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| 1 | Multiple genetic alterations and behavior of cellular biology in gastric cancer and other gastric mucosal lesions:H.pylori infection,histological types and staging显示文摘AIM To investigate the expression of multiplegenes and the behavior of cellular biology ingastric cancer(GC)and other gastric mucosallesions and their relations to Helicobacter pylori(H.pylori)infection,tumor staging andhistological subtypes.METHODS Three hundred and twenty-sevenspecimens of gastric mucosa obtained viaendoscopy or surgical resection,and ABCimmunohistochemical staining were used todetect the expression of p53,p16,Bcl-2 andCOX-2 proteins.H.pylori was determined byrapid urea test combined with pathologicalstaining or14C urea breath test.Cellular image analysis was performed in 66 patients withintestinal metaplasia(IM)and/or dysplasia(Dys).In 30 of them,both cancer and theparacancerous tissues were obtained at the timeof surgery.Histological pattern,tumor staging,lymph node metastasis,grading ofdifferentiation and other clinical data werestudied in the medical records.RESULTS p16 expression of IM or Dys wassignificantly lower in positive H.pylori chronicatrophic gastritis(CAG)than those withnegative H.pylori(CAG:54.8% vs 88.0%,IM:34.4% vs 69.6%,Dys:23.8% vs 53.6%,allP<0.05),Bcl-2 or COX-2 expression of IM orDys in positive H.pylori cases was significantlyhigher than that without H.pylori(Bcl-2:68.8%vs23.9%,90.5% vs 60.7%;COX-2:50.0% vs10.8%,61.8% vs 17.8%;all P<0.05).Themean number of most parameters of cellularimage analysis in positive H.pylori group wassignificantly higher than that in negative H.pylori group(Ellipser:53±14,40±12μm,Area1:748±572,302±202 μm2,Area2:3050±1661,1681±1990 μm2,all P<0.05;Ellipseb:79±23,58±15 μm,Ratio1:22%±5%,13%±4%,Ratio2:79%±17%,53%±20%,all P<0.01).There was significant correlation between Bcl-2and histologic pattern of gastric carcinoma,andbetween COX-2 and tumor staging or lymph nodemetastasis(Bcl-2:75.0% vs 16.7%;COX-2:76.0% vs 20.0%,79.2% vs 16.7%;allP<0.05).CONCLUSION p1l6, Bcl-2, and COX-2 but not p53 gene may play a role in the early genesis/ progression of gastric carcinoma and are associated with H. pylori infection. p53 gene is relatively late event in gastric tumorigenesis and mainly relates to its progression. There is more cellular-biological behavior of malignant tumor in gastric mucosal lesions with H. pylori infection. Aberrant Bcl-2 protein expression appears to be preferentially associated with the intestinal type cancer. COX-2 seems to be related to tumor staging and lymph node metastasis. | Heng Jun Gao Lian Zhen Yu Jian Feng Bai Yan Shen Peng Gu Sun Han Lin Zhao Kun Miu Xiu Zhen Lü Xiao Yong Zhang Zhi Quan Zhao | 2000 | World Journal of Gastroenterology2000，6，6： | 52 |
| 2 | Epidural Analgesia in the Latent Phase of Labor and the Risk of Cesarean Delivery A Five-year Randomized Controlled Trial显示文摘 | Wang, F. Z. Shen, X. F. Guo, X. R. Peng, Y. Z. Gu, X.Q. | 2009 | 南京医科大学学报(自然科学版)2009，29，11： | 41 |
| 3 | Disruption of phytoene desaturase gene results in albino and dwarf phenotypes in Arabidopsis by impairing chlorophyll, carotenoid, and gibberellin biosynthesis显示文摘类胡萝卜素在植物和 phytoene desaturase 基因(PDS3 ) 在许多生理的过程起一个重要作用把重要的酶之一编码为类胡萝卜素生合成小径。这里,我们报导 T-DNA 插入异种 ofPDS3 基因的鉴定和分析。功能的互补证实 thepds3 异种的白化体和矮子显型源于 PDS3 基因的功能的混乱。叶绿体开发在 pds3 异种在专业版质体阶段被逮捕。进一步的分析证明高级 ofphytoene 在 pds3 异种被积累。外长的 GA (3 ) 的增加能部分救矮子显型,建议 pds3 异种的矮子显型可能由于 GAdeficiency。Microarray 和 RT-PCR 分析证明那破坏 PDS3 基因导致了涉及至少 20 条新陈代谢的小径的基因表示变化,包括在类胡萝卜素,叶绿素,和 GA 的许多基因的抑制生合成小径。我们的数据建议在 pds3 异种的积累的 phytoene 可能在某些否定反馈起一个重要作用影响多样的细胞的小径的基因表示。 | Genji Qin Hongya Gu Ligeng Ma Yiben Peng Xing Wang Deng Zhangliang Chen Li-Jia Qu | 2007 | Cell Research2007，17，5： | 39 |
