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| 1 | 慢性肾脏病中的炎症和动脉硬化:慢性肾功能不全队列研究中的发现显示文摘慢性肾脏病(chronic kidney disease,CKD)和动脉硬化程度与心血管病发病率和死亡率增加相关。目前认为炎症在动脉硬化发展中发挥作用,而CKD被认为是一种促炎症反应的状态。CKD患者的动脉僵硬度增加,横断面数据提示CKD中增多的炎症标志物与较高动脉僵硬度值相关。 | Peyster E Chen J Feldman HI Go AS Gupta J Mitra N Pan Q Porter A Rahman M Raj D Reilly M Wing MR Yang W Townsend RR 陈云 叶鹏 | 2017 | 中华高血压杂志2017，25，11： | 12 |
| 2 | A novel protein-repellent dental composite containing 2-methacryloyloxyethyl phosphorylcholine显示文摘Secondary caries due to biofilm acids is a primary cause of dental composite restoration failure.To date,there have been no reports of dental composites that can repel protein adsorption and inhibit bacteria attachment.The objectives of this study were to develop a protein-repellent dental composite by incorporating 2-methacryloyloxyethyl phosphorylcholine(MPC) and to investigate for the first time the effects of MPC mass fraction on protein adsorption,bacteria attachment,biofilm growth,and mechanical properties.Composites were synthesized with 0(control),0.75%,1.5%,2.25%,3%,4.5%and 6%of MPC by mass.A commercial composite was also tested as a control.Mechanical properties were measured in three-point flexure.Protein adsorption onto the composite was determined by the microbicinchoninic acid method.A human saliva microcosm biofilm model was used.Early attachment at 4 h,biofilm at 2 days,live/dead staining and colony-forming units(CFUs) of biofilms grown on the composites were investigated.Composites with MPC of up to 3%had mechanical properties similar to those without MPC and those of the commercial control,whereas 4.5%and 6%MPC decreased the mechanical properties(P<0.05).Increasing MPC from 0 to 3%reduced the protein adsorption on composites(P<0.05).The composite with 3%MPC had protein adsorption that was 1/12 that of the control(P<0.05).Oral bacteria early attachment and biofilm growth were also greatly reduced on the composite with 3%MPC,compared to the control(P<0.05).In conclusion,incorporation of MPC into composites at 3%greatly reduced protein adsorption,bacteria attachment and biofilm CFUs,without compromising mechanical properties.Protein-repellent composites could help to repel bacteria attachment and plaque build-up to reduce secondary caries.The protein-repellent method might be applicable to other dental materials. | Ning Zhang Chen Chen Mary AS Melo Yu-Xing Bai Lei Cheng Hockin HK Xu | 2015 | International Journal of Oral Science2015，7，2： | 8 |
| 3 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 4 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 5 | Comparison of the cardiacelectrophysiological effects between doxazosin and bu-nazosin显示文摘 | Lee AS Chen WP Su MJ | 2008 | J Biomed Sci2008，15，4： | 1 |
| 6 | New observations on atrial fibrillation in patients with the Wollf-Parkinson-White syndrome显示文摘 | Chen PS Pressley JC Tang AS | 1992 | J Am Coll Cardiol1992，19，5： | 1 |
| 7 | Using positron emissiontomography and florbetapir 18 F to image cortical amyloid inpatients with mild cognitive impairment or dementia due toAlzheimer disease显示文摘 | Fleisher AS Chen K Liu X | 2011 | Arch Neurol2011，68，1： | 1 |
| 8 | Cataract surgery and diabetes 显示文摘 | Shah As Chen SH | 2010 | Curt 0pin 0phthalmol2010，21，： | 1 |
| 9 | Node-positive cervical cancer:impact of pelvic irradiation and patterns of failure显示文摘 | Stock RG Chen AS FlickingerJC | 1995 | Int J Radiat Oncol Biol Phys1995，31，1： | 1 |
| 10 | Role of the angiotensin AT( 1 ) receptor in rat aortic and cardiac PAI-1 gene expression 显示文摘 | Chen HC Bouchie JL Perez AS | 2000 | Arterioscler Thromb Vase Biol2000，20，10： | 1 |
| 11 | A 30-year experience in the management of primary carcinoma of the vagina: analysis of prognostic factors and treatment modalities 显示文摘 | STOCK RG CHEN AS SESKI J | 1995 | Gynecol Oncol1995，56，1： | 1 |
| 12 | Florbetapir PET analysis of amyloid-b deposition in the presenilin 1E280A autosomal dominant Alzheimer's disease kindred: a cross- sectional study显示文摘 | Fleisher AS Chen K Quiroz YT | 2012 | Lancet Neurol2012，11，12： | 1 |
| 13 | Using positron emission tomography and florbetapir F18 to image cortical amyloid in patients with mild cognitive impairment or dementia due to Alzheimer disease显示文摘 | Fleisher AS Chen K Liu X | 2011 | Arch Neurol2011，68，11： | 1 |
| 14 | Stable and high energy generation by a strain of Bacillus subtilis in a microbial fuel cell 显示文摘 | Nimje VR Chen CY Chert CC Jean JS Reddy AS Fan CW Pan KY Liu HT Chen JL | 2009 | JPower Sourc2009，190，2： | 1 |
| 15 | Nephroprotective Effects of Polydatin against Ischemia/Reperfusion Injury: A Role for the PI3K/Akt Signal Pathway显示文摘 | Hong-Bao Liu Qiu-Hong Meng Chen Huang Jian-Bo Wang Xiao-Wei Liu Matías Mosqueira | 2015 | Oxidative Medicine and Cellular Longevity2015，，： | 1 |
| 16 | Circulating Type Motor Bearing Current in Inverter Drives显示文摘 | Shaotang Chen Thom as A Lipo | 1998 | IEEE Industry Applications Magazine1998，，1： | 1 |
| 17 | MicroRNA-mediated switching of chromatin-remodelling complexes in neural development 显示文摘 | Yoo AS Staahl BT Chen L | 2009 | Nature2009，460，7255： | 1 |
| 18 | Hippocampal changes associ- ated with early-life adversit and vulnerability to depression显示文摘 | Rao U Chen LA Bidesi AS | 2010 | Biol Psychiatry2010，67，4： | 1 |
| 19 | Hydrogen peroxide stimulates ubiquitinconjugating activity and expression of genes for specific E2 and E3 proteins in skeletal muscle myotubes显示文摘 | Li YP Chen Y Li AS Reid MB | | 0，，： | 1 |
| 20 | Chemical alterations taken place during deep-fat frying based on certain reac- tion products: A review显示文摘 | Zhang Q Saleh AS Chen J | 2012 | Chemistry and Physics of Lipids2012，165，6： | 1 |
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