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| 1 | MUC1 and MUC5AC mucin expression in liver fluke-associated intrahepatic cholangiocarcinoma显示文摘AIM: To investigate the expressions of MUC1 and MUC5AC in intrahepatic cholangiocarcinoma (ICC). Association of expressions of mucins MUC1 and MUC5AC with clinical findings, metastasis, and survival of the liver fluke-associated ICC patients was determined.METHODS: The expressions of MUC1 and MUC5AC mucins were examined by immunohistochemical staining in 87cases of histologically-proven ICC. The expressions of mucins in relationship between clinicopathological significance and prognosis of the patients were evaluated.RESULTS: Fifty-two patients (60%) exhibited both MUC1 and MUC5AC expressions, whereas 31% expressed either MUC1or MUC5AC, and 9% expressed neither. High MUC1immunoreactivity displayed a significant correlation with tumor progression as reflected by vascular invasion (P<0.001),whereas high expression of MUC5AC significantly correlated with neural invasion (P = 0.022) and advanced ICC stage (P = 0.008). Patients with high expression of MUC1 had a significantly shorter survival (P = 0.0002). According to multivariate analyses, MUC1 reactivity (P = 0.026),histological grading and stage of tumor represented the least probability of survival.CONCLUSION: MUC1 is overexpressed in liver flukeassociated cholangiocarcinoma and relates to vascular invasion and poor prognosis, whereas MUC5AC mucin is neoexpressed and relates to neural invasion and advanced ICC stage. High MUC1 expression in tumor may be useful for predicting the poor outcome of ICC patients. | Chanchai Boonla Banchob Sripa Peti Thuwajit Ubon Cha-On Anucha Puapairoj Masanao Miwa Sopit Wongkham | 2005 | World Journal of Gastroenterology2005，11，32： | 6 |
| 2 | Gene expression profiling defined pathways correlated with fibroblast cell proliferation induced by Opisthorchis viverrini excretory /secretory product显示文摘瞄准:为了调查成纤维细胞房间增长的机制,由麝后睾吸虫刺激了分泌 / 能分泌(ES ) 产品。方法:NIH-3T3,老鼠成纤维细胞房间与 O 被对待。由与成年寄生虫 co 有教养的非接触的 viverrini ES 产品。从 NIH-3T3 的全部的 RNA 对待并且与 O 未经治疗。viverrini 被提取,抄录的颠倒和有老鼠 15K 的 hybridized 互补 DNA (cDNA ) 数组。结果被 ArrayVision 版本 5 和 GeneSpring 版本 5 软件分析。在正规化以后,寄生虫的基因表示的比率对待到第 2-a 更多褶层的未经治疗的 NIH-3T3 房间在上面调整当差别表示了基因,被定义。信号转导变异基因的表达式层次被半量的基于 SYBR 的即时 RT-PCR 验证。结果:在 15,000 genes/ESTs 的一个总数之中,有确定的房间的 239 基因增长相关的功能是 2 褶层 -- 并且由 O 的 more-up-regulated。在没有到寄生产品的暴露的房间的与那些相比的 viverrini ES 产品。这些基因被分类进包括的组精力和新陈代谢,信号转导变异,蛋白质合成和翻译,矩阵和结构的蛋白质,抄写控制,房间周期和 DNA 复制。而且, serine-threonine 激酶受体,受体酷氨酸激酶和骨胶原的表情生产相关的基因由 O 是起来调整的。viverrini ES 产品。信号转导变异基因的表达式水平;pkC, pdgfr 高山哈, jak 1, eps 8,即时 RT-PCR 测量的 tgf 贝它 1i4,带和 h 地岬证实了他们的表示层次到从 cDNA 获得的那些数组。然而,仅仅 pkC 的起来调整的表示, eps 8 并且是表皮的生长因素(EGF ) 或转变生长因素贝它(TGF 贝它) 显示出的任何一个的下游的发信号分子的 tgfbeta 1i4 统计意义(P <
0.05 ) 。结论:O。viverrini ES 产品在几个功能的范畴和这些刺激基因表示的重要变化主要包括与房间增长有关的抄本。TGF 贝它和 EGF 信号转导变异小径作为 O 的可能的小径被显示。驾驶 viverrini 的房间增长。 | Chanitra Thuwajit Peti Thuwajit Kazuhiko Uchida Daoyot Daorueang Sasithorn Kaewkes Sopit Wongkham Masanao Miwa | 2006 | World Journal of Gastroenterology2006，12，22： | 5 |
| 3 | Molecular basis of MAP kinase regulation显示文摘 | Peti W Page R | | 0，，12： | 1 |