| 4 | Nitrate leaching of winter wheat grown in lysimeters as affected by fertilizers and irrigation on the North China Plain显示文摘Proper application of nitrogen(N) fertilizers and irrigation management are important production practices that can reduce nitrate leaching into groundwater and improve the N use efficiency(NUE). A lysimeter/rain shelter facility was used to study effects of the rate of N fertilization, type of N fertilizer, and irrigation level on key aspects of winter wheat production over three growing seasons(response variables were nitrate transport, N leaching, and NUE). Results indicated that nitrate concentration in the soil profile and N leaching increased with the rate of N fertilization. At the end of the third season, nitrate concentration in the top 0–75 cm layer of soil was higher with manure treatment while urea treatments resulted in higher concentrations in the 100–200 cm layer. With normal irrigation, 3.4 to 15.3% of N from applied fertilizer was leached from the soil, yet no leaching occurred under a stress irrigation treatment. The manure treatment experienced less N leaching than the urea treatment in all cases except for the 180 kg N ha-1 rate in 2011–2012(season 3). In terms of grain yield(GY), dry matter(DM) or NUE parameters, values for the manure treatment were lower than for the urea treatment in 2009–2010(season 1), yet were otherwise higher for urea treatment in season 3. GY and crop nitrogen uptake(NU) were elevated when the rate of N fertilizer increased, while the NUE decreased; GY, DM, and NU increased with the amount of irrigation. Data indicated that reduced rates of N fertilization combined with increased manure application and proper irrigation management can lower nitrate levels in the subsoil and reduce potential N leaching into groundwater. | GU Li-min LIU Tie-ning ZHAO Jun DONG Shu-ting LIU Peng ZHANG Ji-wang ZHAO Bin | 2015 | Journal of Integrative Agriculture2015，14，2： | 33 |
| 5 | Efficacy and safety of a novel anti-HER2 therapeutic antibody RC48 in patients with HER2-overexpressing,locally advanced or metastatic gastric or gastroesophageal junction cancer:a single-arm phase II study显示文摘Background:Current treatment options for human epidermal growth factor receptor 2(HER2)-overexpressing gastric cancer at third-line have shown limited clinical benefit.Further,there is no specific treatment for HER2 immunohistochemistry(IHC)2+and fluorescence in-situ hybridization-negative patients.Here,we report the efficacy and safety of a novel anti-HER2 antibody RC48 for patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer.Methods:Patients with HER2-overexpressing(IHC 2+or 3+),locally advanced or metastatic gastric or gastroesophageal junction cancer who were under at least second-line therapy were eligible and received RC482.5 mg/kg alone every 2 weeks.The primary endpoint was the objective response rate(ORR)assessed by an independent review committee.Secondary endpoints included progressionfree survival(PFS),overall survival(OS),duration of response,time to progression,disease control rate,and safety.Results:Of 179 patients screened,125 were eligible and received RC48 treatment.The