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| 1 | Protective effects of trilinolein extracted from Panax notoginseng against cardiovascular disease显示文摘Trilinolein is a triacylglycerol purified from a commonly used traditional Chinese medicine Panax notoginseng,Trilinolein has been reported to provide a number of beneficial effects including reducing thrombogenicity and arrhythmias and increasing erythrocyte deformability.Additionally,trilinolein has been reported to be an antioxidant,which can counteract free radical damage associated with atherogenesis,and myocardial damage seen with ischaemia and reperfusion.These pharmacologic effects may explain the perceived benefits derived from treating circulatory disorders with the herb over the centuries. | Paul CHAN G Neil THOMAS Brian TOMLINSON | 2002 | Acta Pharmacologica Sinica2002，23，12： | 45 |
| 2 | 黄芪总黄酮对扑热息痛所致小鼠肝损伤防护作用的研究显示文摘目的 :研究黄芪总黄酮 (TFA)对扑热息痛所致肝损伤的防护作用。方法 :用 1%羧甲基纤维素钠 10ml·kg-1,TFA10 0mg·kg-1或维生素C (Ascorbicacid ,VC) 10 0 0mg·kg-1给小鼠灌胃 1h后 ,灌扑热息痛 10 0 0mg·kg-1,观察小鼠死亡率的变化 ;提前 1h用不同剂量的TFA或VC处理后 ,再灌 40 0mg·kg-1的扑热息痛 ,检测血清酶学和肝脏组织学的改变。结果 :给小鼠扑热息痛 10 0 0mg·kg-1灌胃组 ,2 4h后可致 80 %小鼠死亡 ;提前 1h用TFA10 0mg·kg-1或VC灌胃其死亡率可分别下降至 2 0 %和 0 %。血清转氨酶 (ALT)和病理切片显示当给 40 0mg·kg-1扑热息痛灌胃 2 4h后即可引起严重肝损伤 (ALT升高和肝组织大面积坏死 ,P <0 .0 0 1)。TFA或VC预防组 (提前 1h给药 )的肝损伤程度与对照组比较明显减轻 ,其作用强度与药物浓度成正比。结论 :TFA对扑热息痛所致肝损伤有保护作用。 | 汪德清 丁保国 马艳青 赵海潞 Thomas G Neil Tomlinson Brian 田亚平 王成彬 Critchley Julian AJH | 2001 | 中国中药杂志2001，26，7： | 31 |
| 3 | Relationship between obesity and cardiovascular risk factors in elderly Chinese subjects显示文摘Objective To investigate the relative effects of degree and distribution of body fat with several cardiovascular disease (CVD) risk factors in elderly Chinese subjects.Methods One-hundred and thirty-five elderly Chinese individuals (age range, 60-65 y) without any history of significant renal, hepatic or cardiac disease were recruited. Seated blood pressure, anthropometric and fasting plasma biochemical parameters were measured. Student’s t-test was used to compare the differences in biochemical and anthropometric markers between cohorts.Results Males were heavier (64.6±8.6, 57.2±8.2?kg, P<0.001), taller (1.65±0.06, 1.51± 0.05 m, P<0.001) and their greater body fat was predominantly deposited centrally (Waist-to-hip ratio, 0.91±0.06, 0.88±0.07, P<0.05). Females were more generally obese with increased body mass index (BMI, 23.8±4.6, 25.0±3.5 kg/m 2, P<0.05) and percentage body fat [26.3% (24.5%-28.1%) vs 37.2% (36.0%-38.9%), P<0.001] than the males. However, despite an 11% higher proportion of body fat in females, no significant differences were identified in blood pressure, lipid profile, indices of insulin resistance or albumin-to-creatinine ratios.Conclusion It is likely that central adiposity contributes disproportionately to these metabolic disorders in males even though they are much leaner than elderly Chinese females. | G Neil THOMAS 赵海潞 马艳青 Wilson YS LEUNG Juliana CN CHAN Brian TOMLINSON Julian AJH CRITCHLEY 梁润成 陈重娥 汤宁信 郭志良 | 2002 | Chinese Medical Journal2002，，6： | 11 |
