLC faithfully reproduced the molecular,histopathological,and therapeutic characteristics,as well as the corresponding tumor heterogeneities,which provides a clinically relevant platform for drug screening,biomarker discovery,and translational research. | Xuanming Chen Cheng Shen Zhe Wei Rui Zhang Yongsheng Wang Lili Jiang Ke Chen Shuang Qiu Yuanli Zhang Ting Zhang Bin Chen Yanjun Xu Qiyi Feng Jinxing Huang Zhihui Zhong Hongxia Li Guowei Che Kai Xiao | 2021 | Cancer Biology & Medicine2021，18，1： | 5 |
| 10 | Development characteristics of the fault system and its control on basin structure, Bodong Sag, East China显示文摘The Bodong Sag,located in the Bohai Sea,offshore China,is one of the most petroliferous basins in China.Based on three dimensional seismic reflection data and time slice data,we analyze the fault system of the Bodong area in detail,establish the fault structure pattern of different types and summarize the distribution of the fault system.It is concluded that the development characteristics of the Cenozoic fault system are in accordance with the dextral stress field of the Tanlu Fault,which displayed a brush structure with NNE strike-slip faults as its principal faults,NE-trending extensional faults as secondary faults and EW-trending faults as minor faults.Faults can be divided into (1) strike-slip type,(2) extensional type,(3) strike-slip extensional type and (4) extensional strike-slip type.The spatial structures of different faults have obvious differences because of the fault properties and activity intensity.The fault system at different stages shows tremendous differences because of the transition of the Tanlu Fault from sinistral strike-slip to dextral strike-slip,the transition between extension and strike-slip,and the transition from mantle upwelling to thermal subsidence.According to the controlling effect of faults on basin structure,the Cenozoic basin experienced four evolutionary stages,(a) transition stage from sinistral strike-slip to dextral strike-slip,(b) strike-slip extensional faulted stage,(c) extensional strike-slip faulted stage and (d) strike-slip depression stage.The identification of temporal and spatial differences of faults could be used as a significant guideline for oil and gas exploration in the Bodong area. | Wu Zhiping Cheng Yanjun Yan Shiyong Su Wen Wang Xin Xu Changgui Zhou Xinhuai | 2013 | Petroleum Science2013，10，4： | 4 |
| 11 | A high-resolution, absolute-dated Holocene and deglacial Asian monsoon record from Dongge Cave, China显示文摘 | Carolyn A. Dykoski R. Lawrence Edwards Hai Cheng Daoxian Yuan Yanjun Cai Meiliang Zhang Yushi Lin Jiaming Qing Zhisheng An Justin Revenaugh | 2005 | Earth and Planetary Science Letters2005，，1： | 3 |
| 12 | PHYTOCHROME-INTERACTING FACTORS Interact with the ABA Receptors PYL8 and PYL9 to Orchestrate ABA Signaling in Darkness显示文摘PHYTOCHROME-INTERACTING FACTORS(PIFs)are a group of basic helix-loop-helix transcription factors that can physically interact with photoreceptors,including phytochromes and cryptochromes.It was previously demonstrated that PIFs accumulated in darkness and repressed seedling photomorphogenesis,and that PIFs linked different photosensory and hormonal pathways to control plant growth and development.In this study,we show that PIFs positively regulate the ABA signaling pathway during the seedling stage specifically in darkness.We found that PIFs positively regulate ABI5 transcript and protein levels in darkness in response to exogenous ABA treatment by binding directly to the G-box motifs in the ABI5 promoter.Consistently,PIFs and the G-box motifs in the ABI5 promoter determine ABI5 expression in darkness,and overexpression of ABI5 could rescue the ABA-insensitive phenotypes of pifq mutants in the dark.Moreover,we discovered that PIFs can physically interact with the ABA receptors PYL8 and PYL9,and that this interaction is not regulated by ABA.Further analyses showed that PYL8 and PYL9 promote PIF4 protein accumulation in the dark and enhance PIF4 binding to the ABI5 promoter,but negatively regulate PIF4-mediated ABI5 activation.Taken together,our data demonstrate that PIFs interact with ABA receptors to orchestrate ABA signaling in darkness by controlling ABI5 expression,providing new insights into the pivotal roles of PIFs as signal integrators in regulating plant growth and development. | Lijuan Qi Shan Liu Cong Li Jingying Fu Yanjun Jing Jinkui Cheng Hong Li Dun Zhang Xiaoji Wang Xiaojing Dong Run Han Bosheng Li Yu Zhang Zhen Li William Terzaghi Chun-Peng Song Rongcheng Lin Zhizhong Gong Jigang Li | 2020 | Molecular Plant2020，13，3： | 3 |