ORR was 24.8%(95%confidence interval[CI]:17.5%-33.3%).The median PFS and OS were 4.1 months(95%CI:3.7-4.9 months)and 7.9 months(95%CI:6.7-9.9 months),respectively.The most frequently reported adverse events were decreased white blood cell count(53.6%),asthenia(53.6%),hair loss(53.6%),decreased neutrophil count(52.0%),anemia(49.6%),and increased aspartate aminotransferase level(43.2%).Serious adverse events(SAEs)occurred in 45(36.0%)patients,and RC48-related SAEs were mainly decreased neutrophil count(3.2%).Seven patients had adverse events that led to death were not RC48-related.Conclusions:RC48 showed promising activity with manageable safety,suggesting potential application in patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer who have previously received at least two lines of chemotherapy. | Zhi Peng Tianshu Liu Jia Wei Airong Wang Yifu He Liuzhong Yang Xizhi Zhang Nanfeng Fan Suxia Luo Zhen Li Kangsheng Gu Jianwei Lu Jianming Xu Qingxia Fan Ruihua Xu Liangming Zhang Enxiao Li Yuping Sun Guohua Yu Chunmei Bai Yong Liu Jiangzheng Zeng Jieer Ying Xinjun Liang Nong Xu Chao Gao Yongqian Shu Dong Ma Guanghai Dai Shengmian Li Ting Deng Yuehong Cui Jianmin Fang Yi Ba Lin Shen | 2021 | Cancer Communications2021，41，11： | 29 |
| 6 | Latest Progress of the Chinese Meteorological Satellite Program and Core Data Processing Technologies显示文摘In this paper,the latest progress,major achievements and future plans of Chinese meteorological satellites and the core data processing techniques are discussed.First,the latest three FengYun(FY)meteorological satellites(FY-2H,FY-3D,and FY-4A)and their primary objectives are introduced Second,the core image navigation techniques and accuracies of the FY meteorological satellites are elaborated,including the latest geostationary(FY-2/4)and polar-orbit(FY-3)satellites.Third,the radiometric calibration techniques and accuracies of reflective solar bands,thermal infrared bands,and passive microwave bands for FY meteorological satellites are discussed.It also illustrates the latest progress of real-time calibration with the onboard calibration system and validation with different methods,including the vicarious China radiance calibration site calibration,pseudo invariant calibration site calibration,deep convective clouds calibration,and lunar calibration.Fourth,recent progress of meteorological satellite data assimilation applications and quantitative science produce are summarized at length.The main progress is in meteorological satellite data assimilation by using microwave and hyper-spectral infrared sensors in global and regional numerical weather prediction models.Lastly,the latest progress in radiative transfer,absorption and scattering calculations for satellite remote sensing is summarized,and some important research using a new radiative transfer model are illustrated. | Peng ZHANG Qifeng LU Xiuqing HU Songyan GU Lei YANG Min MIN Lin CHEN Na XU Ling Sun Wenguang BAI Gang MA Di XIAN | 2019 | Advances in Atmospheric Sciences2019，36，9： | 26 |
