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| 1 | Minimally invasive surgery for gastric cancer: A comparison between robotic, laparoscopic and open surgery显示文摘AIM To investigate the role of minimally invasive surgery for gastric cancer and determine surgical, clinical, and oncological outcomes.METHODS This is a propensity score-matched case-control study, comparing three treatment arms: robotic gastrectomy(RG), laparoscopic gastrectomy(LG), open gastrectomy(OG). Data collection started after sharing a specific study protocol. Data were recorded through a tailored and protected web-based system. Primary outcomes: harvested lymph nodes, estimated blood loss, hospital stay, complications rate. Among the secondary outcomes, there are: operative time, R0 resections, POD of mobilization, POD of starting liquid diet and soft solid diet. The analysis includes the evaluation of type and grade of postoperative complications. Detailed information of anastomotic leakages is also provided.RESULTS The present analysis was carried out of 1026 gastrectomies. To guarantee homogenous distribution of cases, patients in the RG, LG and OG groups were 1:1:2 matched using a propensity score analysis with a caliper = 0.2. The successful matching resulted in a total sample of 604 patients(RG = 151; LG = 151; OG = 302). The three groups showed no differences in all baseline patients characteristics, type of surgery(P = 0.42) and stage of the disease(P = 0.16). Intraoperative blood loss was significantly lower in the LG(95.93 ± 119.22) and RG(117.91 ± 68.11) groups compared to the OG(127.26 ± 79.50, P = 0.002). The mean number of retrieved lymph nodes was similar between the RG(27.78 ± 11.45), LG(24.58 ± 13.56) and OG(25.82 ± 12.07) approach. A benefit in favor of the minimally invasive approaches was found in the length of hospital stay(P < 0.0001). A similar complications rate was found(P = 0.13). The leakage rate was not different(P = 0.78) between groups.CONCLUSION Laparoscopic and robotic surgery can be safely performed and proposed as possible alternative to open surgery. The main highlighted benefit is a faster postoperative functional recovery. | Amilcare Parisi Daniel Reim Felice Borghi Ninh T Nguyen Feng Qi Andrea Coratti Fabio Cianchi Maurizio Cesari Francesca Bazzocchi Orhan Alimoglu Johan Gagnière Graziano Pernazza Simone D'Imporzano Yan-Bing Zhou Juan-Santiago Azagra Olivier Facy Steven T Brower Zhi-Wei Jiang Lu Zang Arda Isik Alessandro Gemini Stefano Trastulli Alexander Novotny Alessandra Marano Tong Liu Mario Annecchiarico Benedetta Badii Giacomo Arcuri Andrea Avanzolini Metin Leblebici Denis Pezet Shou-Gen Cao Martine Goergen Shu Zhang Giorgio Palazzini Vito D'Andrea Jacopo Desiderio | 2017 | World Journal of Gastroenterology2017，23，13： | 17 |
| 2 | Clinical management of advanced gastric cancer: The role of new molecular drugs显示文摘Gastric cancer is the fourth most common malignant neoplasm and the second leading cause of death for cancer in Western countries with more than 20000 new cases yearly diagnosed in the United States.Surgery represents the main approach for this disease but,notwithstanding the advances in surgical techniques,we observed a minimal improvement in terms of overall survival with a significant increasing of relapsing disease rates.Despite the