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| 1 | Degradation of lipid droplets by chimeric autophagy-tethering compounds显示文摘Degrading pathogenic proteins by degrader technologies such as PROTACs(proteolysis-targeting chimeras)provides promising therapeutic strategies,but selective degradation of non-protein pathogenic biomolecules has been challenging. | Yuhua Fu Ningxie Chen Ziying Wang Shouqing Luo Yu Ding Boxun Lu | 2021 | Cell Research2021，31，9： | 5 |
| 2 | Suppression of MAPK11 or HIPK3 reduces mutant Huntingtin levels in Huntington's disease models显示文摘 | Meng Yu Yuhua Fu Yijian Liang Haikun Song Yao Yao Peng Wu Yuwei Yao Yuyin Pan Xue Wen Lixiang Ma Saiyin Hexige Yu Ding Shouqing Luo Boxun Lu | 2017 | Cell Research2017，27，12： | 5 |
| 3 | Tau Accumulation via Reduced Autophagy Mediates GGGGCC Repeat Expansion-Induced Neurodegeneration in Drosophila Model of ALS显示文摘Expansions of trinucleotide or hexanucleotide repeats lead to several neurodegenerative disorders,including Huntington disease[caused by expanded CAG repeats(CAGr)in the HTT gene],and amyotrophic lateral sclerosis[ALS,possibly caused by expanded GGGGCC repeats(G4C2r)in the C9ORF72 gene],of which the molecular mechanisms remain unclear.Here,we demonstrated that lowering the Drosophila homologue of tau protein(dtau)significantly rescued in vivo neurodegeneration,motor performance impairments,and the shortened life-span in Drosophila expressing expanded CAGr or expanded G4C2r.Expression of human tau(htau4 R)restored the disease-related phenotypes that had been mitigated by the loss of dtau,suggesting an evolutionarily-conserved role of tau in neurodegeneration.We further revealed that G4C2r expression increased tau accumulation by inhibiting autophagosome-lysosome fusion,possibly due to lowering the level of BAG3,a regulator of autophagy and tau.Taken together,our results reveal a novel mechanism by which expanded G4C2r causes neurodegeneration via an evolutionarily-conserved mechanism.Our findings provide novel autophagy-related mechanistic insights into C9ORF72-ALS and possible entry points to disease treatment. | Xue Wen Ping An Hexuan Li Zijian Zhou Yimin Sun Jian Wang Lixiang Ma Boxun Lu | 2020 | Neuroscience Bulletin2020，36，12： | 4 |
| 4 | New Quaternary Mammalian Faunas and Cave Deposits in the Zhoukoudian Area,Beijing显示文摘From 1985 to 1987, four new localities with abundant fossil mammals were dis-covered by Cao, Tian and others in the Zhoukoudian (Choukoutien) area, Beijing. They are theEast, West, Shangdian and Donglingzi caves. The East Cave fauna consists of 28 speices ofmammals and its age is middle Early Pleistocene. The East Cave assemblage shows that a tem-perature-falling event took place at around 1.20 Ma B.P. at Zhoukoudian. Sixteen species ofmammals were collected from the West Cave, which are mainly forms of late Early Pleistoceneage. The West Cave fauna represents a transitional fauna from the East Cave fauna (dry-cold)to the fauna (warm) at locality 9. The Shangdian Cave fauna is composed of four forms, beingMiddle Pleistocene in age. The Donglingzi Cave fauna contains 21 Late Pleistocene forms. Inthe cave two fossil horizons may be distinguished. The age of the lower horizon is early LatePleistocene, which is equivalent to that of the New Cave fauna; while the fauna of the upper ho-rizon may be correlated with the Upper Cave fauna. | Cheng Jie Tian Mingzhong Cao Boxun and Zhao Zhizhong China University Of Geosciences, Beijing China University of Geosciences,Wuhan, Hubei Institute of Geomechanics, Chinese Academy of Geological Sciences, Beijing Fei Zhenbi | 1997 | Acta Geologica Sinica(English Edition)1997，71，3： | 3 |