| 7 | IN VIVO ~1 H MAGNETIC RESONANCE SPECTROSCOPY IN EVALUATION OF HEPATOCELLULAR CARCINOMA AND ITS EARLY RESPONSE TO TRANSCATHETER ARTERIAL CHEMOEMBOLIZATION显示文摘客观:调查值在 vivo 质子在对 hepatocellular 癌(HCC ) 和监视器的评价的磁性的回声光谱学(太太) 它立即在 transcatheter 以后的新陈代谢的变化动脉的 chemoembolization (不作声) 。方法:在这未来的研究,有大 HCC 的 28 个连续病人(> 或 = 在直径的 3 厘米) 由好针渴望活体检视证实了被招募。所有肝的损害和某 uninvolved 肝实质的 1H 太太与 1 被执行。5T 全部身体先生扫描仪。在他们之中, 15 个案例大约一个星期再被评估在以后不作声。主要代谢物象胆碱和类脂化合物和 afterinterventional 治疗在前那样被测量估计肿瘤的早反应。结果:在肝的 1H 太太的 Thetechnical 成功率高(33/41, 80%) ,仔细与呼吸运动,损害的地点,和 voxel 的尺寸有关。在系列, HCC 的胆碱混合物山峰与 uninvolved 肝实质相比提高了。在以后不作声,振幅和胆碱回声山峰的区域显著地下降了(从 0.352 +/- 的 choline-to-lipid 比率 0.080 ~ 0.167 +/-0.030, P = 0.026;从 0.205 +/- 0.060 ~ 0.070 +/-0.020, P = 0.042,分别地) ;然而,类脂化合物回声山峰上升了。结论:然而,在 vivo 1H,太太为大焦点的肝的损害的评估是技术上可行的重制度和稳定性不是几乎平淡的先生扫描。1H 太太能监视早阶段 HCC 在以后的新陈代谢的变化不作声但是限制 likequantification 仍然存在。 | Bin Wu Wei-jun Peng Pei-jun Wang Ya-jia Gu Wen-tao Li Liang-pin Zhou Feng Tang Guo-ming Zhong | 2006 | Chinese Medical Sciences Journal2006，21，4： | 22 |
| 8 | Comparison of total splenic artery embolization and partial splenic embolization for hypersplenism显示文摘AIM:To evaluate whether total splenic artery embolization(TSAE) for patients with hypersplenism delivers better long-term outcomes than partial splenic embolization(PSE).METHODS:Sixty-one patients with hypersplenism eligible for TSAE(n = 27,group A) or PSE(n = 34,group B) were enrolled into the trial,which included clinical and computed tomography follow-up.Data on technical success,length of hospital stay,white blood cell(WBC) and platelet(PLT) counts,splenic volume and complications were collected at 2 wk,6 mo,and 1,2,3,4 years postoperatively.RESULTS:Both TSAE and PSE were technically successful in all patients.Complications were significantly fewer(P = 0.001),and hospital stay significantly shorter(P = 0.007),in group A than in group B.Postprocedure WBC and PLT counts in group A were significantly higher than those in group B from 6 mo to 4 years(P = 0.001),and post-procedure residual splenic volume in group A was significantly less than that observed in group B at 1,2,3 and 4 years post-procedure(P = 0.001).No significant differences were observed in red blood cell counts and liver function parameters between the two groups following the procedure.CONCLUSION:Our results indicate that TSAE for patients with hypersplenism not only delivers a better longterm outcome,but is also associated with lower complication rates and a shorter hospital stay than PSE. | Xin-Hong He Jian-Jian Gu Wen-Tao Li Wei-Jun Peng Guo-Dong Li Sheng-Ping Wang Li-Chao Xu Jun Ji | 2012 | World Journal of Gastroenterology2012，18，24： | 23 |
| 9 | Introgression of qPE9-1 allele,conferring the panicle erectness,leads to the decrease of grain yield per plant in japonica rice(Oryza sativa L.)显示文摘圆锥花序建筑学是仔细与产量有关形成。qPE9-1 基因被证明了广泛地在产量很高的米饭栽培变种开发被过去常,授与在装饰用的梨树米饭的直立的圆锥花序特性。最近, qPE9-1 成功地被克隆;然而,谷物产量上的基因效果还每直立的圆锥花序等位基因 qPE9-1 的植物是争论的。在现在的学习,低垂的圆锥花序父母 Nongken 57,带 qpe9-1 等位基因,被用作周期性父母到连续地回交到从双 haploid (DH ) 的一根典型直立的圆锥花序线人口(Wuyunjing 8/Nongken 57 ) ,它以前被显示带 qPE9-1 等位基因。因此,一双 near-isogenic 线(无) 被开发。在无之间的农学的特点的比较证明当 qpe9-1 被 qPE9-1 代替时,圆锥花序建筑学从低垂树立被改变;而且,圆锥花序长度,植物高度, 1000 谷物重量和 tillers 显著地被减少,因而在 30% 每植物导致谷物产量的戏剧的减少。因此,我们断定 qPE9-1 是控制圆锥花序建筑学的一个主要因素,并且 qPE9-1 有多种的自然,与每植物的谷物产量上的否定效果。这结果强烈建议直立的圆锥花序等位基因 qPE9-1 应该在产量很高的繁殖实践和另外的有利基因被使用。另外,吃并且煮质量上的 qPE9-1 的效果也在现在的学习被讨论。 | Xiuhua Yi Zujian Zhang Shengyuan Zeng Chunyan Tian Juncheng Peng Min Li Yue Lu Qingcai Meng Minghong Gu Changjie Yan | 2011 | Journal of Genetics and Genomics2011，38，5： | 20 |
