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| 1 | Physiological functions and clinical implications of fibrinogen-like 2:A review显示文摘Fibrinogen-like 2(FGL2) encompasses a transmembrane(m FGL2) and a soluble(s FGL2) form with differential tertiary structure and biological activities. Typically, m FGL2 functions as prothrombinase that is capable of initiating coagulation in tissue without activation of the blood clotting cascade, whereas s FGL2 largely acts as an immunosuppressor that can repress proliferation of alloreactive T lymphocytes and maturation of bone marrow dendritic cells. Protein sequences of FGL2 exhibit evolutionary conservation across wide variety of species, especially at the carboxyl terminus that contains fibrinogen related domain(FRED). The FRED of FGL2 confers specificity and complexity in the action of FGL2, including receptor recognition, calcium affiliation, and substrate binding. Constitutive expression of FGL2 during embryogenesis and in mature tissues suggests FGL2 might be physiologically important. However, excessive induction of FGL2 under certain medical conditions(e.g. pathogen invasion) could trigger complement activation, inflammatory response,cellular apoptosis, and immune dysfunctions. On the other hand, complete absence of FGL2 is also detrimental as lack of FGL2 can cause autoimmune glomerulonephritis and acute cellular rejection of xenografts. All these roles involve m FGL2, s FGL2, or their combination. Although it is not clear how m FGL2 is cleaved off its host cells and secreted into the blood, circulating s FGL2 has been found correlated with disease severity and viral loading among patients with human hepatitis B virus or hepatitis C virus infection. Further studies are warranted to understand how FGL2 expression is regulated under physiological and pathological conditions. Even more interesting is to determine whether m FGL2 can fulfill an immunoregulatory role through its FRED at carboxyl end of the molecule and, and vice versa, whether s FGL2 is procoagulant upon binding to a target cell. Knowledge in this area should shed light on development of s FGL2 as an alternative immunosuppressive agent for organ transplantation or as a biomarker for predicting disease progression, monitoring therapeutic effects, and targeting FGL2 for repression in ameliorating fulminant viral hepatitis. | Genyan Yang W Craig Hooper | 2013 | World Journal of Clinical Infectious Diseases2013，3，3： | 2 |
| 2 | Mutations in the genes regulating methylene tetra- hydrofolate reductase ( MTHR C -T677 ) and cystathione ( 3-synthase ( CBS G-A919, CBS T-C833 ) are not associated with myocardial infarction in African Americans 显示文摘 | ANNE DILLERY W CRAIG HOOPER MUHYDINE EI- JAMIL | 2001 | Thrum Res2001，103，： | 1 |
| 3 | Expression of chemokine by human coronary-artery and umbilical-vein endothelial cells and its regulation by inflammatory cytokines显示文摘 | Michael A. Briones Donald J. Phillips Mary A. Renshaw W. Craig Hooper | 2001 | Coronary Artery Disease2001，，3： | 1 |
| 4 | Compas- sion satisfaction, burnout and compassion fatigue among emergency nurses compared with nurse in other selected inpatient specialties 显示文摘 | Hooper C Craig J Janvrin D R | 2010 | J Emerg Nurs2010，36，5： | 1 |
| 5 | Compassion satisfaction,burnout, and compassion fatigue among emergency nurses compared with nurses in other selected inpatient specialties 显示文摘 | Hooper C Craig J Janvrin D | 2010 | J Emerg Nuts2010，36，5： | 1 |
| 6 | Compassion satisfaction,burnout and compassion fatigue among emergency nurses compared with nurse in other selected inpatient specialties显示文摘 | Hooper C Craig J Janvrin D R | 2010 | J Emerg Nurs2010，36，5： | 1 |