| 5 | M3SC:A Generic Dataset for Mixed Multi-Modal(MMM)Sensing and Communication Integration显示文摘The sixth generation(6G)of mobile communication system is witnessing a new paradigm shift,i.e.,integrated sensing-communication system.A comprehensive dataset is a prerequisite for 6G integrated sensing-communication research.This paper develops a novel simulation dataset,named M3SC,for mixed multi-modal(MMM)sensing-communication integration,and the generation framework of the M3SC dataset is further given.To obtain multimodal sensory data in physical space and communication data in electromagnetic space,we utilize Air-Sim and WaveFarer to collect multi-modal sensory data and exploit Wireless InSite to collect communication data.Furthermore,the in-depth integration and precise alignment of AirSim,WaveFarer,andWireless InSite are achieved.The M3SC dataset covers various weather conditions,multiplex frequency bands,and different times of the day.Currently,the M3SC dataset contains 1500 snapshots,including 80 RGB images,160 depth maps,80 LiDAR point clouds,256 sets of mmWave waveforms with 8 radar point clouds,and 72 channel impulse response(CIR)matrices per snapshot,thus totaling 120,000 RGB images,240,000 depth maps,120,000 LiDAR point clouds,384,000 sets of mmWave waveforms with 12,000 radar point clouds,and 108,000 CIR matrices.The data processing result presents the multi-modal sensory information and communication channel statistical properties.Finally,the MMM sensing-communication application,which can be supported by the M3SC dataset,is discussed. | Xiang Cheng Ziwei Huang Lu Bai Haotian Zhang Mingran Sun Boxun Liu Sijiang Li Jianan Zhang Minson Lee | 2023 | China Communications2023，20，11： | 3 |
| 6 | AlphaLISA detection of alpha-synuclein in the cerebrospinal fluid and its potential application in Parkinson's disease diagnosis显示文摘 | Zhao, Hongli Zhao, Jue Hou, Jiapeng Wang, Siqing Ding, Yu Lu, Boxun Wang, Jian | 2017 | Protein & Cell2017，8，9： | 2 |
| 7 | Technological Exploration of RRAM Crossbar Array for Matrix-Vector Multiplication显示文摘矩阵向量增加是为许多计算地集中的算法的关键操作。抵抗切换的随机的存取存储器(RRAM ) 设备和 RRAM 闩穿的新兴的金属氧化物表明了模拟矩阵向量增加的一条有希望的硬件认识与超离频精力效率。在这篇论文,我们分析设备水平和电路水平的影响非理想的因素包括 RRAM 设备的非线性的当前电压的关系,设备制造的变化并且给操作,和 interconnect 抵抗以及另外的闩数组写参数。在那上,我们建议工艺的探索流动让设备参数配置克服非理想的因素的影响并且为各特定的申请在性能,精力,和可靠性之中完成一宗更好的交易。我们向量机器(SVM ) 和混合公民标准和技术(MNIST ) 模式识别数据集开创的支持的模拟结果证明那个 RRAM 闩数组基于 SVM 是柔韧的输入信号变化但是对通道差距偏差敏感。进一步的抵抗决定测试一台 6 位的 RRAM 设备对有能力的礼品在 90% 附近认识到识别精确性,显示 RRAM 闩数组的物理可行性基于 SVM。另外,建议工艺的探索流动能与以前的工作相比在 MNIST 数据集和 26.4% 精力积蓄上完成识别精确性的 10.98% 改进。试验性的结果也证明节省的超过 84.4% 力量能以很少精确性减小的成本被完成。 | Lixue Xia Peng Gu Boxun Li Tianqi Tang Xiling Yin Wenqin Huangfu Shimeng Yu Yu Cao Yu Wang Huazhong Yang | 2016 | Journal of Computer Science & Technology2016，31，1： | 2 |
| 8 | Postzygotic single-nucleotide mosaicisms in whole-genome sequences of clinically unremarkable individuals显示文摘 | August Y Huang Xiaojing Xu Adam Y Ye Qixi Wu Linlin Yan Boxun Zhao Xiaoxu Yang Yao He Sheng Wang Zheng Zhang Bowen Gu Han-Qing Zhao Meng Wang Hua Gao Ge Gao Zhichao Zhang Xiaoling Yang Xiru Wu Yuehua Zhang Liping Wei | 2014 | Cell Research2014，24，11： | 2 |
