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| 1 | Combined carriership of TLR9 -1237C and CD14 -260T alleles enhances the risk of developing chronic relapsing pouchitis显示文摘AIM: To investigate the single nucleotide polymorphisms (SNPs) in genes involved in bacterial recognition and the susceptibility to pouchitis or pouchitis severity.METHODS: Analyses of CD14 -260C>T, CARD15/NOD2 3020insC, Toll-like receptor (TLR)4 +896A>G,TLR9 -1237T>C, TLR9+ 2848G>A, and IRAKM +22148G>A SNPs were performed in 157 ileal-pouch anal anastomosis (IPAA) patients (79 patients who did not develop pouchitis, 43 infrequent pouchitis patients,35 chronic relapsing pouchitis patients) and 224 Italian Caucasian healthy controls.RESULTS: No significant differences were found in SNP frequencies between controls and IPAA patients.However, a significant difference in carriership frequency of the TLR9-1237C allele was found between the infrequent pouchitis and chronic relapsing pouchitis groups [P = 0.028, odd's ratio (OR) = 3.2, 95%CI = 1.2-8.6].This allele uniquely represented a 4-locus TLR9 haplotype comprising both studied TLR9 SNPs in Caucasians.Carrier trait analysis revealed an enhanced combined carriership of the alleles TLR9 -1237C and CD14 -260T in the chronic relapsing pouchitis and infrequent pouchitis group (P = 0.018, OR = 4.1, 95%CI = 1.4 -12.3).CONCLUSION: There is no evidence that the SNPs predispose to the need for IPAA surgery. The significant increase of the combined carriership of the CD14 -260T and TLR9 -1237C alleles in the chronic relapsing pouchitis group suggests that these markers identify a subgroup of IPAA patients with a risk of developing chronic or refractory pouchitis. | KM Lammers S Ouburg SA Morré JBA Crusius P Gionchetti F Rizzello C Morselli E Caramelli R Conte G Poggioli M Campieri AS Pea | 2005 | World Journal of Gastroenterology2005，11，46： | 7 |
| 2 | Nitric-oxide synthase activity in molluscan hemocytes显示文摘 | CONTE A OTTAVIANI E | 1995 | FEBS Lett1995，365，23： | 1 |
| 3 | Statistical analysis of real clutter at different range resolutions 显示文摘 | Conte E De Maio A Galdi C | 2004 | IEEE Transactions on Aerospace and Electronic Systems2004，40，3： | 1 |
| 4 | Differential gene expression induced by insulin and IGF-Ⅱ through the insulin receptor isoform A显示文摘 | Pandini G Medico E Conte E | 2003 | J Biol Chem2003，278，42： | 1 |
| 5 | Survivin expression in chronic myeloid leukemia显示文摘 | CONTE E STAGNO F GUGLIELMO P | 2005 | Cancer Lett2005，225，1： | 1 |
| 6 | GLRT-Based Adaptive Detection Algorithms for Range-Spread Targets显示文摘 | Conte E De Maio A Ricci G | 2001 | IEEE Trans on Signal Processing2001，49，7： | 1 |
| 7 | GLRT-based adaptive detection algorithms for range-spread targets 显示文摘 | CONTE E DE MAIO A RICCI G | 2001 | IEEE Trans on Signal Processing2001，49，7： | 1 |
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| 10 | GLRT-based adaptive detection algorithms for range-spread targets显示文摘 | Conte E De Maio A and Ricei G | 2001 | IEEE Transactions on Signal Processing2001，49，7： | 1 |
| 11 | CFAR detection of distributed target in non-Gaussian disturbance显示文摘 | Conte E De Maio A and Ricci G | 2002 | IEEE Transactions on Aerospace and Electronic Systems2002，38，2： | 1 |
| 12 | Polarization'diversity detection in compound Gaussian clutter 显示文摘 | De Maio A Alfano G Conte E | 2004 | IEEE Transactions on Aerospace and Electronic Systems2004，40，1： | 1 |
| 13 | Distributed target detection in compound-Gaussian noise with Rao and Wald tests 显示文摘 | CONTE E DE MAIO A | 2003 | IEEE Transactions on Aerospace and Electronic Systems2003，39，2： | 1 |
| 14 | FGF2 translationally induced by hypoxia is involved in negative and positive feedback loops with HIF-lalpha显示文摘 | Conte C Riant E Toutain C | 2008 | PLoS One2008，3，8： | 1 |
| 15 | Stability analysis of slopes in soils with strain-softening behavior显示文摘 | Conte E Silvestri F Troncone A | 2010 | Computers and Geotechnics2010，37，5： | 1 |
| 16 | Comparison between accelerated solvent extraction and traditional extraction methods for the analysis of the herbicide diflufenican in soil显示文摘 | Conte E Milani R Morali G | 1997 | J Chromatogr A1997，765，1： | 1 |
| 17 | Suppression of survivin induced by a BCR-ABL/JAK2/STAT3 pathway sensitizes imatinib-resistant CML cells to different cytotoxic drugs显示文摘 | Stella S Tirro E Conte E | 2013 | Mol Cancer Ther2013，12，6： | 1 |
| 18 | Intrapulmonary pharmacokinetics of linezolid 显示文摘 | Conte J E Jr Golden J A Kipps J | 2002 | Antimicrob Agents Chemother2002，46，5： | 1 |
| 19 | Polarizahon diversity detection of distributed targets in compound- Gaussian clutter 显示文摘 | ALFANO G DE MAIO A CONTE E | 2004 | IEEE Transactions on Aerospace and Electronic Systems2004，40，2： | 1 |
| 20 | Childhood pustular psoriasis elicited by the streptococcal antigen:a case report and review of the literature显示文摘 | Cassandra M Conte E Cortez B | 2003 | Pediatr Dermatol2003，20，6： | 1 |
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