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| 1 | Late-Quaternary strong earthquakes on the seismogenic fault of the 1976 M_s7.8 Tangshan earthquake,Hebei,as revealed by drilling and trenching显示文摘Composite borehole profiling combined with trenching is an effective way to acquire evidence of past ruptures of buried active faults.In this study,three composite borehole profiles and a large-scale trench excavation were carried out across the surface rupture zone of the 1976 Ms 7.8 Tangshan earthquake.The following three major conclusions have been reached.(1) The surface rupture zone of the 1976 earthquake extends more than 47 km long to the south of Tangshan city,passing to the west of Sunjialou,to Daodi town in Fengnan County,to Xihe in Fengnan County.(2) The surface rupture zone is divided into south and north branches.The north branch has mainly right-lateral strike-slip motion,and the vertical displacement of the surface is up on the west and down on the east.On the other hand,the vertical displacement of the south branch is up on the east and down on the west,accompanied by some right-lateral slip.Such a faulting style cannot be explained by the movement of a single normal or reverse fault,but is consistent with the vertical displacement field induced by the right-lateral strike-slip of the fault belt.The drilling and trenching data from this study verify that such activity continued through the Late Quaternary on the Tangshan Fault.(3) The fault planes exhumed by trenching and the dislocations of strata revealed by the boreholes indicate that multiple faulting events occurred on the Tangshan Fault in the Late Quaternary.The timing of three ruptures prior to the 1976 earthquake was 7.61-8.13,>14.57,and 24.21-26.57 ka BP.Counting the earthquake of 1976,the recurrence interval of the four strong events is about 6.7 to 10.8 ka.On one of the three borehole profiles,the Niumaku profile,nine faulting events were detected since 75.18 ka BP with an average interval of 8.4 ka.In addition,this paper also discusses the difference between the Late Quaternary sedimentary environments to the north and south of Tangshan city based on stratum dating. | GUO Hui JIANG WaLi XIE XinSheng | 2011 | Science China Earth Sciences2011，54，11： | 13 |
| 2 | Abnormal Phenomena Recorded by Several Earthquake Precursor Observation Instruments Before the M_s 8.0 Wenchuan,Sichuan Earthquake显示文摘<正>The paper introduces the anomalies observed by digital tiltmeter,cross-fault deformation meter,4-component borehole strainmeter and geothermometer before May 12,2008,M_s8.0 Wenchuan earthquake,Sichuan.The digital tiltmeter installed in the epicentral region in Shifang County recorded the tilt anomalies 15 days before the earthquake with variation amplitude of 3.7 times larger than the annual deviation of 2007.The cross-fault deformation meter installed at Zimakua station on the Xianshuihe-Anninghe fault zone detected displacement anomaly occurring since 2006 with the variation amplitude exceeding the cumulative value of the last ten years.Five borehole strainmeter stations in the Chongqing section of Three Gorges Reservoir area observed unconventional strain changes occurring in the period from May 1 through 12,2008.Among them,the strainmeter at Wanzhou station recorded the great compression strain rate on the EW component at 14:00 o'clock of May 10,and the anomaly amplitude was so large that the instrument output