| 13 | Late Mesozoic rifting and its deep dynamic mechanisms in the central Sulu orogenic belt: Records from Lingshan Island显示文摘The Lingshan Island scientific drill confirms that two episodes(Laiyang period and Qingshan period) of rifting developed in the central Sulu orogenic belt(SOB) in Late Mesozoic. With a set of methods including fieldwork, drilling, core logging, zircon U-Pb dating and whole rock geochemistry applied, the age, the depositional sequence and the deep dynamic mechanisms of rift evolution were unraveled. The stratigraphic sequence of the Laiyang-Qingshan Groups on Lingshan Island was composed of two different rifting sequences:(1) Laiyang Group(147–125 Ma), which consists of deep-water gravity flow deposits with interlayers of intermediate volcanic rocks;and(2) Lower Qingshan Group(125–119 Ma), which unconformably overlies the former sequence and contains subaerial volcanic deposits and terrestrial deposits. The tectonic environment changed during the evolution of these two episodes of rifting: the rift was in a NNW-SSE extensional environment in the Laiyang period and showed the typical passive rifting character that “lithospheric extension and rifting preceded volcanism”. The passive rifting period was ended by a short WNW-ESE compression at about 125 Ma. After that, the tectonic environment transferred to a strong NW-SE extensional environment and the rifting evolved into a volcanic arc basin in the Qingshan period. The igneous rocks are shoshonitic to high-K calc-alkaline trachyandesites to trachytes with a few intercalated lamprophyres and a rhyolite.The geochemical characteristics of the igneous rocks indicate that they are mantle-derived melts with a metasomatized mantle source and/or crustal contamination. In addition, an increased thinning of the lithosphere happened during the rifting episodes.The low-angle subduction of the Paleo-Pacific plate in the Jurassic weakened the thickened SOB lithospheric mantle. The rollback of the subducting plate started in late Jurassic to early Cretaceous, and the SOB lithospheric mantle was delaminated synchronously because of the gravity collapse. Thus, this caused passive rifting in the Laiyang period. Thereafter, the rollback and trench retreat of the high-angle subducting Paleo-Pacific plate would have achieved its climax, resulting in the strong regional extension. Passive rifting was ended by the crustal uplift caused by asthenospheric upwelling beneath the rift. The lower crust was heated by the upwelling asthenosphere and partially melted to form felsic melts, which were emplaced upwards and erupted explosively. The rift evolved into a volcanic arc basin in the Qingshan period and showed some characteristics of active rifting. Above all, a passive rifting in the Laiyang period and a volcanic arc basin in the Qingshan period developed successively in the Lingshan Island area(the central SOB). This records the transfer of the study area from the Paleo-Tethys tectonic domain to the circum-Pacific tectonic domain. The delamination of SOB lithospheric mantle and the upwelling of asthenospheric material were the deep dynamic mechanisms driving the development and evolution of two rift episodes. Additionally, the rift development was controlled remotely by the subduction of the Paleo-Pacific plate. | Tengfei ZHOU Yaoqi ZHOU Nina SФAGER Paul Martin HOLM Zhenkai ZHANG Jun WANG Zhao LIANG Hongyu MU Yanjun CHENG Feifei LIU Miao WANG Yue ZHANG Hui ZHANG Yangjian GU Shihui DONG Hanjie ZHAO Manjie LI Yang CHEN Yanzi LIU | 2022 | Science China Earth Sciences2022，65，9： | 3 |
| 14 | The variation of summer monsoon precipitation in central China since the last deglaciation显示文摘 | Yanjun Cai Liangcheng Tan Hai Cheng Zhisheng An R. Lawrence Edwards Megan J. Kelly Xinggong Kong Xianfeng Wang | 2009 | Earth and Planetary Science Letters2009，，1： | 2 |