| 10 | Effect of exposure to ambient PM2.5 pollution on the risk of respiratory tract diseases: a meta-analysis of cohort studies显示文摘The International Agency for Research on Cancer and the World Health Organization have designated airborne particulates,including particulates of median aerodynamic diameter < 2.5um(PM_(2.5)),as Group 1 carcinogens.It has not been determined,however,whether exposure to ambient PM_(2.5) is associated with an increase in respiratory related diseases.This meta-analysis assessed the association between exposure to ambient fine particulate matter(PM_(2.5)) and the risk of respiratory tract diseases,using relevant articles extracted from PubMed,Web of Science,and Embase.In results,of the 1,126 articles originally identified,35(3.1%) were included in this meta-analysis.PM_(2.5)was found to be associated with respiratory tract diseases.After subdivision by age group,respiratory tract disease,and continent,PM_(2.5) was strongly associated with respiratory tract diseases in children,in persons with cough,lower respiratory illness,and wheezing,and in individuals from North America,Europe,and Asia.The risk of respiratory tract diseases was greater for exposure to traffic-related than non-traffic-related air pollution.In children,the pooled relative risk(RR) represented significant increases in wheezing(8.2%),cough(7.5%),and lower respiratory illness(15.3%).The pooled RRs in children were 1.091(95%CI:1.049,1.135) for exposure to<25 μg/m^3 PM_(2.5),and 1.126(95%CI:1.067,1.190) for exposure to > 25 μg/m^3 PM_(2.5).In conclusion,exposure to ambient PM_(2.5) was significantly associated with the development of respiratory tract diseases,especially in children exposed to high concentrations of PM_(2.5). | Qian Liu Cheng Xu Guixiang Ji Hui Liu Wentao Shao Chunlan Zhang Aihua Gu Peng Zhao | 2017 | The Journal of Biomedical Research2017，31，2： | 16 |
| 11 | Phytolith records of the climate change since the past 15000 years in the middle reach of the Yangtze River in China显示文摘基于 ^ 啜 14 ^ C 标明日期和核心沉积调查, phytolith 记录被采用重建在在中间的 Jianghan 平原的 paleovegetation 和古气候长江到达。识别的 Phytoliths 被分配进 21 描述得好的 morphotypes 并且把组划分了成四(Poaceae,蕨纲植物,具球果、阔叶) 。和温暖索引的 phytolith 集合(我 ^ 潜水艇 w ^) 被划分成 18 个生态的地区,它在过去的 15000 年期间在长江的中间的活动范围反映与气候变化有关的完全的植被历史。根据有从石笋, peatland ,诺思大西洋深海的沉积,华中的黄土高原,和阿拉伯语海的 paleoclimatic 指示物的 phytolith 记录的关联沉积,八个气候的阶段被识别包括的上次冰川的最大值( LGM )( 20-14.8 cal kaBP ),持续冰川的消失( LDG )( 14.8-11.9 cal kaBP ),在早 Holocene ( 11.9-8 cal kaBP )的低温度的阶段, Holocene 最佳( 8-4.9 cal kaBP ), Holocene Katathermal ( 4.9-1.1 cal kaBP ),中世纪的温暖时期( M 自从 LDG,象 Bolling-Allerod 温暖的间隔,更旧的 Dryas, Inter-Allerod 冷时期,和更年轻的 Dryas 那样的气候的事件,和八个霍洛辛·邦德事件(B1-8 ) 被识别了。我们的结果证明在研究区域的气候的进化与印度夏天有一个强壮的连接季风( SW 季风),亚洲夏天季风( SE 季风),和在诺思大西洋的 Holocene 事件同时,它可能显示太阳的可变性在一百年、千年的规模影响地球表面气候系统[出版摘要] | Yansheng GU Hanlin WANG Xianyu HUANG Hongxia PENG Junhua HUANG | 2012 | Frontiers of Earth Science2012，6，1： | 14 |
| 12 | Optimizing integrative cultivation management improves grain quality while increasing yield and nitrogen use efficiency in rice显示文摘A major challenge in rice(Oryza sativa L.)production is to cope with increasing grain yield and fertilizer use efficiency without compromising grain quality.This study was designed to determine if optimizing integrative cultivation management in rice could improve grain quality while increase yield and nitrogen use efficiency(NUE).An indica-japonica hybrid rice cultivar and a japonica rice cultivar were grown in the field,with five cultivation managements including no N application(0 N),local farmer's practice(LFP),and three optimizi ng in teg rati ve cultivati on managements,reducing N rate and increasi ng plant density(ND),ND+alternate wetting and moderate soil drying irrigation(NDW),and NDW+applying rapeseed cake fertilizer(NDWR).The results showed that the optimizi