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404篇 您的检索式:作者名="Laterre"
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1sTREM-1 is a specific biomarker of TREM-1 pathway activation显示文摘TREM-1(triggering receptor expressed on myeloid cells-1)is a transmembrane receptor expressed by innate immune cells,including endothelial cells and platelets.TREM-1 is a crucial mediator of septic shock that acts by synergizing with Toll-like receptors(TLRs)to amplify the inflammatory responses to pathogens,thus promoting sepsis-induced immune dysregulation and organ dysfunction[1,2,3].Lucie Jolly Kévin Carrasco Margarita Salcedo-Magguilli Jean-Jacques Garaud Simon Lambden Tom van der Poll Alexandre Mebazaa Pierre-François Laterre Sebastien Gibot Amir Boufenzer Marc Derive 2021Cellular & Molecular Immunology2021,18,8:8
2Adult-to-adult living-donor liver transplantation: The experience of the Université catholique de Louvain显示文摘Background: Liver transplantation is the treatment for end-stage liver diseases and well-selected malignancies. The allograft shortage may be alleviated with living donation. The initial UCLouvain experience of adult living-donor liver transplantation(LDLT) is presented. Methods: A retrospective analysis of 64 adult-to-adult LDLTs performed at our institution between 1998 and 2016 was conducted. The median age of 29(45.3%) females and 35(54.7%) males was 50.2 years(interquartile range, IQR 32.9–57.5). Twenty-two(34.4%) recipients had no portal hypertension. Three(4.7%) patients had a benign and 33(51.6%) a malignant tumor [19(29.7%) hepatocellular cancer, 11(17.2%) secondary cancer and one(1.6%) each hemangioendothelioma, hepatoblastoma and embryonal liver sarcoma]. Median donor and recipient follow-ups were 93 months(IQR 41–159) and 39 months(22–91), respectively. Results: Right and left hemi-livers were implanted in 39(60.9%) and 25(39.1%) cases, respectively. Median weights of right-and left-liver were 810 g(IQR 730–940) and 454 g(IQR 394–534), respectively. Graft-to-recipient weight ratios(GRWRs) were 1.17%(right, IQR 0.98%-1.4%) and 0.77%(left, 0.59%-0.95%). One-and five-year patient survivals were 85% and 71%(right) vs. 84% and 58%(left), respectively. Oneand five-year graft survivals were 74% and 61%(right) vs. 76% and 53%(left), respectively. The patient and graft survival of right and left grafts and of very small( < 0.6%), small(0.6%–0.79%) and large( ≥0.8%) GRWR were similar. Survival of very small grafts was 86% and 86% at 3-and 12-month. No donor died while five(7.8%) developed a Clavien–Dindo complication IIIa, IIIb or IV. Recipient morbidity consisted mainly of biliary and vascular complications; three(4.7%) recipients developed a small-for-size syndrome according to the Kyushu criteria. Conclusions: Adult-to-adult LDLT is a demanding procedure that widens therapeutic possibilities of many hepatobiliary diseases. The donor procedure can be done safely with low morbidity. The recipient operation carries a major morbidity indicating an important learning curve. Shifting the risk from the donor to the recipient, by moving from the larger right-liver to the smaller left-liver grafts, should be further explored as this policy makes donor hepatectomy safer and may stimulate the development of transplant oncology.Samuele Iesari Milton Eduardo Inostroza Nú?ez Juan Manuel Rico Juri Olga Ciccarelli Eliano Bonaccorsi-Riani Laurent Coubeau Pierre-Fran?ois Laterre Pierre Goffette Chantal De Reyck Beno?t Lengelé Pierre Gianello Jan Lerut 2019Hepatobiliary & Pancreatic Diseases International2019,18,2:5
