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| 1 | 肿瘤恶性转化与C/EBPβ和STAT3基因相关(英文)显示文摘The inference of transcriptional networks that regulate transitions into physiological or pathological cellular states remains a central challenge in systems biology. A mesenchymal phenotype is the hallmark of tumour aggressiveness in human malignant glioma,but the regulatory programs responsible for implementing the associated molecular signature are largely unknown. Here we show that reverse-engineering and an unbiased interrogation of a glioma-specific regulatory network reveal the transcriptional module that activates expression of mesenchymal genes in malignant glioma. Two transcription factors (C/EBPβ and STAT3) emerge as synergistic initiators and master regulators of mesenchymal transformation. Ectopic co-expression of C/EBPβ and STAT3 reprograms neural stem cells along the aberrant mesenchymal lineage,whereas elimination of the two factors in glioma cells leads to collapse of the mesenchymal signature and reduces tumour aggressiveness. In human glioma,expression of C/EBPβ and STAT3 correlates with mesenchymal differentiation and predicts poor clinical outcome. These results show that the activation of a small regulatory module is necessary and sufficient to initiate and maintain an aberrant phenotypic state in cancer cells. | Maria Stella Carro Wei Keat Lim Mariano Javier Alvarez Robert J. Bollo Evan Y. Snyder Erik P. Sulman Sandrine L. Anne Fiona Doetsch Howard Colman Anna Lasorella Ken Aldape Andrea Califano Antonio Iavarone | 2010 | 中华神经外科疾病研究杂志2010，9，1： | 16 |
| 2 | Inhibition of Cdk5 increases osteoblast differentiation and bone mass and improves fracture healing显示文摘Identification of regulators of osteoblastogenesis that can be pharmacologically targeted is a major goal in combating osteoporosis,a common disease of the elderly population. Here, unbiased kinome RNAi screening in primary murine osteoblasts identified cyclin-dependent kinase 5(Cdk5) as a suppressor of osteoblast differentiation in both murine and human preosteoblastic cells. Cdk5 knockdown by si RNA, genetic deletion using the Cre-lox P system, or inhibition with the small molecule roscovitine enhanced osteoblastogenesis in vitro. Roscovitine treatment significantly enhanced bone mass by increasing osteoblastogenesis and improved fracture healing in mice. Mechanistically, downregulation of Cdk5 expression increased Erk phosphorylation, resulting in enhanced osteoblast-specific gene expression. Notably, simultaneous Cdk5 and Erk depletion abrogated the osteoblastogenesis conferred by Cdk5 depletion alone, suggesting that Cdk5 regulates osteoblast differentiation through MAPK pathway modulation. We conclude that Cdk5 is a potential therapeutic target to treat osteoporosis and improve fracture healing. | Mubashir Ahmad Benjamin Thilo Krüger Torsten Kroll Sabine Vettorazzi Ann-Kristin Dorn Florian Mengele Sooyeon Lee Sayantan Nandi Dilay Yilmaz Miriam Stolz Naveen Kumar Tangudu David Carro Vázquez Johanna Pachmayr Ion Cristian Cirstea Maja Vujic Spasic Aspasia Ploubidou Anita Ignatius Jan Tuckermann | 2022 | Bone Research2022，10，3： | 2 |
| 3 | Usefulness of biodegradable polydioxanone stents in the treatment of postsurgical colorectal strictures and fistulas显示文摘 | F. Pérez Roldán P. González Carro M. Villafá?ez García S. Aoufi Rabih M. Legaz Huidobro N. Sánchez-Manjavacas Mú?oz O. Roncero García-Escribano M. Ynfante Ferrús E. Bernardos Martín F. Ruiz Carrillo | 2012 | Endoscopy2012，，03： | 2 |
