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| 1 | EGFR and HER2 expression in advanced biliary tract cancer显示文摘AIM:To analyze the pathogenetic role and potential clinical usefulness of the epidermal growth factor receptor(EGFR)and the human epidermal growth factor receptor 2(HER2)in patients with advanced biliary tract cancer(BTC). METHODS:EGFR and HER2 expression was studied in biopsy samples from 124 patients(51%women; median age 64.8 years),with advanced BTC diagnosed between 1997 and 2004.Five micrometers sections of paraffin embedded tissue were examined by standard, FDA approved immunohistochemistry.Tumors with scores of 2+or 3+for HER2 expression on immunochemistry were additionally tested for HER2 gene amplification by fluorescence in situ hybridisation(FISH).RESULTS:34/124 patients(27.4%)had gallbladder cancer,47(37.9%)had intrahepatic BTC and 43(34.7%)had extrahepatic or perihilar BTC.EGFR expression was examined in a subset of 56 samples. EGFR expression was absent in 22/56 tumors(39.3%). Of the remaining samples expression was scored as 1+in 12(21.5%),2+in 13(23.2%)and 3+in 9(16%), respectively.HER2 expression was as follows:score 0 73/124(58.8%),score 1+27/124(21.8%),score 2+ 21/124(17%)and score 3+4/124(3.2%).HER2 gene amplification was present in 6/124,resulting in an overall amplification rate of 5%. CONCLUSION:Our data suggest that routine testing and therapeutic targeting of HER2 does not seem to be useful in patients with BTC,while targeting EGFR may be promising. | Jan Harder Oliver Waiz Florian Otto Michael Geissler Manfred Olschewski Brigitte Weinhold Hubert E Blum Annette Schmitt-Graeff Oliver G Opitz | 2009 | World Journal of Gastroenterology2009，15，36： | 18 |
| 2 | Folic acid supplementation, MTHFR and MTRR polymorphisms, and the risk of childhood leukemia: the ESCALE study (SFCE)显示文摘 | Alicia Amigou Jérémie Rudant Laurent Orsi Stéphanie Goujon-Bellec Guy Leverger André Baruchel Yves Bertrand Brigitte Nelken Geneviève Plat Gérard Michel Stéphanie Haouy Pascal Chastagner Stéphane Ducassou Xavier Rialland Denis Hémon Jacqueline Clavel | 2012 | Cancer Causes & Control2012，，8： | 2 |
| 3 | PPARγ Activation Primes Human Monocytes into Alternative M2 Macrophages with Anti-inflammatory Properties显示文摘 | M. Amine Bouhlel Bruno Derudas Elena Rigamonti Rébecca Dièvart John Brozek Stéphan Haulon Christophe Zawadzki Brigitte Jude Gérard Torpier Nikolaus Marx Bart Staels Giulia Chinetti-Gbaguidi | 2007 | Cell Metabolism2007，，2： | 2 |
| 4 | Stress in recombinant protein producing yeasts 显示文摘 | Diethard M Brigitte G Hubertus H | 2004 | Journal of Biotechnology2004，113，13： | 1 |
| 5 | Analysis of photoperiod sensitivity within a collection of tropical maize populations 显示文摘 | BRIGITTE G CECILE R CLAUDE W | 2002 | Genetic Resources and Crop Evolution2002，49，： | 1 |
| 6 | Role of the host cell cycle in theAgrobacterium-mediated genetic transformation ofPetunia: Evidence of an S-phase control mechanism for T-DNA transfer显示文摘 | Estelle Villemont Frédéric Dubois Rajbir S. Sangwan Gérard Vasseur Yvan Bourgeois Brigitte S. Sangwan-Norreel | 1997 | Planta1997，，2： | 1 |
| 7 | Dietary essential fatty acid differentially affect tissues of rat显示文摘 | Jeus G Jacques G Brigitte P | 1996 | J Nutr1996，126，： | 1 |
| 8 | Structural Changes of Cassava Starch Granules after Heating at Intermediate Water Contents显示文摘 | Veronique G Paul C Brigitte B | 1997 | Starch1997，49，5： | 1 |
| 9 | Struc-tural Changes of Cassava Starch Granules After Heat- ing at Intermediate Water Contents 显示文摘 | VERONIQUE G PAUL C BRIGITTE B | 1997 | Starch1997，49，5： | 1 |
| 10 | CD44s and CD44v6 expression in head and neck epithelia显示文摘 | Brigitte M Olivier G | 2008 | PLoS ONE2008，3，10： | 1 |
| 11 | Innovation and network structural dynamics study of the alliance network of a ma jor sector of the biotechnology显示文摘 | BRIGITTE G BERNARD D | 2005 | Research Policy2005，34，10： | 1 |
| 12 | Endocrine therapy Plus zoledronic acid in premenopausal breast cancer 显示文摘 | Michael G Brigitte M Walter S | 2009 | N Engl J Med2009，360，7： | 1 |
| 13 | Dietary essential fatty acid differentially affect tissues of rat显示文摘 | Jeus G Jacques G brigitte P et a1 | 1996 | J Nutr1996，126，： | 1 |
| 14 | Analysis of photoperiod sensitivity with in a collection of tropical maize populations 显示文摘 | Brigitte G Cebile R Claude W | 2002 | Genetic Resources and Crop Evolution2002，49，： | 1 |
| 15 | Comparison of an array of in vitro assays for the assessment of the estrogenic potential of natural and synthetic estrogens,phytoestrogens and xenoestrogens显示文摘 | Brigitte G Johannes W | 2001 | Toxicology2001，166，1： | 1 |
| 16 | Structural Changes of Cassava Starch Granules after Heating at Intermediate Water Contents显示文摘 | Veronique G Paul C Brigitte B | 1997 | Starch1997，49，5： | 1 |
| 17 | Analysis of abscisic acid responsive proteins in Brassica napus guard cells by multiplexed isobaric tagging 显示文摘 | Zhu M M Brigitte S Ning Z David G Chen S X | 2010 | Journal of Proteomics2010，73，4： | 1 |
| 18 | Disposition and metabolism of quercetin-4'-glucoside in rats 显示文摘 | BRIGITTE A G WILLIAM M STUART T C | 2005 | Drug Metab Dispos2005，33，7： | 1 |
| 19 | Postprandial variations in the activity of polysaccharide-degrading enzymes of fluid- and particle-associated ruminal microbial populations显示文摘 | Dr. Cécile Martin Brigitte Michalet-Doreau Gérard Fonty Alan Williams | 1993 | Current Microbiology1993，，4： | 1 |
| 20 | Histone Deacetylases Activate Hepatocyte Growth Factor Signaling by Repressing MicroRNA-449 in Hepatocellular Carcinoma Cells显示文摘 | Reena Buurman Engin Gürlevik Vera Sch?ffer Marlies Eilers Maria Sandbothe Hans Kreipe Ludwig Wilkens Brigitte Schlegelberger Florian Kühnel Britta Skawran | 2012 | Gastroenterology2012，，3： | 1 |
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