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| 1 | Diffusion-weighted MRI in a liver protocol: Its role in focal lesion detection显示文摘AIM: To evaluate the role of diffusion-weighted imaging (DWI) in the detection of focal liver lesions (FLLs), using a conventional magnetic resonance imaging (MRI) protocol. METHODS: Fifty-two patients (22 males, average age 55.6 years, range: 25-82 years), studied using a 1.5 Tesla magnetic resonance scanner, were retrospectively analyzed; detection of FLLs was evaluated by considering the number of lesions observed with the following sequences: (1) respiratory-triggered diffusion-weighted single-shot echo-planar (DW SS-EP) sequences; (2) fat-suppressed fast spin-echo (fs-FSE) T2 weighted sequences; (3) steady-state free precession (SSFP) images; and (4) dynamic triphasic gadolinium-enhanced images, acquired with three-dimensional fast spoiled gradient-echo (3D FSPGR). Two radiologists independently reviewed the images: they were blinded to their respective reports. DW SS-EP sequences were compared to fs-FSE, SSFP and dynamic gadolinium-enhanced acquisitions using a t -test. Pairs were compared for the detection of: (1) all FLLs; (2) benign FLLs; (3) malignant FLLs; (4) metastases; and (5) hepatocellular carcinoma (HCC). RESULTS: Interobserver agreement was very good (weighted = 0.926, CI = 0.880-0.971); on the consensus reading, 277 FLLs were detected. In the comparison with fs-FSE, DW SS-EP sequences had a significantly higher score in the detection of all FLLs, benign FLLs, malignant FLLs and metastases; no statistical difference was observed in the detection of hepatocellular carcinoma (HCCs). In the comparison with SSFP sequences, DW SS-EP had significantly higher scores (P < 0.05) in the detection of all lesions, benign lesions, malignant lesions, metastases and HCC. All FLLs were better detected by dynamic 3D FSGR enhanced acquisition, with P = 0.0023 for reader 1 and P = 0.0086 for reader 2 in the comparison with DW SS-EP sequences; with reference to benign FLLs, DW SS-EP showed lower values than 3D FSPGR enhanced acquisition (P < 0.05). No statistical differences were observed in the detection of malignant lesions and metastases; considering HCCs, a very slight difference was reported by reader 1 (P = 0.049), whereas no difference was found by reader 2 (P = 0.06). CONCLUSION: In lesion detection, DWI had higher scores than T2 sequences; considering malignant FLLs, no statistical difference was observed between DWI and dynamic gadolinium images. | Stefano Palmucci Letizia Antonella Mauro Martina Messina Brunella Russo Giovanni Failla Pietro Milone Massimiliano Berretta Giovanni Carlo Ettorre | 2012 | World Journal of Radiology2012，4，7： | 11 |
| 2 | Bariatric surgery and long-term nutritional issues显示文摘Bariatric surgery is recognized as a highly effective therapy for obesity since it accomplishes sustained weight loss, reduction of obesity-related comorbidities and mortality, and improvement of quality of life. Overall, bariatric surgery is associated with a 42% reduction of the cardiovascular risk and 30% reduction of all-cause mortality. This review focuses on some nutritional consequences that can occur in bariatric patients that could potentially hinder the clinical benefits of this therapeutic option. All bariatric procedures, to variable degrees, alter the anatomy and physiology of the gastrointestinal tract; this alteration makes these patients more susceptible to developing nutritional complications, namely, deficiencies of macro-and micro-nutrients, which could lead to disabling diseases such as anemia, osteoporosis, protein malnutrition. Of note is the evidence that most obese patients present a number of nutritional deficits already prior to surgery, the most important being vitamin D and iron deficiencies. This finding prompts the need for a complete nutritional assessment and, eventually, an adequate correction of pre-existing deficits before surgery. Another critical issue that follows bariatric surgery is post-operative weight regain, which is commonly associated with the relapse of obesity-related comorbidities. Nu-tritional complications associated with bariatric surgery can be prevented by life-long nutritional monitoring with the administration of multivitamins and mineral supplements according to the patient's needs. | Roberta Lupoli Erminia Lembo Gennaro Saldalamacchia Claudia Kesia Avola Luigi Angrisani Brunella Capaldo | 2017 | World Journal of Diabetes2017，8，11： | 8 |
