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| 1 | Combined carriership of TLR9 -1237C and CD14 -260T alleles enhances the risk of developing chronic relapsing pouchitis显示文摘AIM: To investigate the single nucleotide polymorphisms (SNPs) in genes involved in bacterial recognition and the susceptibility to pouchitis or pouchitis severity.METHODS: Analyses of CD14 -260C>T, CARD15/NOD2 3020insC, Toll-like receptor (TLR)4 +896A>G,TLR9 -1237T>C, TLR9+ 2848G>A, and IRAKM +22148G>A SNPs were performed in 157 ileal-pouch anal anastomosis (IPAA) patients (79 patients who did not develop pouchitis, 43 infrequent pouchitis patients,35 chronic relapsing pouchitis patients) and 224 Italian Caucasian healthy controls.RESULTS: No significant differences were found in SNP frequencies between controls and IPAA patients.However, a significant difference in carriership frequency of the TLR9-1237C allele was found between the infrequent pouchitis and chronic relapsing pouchitis groups [P = 0.028, odd's ratio (OR) = 3.2, 95%CI = 1.2-8.6].This allele uniquely represented a 4-locus TLR9 haplotype comprising both studied TLR9 SNPs in Caucasians.Carrier trait analysis revealed an enhanced combined carriership of the alleles TLR9 -1237C and CD14 -260T in the chronic relapsing pouchitis and infrequent pouchitis group (P = 0.018, OR = 4.1, 95%CI = 1.4 -12.3).CONCLUSION: There is no evidence that the SNPs predispose to the need for IPAA surgery. The significant increase of the combined carriership of the CD14 -260T and TLR9 -1237C alleles in the chronic relapsing pouchitis group suggests that these markers identify a subgroup of IPAA patients with a risk of developing chronic or refractory pouchitis. | KM Lammers S Ouburg SA Morré JBA Crusius P Gionchetti F Rizzello C Morselli E Caramelli R Conte G Poggioli M Campieri AS Pea | 2005 | World Journal of Gastroenterology2005，11，46： | 7 |
| 2 | The impact of patient age and aortic size on the results of aortobifemoral bypass grafting 1 1 Competition of interest: none. Published online Mar 6, 2003显示文摘 | Amy B Reed Michael S Conte Magruder C Donaldson John A Mannick Anthony D Whittemore Michael Belkin | 2003 | Journal of Vascular Surgery2003，，： | 2 |
| 3 | Thirty years of graph matching in pattern recognition 显示文摘 | CONTE D FOGGIA P SANSONE C | 2004 | International Journal of Pattern Recognition and Artificial Intelligence2004，18，3： | 2 |
| 4 | Immunotherapy of metas tatic kidney cancer显示文摘 | De Vinci C Lo Conte G | 2001 | Int J Cancer2001，94，1： | 1 |
| 5 | Revealing the world of RNA interference 显示文摘 | Mello C C Conte D | 2004 | Nature2004，431，7006： | 1 |
| 6 | Circulating ghrelin levels in celiac patients 显示文摘 | Peracchi M Conte D Terrani C | 2003 | Am J Gastroenterol2003，98，11： | 1 |
| 7 | Planned gait termina- tion in cerebellar ataxias 显示文摘 | Conte C Serrao M Casali C | 2012 | Cerebellum2012，11，4： | 1 |
| 8 | Thirty years ofgraph matching in pattern recognition显示文摘 | CONTE D F()GGIA P SANSONE C | 2004 | International Jour-nal of Pattern Recognition and Artificial Intelligence2004，18，3： | 1 |
| 9 | Identification of novel RP2 mutations in a subset of X-linked retilfitis pigmentosa families and prediction of new domains 显示文摘 | Miano MG Testa F Filippini F Trujifio M Conte I Lanzara C | 2001 | Hum Murat2001，18，2： | 1 |
| 10 | The Effect of Individual Perceptions of Deadlines on Team Performance显示文摘 | WALI ER M J CONTE J M GIBSON C B | 2001 | The Academy of Management Review2001，26，4： | 1 |
| 11 | Statistical analysis of real clutter at different range resolutions 显示文摘 | Conte E De Maio A Galdi C | 2004 | IEEE Transactions on Aerospace and Electronic Systems2004，40，3： | 1 |
| 12 | ARHGEF3 controls HDACi-induced differentiation via Rho A-dependent pathw ays in acute myeloid leukemias显示文摘 | D'Amato L Dell'Aversana C Conte M | 2015 | Epigenetics2015，10，1： | 1 |
| 13 | Frequent sequence variation in the human myostatin(GDFS) gene as a marker for analysis of muscle-related phenotypes 显示文摘 | Ferrell R E conte V Lawrence E C | 1999 | Genomic1999，62，2： | 1 |
| 14 | Gastric bypass and banding equally improve insulin sensitivity and β cell function显示文摘 | Bradley D Conte C Mittendorfer B | 2012 | J Clin Invest2012，122，12： | 1 |
| 15 | FGF2 translationally induced by hypoxia is involved in negative and positive feedback loops with HIF-lalpha显示文摘 | Conte C Riant E Toutain C | 2008 | PLoS One2008，3，8： | 1 |
| 16 | The tyrosine phosphatase Shp2 interacts with NPM-ALK and regulates anaplastic lymphoma cell growth and migration显示文摘 | Voena C Conte C Ambrogio C | | 0，，09： | 1 |
| 17 | Lactoferrin inhibits herpes simplex virus type 1 adsorption to Vero cells显示文摘 | Marchetti M C Longhi M P Conte | 1996 | Antiviral Res1996，29，： | 1 |
| 18 | Influence of lactoferrin on the entry process of Escherichia coli I-IB 101 (pRI203) in HeLa cells显示文摘 | LONGHI C CONTE M P SEGANTI L | 1993 | Med Microbiol Immunol1993，182，1： | 1 |
| 19 | Un-derstanding the different functions of vitamin D显示文摘 | PASQUALI M MANDANICI G CONTE C | 2009 | GItal Nefrol2009，26，46： | 1 |
| 20 | Revealing the world of RNA interference 显示文摘 | Mello C C Conte D J | 2004 | Nature2004，431，7006： | 1 |
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