exceeded its dynamic range,corresponding to a level of~10~4 nanostrains.The geothermometers installed in Xi'an, Chongqing and Xichang recorded the sudden temperature changes from November 2007 to January 2008 with the variation amplitudes several times larger than the ordinary deviation.The above phenomena and the criteria for distinguishing the anomalies from background fluctuations are discussed in this paper. | OUYANG Zuxi ZHANG Hongxun FU Zizhong GOU Bo JIANG Wali | 2009 | Acta Geologica Sinica(English Edition)2009，83，4： | 12 |
| 3 | 胰岛素样生长因子-1对高氧诱导的A549细胞凋亡的影响显示文摘目的胰岛素样生长因子-1(IGF-1)具有促进细胞分化、抑制细胞凋亡等多种生物学活性。该研究旨在探讨IGF-1对高氧诱导的A549细胞凋亡的影响及其抗凋亡机制。方法将传代培养的A549细胞暴露于高氧环境,并以不同浓度IGF-1(1、10、100 ng/mL)干预48 h,采用四甲基偶氮唑蓝(MTT)法检测细胞存活率,Annexin V-FITC/PI双染流式细胞术检测细胞凋亡变化,同时用流式细胞仪检测凋亡调控相关蛋白(Bax、Bcl-2)表达水平的变化。结果高氧组细胞存活率为(51±3)%,IGF-1干预组细胞存活率随着IGF-1药物浓度的递增逐渐升高,中、高剂量IGF-1干预组细胞存活率分别为(64±3)%和(88±4)%,与高氧组相比,差异均有统计学意义(P<0.05)。高氧组A549细胞凋亡率为(38.3±5.4)%,较空气组(2.4±0.9)%明显增多;高氧组Bcl-2的蛋白表达水平为(72±5)%,较空气组(91±4)%明显下降;高氧组Bax的表达水平为(54±6)%,较空气组(3±2)%明显升高,差异均有统计学意义(P<0.05)。与高氧组比较,IGF-1干预组细胞凋亡率随着药物浓度的增加逐渐下降,分别为(16.1±4.7)%、(9.2±2.8)%和(6.9±2.5)%,差异有统计学意义(P<0.05)。与高氧组比较,IGF-1干预组细胞Bcl-2的表达逐渐增高,分别为(79±4)%、(94±4)%和(100±5)%,而Bax的表达逐渐下降,分别为(26±4)%、(5±2)%和(4±2)%,差异均有统计学意义(P<0.05)。结论高氧明显抑制A549细胞的增殖,促进其凋亡;IGF-1具有促进A549细胞增殖,通过调节凋亡调控蛋白Bcl-2和Bax表达,抑制高氧诱导的A549细胞凋亡的作用。 | 金贞爱 赵以坤 金正勇 祁海峰 Mokhles Wali Gul 公明花 | 2013 | 中国当代儿科杂志2013，15，6： | 9 |
| 4 | Organic carbon isotope and molecular fossil records of vegetation evolution in central Loess Plateau since 450 kyr显示文摘Significant uncertainties remain regarding the temporal evolution of natural vegetation during the Quaternary, and drivers of past vegetation change, on the Chinese Loess Plateau(CLP). This study presents analyses of total organic carbon isotopic composition(TOC) and n-alkane ratios(C31/C27) from the Lingtai loess-palaeosol sequence on the central CLP over the last 450 kyr. The results demonstrate that the vegetation in this region comprised a mix of C_3 and C_4 plants of herb and woody growth-form. C_3 plants dominated for most of the last 450 kyr, but this did not lead to extensive forest. C_3 woody plants were more abundant in MIS9(S3 period) and MIS5(S1 period) during warm and humid climate conditions. Herbs increased in the region since 130 kyr, possibly as a result of increased aridity. On the orbital timescales, there was a reduction of C_3 herbal plants in MIS11(S4) than in MIS12(L5), and in Holocene than in the last glacial period. Our isotope and n-alkane proxy records are in agreement with Artemisia pollen changes in the region, which is/was the dominant species in this area and varying due to different heat and water conditions between glacial and interglacial periods. Though the climate in MIS1(S0) was similar to that in MIS11(S4), a significant increase in woody plants during the Holocene suggests the impact of human activities and ecological effects of changes in fire activity. | ZHOU Bin WALI Guzalnur Francien PETERSE Michael I BIRD | 2016 | Science China Earth Sciences2016，59，6： | 7 |