ng integrative cultivati on man ageme nts could not only in crease grain yield,but also enhance NUE compared to LFP.Compared to LFP,NDWR sign ifica ntly in creased brow n,milled,head milled rice rate,ratio of the kern el le ngth to breadth and breakdown value of starch,whereas decreased amylose content,gel consiste ncy,prolamin con tent,setback value,perce ntage of chalky kern els,and chalki ness.The three optimizing in tegrative cultivation managements increased con tents of total protei ns,albumin and glutelin,activities of the key enzymes involved in the sucrose-starch con version in grains,root oxidati on activity,and malic and succinic acid concentrations in root exudates during the grain-filling period.The results suggested that optimizing integrative cultivation managements could improve grain quality meanwhile increase grain yield and NUE by enhancing physiological activities of rice plants. | ZHANG Hao HOU Dan-ping PENG Xian-long MA Bing-ju SHAO Shi-mei JING Wen-jiang GU Jun-fei LIU Li-jun WANG Zhi-qin LIU Yuan-ying YANG Jian-chang | 2019 | Journal of Integrative Agriculture2019，18，12： | 14 |
| 13 | Size-dependent peroxidase-like catalytic activity of Fe_3O_4 nanoparticles显示文摘有三种不同尺寸的 Fe3O4 nanoparticles (NP ) 的象 Peroxidase 一样催化性质,由化学一起沉淀和大音阶的第五音鈥揼e l 方法综合了,被紫外鈥搗i s 光谱分析调查。由把 Fe3O4 NP 与 11, 20,和 150 nm 的平均直径作比较,我们发现催化活动与减少的 nanoparticle 尺寸增加。用反应产品和底层的反应水流描绘 Fe3O4 NP 的催化活动的电气化学的方法也被开发。 | Fang Fang Peng YU Zhang Ning Gu | 2008 | Chinese Chemical Letters2008，19，6： | 14 |
| 14 | Cigarette Smoking Increases Risk for Incident Metabolic Syndrome in Chinese Men—Shanghai Diabetes Study显示文摘Objective To determine whether smoking increases the risk for developing metabolic syndrome (MetS) in Chinese men.Methods A total of 693 men with no MetS at baseline were followed for 2.9‐5.5 years.Subjects were divided into nonsmokers,ex‐smokers,and current smokers according to baseline smoking status.Results After adjusting for age,education level,alcohol intake,fasting plasma insulin,HOMA‐IR index,and BMI at baseline and weight change,current smokers were dose‐dependently associated with increased risk for developing new MetS compared with nonsmokers.The odds ratio (OR) was 2.131 (95% CI,1.264,3.592;P<0.01) for the NCEPIII definition or 3.083 (95% CI,1.807,5.295;P<0.01) for the JCDCG definition of MetS.Ex‐smokers who had quit for ≥13 years significantly decreased the risk for developing new MetS defined by the JCDCG definition.Compared with nonsmokers,current smokers were significantly associated with increased incidence of hypertriglyceridemia and low HDL‐C.Conclusion Smoking is a risk factor for developing MetS in Chinese men after adjusting for age,education level,alcohol intake,fasting plasma insulin,HOMA‐IR,BMI,and weight change.This could be due to an increased incidence of dyslipidemia.Smoking cessation for >13 years decreased the risk for developing MetS defined by the JCDCG definition. | ZHU YunXia ZHANG MingLiang HOU XuHong LU JunXi PENG LiangPu GU HuiLin WANG Chen JIA WeiPing | 2011 | Biomedical and Environmental Sciences2011，24，5： | 13 |
| 15 | Biphasic effects of sodium danshensu on vesse function in isolated rat aorta显示文摘 | Ning ZHANG Hao ZOU Lei JIN Jian WANG Mei-fang ZHONG Peng HUANG Bing-qing GU Shi-long MAO Chuan ZHANG Hong CHEN | 2010 | Acta Pharmacologica Sinica2010，31，4： | 13 |
