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| 1 | Tau Accumulation via Reduced Autophagy Mediates GGGGCC Repeat Expansion-Induced Neurodegeneration in Drosophila Model of ALS显示文摘Expansions of trinucleotide or hexanucleotide repeats lead to several neurodegenerative disorders,including Huntington disease[caused by expanded CAG repeats(CAGr)in the HTT gene],and amyotrophic lateral sclerosis[ALS,possibly caused by expanded GGGGCC repeats(G4C2r)in the C9ORF72 gene],of which the molecular mechanisms remain unclear.Here,we demonstrated that lowering the Drosophila homologue of tau protein(dtau)significantly rescued in vivo neurodegeneration,motor performance impairments,and the shortened life-span in Drosophila expressing expanded CAGr or expanded G4C2r.Expression of human tau(htau4 R)restored the disease-related phenotypes that had been mitigated by the loss of dtau,suggesting an evolutionarily-conserved role of tau in neurodegeneration.We further revealed that G4C2r expression increased tau accumulation by inhibiting autophagosome-lysosome fusion,possibly due to lowering the level of BAG3,a regulator of autophagy and tau.Taken together,our results reveal a novel mechanism by which expanded G4C2r causes neurodegeneration via an evolutionarily-conserved mechanism.Our findings provide novel autophagy-related mechanistic insights into C9ORF72-ALS and possible entry points to disease treatment. | Xue Wen Ping An Hexuan Li Zijian Zhou Yimin Sun Jian Wang Lixiang Ma Boxun Lu | 2020 | Neuroscience Bulletin2020，36，12： | 4 |
| 2 | M3SC:A Generic Dataset for Mixed Multi-Modal(MMM)Sensing and Communication Integration显示文摘The sixth generation(6G)of mobile communication system is witnessing a new paradigm shift,i.e.,integrated sensing-communication system.A comprehensive dataset is a prerequisite for 6G integrated sensing-communication research.This paper develops a novel simulation dataset,named M3SC,for mixed multi-modal(MMM)sensing-communication integration,and the generation framework of the M3SC dataset is further given.To obtain multimodal sensory data in physical space and communication data in electromagnetic space,we utilize Air-Sim and WaveFarer to collect multi-modal sensory data and exploit Wireless InSite to collect communication data.Furthermore,the in-depth integration and precise alignment of AirSim,WaveFarer,andWireless InSite are achieved.The M3SC dataset covers various weather conditions,multiplex frequency bands,and different times of the day.Currently,the M3SC dataset contains 1500 snapshots,including 80 RGB images,160 depth maps,80 LiDAR point clouds,256 sets of mmWave waveforms with 8 radar point clouds,and 72 channel impulse response(CIR)matrices per snapshot,thus totaling 120,000 RGB images,240,000 depth maps,120,000 LiDAR point clouds,384,000 sets of mmWave waveforms with 12,000 radar point clouds,and 108,000 CIR matrices.The data processing result presents the multi-modal sensory information and communication channel statistical properties.Finally,the MMM sensing-communication application,which can be supported by the M3SC dataset,is discussed. | Xiang Cheng Ziwei Huang Lu Bai Haotian Zhang Mingran Sun Boxun Liu Sijiang Li Jianan Zhang Minson Lee | 2023 | China Communications2023，20，11： | 3 |