| 4 | Effects of malate on diet digestibility, microbial protein synthesis, plasma me-tabolites, and performance of growing lambs fed a high-concentrate diet显示文摘 | Carro M D Ranilla M J Girdldez F J | 2006 | Journal of Animal Science2006，84，2： | 1 |
| 5 | Clinical history and new prognostic indicators in metachromatic leukodystrophy 显示文摘 | Del Carro U Bifffi A Boldoll C | 2004 | J Peripher Nerv Syst2004，9，： | 1 |
| 6 | Journal of Chromatography A显示文摘 | Carro A M Lorenzo R A Fernandez F Rodil R Cela R | 2005 | 1071: 932005，1071，： | 1 |
| 7 | Role of serum insulin-like growth factor I in mammalian brain aging显示文摘 | Trejo JL Carro E Lopez-Lopez C | 2004 | Growth Horm IGF Res2004，，： | 1 |
| 8 | Therapeutic actions of insulin- like growth factor 1 on APP/PS2 mice with severe brain amyloidosis 显示文摘 | Carro E Trejo JL Gerber A | 2006 | Neurobiol Aging2006，27，： | 1 |
| 9 | Serum insulin-like growth factor 1 regulates brain amyloid-beta levels 显示文摘 | Carro E Trejo JL Gomez-Isla T | 2002 | Nat Med2002，8，： | 1 |
| 10 | Bioactive peptides in water-soluble extracts of ovine cheeses from Southern Brazil and Uruguay显示文摘 | Stela Maris Meister Meira Daniel Joner Daroit Virginia Etges Helfer Ana Paula Folmer Corrêa Jéferson Segalin Silvana Carro Adriano Brandelli | 2012 | Food Research International2012，，1： | 1 |
| 11 | Multivariate optimization approach for the analysis of butyltin compounds in mussel tissues by gas chromatography-mass spectrometry 显示文摘 | MAGI E LISCIO C di CARRO M | 2008 | Journal of Chromatography A2008，1210，1： | 1 |
| 12 | Increased expression of ICAM-1 during reoxggenation in brain endothelial cells显示文摘 | HESS DC ZHAO W CARRO | 1994 | Stroke1994，25，7： | 1 |
| 13 | Effect of the addition of malate on in vitro rumen fermentation of cereal grains显示文摘 | Carro M D Ranilla M J | 2003 | British Journal of Nutrition2003，89，： | 1 |
| 14 | A multi- ple bit upset tolerant SRAM memory 显示文摘 | Neuberger G De Lima F Carro L | 2003 | Acre Transactions on Design Automation of Electronic Systems2003，8，4： | 1 |
| 15 | Picking needles from nano-haystacks显示文摘 | Carro D L Ajayan P M | 1998 | Advanced Materials1998，10，4： | 1 |
| 16 | Effect of malate on mixed ruminal microorganism fermentation using the remen simulation technique 显示文摘 | Carro M D Lopez S Valdes C | 1999 | Animal Feed Science and Technology1999，79，4： | 1 |
| 17 | Changes in high-frequency QRS components are more sensitive than ST-segment deviation for detecting acute coronary ar- tery occlusion 显示文摘 | PETI'ERSSON J PAHLM O CARRO E | 2000 | Journal of the American College of Cardiology2000，36，6： | 1 |
| 18 | New aspects and strategies for methane mitigation from ruminants显示文摘 | Sanjay Kumar Prasanta Kumar Choudhury Maria Dolores Carro Gareth Wyn Griffith Sumit Singh Dagar Monica Puniya Serena Calabro Sreenivas Rao Ravella Tejpal Dhewa Ramesh Chandra Upadhyay Sunil Kumar Sirohi Shivlal Singh Kundu Metha Wanapat Anil Kumar Puniya | 2014 | Applied Microbiology and Biotechnology2014，，： | 1 |
| 19 | Non-aqueous encapsulation of excipient-stabilized spray freeze-dried BSA into poly (lactide-co-glycolide) microspheres results in release of native protein 显示文摘 | Carrasquillo KG Stanley AM Aponte Carro JC | 2001 | J Controlled Release2001，76，3： | 1 |
| 20 | Influence of endoge- nous leptin tone on the estrous cycle and luteinizing hormone pulsa- tility in female rats 显示文摘 | CARRO E PINILLA L SEOANE L M | 1997 | Neuroendocrinology1997，66，6： | 1 |
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