3Ruptured hydatid cyst in a patient with shock显示文摘Echinococcosis is a severe helminthic zoonosis largely caused by Echinococcus granulosus and frequently encountered in endemic areas.The liver and lung are the most frequently involved organs.Cyst rupture into the peritoneal cavity represents a rare but serious complication.Herein,we describe an acute occurrence of anaphylactic shock due to a spontaneous rupture of hydatid cyst in a 21-year-old Turkish patient unwittingly infected by Echinococcosis.Resection surgery of the perforated cyst in combination with cleaning of the abdominal cavity was performed.The patient rapidly improved and no relapse occurred during a follow-up of 8 months.Anaphylaxis is a serious complication of hydatid cyst rupture and needs to be promptly diagnosed.The main objective of our report is to underscore this life-threatening complication that should be considered when anaphylactic shock of unknown origin occurs,even in non-endemic regions.Moreover,we emphasize the need for a radical surgical approach to avoid widespread dissemination.Diego Castanares-Zapatero Pierre Franois Laterre 2009Hepatobiliary & Pancreatic Diseases International2009,8,6:2
4Electrophretic morphology of gamma globulins in cerebrospinal fluid of multiple sclerosis and other diseases of the nervous system 显示文摘Laterre EC Callewaert A Hereans JF 1970Neurology1970,20,:1
5Efficacy and safety of recombinant human activaled protein C for severe sepsis 显示文摘Bernard GR Vincent JL Laterre PF 2001N Engl J Med2001,344,10:1
6CURB-65, PSI, and APACHE Ⅱ to assess mortality risk in patients with severe sepsis and community acquired pneumonia in PROWESS 显示文摘Richards G Levy H Laterre PF 2011J Intensive Care Med2011,26,1:1
7Drotrecoginalfa (acti- vated) for adults with severe sepsis and a low risk of death 显示文摘Abraham E Laterre PF Garg R 2010New Engl J Med2010,353,13:1
8A pilot-controlled study of a polymyxin B-immobilized hemoperfusion cartridge in patients with severe sepsis secondary to intra-abdominal infection显示文摘Vincent JL Laterre PF Cohen J 2005Shock2005,23,5:1
9Efficacy and safety of recombinant human activated protein C for severe sepsis 显示文摘Bernm'd GR Vincent JL Laterre PF 2001N Engl J Med2001,344,10:1
10Efficacy and safety of recombinant human activated protein C for severe sepsis显示文摘Bernard GR Vincent JL Laterre PF 2001N Engl J Med2001,344,10:1
11Electrocardiographic changes after head trauma 显示文摘Wittebole X Hantson P Laterre PF 2005J Electrocardiol2005,1,:1
12A clinical evaluation committee assessment of recombinant human tissue factor pathway inhibitor (tifacogin) in patients with severe community-acquired pneumonia 显示文摘Laterre PF Opal SM Abraham E 2009Crit Care2009,13,2:1
13Efficacy and safety of recombinant human activated protein C for severe sepsis 显示文摘Bernard GR Vincent JL Laterre PF 2001NEJM2001,344,10:1
14Efficacy and safety of recombinant human activated protein C for severe sepsis显示文摘Bernard GR Vincent JL Laterre PF 2001N Engl J Med2001,344,:1
15Compartmentalization of the inflammatory response during acute pancreatitis: correlation with local and systemic complications 显示文摘Dugernier TL Laterre PF Wittebole X 2003Am J Respir Crit Care Med2003,168,2:1
16Efficacy and safety of recombinant human activated protein Cfor severe sepsis 显示文摘Gordon R Vincent JL Laterre PF 2001New Eng J Med2001,344,10:1
17Efficacy and safety of recombinant human activated protein C for severe sepsis显示文摘Bernard GR Vincent JL Laterre PF 2001New Engl J Med2001,344,10:1
18Recombinant tissue factor pathway inhibitor in severe community-acquired pneumonia: a randomized trial显示文摘Wunderink RG Laterre PF Francois B 2011Am J Respir Crit Care Med2011,183,11:1
19Toll-like receptor 4 modulation as a strategy to treat sepsis 显示文摘Wittebole X Castanares-Zapatero D Laterre PF 2010Mediators Inflamm2010,2010,56:1
20Adult liver transplantation:UCL experience显示文摘Lerut J Laterre PF Roggen F 1999Acta Gastroenlerol Belg1999,62,3:1
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