| 15 | n-Octadecanethiol Self-Assembled Monolayer Coating with Microscopic Roughness for Dropwise Condensation of Steam显示文摘Here we presented a novel technology to achieve a Super-hydrophobic coating with microscopic roughness oncopper surface. First, make a layer of verdigris grow on the fresh pure copper surface. Gain it by exposing thecopper to air and the mist of acetic acid solution. The green coating is a mixture of basic copper(Ⅱ) carbonate andcopper(Ⅱ) acetate. Second heat the coating and make it decompose to CuO. Lastly, form an n-octadecanethiolself-assembled monolayers coating on the outermost surface. Contact angle test, scanning electron microscopeanalysis and electrochemical testing were carried out to characterize the surface, and a heat transfer experimentfor dropwise condensation of steam was performed also. Results show that the modified surface bears a few Super-hydrophobicfeatures, the static contact angle is higher than that in literatures, reaching 153.1±1.7°. The microscopicroughness can be seen in SEM images, differing much from H2O2 etched surface and bare copper surface.The condensation of steam on the surface is a typical form of dropwise condensation, in the measured rangeof temperature difference, under 0.1 MPa, the average convection heat transfer coefficients of the vertical surfaceare 1.7~2.1 times for those of film condensation. At the same time, the inhibition efficiency of surface is improvedto some extent comparing with the same kind of SAMs, which suggests that the lifetime of maintenancedropwise condensation would have the possibility to surpass the existing record. | Liang CHEN Shiqiang LIANG Runsheng YAN Yanjun CHENG Xiulan HUA Shuling CHEN | 2009 | Journal of Thermal Science2009，18，2： | 2 |
| 16 | Summer monsoon precipitation variations in central China over the past750years derived from a high-resolution absolute-dated stalagmite显示文摘 | Tan Liangcheng Cai Yanjun Cheng Hai | 2009 | Palaeogeography Palaeoclimatology Palaeoecology2009，280，34： | 1 |
| 17 | Core -shell latex containing fluorinated polymer rich in shell 显示文摘 | Cheng Shiyuan Chen Yanjun Chen ZhengGuo | 2002 | Journal of Applied Polymer Science2002，85，： | 1 |
| 18 | A high-resolution,absolute-dated Holocene and deglacial Asian monsoon record from Dongge Cave,China显示文摘 | Dykoski C A Edwards R L Cheng Hai Yuan Daoxian Cai Yanjun Zhang Meiliang Lin Yushi Qing Jiaming An Zhisheng Revenangh J | | 0，，1： | 1 |
| 19 | Immobilized transglucosidase in biomimetic polymer–inorganic hybrid capsules for efficient conversion of maltose to isomaltooligosaccharides显示文摘 | Lei Zhang Yanjun Jiang Zhongyi Jiang Xiaohui Sun Jiafu Shi Wei Cheng Qianyun Sun | 2009 | Biochemical Engineering Journal2009，，2： | 1 |
| 20 | DNA methylation affects photoperiodic tuberization in potato (Solanum tuberosum L.) by mediating the expression of genes related to the photoperiod and GA pathways显示文摘Overcoming short-day-dependent tuberization to adapt to long-day conditions is critical for the widespread geographical success of potato.The genetic pathways of photoperiodic tuberization are similar to those of photoperiodic flowering.DNA methylation plays an important role in photoperiodic flowering.However,little is known about how DNA methylation affects photoperiodic tuberization in potato.Here,we verified the effect of a DNA methylation inhibitor on photoperiodic tuberization and compared the DNA methylation levels and differentially methylated genes(DMGs)in the photoperiodic tuberization process between photoperiod-sensitive and photoperiod-insensitive genotypes,aiming to dissect the role of DNA methylation in the photoperiodic tuberization of potato.We found that a DNA methylation inhibitor could promote tuber initiation in strict short-day genotypes.Whole-genome DNA methylation sequencing showed that the photoperiod-sensitive and photoperiod-insensitive genotypes had distinct DNA methylation modes in which few differentially methylated genes were shared.Transcriptome analysis confirmed that the DNA methylation inhibitor regulated the expression of the key genes involved in the photoperiod and GA pathways to promote tuber initiation in the photoperiod-sensitive genotype.Comparison of the DNA methylation levels and transcriptome levels identified 52 candidate genes regulated by DNA methylation that were predicted to be involved in photoperiodic tuberization.Our findings provide a new perspective for understanding the relationship between photoperiod-dependent and GA-regulated tuberization.Uncovering the epigenomic signatures of these pathways will greatly enhance potato breeding for adaptation to a wide range of environments. | Yanjun Ai Shenglin Jing Zhengnan Cheng Botao Song Conghua Xie Jun Liu Jun Zhou | 2021 | Horticulture Research2021，8，1： | 1 |
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