| 16 | Chemical and biological research of Clematis medicinal resources显示文摘Clematis is a botanical source for various pharmaceutically active components,which has long been used in conventional medicine since the beginning of Chinese civilization.Increasing interest in Clematis medicinal resources has led to additional discoveries of triterpenoid saponins,flavonoids,coumarins,alkaloids and many other compounds in various Clematis species,and to investigations on their chemotaxonomy,molecular phylogeny and pharmacology.In continuation with our studies on Clematis chemistry and biology,we review the chemistry,chemotaxonomy,molecular biology and phylogeny of Clematis and their relevance to drug efficacy and drug development.Various databases and technology have been used in literature search in order to characterize the global scientific effort.It is essential to study more species for both the sustainable utilization of Clematis medicinal resources and finding novel compounds with potential clinical utility.Systems biology and omics technologies will play an increasingly important role in future medicinal research involving bioactive compounds of Clematis. | HAO DaCheng GU XiaoJie XIAO PeiGen PENG Yong | 2013 | Chinese Science Bulletin2013，58，10： | 13 |
| 17 | A vicinal effect for promoting catalysis of Pd1/TiO2:supports of atomically dispersed catalysts play more roles than simply serving as ligands显示文摘Atomically dispersing metal atoms on supports has been emerging as an effective strategy to maximize the atom utilization of metals for catalysis. However, due to the lack of effective tools to characterize the detailed structure of metal-support interface, the chemical functions of supports in atomically dispersed metal catalysts are hardly elucidated at the molecular level. In this work, an atomically dispersed Pd_1/TiO_2 catalyst with Ti(Ⅲ) vicinal to Pd is prepared and used to demonstrate the direct involvement of metal atoms on support in the catalysis of dispersed metal atoms. Systematic studies reveal that the Ti(Ⅲ)-O-Pd interface facilitates the activation of O_2 into superoxide(O_2^-), thus promoting the catalytic oxidation. The catalyst exhibits the highest CO turn-over frequency among ever-reported Pd-based catalysts,and enhanced catalysis in the combustion of harmful volatile organic compound(i.e., toluene) and greenhouse gas(i.e., methane). The demonstrated direct involvement of metal atoms on oxide support suggests that the real active sites of atomically dispersed metal catalysts can be far beyond isolated metal atoms themselves. Metal atoms on oxide supports in the vicinity serve as another vector to promote the catalysis of atomically dispersed metal catalysts. | Pengxin Liu Yun Zhao Ruixuan Qin Lin Gu Peng Zhang Gang Fu Nanfeng Zheng | 2018 | Science Bulletin2018，63，11： | 13 |
| 18 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 19 | Circular RNA circVAPA promotes chemotherapy drug resistance in gastric cancer progression by regulating miR-125b-5p/STAT3 axis显示文摘BACKGROUND Gastric cancer(GC)is a prevalent malignancy,leading to a high incidence of cancer-associated death.Cisplatin(DDP)-based chemotherapy is the principal therapy for clinical GC treatment,but DDP resistance is a severe clinical challenge and the mechanism remains poorly understood.Circular RNAs(circRNAs)have been identified to play crucial roles in modulating the chemoresistance of gastric cancer cells.AIM To explore the effect of circVAPA on chemotherapy resistance during GC progression.METHODS The effect of circVAPA on GC progression and chemotherapy