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| 1 | Reduction of Cancer Risk With an Oral Supplement of Selenium显示文摘The hypothesis that a dietary Supplement of selenium (Se) may reduce cancer risk was tested experimetally in humans. Patients with histories of basal/squarnous cell carcinomas of the skin were assigned randomly in double-blind fashion to dally oral supplements of either Seenriched yeast (200 μg Se/day), or a low-Se yeast placebo. A total of 1312 patients recruited in 1983-1990 were followed with regular dermatologic examinations through 1993 for a total of 8269 person-years of observation. Skin cancer diagnoses were confirmed histologically.Plasma Se concentration was determined at 6-12 months intervals. All deaths and patient-reported illnesses were recorded; reported cancers were confirmed and documented by consultation with the patient medical care providers. The results indicate that Se did not significantly affect the primary endpoints: incidences of recurrent basal/squarnous cell carcinomas of the skin. However, Setreatment was associated with reductions in several secondary endpoints:total mortality, mortality from all cancers combined, as well as the incidence of all cancers combined, lung cancer, colorectal cancer and prostate cancer. The consistencies of these associations over time, between study clinics and for the leading cancer sltes strongly suggests benefits of Se-supplementation for this cohort of patients, supporting the hypopthesis that supplemental Se can reduce cancer risk. Although Se did no shown protective effects against nonmelanoma skin cancers, the suggested reductions in risks to other frequent cancers demand further evaluation in well controlled cliflical intervention | G·F·COMBSJR L·C·CLARK 等 | 1997 | Biomedical and Environmental Sciences1997，10，2： | 21 |
| 2 | Irritable bowel syndrome: A microbiome-gut-brain axis disorder?显示文摘Irritable bowel syndrome(IBS) is an extremely prevalent but poorly understood gastrointestinal disorder. Consequently, there are no clear diagnostic markers to help diagnose the disorder and treatment options are limited to management of the symptoms. The concept of a dysregulated gut-brain axis has been adopted as a suitable model for the disorder. The gut microbiome may play an important role in the onset and exacerbation of symptoms in the disorder and has been extensively studied in this context. Although a causal role cannot yet be inferred from the clinical studies which have attempted to characterise the gut microbiota in IBS, they do confirm alterations in both community stability and diversity. Moreover, it has been reliably demonstrated that manipulation of the microbiota can influence the key symptoms, including abdominal pain and bowel habit, and other prominent features of IBS. A variety of strategies have been taken to study these interactions, including probiotics, antibiotics, faecal transplantations and the use of germ-free animals. There are clear mechanisms through which the microbiota can produce these effects, both humoral and neural. Taken together, these findings firmly establish the microbiota as a critical node in the gut-brain axis and one which is amenable to therapeutic interventions. | Paul J Kennedy John F Cryan Timothy G Dinan Gerard Clarke | 2014 | World Journal of Gastroenterology2014，20，39： | 20 |
| 3 | CALUX生物学检测二噁方法在环境流行病学调查中的应用显示文摘目的探讨Chemically-ActivatedLuciferaseeXpression(CALUX)生物学方法作为检测二的一种方法在环境流行病学调查中的实用性。方法分别采用高分辨率气相色谱和质谱仪联机(HRGC-MS)法和CALUX方法测定同一来源的人体脂肪、血液和母乳中二毒性当量,观察两种不同方法测定结果间的相关性。结果两种方法测定脂肪组织和母乳中二毒性当量结果之间的相关系数分别为0.8675和0.9581,具有显著的正相关关系(P<0.05)。二毒性当量>20pg/gfat的血液样品,两种方法测定结果之间也具有密切的相关关系(P<0.05或<0.01)。结论CALUX生物学方法可适用于一般人群的脂肪组织和乳汁样品以及二类暴露人群的血液中二类污染物的筛查。 | 金一和 陈慧池 唐慧君 金秀花 刘惠芳 李珍 香山不二雄 滨松昌彦 匂坂馨 Brown D Clark G 中村昌文 | 2003 | 环境与健康杂志2003，20，3： | 6 |
| 4 | Passive Immunization of Channel Catfish (Ictalurus punctatus) against the Ciliated Protozoan Parasite Ichthyophthirius multifiliis by Use of Murine Monoclonal Antibodies显示文摘 | Lin Tian-Long Clark T G Dickerson H W | 1996 | Infection and Immunity1996，64，10： | 2 |
| 5 | Immunisation of Channel Catfish, Ictalurus punctatus, with Ichthyophthirius multifiliis Immobilisation antigens elicits serotype-specific protection 显示文摘 | Wang Xu-Ting Clark T G Jane Noe | 2002 | Fish Shellfish Immunol2002，13，： | 2 |
| 6 | The Effects of Pedicle Screw Fit: An In Vitro Study显示文摘 | Anna G U Brantley Jack K. Mayfield James B. Koeneman Kathleen R. Clark | 1994 | Spine1994，，15： | 2 |
| 7 | The gene for an abundant parasite coat protein predicts tandemly repetitive mental binding domains 显示文摘 | Clark T G Lin Tian-Long Jackwood D A | 1999 | Gene1999，229，： | 2 |
| 8 | Immune response of fish to ciliates显示文摘 | Dickerson H W Clark T G | 1996 | Annu Rev of Fish Dis1996，6，： | 2 |
| 9 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 10 | Circular voided slab stiffness显示文摘 | ELLIOT G CLARK L A | 1982 | Journal of the Structural Division ASCE1982，108，11： | 2 |
| 11 | Scheduling of vehicles from a central depot to a number of delivery points显示文摘 | CLARK G WRIGHT J W | 1964 | Operations Research1964，12，： | 2 |
| 12 | Epigenetic pathways and glioblastoma treatment显示文摘 | Jennifer Clarke Clara Penas Chiara Pastori Ricardo J Komotar Amade Bregy Ashish H Shah Claes Wahlestedt Nagi G Ayad | 2013 | Epigenetics2013，，8： | 2 |
| 13 | Fate of metals in waste combustion systems 显示文摘 | Barton R G Clark W D Seeker W R | 1990 | Combustion Science and Technology1990，74，： | 1 |
| 14 | A novel integrated in vitro maturation and in vitro fertilization system for swine显示文摘 | Clark S G Walters E M Beebe D J | 2003 | Theriogenology2003，59，： | 1 |
| 15 | Meningeal melanocytoma:Report of a case and a historical comparison显示文摘 | Clarke DB Leblane R Bertrand G | 1998 | J Neurosurg1998，88，1： | 1 |
| 16 | Stabilization of IFN-{gamma} mRNA by MAPK p38 in IL-12-and IL-18-stimulated human NK cells显示文摘 | Sully G Cope AP Clark AR | 2004 | Blood2004，2，： | 1 |
| 17 | Lipidomic analysis of the molecular specificity of a cholinephosphotransferase in situ显示文摘 | FENN H C CLARK G T | 2004 | Biochem Soc Trans2004，32，6： | 1 |
| 18 | Targeting and therapy of carcinoembryonic antigen-expressing tumors in transgenic mice with an antibody-interleukin 2 fusion protein显示文摘 | Clarke P Szalai G | 2000 | Cancer Res2000，60，16： | 1 |
| 19 | Collecting 48000 CT exams for the lung screening study of the National lung screening trial显示文摘 | Clark KW Gierada DS Marquez G | 2009 | J Diagit Imaging2009，22，6： | 1 |
| 20 | Amniotic fluid concentrations of matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase during pregnancy and labor 显示文摘 | Lock smith G J Clark P DuffP | 2001 | Am J Obstet Gynecol2001，184，2： | 1 |
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