| 4 | Numerical simulation on inclusion transport in continuous casting mold显示文摘Turbulent flow, the transport of inclusions and bubbles, and inclusion removal by fluid flow transport and by bubble flota- tion in the strand of the continuous slab caster are investigated using computational models, and validated through comparison with plant measurements of inclusions. Steady 3-D flow of steel in the liquid pool in the mold and upper strand is simulated with a fi- nite-difference computational model using the standard k-ε turbulence model. Trajectories of inclusions and bubbles are calculated by integrating each local velocity, considering its drag and buoyancy forces. A “random walk” model is used to incorporate the effect of turbulent fluctuations on the particle motion. The attachment probability of inclusions on a bubble surface is investigated based on fundamental fluid flow simulations, incorporating the turbulent inclusion trajectory and sliding time of each individual inclusion along the bubble surface as a function of particle and bubble size. The change in inclusion distribution due to removal by bubble transport in the mold is calculated based on the computed attachment probability of inclusions on each bubble and the computed path length of the bubbles. The results indicate that 6%-10% inclusions are removed by fluid flow transport, 10% by bubble flotation, and 4% by entrapment to the submerged entry nozzle (SEN) walls. Smaller bubbles and larger inclusions have larger attachment prob- abilities. Smaller bubbles are more efficient for inclusion removal by bubble flotation, so long as they are not entrapped in the solidi- fying shell. A larger gas flow rate favors inclusion removal by bubble flotation. The optimum bubble size should be 2-4 mm. | Lifeng Zhang Brian G Thomas | 2006 | Journal of University of Science and Technology Beijing2006，13，4： | 10 |
| 5 | 黄芪总黄酮抗肝损伤作用初探显示文摘目的研究黄芪总黄酮(total navonoids 0f Astragalus,TFA)对扑热息痛所致小鼠肝损伤的预防功效。方法观察不同剂量(0、100、300、400、500 ms/kg)扑热息痛对c57BL/6J小鼠肝脏的损伤作用,比较经1天或5天(每天2次)的TFA预处理后对扑热息痛(400 mg/kg)所致肝损伤的防护作用。结果扑热息痛对小鼠肝损伤作用具有明显的量效关系。不同剂量的TFA对扑热息痛诱导小鼠肝损伤有不同程度的防护作用,其作用强度与药物浓度成正比;TFA可增加血清中SOD活性(P<0.05);高剂量的TFA(100mg/kg)具有降低肝组织中脂质过氧化物质的作用;此外,在相同TFA剂量下,5天组对扑热息痛诱导小鼠肝损伤的预防作用优于1天组。结论提示TFA可预防扑热息痛诱导的肝损伤,其预防作用与其使用时间有密切关系。 | 汪德清 田亚平 Thomas G Neil Tomlinson Brian | 2005 | 中国中西医结合杂志2005，25，S1： | 9 |
| 6 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 7 | Prediction of centerline cracks incurred in the bloom continuous casting of steel显示文摘An elastic-viscoplastic model is used on the finite element package Abaqus to simulate the thermal and mechanical behavior of bloom casting strand and predict the location and scale of centerline cracks.The formation of centerline cracks can be investigated by the application of this model,which is of benefit to the improvement of processing. | Li Chengbin Brian G THOMAS MEI Feng FAN Zhengjie | 2010 | Baosteel Technical Research2010，4，2： | 3 |
| 8 | Diagnostic accuracy of tests for Helicobacter pylori in an Alaska Native population显示文摘AIM:To evaluate the accuracy of two non-invasivetests in a population of Alaska Native persons. Highrates of Helico bacter pylori(H. pylori) infection,H. pylori treatment failure,and gastric cancer in this population necessitate documentation of infection status atmultiple time points over a patient's life.METHODS:In 280 patients undergoing endoscopy,H. pylori was diagnosed by culture,histology,rapidurease test,13C urea breath test(UBT) ,and immuno-globulin G antibodies to H. pylori in serum. The performances of 13C-UBT and antibody test were compared to a gold standard defined by a positive H. pylori testby culture or,in case of a negative culture result,bypositive histology and a positive rapid urease test.RESULTS:The sensitivity and specificity of the 13C-UBT were 93% and 88%,respectively,relative to thegold standard. The antibody test had an equivalents ensitivity of 93% with a reduced specificity of 68%.The false positive results for the antibody test were as-sociated with previous treatment for an H. pylori infection [relative risk(RR) = 