development of new drugs has significantly improved the effectiveness of chemothera-py,the prognosis of patients with unresectable or metastatic gastric adenocarcinoma remains poor.Recently,several molecular target agents have been investigated;in particular,trastuzumab represents the first target molecule showing improvements in overall survival in human epithelial growth factor 2-positive gastric cancer patients.New molecules targeting vascular epithelial growth factor,mammalian target of rapamycin,and anti hepatocyte growth factor-c-Met pathway are also under investigation,with interesting results.Anyway,it seems necessary to select more accurately the population to treat with new agents by the identification of new biomarkers in order to optimize the results.In this paper we review the actual'scenario'of targeted treatments,also focusing on the new agents in development for gastric cancer and gastro-esophageal carcinoma,discussing their efficacy and potential applications in clinical practice. | Ferdinando De Vita Natale Di Martino Alessio Fabozzi Maria Maddalena Laterza Jole Ventriglia Beatrice Savastano Angelica Petrillo Valentina Gambardella Vincenzo Sforza Luigi Marano Annamaria Auricchio Gennaro Galizia Fortunato Ciardiello Michele Orditura | 2014 | World Journal of Gastroenterology2014，20，40： | 12 |
| 3 | Helicobacter pylori infection and gastric carcinoma:Not all the strains and patients are alike显示文摘Gastric carcinoma(GC) develops in only 1%-3% of Helicobacter pylori(H. pylori) infected people. The role in GC formation of the bacterial genotypes, gene polymorphisms and host's factors may therefore be important. The risk of GC is enhanced when individuals are infected by strains expressing the oncoprotein CagA, in particular if CagA has a high number of repeats containing the EPIYA sequence in its C'-terminal variable region or particular amino acid sequences flank the EPIYA motifs. H. pylori infection triggers an inflammatory response characterised by an increased secretion of some chemokines by immunocytes and colonised gastric epithelial cells; these molecules are especially constituted by proteins composing the interleukin-1beta(IL-1β) group and tumour necrosis factor-alpha(TNF-α). Polymorphisms in the promoter regions of genes encoding these molecules, could account for high concentrations of IL-1β and TNF-α in the gastric mucosa, which may cause hypochlorhydria and eventually GC. Inconsistent results have been attained with other haplotypes of inflammatory and anti-inflammatory cytokines. Genomic mechanisms of GC development are mainly based on chromosomal or microsatellite instability(MSI) and deregulation of signalling transduction pathways. H. pylori infection may induce DNA instability and breaks of double-strand DNA in gastric mucocytes. Different H. pylori strains seem to differently increase the risk of cancer development run by the host. Certain H. pylori genotypes(such as the cagA positive) induce high degrees of chronic inflammation and determine an increase of mutagenesis rate, oxidative-stress, mismatch repair mechanisms, down-regulation of base excision and genetic instability, as well as generation of reactive oxygen species that modulate apoptosis; these phenomena may end to trigger or concur to GC development. | natale figura luigi marano elena moretti antonio ponzetto | 2016 | World Journal of Gastrointestinal Oncology2016，8，1： | 8 |