resistance was analyzed by MTT assay,colony formation assay,Transwell assay,wound healing assay,and flow cytometry analysis in GC cells and DDP resistant GC cell lines,and tumorigenicity analysis in nude mice in vivo.The mechanism was investigated by luciferase reporter assay,quantitative real-time PCR,and Western blot analysis.RESULTS CircVAPA expression was up-regulated in clinical GC tissues compared with normal samples.CircVAPA depletion inhibited proliferation,migration,and invasion and increased apoptosis of GC cells.The expression of circVAPA,STAT3,and STAT3 downstream genes was elevated in DDP resistant SGC7901/DDP cell lines.CircVAPA knockdown attenuated the DDP resistance of GC cells.Mechanically,circVAPA was able to sponge miR-125b-5p,and miR-125b-5p could target STAT3 in the GC cells.MiR-125b-5p inhibitor reversed circVAPA depletion-enhanced inhibitory effect of DDP on GC cells,and STAT3 knockdown blocked circVAPA overexpression-induced proliferation of DDPtreated SGC7901/DDP cells.The depletion of STAT3 and miR-125b-5p inhibitor reversed circVAPA depletion-induced GC cell apoptosis.Functionally,circVAPA contributed to the tumor growth of SGC7901/DDP cells in vivo.CONCLUSION CircVAPA promotes chemotherapy resistance and malignant progression in GC by miR-125b-5p/STAT3 signaling.Our findings present novel insights into the mechanism by which circVAPA regulates chemotherapy resistance of GC cells.CircVAPA and miR-125b-5p may be considered as the potential targets for GC therapy. | Peng Deng Ming Sun Wen-Yan Zhao Bin Hou Kai Li Tao Zhang Feng Gu | 2021 | World Journal of Gastroenterology2021，27，6： | 11 |
| 20 | Effects of Nitrogen Application Time on Caryopsis Development and Grain Quality of Rice Variety Yangdao 6显示文摘A pot experiment was conducted to study the effects of different nitrogen application time (during the tillering or the booting stages) with the same nitrogen rates on the caryopsis development and grain quality of rice variety Yangdao 6. The increased nitrogen fertilizer (urea), especially applied during the booting stage, could evidently increase the milled rice rate, head rice rate and protein content in rice grains compared with the control (no nitrogen application), and decrease chalky grain rate and amylose content. Moreover, the increased nitrogen fertilizer significantly affected the caryopsis development and enhanced the grain weight when nitrogen applied during the tillering and the booting stages, especially during the booting stage. During caryopsis development the increased nitrogen fertilizer applied during the tillering and booting stages could obviously decrease the total starch and amylose contents, but not obviously for the amylopectin content in rice grain. Increased topdressing of nitrogen fertilizer, especially applied during the booting stage, had significant effect on the development and structures of amyloplasts and proteinoplasts. That is, it could change the distribution, number and shape of amyloplasts and proteinoplasts in the endosperm cells especially in grain abdomen. Compared with the control the arrangements of amyloplasts and proteinoplasts were closer, with more numbers, higher density and less interspaces each ohter. Furthermore, most amyloplasts showed polyhedron under the increased nitrogen fertilizer level. | XIONG Fei WANG Zhong Gu Yun-jie CHEN Gang ZHOU Peng | 2008 | Rice science2008，15，1： | 11 |
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