2.8]. High levels of antibodiesto H. pylori were associated with chronic gastritis and male gender,while high scores in the 13C-UBT testwere associated with older age and with the H. pyloribacteria load on histological examination(RR = 4.4) .CONCLUSION:The 13C-UBT out performed the anti-body test for H. pylori and could be used when a non-invasive test is clinically necessary to document treatment out come or when monitoring for reinfection. | Dana L Bruden Michael G Bruce Karen M Miernyk Julie Morris Debby Hurlburt Thomas W Hennessy Helen Peters Frank Sacco Alan J Parkinson Brian J McMahon | 2011 | World Journal of Gastroenterology2011，17，42： | 3 |
| 9 | Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial显示文摘 | Brian I Rini Bernard Escudier Piotr Tomczak Andrey Kaprin Cezary Szczylik Thomas E Hutson M Dror Michaelson Vera A Gorbunova Martin E Gore Igor G Rusakov Sylvie Negrier Yen-Chuan Ou Daniel Castellano Ho Yeong Lim Hirotsugu Uemura Jamal Tarazi David Cella | 2011 | The Lancet . 2011 (9807)2011，，9807： | 2 |
| 10 | Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial显示文摘 | Brian I Rini Bernard Escudier Piotr Tomczak Andrey Kaprin Cezary Szczylik Thomas E Hutson M Dror Michaelson Vera A Gorbunova Martin E Gore Igor G Rusakov Sylvie Negrier Yen-Chuan Ou Daniel Castellano Ho Yeong Lim Hirotsugu Uemura Jamal Tarazi David Cella | 2011 | The Lancet2011，，9807： | 2 |
| 11 | Long-term outcome in patients with apical hypertrophic cardiomyopathy显示文摘 | Maria J Eriksson Brian Sonnenberg Anna Woo Paul Rakowski Thomas G Parker E.Douglas Wigle Harry Rakowski | 2002 | Journal of the American College of Cardiology2002，，4： | 2 |
| 12 | Microencapsulated cell-mediated treatment of inoperable pancreatic carcinoma显示文摘 | Matthias L?hr Anne Hoffmeyer Jens-Christian Kr?ger Mathias Freund Johannes Hain Albrecht Holle Peter Karle Wolfram T Kn?fel Stefan Liebe Petra Müller Horst Nizze Matthias Renner Robert M Saller Thomas Wagner Karlheinz Hauenstein Walter H Günzburg Brian Sa | 2001 | The Lancet2001，，9268： | 1 |
| 13 | Transient Thermal Model of the Continuous Single-Wheel Thin-Strip Casting Process显示文摘 | Guowei Li Brian G Thomas | 1996 | Metallurgical and Materials Transactions B1996，，7： | 1 |
| 14 | Simple model of mi- crosegregation during solidification of steels显示文摘 | Young-Mok Won Brian G Thomas | 2001 | Metallur- gical and Materials Transactions A2001，32，7： | 1 |
| 15 | State of the Art in Evaluation and Control of Steel Cleanliness显示文摘 | ZHANG Li-feng Brian G Thomas | 2003 | ISIJ International2003，43，3： | 1 |
| 16 | A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis显示文摘 | Vanda A Lennon Dean M Wingerchuk Thomas J Kryzer Sean J Pittock Claudia F Lucchinetti Kazuo Fujihara Ichiro Nakashima Brian G Weinshenker | 2004 | 2004 (9451)2004，，9451： | 1 |
| 17 | Probable Venous Air Embolism Associated with Removal of the Mayfield skull clamp显示文摘 | Francisco G Thomas FS Brian JM | 1995 | Anesth Analg1995，80，： | 1 |
| 18 | A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis显示文摘 | Vanda A Lennon Dean M Wingerchuk Thomas J Kryzer Sean J Pittock Claudia F Lucchinetti Kazuo Fujihara Ichiro Nakashima Brian G Weinshenker | 2004 | The Lancet2004，，9451： | 1 |
| 19 | Heat Transfer and Solidification Model of Continuous Slab Casting: Conld显示文摘 | Ya Meng Brian G Thomas | 2003 | Metallurgical and Materials Transactions2003，34，5： | 1 |
| 20 | Large inclusions in plain-carbon steel ingots cast by bottom teeming显示文摘 | Zhang Lifeng Rietow Bret Thomas Brian G | 2006 | ISIJ International2006，46，5： | 1 |
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