| 4 | Subcutaneous Golimumab Induces Clinical Response and Remission in Patients with Moderate-To-Severe Ulcerative Colitis显示文摘 | William J. Sandborn Brian G. Feagan Colleen Marano Hongyan Zhang Richard Strauss Jewel Johanns Omoniyi J. Adedokun Cynthia Guzzo Jean-Frederic Colombel Walter Reinisch Peter R. Gibson Judith Collins Gunnar J?rnerot Toshifumi Hibi Paul Rutgeerts | 2013 | Gastroenterology2013，，： | 6 |
| 5 | Subcutaneous Golimumab Maintains Clinical Response in Patients with Moderate-To-Severe Ulcerative Colitis显示文摘 | William J. Sandborn Brian G. Feagan Colleen Marano Hongyan Zhang Richard Strauss Jewel Johanns Omoniyi J. Adedokun Cynthia Guzzo Jean-Frederic Colombel Walter Reinisch Peter R. Gibson Judith Collins Gunnar J?rnerot Paul Rutgeerts | 2013 | Gastroenterology2013，，： | 5 |
| 6 | Laparoscopic calibrated total vs partial fundoplication following Heller myotomy for oesophageal achalasia显示文摘AIM:To compare the mid-term outcomes of laparoscopic calibrated Nissen-Rossetti fundoplication with Dor fundoplication performed after Heller myotomy for oesophageal achalasia.METHODS:Fifty-six patients(26 men,30 women;mean age 42.8±14.7 years)presenting for minimally invasive surgery for oesophageal achalasia,were enrolled.All patients underwent laparoscopic Heller myotomy followed by a 180°anterior partial fundoplication in 30 cases(group 1)and calibrated NissenRossetti fundoplication in 26(group 2).Intraoperative endoscopy and manometry were used to calibrate the myotomy and fundoplication.A 6-mo follow-up period with symptomatic evaluation and barium swallow was undertaken.One and two years after surgery,the patients underwent symptom questionnaires,endoscopy,oesophageal manometry and 24 h oesophago-gastric pH monitoring.RESULTS:At the 2-year follow-up,no significant difference in the median symptom score was observed between the 2 groups(P=0.66;Mann-WhitneyU-test).The median percentage time with oesophageal pH< 4 was significantly higher in the Dor group compared to the Nissen-Rossetti group(2;range 0.8-10 vs 0.35;range 0-2)(P<0.0001;Mann-WhitneyU-test).CONCLUSION:Laparoscopic Dor and calibrated Nissen-Rossetti fundoplication achieved similar results in the resolution of dysphagia.Nissen-Rossetti fundoplication seems to be more effective in suppressing oesophageal acid exposure. | Natale Di Martino Antonio Brillantino Luigi Monaco Luigi Marano Michele Schettino Raffaele Porfidia Giuseppe Izzo Angelo Cosenza | 2011 | World Journal of Gastroenterology2011，17，29： | 4 |
| 7 | 采用意大利多中心前瞻性研究以评估16层及64层MDCT对计划行冠状动脉造影病人的阴性预测值(NIMISCAD-意大利冠心病无创性多中心性研究)显示文摘这是一项多中心的前瞻性研究.通过应用不同制造商生产的MDCT设备,对计划行选择性冠状动脉造影(CA)的病人行MDCT检查以对其诊断冠心病(CAD)的价值进行评估。2004年7月-2006年6月间.在20所国家医院前瞻性地征集了367例病人。对于每种类型的MDCT(≥16层),CT检查均采用标准化/优化的扫描方案,并且与2周内进行的定量冠状动脉造影比较。共有284例病人(81%)应用16层MDCT进行检查,66例病人(19%)应用64层MDCT进行检查。初步分析采用院内/院外的方法,评估对1例病人的阴性预测值(NPV)。 | R. Marano F. De Cobelli I. Floriani C. Becker C. Herzog M. Centonze 王卿(译) 李威(校) | 2009 | 国际医学放射学杂志2009，32，4： | 3 |
| 8 | Early Mucosal Healing With Infliximab Is Associated With Improved Long-term Clinical Outcomes in Ulcerative Colitis显示文摘 | Jean Frédéric Colombel Paul Rutgeerts Walter Reinisch Dirk Esser Yanxin Wang Yinghua Lang Colleen W. Marano Richard Strauss Bj?rn J. Oddens Brian G. Feagan Stephen B. Hanauer Gary R. Lichtenstein Daniel Present Bruce E. Sands William J. Sandborn | 2011 | Gastroenterology2011，，4： | 3 |