| 9 | Osseointegration of hollow porous titanium prostheses loaded with cancellous bone matrix in rabbits显示文摘This study aimed to observe the osseointegration of hollow porous titanium prostheses (HPTP) loaded with cancellous bone matrix (CBM) in rabbits using histological and biomechanical perspectives.Experimental samples were implanted into the lateral femoral condyles of 66 New Zealand rabbits,allocated into the following groups:non-porous prosthesis group (Group A,n=22);HPTP group (Group B,n=22);HPTP+CBM group (Group C,n=22).The rabbits were sacrificed at 3,8 and 12 weeks,postoperatively.X-ray analyses,microscopy techniques and morphological measurement software and mechanical tests were used for evaluation.At each time point,the tissues surrounding the implants were similar in all of the groups,with bony in-growth into the 2-mm round holes observed for the defects in Groups B and C.However,the internal bone formation was significantly better in Group C than in Group B at different time points (P<0.01).Biomechanically,the pull-out forces were significantly greater in Groups B and C than in Group A (P<0.01),with no difference between Groups B and C (P>0.05).These results suggest that bone can grow into the cavities of HPTP to achieve more stable locking fixation,and those osteogenic materials,such as CBM,can enhance osteogenesis to achieve better osseointegration between the implant and the host bone. | WEI JunQiang CAI Xu WANG Yan ZHANG BoXun CHEN Hua ZHANG Li ZHAO Bin WANG AiYua | 2012 | Chinese Science Bulletin2012，57，20： | 2 |
| 10 | A New Mid Early Pleistocene Mammalian FaunaDiscovered in Choukoutien,China and Its Application in Biostratigraphy显示文摘A New Mid Early Pleistocene Mammalian FaunaDiscovered in Choukoutien,ChinaandItsApplication in Biostratigraphy￥ChengJie(Depar... | Cheng Jie(Department of Geology and Mineral Resources, China University of Geosciences,Beijing 100083)Cao Boxun(Faculty of Earth Sciences, China University of Geosciences,Wuhan 430074)Tian MingZhong(Department of Geology and Mineral Resources, China Unive | 1995 | Journal of Earth Science1995，14，1： | 2 |
| 11 | Degeneration Versus Development: Hunting-Out the D-Unit of Huntington's Disease显示文摘Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder caused by a CAG trinucleotide repeat expansion exceeding a threshold length (>35repeats) in exon 1 of the huntingtin gene (HTT)[1]. The age at onset is typically 40–50 years, except for a very low percentage (approximately 6%) of juvenile-onset HD patients carrying 75 or more CAG repeats;longer CAG repeats predict an earlier onset [1]. | Shengyi Lu Boxun Lu | 2021 | Neuroscience Bulletin2021，37，5： | 1 |
| 12 | Langmuir显示文摘 | Ting Wang Boxun Leng Renchao Che and Zhengzhong Shao | 2010 | 26(16)2010，，13： | 1 |
| 13 | Facile Synthesis of Fe3Pt-Ag Nanocomposites for Catalytic Reduction of Methyl Orange显示文摘 | HAN Donglai LI Boxun XING Guoliang ZHANG Yuanyuan CHEN Yue SUN Yantao ZHANG Yongjun LIU Yang YANG Jinghai | 2018 | Chemical Research in Chinese Universities2018，34，6： | 1 |
| 14 | Manganese dioxide as a new cathode catalyst in microbial fuel cells显示文摘 | Xiang Li Boxun Hu Steven Suib Yu Lei Baikun Li | 2009 | Journal of Power Sources2009，，9： | 1 |
