|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Does laser surface texturing really have a negative impact on the fatigue lifetime of mechanical components?显示文摘Laser surface texturing(LST)has been proven to improve the tribological performance of machine elements.The micro-scale patterns manufactured by LST may act as lubricant reservoirs,thus supplying oil when encountering insufficient lubrication.However,not many studies have investigated the use of LST in the boundary lubrication regime,likely due to concerns of higher contact stresses that can occur with the increasing surface roughness.This study aims to examine the influence of LST on the fatigue lifetime of thrust rolling bearings under boundary lubrication.A series of periodic patterns were produced on the thrust rolling bearings,using two geometrically different designs,namely cross and dimple patterns.Base oil ISO VG 100 mixed with 0.05 wt%P of zinc dialkyldithiophosphate(ZDDP)was supplied.The bearings with cross patterns reduce the wear loss by two orders of magnitude.The patterns not only retain lubricant in the textured pockets but also enhance the formation of an anti-wear tribofilm.The tribofilm generation may be improved by the higher contact stresses that occur when using the textured surface.Therefore,in contrast to the negative concerns,the ball bearings with cross patterns were instead found to increase the fatigue life by a factor of three. | Chia-Jui HSU Andreas STRATMANN Simon MEDINA Georg JACOBS Frank MÜCKLICH Carsten GACHOT | 2021 | Friction2021，9，6： | 3 |
| 2 | Hypoxia and cytokines regulate carbonic anhydrase 9 expression in hepatocellular carcinoma cells in vitro显示文摘AIM: To study the expression of carbonic anhydrase(CA) 9 in human hepatocellular carcinoma(HCC) cells.METHODS: We studied CA9 protein, CA9 m RNA and hypoxia-inducible factor-1 alpha(HIF-1α) protein levels in Hep3 B cells exposed in different parallel approaches. In one of these approaches, HCC cells were exposed to extreme in vitro hypoxia(24 h 0.1% O2) without or with interleukin(IL)-1, IL-6, tumor necrosis factoralpha(TNF-α) and transforming growth factor-beta(TGF-β) stimulation for the same hypoxic exposure time or exposed to normoxic oxygenation conditions without or with cytokine stimulation.RESULTS: The tumour cell line analysed showed a strong hypoxic CA9 m RNA expression pattern in response to prolonged severe hypoxia with cell-line specific patterns and a marked induction of CA9 protein in response to severe hypoxia. These results were paralleled by the results for HIF-1α protein under identical oxygenation conditions with a similar expression tendency to that displayed during the CA9 protein expression experimental series. Continuous stimulation with the cytokines, IL-1, IL-6, TNF-α and TGF-β, under normoxic conditions significantly increased the carbonic anhydrase 9 expression level at both the protein and m RNA level, almost doubling the CA9 m RNA and CA9 and HIF-1α protein expression levels found under hypoxia. The findings from these experiments indicated that hypoxia is a positive regulator of CA9 expression in HCC, and the four signal transduction pathways, IL-1, IL-6, TNF-α and TGF-β, positively influence CA9 expression under both normoxic and hypoxic conditions.CONCLUSION: These findings may potentially be considered in the design of anti- cancer therapeutic approaches involving hypoxia-induced or cytokine stimulatory effects on expression. In addition, they provideevidence of the stimulatory role of the examined cytokine families resulting in an increase in CA9 expression under different oxygenation conditions in human cancer, especially HCC, and on the role of the CA9 gene as a positive disease regulator in human cancer. | Feray Kockar Hatice Yildrim Rahsan Ilikci Sagkan Carsten Hagemann Yasemin Soysal Jelena Anacker Ahmed Ayad Hamza Dirk Vordermark Michael Flentje Harun M Said | 2012 | World Journal of Clinical Oncology2012，3，6： | 2 |