| 7 | Immunization with a plant-produced colorectal cancer antigen显示文摘 | Thorsten Verch D. Craig Hooper Anatoly Kiyatkin Zenon Steplewski Hilary Koprowski | 2004 | Cancer Immunology Immunotherapy2004，，2： | 1 |
| 8 | Compassion Satisfaction, Burnout, and Compassion Fatigue Among Emergency Nurses Compared With Nurses in Other Selected Inpatient Specialties显示文摘 | Crystal Hooper Janet Craig David R. Janvrin Margaret A. Wetsel Elaine Reimels | 2010 | Journal of Emergency Nursing2010，，5： | 1 |
| 9 | Compassion satisfaction, burnout andcompassion fatigue among emergency nurses com- pared with nurse in otherselected inpatient specialties 显示文摘 | Hooper C Craig J Janvrin D R | 2010 | J Emerg Nurs2010，36，5： | 1 |
| 10 | Compassion satisfac- tion, burnout, and compassion fatigue among emergency nur- ses compared with nurses in other selected inpatient specialties 显示文摘 | Hooper C Craig J Janvrin D R | 2010 | J Emerg Nuts2010，36，5： | 1 |
| 11 | Magnetic resonance angiography‐defined intracranial vasculopathy is associated with silent cerebral infarcts and glucose‐6‐phosphate dehydrogenase mutation in children with sickle cell anaemia显示文摘 | Mathula Thangarajh Genyan Yang Dana Fuchs Maria R. Ponisio Robert C. McKinstry Alok Jaju Michael J. Noetzel James F. Casella Emily Barron‐Casella W. Craig Hooper Sheree L. Boulet Christopher J. Bean Meredith E. Pyle Amanda B. Payne Jennifer Driggers Heidi | 2012 | Br J Haematol2012，，3： | 1 |
| 12 | Compassion satisfaction, burnout, and compassion fatigue among emergency nurses compared with nurses in other selected inpatient specialties 显示文摘 | Hooper C Craig J Janvrin DR | 2010 | J Emerg Nurs2010，36，5： | 1 |
| 13 | Vitamin D Status Is Associated With Arterial Stiffness and Vascular Dysfunction in Healthy Humans显示文摘 | Ibhar Al Mheid Riyaz Patel Jonathan Murrow Alanna Morris Ayaz Rahman Lucy Fike Nino Kavtaradze Irina Uphoff Craig Hooper Vin Tangpricha R. Wayne Alexander Kenneth Brigham Arshed A. Quyyumi | 2011 | Journal of the American College of Cardiology2011，，2： | 1 |
| 14 | Mutations in the genes regulating methylene tetrahydrofolate reductase (MTHR C-T677) and cystathione (3-synthase (CBS G-A919,CBS T-C833) are not associated with myocardial infarction in African Americans显示文摘 | ANNE DILLERY W CRAIG HOOPER MUHYDINE EI-JAMIL | 2001 | Thrum Res2001，103，： | 1 |
| 15 | Compassion satisfaction, burnout ,and compassion fatigue among emergency nurses com- pared with nurses in other selected inpatient specialties 显示文摘 | Hooper C Craig J Janvrin DR | 2010 | Journal of emergency nursing2010，36，5： | 1 |
| 16 | Compassion satisfac- tion, burnout, and compassion fatigue among emergency nurses compared with nurses in other selected inpatient specialties显示文摘 | Hooper C Craig J Janvrin D R | 2010 | J Emerg Nurs2010，36，5： | 1 |
| 17 | Compassion satisfaction, burnout, and compassion fatigue among emergency nurses compared with nurses in other selected inpatient specialties显示文摘 | Hooper C Craig J Janvrin DR | 2010 | J Emerg Nurs2010，36，5： | 1 |
| 18 | Compassion satisfaction, hum out, and compassion tigue among emergency nurses compared with nurses in other selected inpatient specialties 显示文摘 | Hooper C Craig J Janvrin DR | 2010 | J Emerg Nurs2010，36，5： | 1 |
| 19 | Compassion satisfaction,burnout,and compassion fatigue among emergency nurses compared with nurses in other selected inpatient specialties显示文摘 | HOOPER C CRAIG J JANVRIN D R | 2010 | J Emerg Nurs2010，36，5： | 1 |
| 20 | Compassion satisfaction,burnout and compassion fatigue among emergency nurses com-pared with nurse in other selected inpatient specialties 显示文摘 | Hooper C Craig J Janvrin DR | 2010 | JEmerg Nurs2010，36，5： | 1 |
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