| 3 | Technological Exploration of RRAM Crossbar Array for Matrix-Vector Multiplication显示文摘矩阵向量增加是为许多计算地集中的算法的关键操作。抵抗切换的随机的存取存储器(RRAM ) 设备和 RRAM 闩穿的新兴的金属氧化物表明了模拟矩阵向量增加的一条有希望的硬件认识与超离频精力效率。在这篇论文,我们分析设备水平和电路水平的影响非理想的因素包括 RRAM 设备的非线性的当前电压的关系,设备制造的变化并且给操作,和 interconnect 抵抗以及另外的闩数组写参数。在那上,我们建议工艺的探索流动让设备参数配置克服非理想的因素的影响并且为各特定的申请在性能,精力,和可靠性之中完成一宗更好的交易。我们向量机器(SVM ) 和混合公民标准和技术(MNIST ) 模式识别数据集开创的支持的模拟结果证明那个 RRAM 闩数组基于 SVM 是柔韧的输入信号变化但是对通道差距偏差敏感。进一步的抵抗决定测试一台 6 位的 RRAM 设备对有能力的礼品在 90% 附近认识到识别精确性,显示 RRAM 闩数组的物理可行性基于 SVM。另外,建议工艺的探索流动能与以前的工作相比在 MNIST 数据集和 26.4% 精力积蓄上完成识别精确性的 10.98% 改进。试验性的结果也证明节省的超过 84.4% 力量能以很少精确性减小的成本被完成。 | Lixue Xia Peng Gu Boxun Li Tianqi Tang Xiling Yin Wenqin Huangfu Shimeng Yu Yu Cao Yu Wang Huazhong Yang | 2016 | Journal of Computer Science & Technology2016，31，1： | 2 |
| 4 | Osseointegration of hollow porous titanium prostheses loaded with cancellous bone matrix in rabbits显示文摘This study aimed to observe the osseointegration of hollow porous titanium prostheses (HPTP) loaded with cancellous bone matrix (CBM) in rabbits using histological and biomechanical perspectives.Experimental samples were implanted into the lateral femoral condyles of 66 New Zealand rabbits,allocated into the following groups:non-porous prosthesis group (Group A,n=22);HPTP group (Group B,n=22);HPTP+CBM group (Group C,n=22).The rabbits were sacrificed at 3,8 and 12 weeks,postoperatively.X-ray analyses,microscopy techniques and morphological measurement software and mechanical tests were used for evaluation.At each time point,the tissues surrounding the implants were similar in all of the groups,with bony in-growth into the 2-mm round holes observed for the defects in Groups B and C.However,the internal bone formation was significantly better in Group C than in Group B at different time points (P<0.01).Biomechanically,the pull-out forces were significantly greater in Groups B and C than in Group A (P<0.01),with no difference between Groups B and C (P>0.05).These results suggest that bone can grow into the cavities of HPTP to achieve more stable locking fixation,and those osteogenic materials,such as CBM,can enhance osteogenesis to achieve better osseointegration between the implant and the host bone. | WEI JunQiang CAI Xu WANG Yan ZHANG BoXun CHEN Hua ZHANG Li ZHAO Bin WANG AiYua | 2012 | Chinese Science Bulletin2012，57，20： | 2 |
| 5 | Facile Synthesis of Fe3Pt-Ag Nanocomposites for Catalytic Reduction of Methyl Orange显示文摘 | HAN Donglai LI Boxun XING Guoliang ZHANG Yuanyuan CHEN Yue SUN Yantao ZHANG Yongjun LIU Yang YANG Jinghai | 2018 | Chemical Research in Chinese Universities2018，34，6： | 1 |
| 6 | Manganese dioxide as a new cathode catalyst in microbial fuel cells显示文摘 | Xiang Li Boxun Hu Steven Suib Yu Lei Baikun Li | 2009 | Journal of Power Sources2009，，9： | 1 |
| 7 | Electrospun poly(L-lactic acid)/gelatine membranes loaded with doxorubicin for effective suppression of glioblastoma cell growth in vitro and in vivo显示文摘Electrospun membranes are attracting interest as a drug delivery system because of their material composition flexibility and versatile drug loading.In this study,the electrospun membrane was loaded with doxorubicin(DOX)via electrostatic adsorption for long-term drug delivery.DOX loading process was optimized by varying temperature,time,drug concentration,pH and ionic strength of solutions.The loading process did not impair the structural properties of the membrane.Next,we investigated the drug release kinetics using spectroscopic techniques.The composite membranes released 22%of the adsorbed DOX over the first 48 h,followed by a slower and sustained release over 4 weeks.The DOX release was sensitive to acidic solutions that the release rate at pH 6.0 was 1.27 times as that at pH 7.4.The DOX-loaded membranes were found to be cytotoxic to U-87 MG cells in vitro that decreased the cell viability from 82.92%to 