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| 1 | Function and regulation of self-reactive marginal zone B cells in autoimmune arthritis显示文摘Polyreactive 天生类型的 B 房间说明在圆周表示自我反应的许多 B 房间。这些 B 房间的不适当的规定可以是位于自体免疫的疾病下面的一个重要因素。这里,我们在导致骨胶原的关节炎(中央情报局) 的开发探索了自我反应的天生的 B 房间的影响,风湿性关节炎的一个鼠标模型。我们显示出那个脾的边缘的地区(MZ ) ,然而并非 B-1 B 房间在 naı 展出自发的 IgM 反应到自体同源的骨胶原 II; ¨ ve 老鼠。在有在完全的 Freund’ 的 heterologous 骨胶原 II 的免疫之上;骨胶原反应的 MZ B 房间很快扩展了的 s 助手,当 B-1 B 房间显示出谦虚反骨胶原回答时。MZ B 房间被像使用费的受体(TLR ) 容易激活 4 并且在 vitro,导致的增长和 cytokine 分泌物的 9-ligands,暗示 B 房间受体和 TLR 的那个双约会可以把有免疫力的反应提升到自我抗原。而且,告知骨胶原的 MZ B 房间显示出在 vivo 在 IgG 反骨胶原抗体的 vitro 和正式就职由血缘的 T 房间增长思考了的重要介绍抗原的能力。在 1 和 2 表明了的补充受体是缺乏的 MZ B 房间增加了增长和 cytokine 生产,当时 Fcγ房间的受体 IIb 缺乏导致增加的 cytokine 生产和抗原表示。在结论,我们的数据在中央情报局作为自体免疫的反应的开始者加亮自我反应的 MZ B 房间,在补充和 Fc 受体在在房间控制自我反应是相关的的地方。 | Anna-Karin E Palm Heike C Friedrich Anja Mezger Maya Salomonsson Linda K Myers Sandra Kleinau | 2015 | Cellular & Molecular Immunology2015，12，4： | 3 |
| 2 | Final safety results of BO17704(A-VAiL):a phase III randomized study of first-line bevacizumab(BV)and cisplatin/gemcitabine(CG)in patients(pts)with ad-vanced or recurrent nonsquamous non-small cell lung cancer(NSCLC)显示文摘 | Hirsh V Ramlau R von Pawel J Zatloukal P Vera G Leighl N Mezger J Archer V Reck M | 2009 | J Clin Oncol2009，，： | 1 |
| 3 | Rapid accretion and early core formation on asteroid and the terrestrial planets from Hf-W chronometry显示文摘 | Kleine T Manker C Mezger K | 2002 | Nature2002，418，： | 1 |
| 4 | Hierarchical techniques in collision detection for cloth animation 显示文摘 | Mezger J Kimmerle S Etzmu O | 2003 | Journal of WSCG2003，11，1： | 1 |
| 5 | Safety of bevacizumab-based therapy as first-line treatment of patients with advanced or recurrent non-squamous non-small cell lung cancer (NSCLC): M019390 (SAIL)显示文摘 | Dansin E Mezger J Isla D | 2008 | J Clin Oncol2008，26，： | 1 |
| 6 | Titanium nitride coating sin clinical dentistry显示文摘 | Mezger PR Creugers NH | 1992 | J Dent1992，20，6： | 1 |
| 7 | Constraints on the U-Pb systematics of metamorphic rutile from in situ LA-ICP-MS analysis 显示文摘 | KOOIJMAN E MEZGER K BERNDT J | 2010 | Earth and Planetary Science Letters2010，293，34： | 1 |
| 8 | Elevated serum CA 125 levels in patients with benign ascitic or pleural effusions显示文摘 | Mezger J Wilmanns W Lamerz R | 1988 | Tuner Biol1988，9，1： | 1 |
| 9 | Information processing in severe disorders of consciousness: Vegetative state and minimally conscious state 显示文摘 | Kotchoubey B Lang S Mezger G | 2005 | Clinical Neurophysiology2005，116，： | 1 |
| 10 | Nb/Ta, Zr/Hf and REE in the depleted mantle: implications for the differentiation history of the crust–mantle system显示文摘 | Stefan Weyer Carsten Münker Klaus Mezger | 2002 | Earth and Planetary Science Letters2002，，3： | 1 |
| 11 | Rapid accretion and early core formation on asteroids and the terrestrial planets from Hf-W chronometry 显示文摘 | Kleine T Munker C Mezger K Palme H | 2002 | Nature2002，418，6901： | 1 |
| 12 | TLR5 stop codon poly- morphism is associated with invasive aspergillosis after alloge- neic stem cell transplantation显示文摘 | Grube M Loeffler J Mezger M | 2013 | Med Mycol2013，51，8： | 1 |
| 13 | Efficacy and safety of bevaci zumab-based therapy in elderly patients with advanced or recurrent nonsquamous non-small cell lung cancer in the phase Ⅲ BO17704 study (AVAiL)显示文摘 | Leighl NB Zatloukal P Mezger J | 2010 | J Thorac Oncol2010，5，12： | 1 |
| 14 | Petrology and geochemistry of syn- to post-collisional met aluminous A-type granite-A major and trace element and Nd-Sr-Pb-O isotope study from the Proterozoic Damara Belt, Namibia 显示文摘 | JUNG S MEZGER K HOERNES S | 1998 | Lithos1998，45，： | 1 |
| 15 | Recent develop- ments in dating ancient crustal fluid flow显示文摘 | Halliday A N Ohr M Mezger K | 1991 | Reviews of Ge- ophysics1991，29，： | 1 |
| 16 | Rapid Accretion and Early Core Formation on Asteroids and the Terrestrial Planets From Hf-W Chronometry 显示文摘 | Kleine T Mtinker C Mezger K | 2002 | Nature2002，418，： | 1 |
| 17 | ^182Hf-^182W Isotope Systematics of Chondrites, Eucrites, and Martian Meteorites: Chronology of Core Formation and Early Mantle Differentiation in Vesta and Mars显示文摘 | Kleine T Mezger K Munker C | 2004 | GeochimCosmochim Acta2004，68，13： | 1 |
| 18 | Cadmium stable isotope cosmochemistry显示文摘 | Wombacher F Rehkfimper M Mezger K Bischoff A Mfinker C | 2008 | Geochim Cosmochim Acta2008，72，2： | 1 |
| 19 | Hf-W chronometry of lunar metals and the age and early differentiation of the Moon 显示文摘 | Kleine T Palme H Mezger M Halliday A N | 2005 | Science2005，310，5754： | 1 |
| 20 | Evolution of the Continental Crust in the Proterozoic Eastern Ghats Belt,India and New Constraints for Rodinia Reconstruction:Implications from Sm-Nd,Rb-Sr,Pb-Pb Isotopes显示文摘 | Rickers K Mezger K Raith M M | 2001 | Precambrian Research2001，112，： | 1 |
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