| 5 | 3D Printed Integrated Gradient-Conductive MXene/CNT/Polyimide Aerogel Frames for Electromagnetic Interference Shielding with Ultra-Low Reflection显示文摘Construction of advanced electromagnetic interference(EMI)shielding materials with miniaturized,programmable structure and low reflection are promising but challenging.Herein,an integrated transition-metal carbides/carbon nanotube/polyimide(gradient-conductive MXene/CNT/PI,GCMCP)aerogel frame with hierarchical porous structure and gradient-conductivity has been constructed to achieve EMI shielding with ultra-low reflection.The gradient-conductive structures are obtained by continuous 3D printing of MXene/CNT/poly(amic acid)inks with different CNT contents,where the slightly conductive top layer serves as EM absorption layer and the highly conductive bottom layer as reflection layer.In addition,the hierarchical porous structure could extend the EM dissipation path and dissipate EM by multiple reflections.Consequently,the GCMCP aerogel frames exhibit an excellent average EMI shielding efficiency(68.2 dB)and low reflection(R=0.23).Furthermore,the GCMCP aerogel frames with miniaturized and programmable structures can be used as EMI shielding gaskets and effectively block wireless power transmission,which shows a prosperous application prospect in defense industry and aerospace. | Tiantian Xue Yi Yang Dingyi Yu Qamar Wali Zhenyu Wang Xuesong Cao Wei Fan Tianxi Liu | 2023 | Nano-Micro Letters2023，15，3： | 5 |
| 6 | Evidence of multistage late Quaternary strong earthquakes on typical segments of Longmenshan Active Fault Zone in Sichuan, China显示文摘Investigation of offset landforms and trench excavation are important means to acquire the evidence of multistage activities of active faults. Here we present the result of fault trough investigation in Beichuan County and the Pingtong Town of Pingwu County along the Longmenshan Central Fault Belt, as well as the result from trench excavation at the platform foreslope in Hanwang Town of Mianzhu County on the Longmenshan Front Range Fault Belt. These results show that at least three fault activity events, including the Wenchuan earthquake, occurred in the Beichuan fault trough, at least two, including the Wenchuan earthquake, at Pingtong fault trough, and 2-3 paleoearthquakes in the Hanwang trench. Among these three localities, the times of the last strong earthquake prior to Wenchuan earthquake at Beichuan fault trough and Hanwang trench are close, approximately 6000 years ago, i.e., greater than 5.8 ka and smaller than 6.63 ka ago. This provides the evidence of synchronous activity of the Central Fault Belt and the Front Range Fault Belt of the Longmenshan Active Fault Zone during the previous strong earthquake activities prior to Wenchuan earthquake. | JIANG WaLi XIE XinSheng ZHANG JinFa SUN ChangBin HUANG Wei SHENG Qiang FENG XiYing | 2009 | Science China Earth Sciences2009，52，9： | 3 |
| 7 | Anticancer activity of Aloe vera and Calligonum comosum extracts separetely on hepatocellular carcinoma cells显示文摘Objective: To investigate the in vitro anticancer effect of Aloe vera(A. vera) and Calligonum comosum(C. comosum) extracts against hepatocellular carcinoma(HepG 2) cells. Methods: Hep G2 cells were tested against different doses of A. vera and C. comosum. Viability of the cells was assessed by MTT assay. Evaluation of apoptosis and DNA damage in HepG 2 cells were performed using annexin V apoptosis detection kit. The expression of p53 and anti-apoptotic(Bcl-2) were tested by real time-PCR and flow cytometer analyser. Hematoxylin and eosin stained sections from untreated and treated HepG 2 cells were observed using light microscopy.Results: The IC50 values of A. vera and C. comosum extracts were(10.45 ± 0.31) and(9.60 ± 0.01) μg/mL respectively. The extracts separately increased cytotoxicity against HepG 2 cells in a time and dose dependent manners. Also, it apparently induced apoptosis through increase P53 and decrease Bcl-2 genes expressions.Conclusions: The results indicated that the extracts could have anti-hepatocarcinogenic effect, at least in part, through modulation of apoptosis. | Maram Shalabi Kh.Khilo Mahmoud M.Zakaria Mahmoud G.Elsebaei Walied Abdo Walaa Awadin | 2015 | Asian Pacific Journal of Tropical Biomedicine2015，5，5： | 2 |