25.49%from 24 to 72 h of coincubation.These membranes showed strong efficacy in suppressing tumour growth in vivo in glioblastoma-bearing mice that decreased the tumour volume by 77.33%compared with blank membrane-treated group on Day 20.In conclusion,we have developed an effective approach to load DOX within a clinically approved poly(L-lactic acid)/gelatine membrane for local and longterm delivery of DOX for the treatment of glioblastoma. | Boxun Liu Zhizhong Jin Haiyan Chen Lun Liang Yao Li Guo Wang Jing Zhang Tao Xu | 2021 | Regenerative Biomaterials2021，8，5： | 0 |
| 8 | Coaxial bioprinted microfibers with mesenchymal stem cells for glioma microenvironment simulation显示文摘Due to their special anatomical and physiological features,central nervous system diseases still presented challenges,despite the fact that some advances have been made in early diagnosis and precision medicine.One of the complexities in treating tumors is the tumor microenvironment,which includes mesenchymal stem cells(MSCs)that exhibit tumor tropism and can be used for cell therapy.However,whether MSCs promote or suppress gliomas is still unclear,especially in glioma microenvironments.In this study,a coaxial microfiber was designed to mimic the tumor microenvironment and to reveal the effect of MSCs on glioma cells.The fiber shell was composed of MSCs and alginate,and the core was filled with U87 MG(glioblastoma)cells and gelatin methacrylate.This Shell-MSC/Core-U87 MG microenvironment improved the proliferation,survival,invasion,metastasis,and drug resistance of glioma cells,while simultaneously maintaining the stemness of glioma cells.In summary,coaxial extrusion bioprinted Shell-MSC/Core-U87 MG microfiber is an ideal platform for tumor and stromal cell coculture to observe tumor biological behavior in vitro. | Zhizhong Jin Xinda Li Boxun Liu Xinru Yan Shuai Han Tao Xu Anhua Wu | 2022 | Bio-Design and Manufacturing2022，5，2： | 0 |
| 9 | Optogenetic control of GGGGCC repeat-containing RNA phase transition显示文摘The GGGGCC(G_(4)C_(2))hexanucleotide repeat expansion in the C9ORF72 gene is a major cause of both hereditary amyotrophic lateral sclerosis and familial frontotemporal dementia.Recent studies have shown that G_(4)C_(2)hexanucleotide repeat-containing RNA transcripts((G_(4)C_(2))_(n)RNA)could go through liquid-liquid phase separation to form RNA foci,which may elicit neurodegeneration.However,the direct causality between these abnormal RNA foci and neuronal toxicity remains to be demonstrated.Here we introduce an optogenetic control system that can induce the assembly and phase separation of(G_(4)C_(2))_(n)RNA foci with blue light illumination in human cells,by fusing a specific(G_(4)C_(2))_(n)RNA binding protein as the linker domain to Cry2,a protein that oligomerizes in response to blue light.Our results demonstrate that a higher number of G_(4)C_(2)repeats have the potential to be induced into more RNA foci in the cells.Both spontaneous and induced RNA foci display liquid-like properties according to FRAP measurements.Computational simulation shows strong consistency with the experimental results and supports the effect of our system to promote the propensity of(G_(4)C_(2))_(n)RNA towards phase separation.This system can thus be used to investigate whether(G_(4)C_(2))_(n)RNA foci would disrupt normal cellular processes and lead to pathological phenotypes relevant to repeat expansion disorders. | Xiong Li Shengyi Lu Boxun Lu Xiaoli Sun | 2022 | Fundamental Research2022，2，6： | 0 |
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