| 3 | Methyle- netetrahydrofolate reductase ( MTHFR ) C677T polymorphism is associated with osteoporotic vertebral frac- tures, but is a weak predictor of BMD 显示文摘 | Villadsen MM Bringer MH Carstens M | 2005 | Osteoporos Int2005，16，4： | 1 |
| 4 | Identification of a domain of the baculov- irus Autographa californica multiple nucleopolyhedrovirus single strand DNA-binding protein LEF-3 essential for viral DNA replication 显示文摘 | Yu M Carstens E B | 2010 | J Virol2010，84，： | 1 |
| 5 | Mapping QTL confer- ring resistance in maize to gray leaf spot disease caused by Cerco- spora zeina显示文摘 | Berger D K Carstens M Korsman J N | 2014 | BMC Genet2014，15，： | 1 |
| 6 | Generation of activated and antigen-specific T cells with cytotoxic activity after co-culture with dendritic cells显示文摘 | Angela M Tim G Carsten Z | 2002 | Cancer immunol immunother2002，51，： | 1 |
| 7 | FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex显示文摘 | Marta Muzio Arul M Chinnaiyan Frank C Kischkel Karen O’Rourke Andrej Shevchenko Jian Ni Carsten Scaffidi James D Bretz Mei Zhang Reiner Gentz Matthias Mann Peter H Krammer Marcus E Peter Vishva M Dixit | 1996 | Cell1996，，： | 1 |
| 8 | Resveratrol reduces radiation-induced chromosome aberration frequencies in mouse bone marrow cells显示文摘 | CARSTEN R E BACHAND A M BAILEY S M | 2008 | Radiat Res2008，169，6： | 1 |
| 9 | Nb/Ta, Zr/Hf and REE in the depleted mantle: implications for the differentiation history of the crust–mantle system显示文摘 | Stefan Weyer Carsten Münker Klaus Mezger | 2002 | Earth and Planetary Science Letters2002，，3： | 1 |
| 10 | Unstable diaphyseal fractures of both bones of the forearm in children:plate fixation versus intramedullary nailing显示文摘 | Fernandez FF Egenolf M Carsten C | | 0，，10： | 1 |
| 11 | Ratification vote on taxonomic proposals to the International Committee on Taxonomy of Viruses(2012)显示文摘 | ADAMS M J CARSTENS E B | 2012 | Arch Virol2012，157，： | 1 |
| 12 | Generation of activated and antigen-specific T cells with cytotoxic activity after co-culture with dendritic cells显示文摘 | Angela M?rten Tim Greten Carsten Ziske Sabine Renoth Bj?rn Sch?ttker Peter Buttgereit Frank Schakowski Alexander von Rücker Tilman Sauerbruch Ingo G. Schmidt-Wolf | 2002 | Cancer ImmunologyImmunotherapy2002，，1： | 1 |
| 13 | Spontaneous itch in the ab- sence of hyperalgesia in a mouse hindpaw dry skin model 显示文摘 | Akiyarna T Carstens M I Carstens E | 2010 | Neurosci Lett2010，484，1： | 1 |
| 14 | Optimal Lymph Node Harvest in Rectal Cancer (UICC Stages II and III) after Preoperative 5-FU–based Radiochemotherapy. Acetone Compression is a New and Highly Efficient Method显示文摘 | Anastasia Gehoff Oliver Basten Thilo Sprenger Lena-Christin Conradi Carsten Bismarck Dirk Bandorski Sabine Merkelbach-Bruse Regine Schneider-Stock Robert Stoehr Ralph M. Wirtz Julia Kitz Annegret Müller Arndt Hartmann Heinz Becker B. Michael Ghadimi Torst | 2012 | The American Journal of Surgical Pathology2012，，2： | 1 |
| 15 | Polymorphisms in the transforming growth factor beta 1 gene and osteoporosis显示文摘 | Langdahl BL Carstens M Stenkjaer L | 2003 | Bone2003，32，3： | 1 |
| 16 | Polymorphisms in the Osteoprotegerin gene are associated with osteoporotic fractures显示文摘 | Langahl BL Carstens M Stenkjaer L | 2002 | J Bone Miner Res2002，17，7： | 1 |
| 17 | The relevance of the sagittal pro- file in cervical artificial discs显示文摘 | Carstens C Carstens M Copf F | 2011 | Orthopade2011，40，8： | 1 |
| 18 | Apolipoprotein E Induces Antiinflammatory Phenotype in Macrophages显示文摘 | Daniel Baitsch Hans H. Bock Thomas Engel Ralph Telgmann Carsten Müller-Tidow Georg Varga Martine Bot Joachim Herz Horst Robenek Arnold von Eckardstein Jerzy-Roch Nofer | 2011 | Arteriosclerosis, Thrombosis, and Vascular Biology2011，，5： | 1 |
| 19 | Enzymatic hydrolysis of Ovomucin and effect on foaming properties显示文摘 | HAMMERSHOJ M NEBELA C CARSTENS J | 2008 | Food Research International2008，41，5： | 1 |
| 20 | Multi-objective output-feedback control via LMI optimization显示文摘 | Carsten W S Gahinet P Chilali M | 1997 | IEEE Trans on Autom Contr1997，42，7： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员