| 8 | Biomedical polymers: synthesis, properties, and applications显示文摘Biomedical polymers have been extensively developed for promising applications in a lot of biomedical fields, such as therapeutic medicine delivery, disease detection and diagnosis, biosensing, regenerative medicine, and disease treatment. In this review, we summarize the most recent advances in the synthesis and application of biomedical polymers, and discuss the comprehensive understanding of their property-function relationship for corresponding biomedical applications. In particular, a few burgeoning bioactive polymers, such as peptide/biomembrane/microorganism/cell-based biomedical polymers, are also introduced and highlighted as the emerging biomaterials for cancer precision therapy. Furthermore, the foreseeable challenges and outlook of the development of more efficient, healthier and safer biomedical polymers are discussed. We wish this systemic and comprehensive review on highlighting frontier progress of biomedical polymers could inspire and promote new breakthrough in fundamental research and clinical translation. | Wei-Hai Chen Qi-Wen Chen Qian Chen Chunyan Cui Shun Duan Yongyuan Kang Yang Liu Yun Liu Wali Muhammad Shiqun Shao Chengqiang Tang Jinqiang Wang Lei Wang Meng-Hua Xiong Lichen Yin Kuo Zhang Zhanzhan Zhang Xu Zhen Jun Feng Changyou Gao Zhen Gu Chaoliang He Jian Ji Xiqun Jiang Wenguang Liu Zhuang Liu Huisheng Peng Youqing Shen Linqi Shi Xuemei Sun Hao Wang Jun Wang Haihua Xiao Fu-Jian Xu Zhiyuan Zhong Xian-Zheng Zhang Xuesi Chen | 2022 | Science China Chemistry2022，65，6： | 2 |
| 9 | Microstructural development of a C f /ZrC composite manufactured by reactive melt infiltration显示文摘 | Linhua Zou Natalie Wali Jenn-Ming Yang Narottam P. Bansal | 2009 | Journal of the European Ceramic Society2009，，6： | 2 |
| 10 | 出生前接触酒精对新生大鼠大脑发育中BDNF和TrkB的影响显示文摘[目的]探讨出生前接触酒精对新生大鼠大脑皮质发育中脑源性神经营养因子(BDNF)及其受体酪氨酸激酶受体B(TrkB)水平的影响.[方法]选择SD母鼠,酒精组母鼠每日摄取热量为35cal的酒精,正常对照组母鼠每日摄取与酒精组相等热量的奶粉(含质量分数为8%的糖),代理母组给予普通大鼠饲料.酒精组和正常对照组母鼠分娩6h后与其子鼠分开,麻醉后心脏采血,检测血液中乙醇和甲状腺素水平.酒精组及正常对照组新生子鼠由代理母组的代理母鼠养育,并分别于出生后0,7,14,21,28d(P0,P7,P14,P21,P28)时麻醉处死,采用免疫组织化学ABC染色法在大脑皮质中观察含有BDNF和TrkB的神经细胞的分布及形态,并采用ELISA法检测大脑中BDNF含量.[结果]酒精组母鼠血液中酒精水平明显高于正常对照组(P<0.05);而酒精组母鼠血液中甲状腺素含量显著低于正常对照组(P<0.05).正常对照组新生子鼠P7始在大脑皮质中可观察到长而明显突起的成熟的含有BDNF和TrkB的神经细胞;酒精组新生子鼠大脑皮质中始终未出现具有明显突起的成熟的含有BDNF和TrkB的神经细胞.酒精组新生子鼠出生后各时期大脑中BDNF蛋白含量均较正常对照组明显减少(P<0.05),P14时较正常对照组显著减少(P<0.000 1).[结论]大鼠母鼠孕期摄取酒精时引起血液中甲状腺素含量减少,还可导致其后代大脑皮质发育中BDNF和TrkB的合成障碍,进而导致大脑发育异常. | Wali Gul Mokhles 金正勇 许春花 南虎松 金福 | 2013 | 延边大学医学学报2013，36，2： | 2 |
| 11 | Histopathological changes in the wall of varicose veins显示文摘 | Wali MA Dewan M Eid RA | 2003 | Int Angiol2003，22，2： | 1 |
| 12 | Prevention of myoclonus 'after etomidate using a priming dose显示文摘 | Aissaoui Y Belyamani L E1 Wali A | 2006 | Ann Fr Anesth Reanim2006，25，10： | 1 |
| 13 | The Effect of Individual Perceptions of Deadlines on Team Performance显示文摘 | WALI ER M J CONTE J M GIBSON C B | 2001 | The Academy of Management Review2001，26，4： | 1 |