| 4 | Attitudes and attitude change 显示文摘 | PETI'Y R E WEGENER D T FABRIGAR L R | 1997 | Annu Rev Psychol1997，48，1： | 1 |
| 5 | Graphic reminder of Rouviere's sulcus:a useful landmark in cholecystectomy显示文摘 | Peti N Moser MAJ | 2012 | ANZ Journal of Surgery2012，82，5： | 1 |
| 6 | Modeling of H2SO4 - FeSO4-H2O systems for metallurgical applications显示文摘 | Peti Kobylin Toni Kaskiala Justin Salminen | 2007 | Ind Eng Chen Res2007，46，： | 1 |
| 7 | Strict parternal inheritance of chloroplast DNA and maternal inheritance of mitochondrial DNA in intraspecific crosses of kiwifruit 显示文摘 | Chat J Chalak L Petie R J | 1999 | Theor Appl Genet1999，99，： | 1 |
| 8 | Changes in high-frequency QRS components are more sensitive than ST-segment deviation for detecting acute coronary ar- tery occlusion 显示文摘 | PETI'ERSSON J PAHLM O CARRO E | 2000 | Journal of the American College of Cardiology2000，36，6： | 1 |
| 9 | Combining FDG-PET/CT with laboratory data yields superior results for prediction of relapse in multiple myeloma显示文摘 | Elliott BM Peti S Osman K | | 0，，04： | 1 |
| 10 | 47 A显示文摘 | Kelker MS Foss TR Peti W Crystal structure of human trig gering receptor expressed on myeloid cells (TREM-1) at 1 | 2004 | J Mol Bid2004，342，4： | 1 |
| 11 | U- sing the satellite-derived NDVI to assess ecological re- sponses to environmental change 显示文摘 | PETI'ORELLI N VIK J O MYSTERUD A | 2005 | Trends in Ecolo- gy & Evolution2005，20，9： | 1 |
| 12 | No difference in the effects of clopidogrel and aspirin on inflammatory markers in patients with coronary heart disease显示文摘 | SOLHEIM S PETI'ERSEN A A ARNESEN H | 2006 | Thromb Haemost2006，96，5： | 1 |
| 13 | The man- agement of flail chest 显示文摘 | PETI'IFORD B L LUKETICH J D LANDRENEAU R J | 2007 | Thorac Surg Clin2007，17，1： | 1 |
| 14 | Suppression of glucose production by GLP21 independent of islet hormones: a novel ex- tra pancreatic effect显示文摘 | Prigeon RL Quddusi S Pety B | 2013 | Am J Physiol Endocrinol Metab2013，285，4： | 1 |
| 15 | ATP releasing con- nexin 30 hemichannels mediate flow - induced calcium signaling in the collecting duct显示文摘 | Svenningsen P Burford JL Peti - Peterdi J | 2013 | Front Physiol2013，4，： | 1 |
| 16 | Family adversity, pos- itive peer relationships and children's externalizing behav- ior: a longitudinal perspective on risk and resilience 显示文摘 | CRISS M M PETI~T G S Bates J E | 2002 | Child Development2002，73，4： | 1 |
| 17 | Sharing of endogenous risk in construction 显示文摘 | TROND E O PETI'ER O | 2005 | Journal of Economic Behavior & Organization2005，，3： | 1 |
| 18 | Combining FDG-PET / CT with laboratory data yields superior results for prediction of relapse in multiple myeloma 显示文摘 | Elliott BM Peti S Osman K | 2011 | Eur J Haematol2011，86，4： | 1 |
| 19 | Early lead explosure and the hippocampus: a review and recentadvance显示文摘 | Peti TL Alfano DP Leboutillier JC | 1993 | Neurotoxicology1993，4，： | 1 |
| 20 | Combining FDG- PET/CT with laboratory data yields superior results for prediction of relapse in multiple myeloma 显示文摘 | Elliott BM Peti S Osman K | 2011 | Eur J Hematol2011，86，4： | 1 |
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