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| 1 | How to assess the efficacy or failure of targeted therapy:deciding when to stop sorafenib in hepatocellular carcinoma显示文摘Sorafenib is thus far the only systemic treatment for hepatocellular carcinoma(HCC) based on the results of two randomized controlled trials performed in Western and in Eastern countries, despite a poor response rate(from 2% to 3.3%) following conventional evaluation criteria. It is now recognized that the criteria(European Association of the Study of the Liver criteria, modified response evaluation criteria in solid tumors) based on contrast enhanced techniques(computed tomography scan, magnetic resonance imaging) aimed to assess the evolution of the viable part of the tumor(hypervascularized on arterial phase) are of major interest to determine the efficacy of sorafenib and of most antiangiogenic drugs in patients with HCC. The role of alphafetoprotein serum levels remains unclear. In 2016, in accordance with the SHARP and the Asia-Pacific trials, sorafenib must be stopped when tolerance is poor despite dose adaptation or in cases of radiological and symptomatic progression. This approach will be different in cases of available second-line therapy trials. Some recent data(in renal cell carcinoma) revealed that despite progression in patients who received sorafenib, this drug can still decrease tumor progression compared to drug cessation. Then, before deciding to continue sorafenib post-progression or shift to another drug, knowing other parameters of post-progression survival(Child-Pugh class, Barcelona Clinic Liver Cancer, alphafetoprotein, post-progression patterns in particular, the development of extrahepatic metastases and of portal vein thrombosis) will be of major importance. | Jean-Luc Raoul Xavier Adhoute Marine Gilabert Julien Edeline | 2016 | World Journal of Hepatology2016，8，35： | 8 |
| 2 | Systemic chemotherapy for hepatocellular carcinoma in non-cirrhotic liver:A retrospective study显示文摘AIM:To investigate the efficacy and toxicity of systemic chemotherapy in a retrospective study of patients with hepatocellular carcinoma(HCC)occurring in normal or fibrotic liver without cirrhosis. METHODS:Twenty-four patients with metastatic or locally advanced HCC in a normal or a fibrotic liver were given systemic chemotherapy(epirubicin,cis- platin and 5-fluorouracil or epirubicin,cisplatin and capecitabine regimens).Tumor response,time to pro- gression,survival,and toxicity were evaluated. RESULTS:There were 7 women and 17 men,mean age 54±10 years;18 patients had a normal liver and 6 had a fibrotic liver(F1/F2 on biopsy).Mean tumor size was 14 cm,5 patients had portal vein thrombosis and 7 had metastasis.Patients received a median of 4 chemotherapy sessions.Overall tolerance was good. There were 5 partial responses(objective response rate =22%),and tumor control rate was 52%.Second line surgical resection was possible in two patients.Median survival was 11 mo,and 1-and 2-year overall survival rates were 50%±10%and 32%±11%,respectively. CONCLUSION:In patients with HCC in a non-cirrhotic liver,chemotherapy was well tolerated and associated with an objective response rate of 22%,including two patients who underwent secondary surgical resection. | Julien Edeline Jean-Luc Raoul Elodie Vauleon Anne Guillygomac'h Karim Boud jema Eveline Boucher | 2009 | World Journal of Gastroenterology2009，15，6： | 4 |
| 3 | Volumetric Changes after 90 Y Radioembolization for Hepatocellular Carcinoma in Cirrhosis: An Option to Portal Vein Embolization in a Preoperative Setting?显示文摘 | Julien Edeline Laurence Lenoir Karim Boudjema Yan Rolland Anne Boulic Fanny Le Du Marc Pracht Jean-Luc Raoul Bruno Clément Etienne Garin Eveline Boucher | 2013 | Annals of Surgical Oncology2013，，8： | 3 |
| 4 | Plant models faithful to botanical structure and development显示文摘 | Phillippe de Reffye Claude Edelin Jean Fran?on Marc Jaeger Claude Puech | 1988 | ACM SIGGRAPH Computer Graphics1988，，4： | 2 |
| 5 | Plant models faithful to botanical structure and development显示文摘 | De Reffye P Edelin C Francon J | 1988 | Computer Graphics1988，22，4： | 1 |
| 6 | Plant models faith- ful to botanical structure and development显示文摘 | DeReffye P Edelin C Francon Jetal | 1988 | Computer Graphics1988，22，4： | 1 |
| 7 | Rapid development of learninginduced receptive field plasticity inthe auditory cortex 显示文摘 | Edeline JM Pham P Weinberger NM | 1993 | Behav Neurosci1993，107，4： | 1 |
| 8 | Cementoplasty for painful bone metastases: a series of 42 cases 显示文摘 | Botton E Edeline J Rolland Y | 2012 | Medical Ontology2012，29，2： | 1 |
| 9 | Lobar Hepatocellular Carcinoma with Ipsilateral Portal Vein Tumor Thrombosis Treated with Yttrium-90 Glass Microsphere Radioembolization: Preliminary Results显示文摘 | M. Pracht J. Edeline L. Lenoir M. Latournerie H. Mesbah O. Audrain Y. Rolland B. Clément J. L. Raoul E. Garin E. Boucher Zhi Dai | 2013 | International Journal of Hepatology2013，，： | 1 |
| 10 | Does head -only exposure to GSM -900 electromagnetic fields affect the performance of rats in spatial learningtasks 显示文摘 | DUBREUIL D JAY T EDELINE J M | 2002 | Behav Brain Res2002，129，： | 1 |
| 11 | Plant models faithful to botani-cal structure and development显示文摘 | DeReffy P Edelin C Francon J | 1988 | Computer Graphics1988，22，4： | 1 |
| 12 | Does head-only ex- posure to GSM-900 electromagnetic fields affect the performance of rats in spatial learning tasks? 显示文摘 | Dubreuil D Jay T Edeline J M | 2002 | Behav Brain Res2002，129，12： | 1 |
| 13 | Comparison of tumor response by Response Evaluation Criteria in Solid Tumors (RECIST) and modi- fied RECIST in patients treated with sorafenib for hepatocellular carci- noma显示文摘 | Edeline J Boucher E Rolland Y | 2012 | Cancer2012，118，1： | 1 |
| 14 | Plant Models Faithful to Botanical Structure and Development 显示文摘 | de Reffye P Edelin C Francon J | 1988 | Computer Graphics (S0097-8493)1988，22，4： | 1 |
| 15 | Plant models faithful to botanical structure and development显示文摘 | Reffye P Edelin C Franqon J | 1988 | Computer Graphics1988，22，4： | 1 |
| 16 | Plants models faithful to botanical structure and development显示文摘 | de Reffye P Edelin C Franqon J | 1998 | ComputerGraphics1998，，： | 1 |
| 17 | Comparison of tumor res-ponse by response evaluation criteria in solid tumors (RECIST)and modified RECIST in patients treated with sorafenib forhepatocellular carcinoma显示文摘 | Edeline J Boucher E Rolland Y | 2012 | Cancer2012，118，： | 1 |
| 18 | Plant models faithful to botanical structure and development显示文摘 | de Reffye P Edelin C Franqon J | 1988 | Computer Graphics1988，22，4： | 1 |
| 19 | Plant models faithful to botanical structure and development显示文摘 | de Reffye P Edelin C Francon J | 1988 | ACM Siggraph1988，22，4： | 1 |
| 20 | Plant models faithful to botanical structure and development显示文摘 | De Reffye P Edelin C Franqon J | 1988 | Computer Graphics1988，22，4： | 1 |
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