| 14 | Treatment of idiopathic pulmonary fibrosis: is there anything new显示文摘 | ABDELAZIZ M M SAMMAN Y S WALI SO | 2005 | Respirology2005，10，3： | 1 |
| 15 | Efficacy and Safety of Renal Tubule Cell Therapy for Acute Renal Failure显示文摘 | Tumlin J Wali R Williams W | 2008 | J Am Soc Nephrol2008，19，： | 1 |
| 16 | Evolution of endophyte-plant symbioses 显示文摘 | Saikkonen K Wali P Helander M 2004 | 2004 | Trends Plant Sci2004，9，6： | 1 |
| 17 | Topical polyethylene glycol as a novel chemopreventive agent for oral cancer via targeting of epi- dermal growth factor response 显示文摘 | Wali RK Kunte DP De La Cruz M | 2012 | PLoS One2012，7，38： | 1 |
| 18 | Effect of high-intensity ultrasonic treatment on modification of primary Mg 2 Si in the hypereutectic Mg–Si alloys显示文摘 | M.E. Moussa M.A. Waly A.M. El-Sheikh | 2013 | Journal of Alloys and Compounds2013，，： | 1 |
| 19 | Demonstration of malaria situation analysis,stratification and planning in Minab District,southern Iran显示文摘Objective:To demonstrate malaria situation analysis,stratification and planning for an endemic area in southern Iran.Methods:Data on health system,population,meteorological parameters, malaria cases,anopheline vectors,and control activities during 2005-2007 was obtained from Minab Health Center,Minab Meteorological Station and published documents about malaria elements in the study area.A datasheet was created in excel 2003 for analysis.Results:There were 644 health staff working in Minab District including 99 health staff in malaria control program.The health facilities are distributed as follow:1 hospital with 96 beds,23 health centers including private centers(10 in Minab city and 13 in rural area of Minab District) and 119 health houses in rural areas of Minab District.Anopheles stephensi was the dominant species in Minab District,however,Anopheles dthali,Anopheles superpictus,Anopheles fluviatilis,Anopheles multicolor,Anopheles pulcherrimus and Anopheles turkhudi can also be found in the area. Anopheles stephensi was reported susceptible to malathion,propoxur,primphos-methyl,lambdacyhalothrin permethrin and deltamethrin,and resistant to DDT and dieldrin in the area.During the study period a total of 10 665 positive cases were reported,mainly due to local transmission (99.6%).Plasmodium vivax was the main causative agent followed by Plasmodium falciparum. There were reports about drug resistance of Plasmodium falciparum in the area.Conclusions: Using different parameters,Minab was classified into 3 strata.A plan was designed based on described goal,objectives and targets.The approaches of this plan were categorized into:health education,early detection and correct treatment,and vector control.Main constraints of these approaches are population movement between Iran,Pakistan and Afghanistan;vector control challenges at district,inadequate skilled medical staff in malaria case management and weak inter-sectorial coordination for malaria control,especially in urban areas. | Vatandoost Hassan Rashidian Arash Jafari Mehdi Raeisi Ahmad Hanafi-Bojd Ahmad Ali Yousofzai Abdul Wali Daryanavard Ali Mojahedi AbdulRasool Pakari Abbas | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，1： | 1 |
| 20 | Prevalence of chronic obstructive pulmonary disease in Saudi Arabia 显示文摘 | Wali SO Idrees MM Alamoudi OS | 2014 | Saudi Med J2014，35，7： | 1 |
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