| 3 | Poly(NIPAM-co-MPS)-grafted multimodal porous silica nanoparticles as reverse thermoresponsive drug delivery system显示文摘Hybrid drug delivery systems(DDS) have been prepared by grafting poly(NIPAM-co-MPS) chains on multimodal porous silica nanoparticles having an inner mesoporous structure and an outer thin layer of micropores. The hybrid thermoresponsive DDS were fully characterized and loaded with a model drug. The in vitro drug release tests are carried out at below and above the lower critical solution temperature(LCST) of the copolymer. The results have revealed that due to the presence of small diameter(~1.3 nm) micropores at the periphery of the particles, the collapsed globules of the thermoresponsive copolymer above its LCST hinders the complete release of the drug which resulted in a reverse thermoresponsive drug release profile by the hybrid DDS. | Sushilkumar A.Jadhav Valentina Brunella Dominique Scalarone Gloria Berlier | 2017 | Asian Journal of Pharmaceutical Sciences2017，12，3： | 3 |
| 4 | Magnetic Resonance Imaging of Cholangiocarcinoma显示文摘 | Riccardo Manfredi Brunella Barbaro Gabriele Masselli Amorino Vecchioli Pasquale Marano | 2004 | Semin Liver Dis2004，，02： | 2 |
| 5 | Topological equivalence of a place vector field with its principal past defined through Newton polyhedra显示文摘 | BRUNELLA M MIARIM | 1990 | J Differential Equations1990，85，： | 1 |
| 6 | Tandem mass spec- trometry in food safety assessment: The determination of phthalates in olive oil显示文摘 | Brunella C Barbara M Giovanni S | 2008 | J Chromatogr A2008，1205，12： | 1 |
| 7 | Characterization of bacterial pectinolytic strains involved in the water retting process显示文摘 | Elena Tamburini Alicia Gordillo León Brunella Perito | 2003 | Environmental Microbiology2003，5，9： | 1 |
| 8 | Calorimetry of or- dering and disordering in AuCu alloys 显示文摘 | Battezzati L Belotti M Brunella V | 2001 | Scripta Ma- terialia2001，44，： | 1 |
| 9 | Complete and efficient enzymic hydrolysis of pretreated wheat straw显示文摘 | NicolettaCurreli Mario Agelli Brunella Pisu | 2002 | Process Biochemistry2002，37，： | 1 |
| 10 | Complete and efficient enzymatic hydrolysis of pretreated wheat straw显示文摘 | Nicoletta C Mario A Brunella P | 2002 | Process Biochemistry2002，37，： | 1 |
| 11 | Effect of Medium-term Supplementation with a Moderate Dose of n-3 Polyunsaturated Fatty Acids on Blood Pressure in Mild Hypertensive Patients显示文摘 | Domenico Prisco Rita Paniccia Brunella Bandinelli Monica Filippini Isa Francalanci Betti Giusti Letizia Giurlani Gian Franco Gensini Rosanna Abbate Gian Gastone Neri Serneri | 1998 | Thrombosis Research1998，，3： | 1 |
| 12 | Nitroge- nous ComPonents of Human Milk: Non-Protein Nitrogen, True Pro- tein and Free Amino Acids显示文摘 | BRUNELLA C CONCETTA B FRANCESCO S | 2003 | Food Chemistry2003，81，3： | 1 |
| 13 | Diffusion-weighted MRI in a liver protocol: Its role in focal lesion detection显示文摘 | Stefano Palmucci Letizia Antonella Mauro Martina Messina Brunella Russo Giovanni Failla Pietro Milone Massimiliano Berretta Giovanni Carlo Ettorre | | World Journal of Radiology0，，： | 1 |
| 14 | Stabilisation of ultra- high molecular weight polyethylene with vitamin E显示文摘 | Bracco P Brunella V Zanetti M | 2007 | PolymerDegradation and Stability2007，92，12： | 1 |
| 15 | Fatigue behavior of pipeline steel under hydrogen environment and low temperature显示文摘 | Fassina P Brunella F Lazzari L | 2011 | Procedia Engineering2011，10，： | 1 |
| 16 | Microcal cification and and psammomabo diesinthyroidtumors 显示文摘 | Vincenzo T Edoardo G Brunella L | 2008 | Thyroid2008，18，9： | 1 |
| 17 | Determinants of Reduction of Coronary Flow Reserve in Patients With Type 2 Diabetes Mellitus or Arterial Hypertension Without Angiographically Determined Epicardial Coronary Stenosis显示文摘 | Maurizio Galderisi Brunella Capaldo Milena Sidiropulos Arcangelo D’Errico Luigi Ferrara Annamelia Turco Pasquale Guarini Gabriele Riccardi Oreste de Divitiis | 2007 | American Journal of Hypertension2007，，： | 1 |
| 18 | Microcalcifications and psammoma bodies in thyroid tumors显示文摘 | Vincenzo T Edoardo G Brunella L | 2008 | Thyroid2008，18，9： | 1 |
| 19 | in vitro activities of anidulafungin and other antifungal agents against biofilms formed by clinical isolates of different candida and aspergillus species antimicrob 显示文摘 | Barbara Fiori Brunella Posteraro Riccardo Torelli | 2011 | Agents Chemother2011，55，6： | 1 |
| 20 | Crosslinked SPEEK membranes:Mechanical, thermal, and hydrothermal properties显示文摘 | Hou Hongying Brunella M Jean-Francois C | 2012 | J Mater Research2012，27，15： | 1 |
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