| 15 | A high-throughput-compatible assay to measure the degradation of endogenous Huntingtin proteins显示文摘瞄准:引起疾病的蛋白质的累积是许多 neurodegenerative 混乱的一个普通特点。用 high-throughput-compatible 试金测量如此的蛋白质的降级高度为降级的基因、化学的调节的人的鉴定被需要。例如, Huntingtons 疾病(HD ) 是变异的 huntingtin 蛋白质(mHTT ) 的 cytotoxicity 引起的医不好的世袭 neurodegenerative 混乱。mHTT 降级的高产量的测量在 HD 药发现和研究是重要的。为如此的目的存在方法在蛋白质标签或平底锅蛋白质合成禁止者上由于他们的依赖有限制。这里,我们为蛋白质(HTT ) 降级基于按化学和同类的时间解决了的内长的没有标签的 huntingtin 的测量报导一个 high-throughput-compatible 脉搏追逐方法(CH 追逐) 荧光(HTRF ) technologies.Methods:标记脉搏的蛋白质用按反应与 biotin 被结合支持紧张的炔属羟叠氮化物 cycloaddition (SPAAC ) ,和追逐信号被与 streptavidin beads.Results 在下拉以后测量 HTT HTRF 信号的减小百分比计算:我们验证了信号在线性察觉范围以内并且是 HTT 特定的。我们成功地用 96 井盘子在一种 high-throughput-compatible 格式测量了内长的 HTT 的降级。由已知的修饰词的 HTT 降级的预言的变化被观察,它证实试金对 HTT 降级 modifiers.Conclusion 的鉴定合适:我们建立了能够测量内长的、没有标签的 HTT 降级的第一 high-throughput-compatible 试金,提供为 HD 研究和药发现的一个珍贵工具。方法能被用于另外的蛋白质并且能在另外的 neurodegenerative 混乱和 proteinopathies 上便于研究。 | Peng WU Ming-xing LU Xiao-tian CUI He-qing YANG Shen-liang YU Jian-bin ZHU Xiao-li SUN Boxun LU | 2016 | Acta Pharmacologica Sinica2016，37，10： | 1 |
| 16 | Inspiration from Natural Silks and Their Proteins显示文摘 | Boxun Leng Lei Huang Zhengzhong Shao | 2009 | Advances In Chemical Engineering2009，35，： | 1 |
| 17 | Research on handover algorithm to reduce the blocking probability in LEO satellite network显示文摘Based on the characteristics of guaranteed handover (GH) algorithm, the finite capacity in one system makes the blocking probability (PB) of GH algorithm increase rapidly in the case of high traffic load. So, when large amounts of multimedia services are transmitted via a single low earth orbit (LEO) satellite system, the PB of it is much higher. In order to solve the problem, a novel handover scheme defined by multi-tier optimal layer selection is proposed. The scheme sufficiently takes into account the characteristics of double-tier satellite network, which is constituted by LEO satellites combined with medium earth orbit (MEO) satellites, and the multimedia transmitted by such network, so it can augment this systematic capacity and effectively reduces the traffic load in the LEO which performs GH algorithm. The detailed processes are also presented. The simulation and numerical results show that the approach integrated with GH algorithm achieves a significant improvement in the PB and practicability, as compared to the single LEO layer network. | Chen Bingcai Zhang Naitong Nie Boxun Zhou Tingxian | 2006 | Journal of Systems Engineering and Electronics2006，17，1： | 1 |
| 18 | Effects of Mn O on Crystallization,Melting,and Heat Transfer of Ca O-Al2O3-Based Mold Flux Used for High Al-Trip Steel Casting显示文摘 | Huan Zhao Wanlin Wang Lejun Zhou Boxun Lu Youn-Bae Kang | 2014 | Metallurgical and Materials Transaction B2014，45，4： | 1 |
| 19 | Improvements to the hybrid MM-PO technique for Scattering of Plane wave by an infinite wedge 显示文摘 | Zhuqian Gong Boxun Xiao G Zhu and H Ke | 2006 | IEEE Trans on AP2006，54，1： | 1 |
| 20 | Progressive multiple sclerosis cerebrospinal fluid induces inflammatory demyelination, axonal loss, and astrogliosis in mice显示文摘 | Massimiliano Cristofanilli Hannah Rosenthal Barbara Cymring Daniel Gratch Benjamin Pagano Boxun Xie Saud A. Sadiq | 2014 | Experimental Neurology2014，，： | 1 |
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