| 9 | 实测模态下三跨整体桥精细化基准有限元模型显示文摘以一座新建的整体式桥台桥梁(简称整体桥)为工程背景,建立服务于健康监测的精细化基准动力有限元模型.将设计阶段基于梁格法建立的全桥三维模型与采用梁-壳单元的精细化模型作为初始有限元模型,把环境激励下获取的实测模态信息(自振频率与振型)作为参照,基于参数灵敏度分析修正了上述两种结构模型.结果表明:尽管两种模型修正后都可以获得与实测模态尤其是频率值较好的吻合度,但修正后的梁格模型的模型参数严重偏离其真实的物理意义,难以作为长期监测的基准模型;而修正后的精细化梁-壳单元模型的模型参数物理意义明确,可以作为计入环境因素影响(如温度、湿度等)的结构长期监测的基准模型.该研究还基于动力试验和模型分析结果讨论了整体桥特有的结构-土相互作用的问题. | 张志勇 何乐洽 薛俊青 陈梦圆 黄福云 Giuseppe Carlo Marano Bruno Briseghella | 2022 | 福州大学学报(自然科学版)2022，50，2： | 2 |
| 10 | A prospective trial comparing small bowel radiographs and video capsule endoscopy for suspected small bowel disease显示文摘 | Guido Costamagna Saumil K. Shah Maria Elena Riccioni Francesca Foschia Massimiliano Mutignani Vincenzo Perri Amorino Vecchioli Maria Gabriella Brizi Aurelio Picciocchi Pasquale Marano | 2002 | Gastroenterology2002，，4： | 2 |
| 11 | Magnetic Resonance Imaging of Cholangiocarcinoma显示文摘 | Riccardo Manfredi Brunella Barbaro Gabriele Masselli Amorino Vecchioli Pasquale Marano | 2004 | Semin Liver Dis2004，，02： | 2 |
| 12 | 地铁列车驾驶技术发展综述:从人工驾驶到智能无人驾驶显示文摘基于国内外地铁列车驾驶技术的发展现状,提出并阐述了地铁列车驾驶技术发展的4个阶段为人工驾驶、自动驾驶、无人驾驶、智能无人驾驶。概括了我国无人驾驶地铁列车的建设情况,针对目前基于神经网络这类机器学习方法的列车控制方法可解释性差的弊端,引入了深度模糊系统的概念,提出了基于人机混合智能的地铁智能无人驾驶基本框图,为将处理紧急情况的专家经验、人工智能算法和无人驾驶系统结合起来,实现智能无人驾驶提供了一种具有前景的解决思路。 | 赖文柱 陈德旺 何振峰 邓新国 GIUSEPPE CARLO Marano | 2022 | 智能科学与技术学报2022，4，3： | 2 |
| 13 | Call admission control and resource management issues for real-time VBR traffic in ATM-satellite networks 显示文摘 | Iera A Molinaro A Marano S | 2000 | IEEE J Select Areas Commun2000，18，11： | 1 |
| 14 | Damage and ductility demand spectra assessment of hysteretic degrading systems subject to stochastic seismic loads 显示文摘 | Marano G C Greco R | 2006 | Journal of Earthquake Engineering2006，10，5： | 1 |
| 15 | MR imaging and MRCP of hilar cholangiocarcinoma显示文摘 | R. Manfredi G. Masselli G. Maresca M. G. Brizi A. Vecchioli P. Marano | 2003 | Abdominal Imaging2003，，3： | 1 |
| 16 | Clinical and Immunological Impact of Early Postoperative Enteral Immunonutrition After Total Gastrectomy in Gastric Cancer Patients: A Prospective Randomized Study显示文摘 | Luigi Marano Raffaele Porfidia Modestino Pezzella Michele Grassia Marianna Petrillo Giuseppe Esposito Bartolomeo Braccio PierLuigi Gallo Virginia Boccardi Angelo Cosenza Giuseppe Izzo Natale Di Martino | 2013 | Annals of Surgical Oncology2013，，12： | 1 |
| 17 | PAGER-CAT:A Composite Earthquake Catalog for Calibrating Global Fatality Models显示文摘 | TrevorI Allen Kristin D Marano | | 0，，01： | 1 |
| 18 | Zika virus and the never-ending story of emerging pathogens and transfusion medicine显示文摘 | MARANO G PUPELLA S VAGLIO S | 2016 | Blood Transfus2016，14，2： | 1 |
| 19 | Increased pr- evalence of type 2 diabetes mellitus among psychiatric in- patients with bipolar I affective and schizoaffective disor- ders independent of psychotropic drug use 显示文摘 | Regenold WT Thapar RK Marano C | 2002 | J Affect Disord2002，70，1： | 1 |
| 20 | Traffic management techniques to face the effects of intrinsic delays in geostationary satellite networks 显示文摘 | Iera A Molinaro A Marano S | 2002 | IEEE Trans on Wireless Communications2002，1，1： | 1 |
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