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| 1 | Circulating tumor cells(CTCs)in breast cancer:a diagnostic tool for prognosis and molecular analysis显示文摘Metastatic breast cancer(MBC)is characterized by a combination of tumor growth,proliferation and metastatic progression and is typically managed with palliative intent.The benefit of standard systemic therapies is relatively limited and the disease is considered incurable suggesting the need to investigate the biological drivers of the various phases of the metastatic process in order to improve the selection of molecularly driven therapies.The detection,enumeration and molecular analysis of circulating tumor cells(CTCs)provide an intriguing opportunity to advance this knowledge.CTCs enumerated by the Food and Drugs Administration-cleared CellSearch TM system are an independent prognostic factor of progressionfree survival(PFS)and overall survival(OS)in MBC patients.Several published papers demonstrated the poor prognosis for MBC patients that presented basal CTC count ≥5 in 7.5mL of blood.Therefore,the enumeration of CTCs during treatment for MBC provides a tool with the ability to predict progression of disease earlier than standard timing of anatomical assessment using conventional radiological tests.During the metastatic process cancer cells exhibit morphological and phenotypic plasticity undergoing epithelialmesenchymal transition(EMT).This important phenomenon is associated with down regulation of epithelial marker(e.g.,EpCAM)with potential limitations in the applicability of current CTCs enrichment methods.Such observations translated in a number of investigations aimed at improving our capabilities to enumerate and perform molecular characterization of CTCs.Theoretically,the phenotypic analysis of CTCs can represent a 'liquid' biopsy of breast tumor that is able to identify a new potential target against the metastatic disease and advance the development and monitoring of personalized therapies. | Xiaoshen Dong R.Katherine Alpaugh Massimo Cristofanilli | 2012 | Chinese Journal of Cancer Research2012，24，4： | 5 |
| 2 | Circu- lating tumor cells predict progression-free and overall survival in Chinese patients with metastatic breast cancer, HER2-posi- tire or triple-negative (CBCSG004) a multicenter, double- blind, prospective trial显示文摘 | JIANG Z F CRISTOFANILLI M SHAO Z M | 2013 | Annals of Oncology: Official Jour- nal of the European Society for Medical Oncology/ESMO2013，24，11： | 1 |
| 3 | Circulating tumor cells versus imaging--predicting overall survival in metastatic breast cancer显示文摘 | Budd GT Cristofanilli M Ellis M J | 2006 | Clin Cancer Res2006，12，： | 1 |
| 4 | Nanotechnology for breast cancer therapy显示文摘 | Tanaka T Paolo D Cristofanilli M | 2009 | Biomed Microdevices2009，11，1： | 1 |
| 5 | Circu- lating tumor cells versus imaging--predicting overall survival in metastatic breast cancer显示文摘 | BUDD G T CRISTOFANILLI M ELLIS M J | 2006 | Clinical Cancer Research: an Official Journal of the American Association for Cancer Re- search2006，12，21： | 1 |
| 6 | Circulating tumor cells, disease progression, and survival in metastatic breast cancer显示文摘 | Cristofanilli M Budd G T Ellis M J | 2004 | N EnglJ Med2004，351，8： | 1 |
| 7 | Dielectric cell separation of fine needle aspirates from tumor xenografts 显示文摘 | Cristofanilli M Krishnamurthy S Das C M | 2008 | J Sep Sci2008，31，： | 1 |
| 8 | Circulating Cumor cells, disease progression, and survival in metastatic breast cancer 显示文摘 | Cristofanilli M Budd GT Ellis M J | 2004 | Cancer2004，351，8： | 1 |
| 9 | HER2 status predicts the presence of circulating tumor cells in patients with operable breast cancer显示文摘 | Long JE Mosalpuria K Cristofanilli M | | 0，，03： | 1 |
| 10 | Circulating tumor cells, disease progression, and survival in metastatic breast cancer 显示文摘 | Cristofanilli M Budd GT Ellis MJ | 2004 | N Engl J Med2004，351，8： | 1 |
| 11 | Circulating tumor cells, disease progression, and survival in metastatic breast cancer 显示文摘 | Cristofanilli M Budd G T Ellis M J | 2004 | N Engl J Med2004，351，8： | 1 |
| 12 | Circulating tumor cells, disease progression, and survival in metastatic breast cancer 显示文摘 | Cristofanilli M Budd GT Ellis MJ | 2004 | N Engl J Med2004，351，： | 1 |
| 13 | Circulating Cumor eells:a novel prognostic factor for newly diagnosed metastatic breast cancer显示文摘 | Cristofanilli M Hayes DF Budd GT | 2005 | J Clin Oncol2005，23，7： | 1 |
| 14 | Circulatingtumor cells, disease progression, and survival in metastatic breastcancer显示文摘 | CRISTOFANILLI M BUDD G T ELLIS M J | 2004 | N Engl J Med2004，351，8： | 1 |
| 15 | Circulating tumor cells at each follow-up time point during therapy of metastatic breast cancer patients predict progression-free and overall survival 显示文摘 | Hayes DF Cristofanilli M Budd GT | 2006 | Clin Cancer Res2006，12，141： | 1 |
| 16 | Circulating tumor cells in metastatic breast cancer: biologic staging beyond tumor burden显示文摘 | Cristofanilli M Broglio KR Guarneri V | 2007 | Clin Breast Cancer2007，7，： | 1 |
| 17 | A CXCR4 antagonist CTCE-9908 inhibits primary tumor growth and metastasis of breast cancer显示文摘 | Huang EH Singh B Cristofanilli M | 2009 | J Surg Res2009，155，2： | 1 |
| 18 | Circalating tumor cells, disease progression, and survival in metastatic breast cancer显示文摘 | CRISTOFANILLI M BUDD G T ELLIS M J | 2004 | N Engl J Med2004，351，8： | 1 |
| 19 | Neuronal MAP2 Mrna: species-depedet diffretial dendritic targeting competence显示文摘 | Cristofanilli M Thanas S Brosius J | 2004 | J Mol Biol2004，341，4： | 1 |
| 20 | Inflammatory breast cancer (IBC) and patterns of recurrence:understanding the biolo- gy of a unique disease显示文摘 | Cristofanilli M Valero V Buzdar AU | 2007 | Cancer2007，110，7： | 1 |
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