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| 1 | sTREM-1 is a specific biomarker of TREM-1 pathway activation显示文摘TREM-1(triggering receptor expressed on myeloid cells-1)is a transmembrane receptor expressed by innate immune cells,including endothelial cells and platelets.TREM-1 is a crucial mediator of septic shock that acts by synergizing with Toll-like receptors(TLRs)to amplify the inflammatory responses to pathogens,thus promoting sepsis-induced immune dysregulation and organ dysfunction[1,2,3]. | Lucie Jolly Kévin Carrasco Margarita Salcedo-Magguilli Jean-Jacques Garaud Simon Lambden Tom van der Poll Alexandre Mebazaa Pierre-François Laterre Sebastien Gibot Amir Boufenzer Marc Derive | 2021 | Cellular & Molecular Immunology2021,18,8: | 8 |
| 2 | Adult-to-adult living-donor liver transplantation: The experience of the Université catholique de Louvain显示文摘Background: Liver transplantation is the treatment for end-stage liver diseases and well-selected malignancies. The allograft shortage may be alleviated with living donation. The initial UCLouvain experience of adult living-donor liver transplantation(LDLT) is presented. Methods: A retrospective analysis of 64 adult-to-adult LDLTs performed at our institution between 1998 and 2016 was conducted. The median age of 29(45.3%) females and 35(54.7%) males was 50.2 years(interquartile range, IQR 32.9–57.5). Twenty-two(34.4%) recipients had no portal hypertension. Three(4.7%) patients had a benign and 33(51.6%) a malignant tumor [19(29.7%) hepatocellular cancer, 11(17.2%) secondary cancer and one(1.6%) each hemangioendothelioma, hepatoblastoma and embryonal liver sarcoma]. Median donor and recipient follow-ups were 93 months(IQR 41–159) and 39 months(22–91), respectively. Results: Right and left hemi-livers were implanted in 39(60.9%) and 25(39.1%) cases, respectively. Median weights of right-and left-liver were 810 g(IQR 730–940) and 454 g(IQR 394–534), respectively. Graft-to-recipient weight ratios(GRWRs) were 1.17%(right, IQR 0.98%-1.4%) and 0.77%(left, 0.59%-0.95%). One-and five-year patient survivals were 85% and 71%(right) vs. 84% and 58%(left), respectively. Oneand five-year graft survivals were 74% and 61%(right) vs. 76% and 53%(left), respectively. The patient and graft survival of right and left grafts and of very small( < 0.6%), small(0.6%–0.79%) and large( ≥0.8%) GRWR were similar. Survival of very small grafts was 86% and 86% at 3-and 12-month. No donor died while five(7.8%) developed a Clavien–Dindo complication IIIa, IIIb or IV. Recipient morbidity consisted mainly of biliary and vascular complications; three(4.7%) recipients developed a small-for-size syndrome according to the Kyushu criteria. Conclusions: Adult-to-adult LDLT is a demanding procedure that widens therapeutic possibilities of many hepatobiliary diseases. The donor procedure can be done safely with low morbidity. The recipient operation carries a major morbidity indicating an important learning curve. Shifting the risk from the donor to the recipient, by moving from the larger right-liver to the smaller left-liver grafts, should be further explored as this policy makes donor hepatectomy safer and may stimulate the development of transplant oncology. | Samuele Iesari Milton Eduardo Inostroza Nú?ez Juan Manuel Rico Juri Olga Ciccarelli Eliano Bonaccorsi-Riani Laurent Coubeau Pierre-Fran?ois Laterre Pierre Goffette Chantal De Reyck Beno?t Lengelé Pierre Gianello Jan Lerut | 2019 | Hepatobiliary & Pancreatic Diseases International2019,18,2: | 5 |
| 3 | Ruptured hydatid cyst in a patient with shock显示文摘Echinococcosis is a severe helminthic zoonosis largely caused by Echinococcus granulosus and frequently encountered in endemic areas.The liver and lung are the most frequently involved organs.Cyst rupture into the peritoneal cavity represents a rare but serious complication.Herein,we describe an acute occurrence of anaphylactic shock due to a spontaneous rupture of hydatid cyst in a 21-year-old Turkish patient unwittingly infected by Echinococcosis.Resection surgery of the perforated cyst in combination with cleaning of the abdominal cavity was performed.The patient rapidly improved and no relapse occurred during a follow-up of 8 months.Anaphylaxis is a serious complication of hydatid cyst rupture and needs to be promptly diagnosed.The main objective of our report is to underscore this life-threatening complication that should be considered when anaphylactic shock of unknown origin occurs,even in non-endemic regions.Moreover,we emphasize the need for a radical surgical approach to avoid widespread dissemination. | Diego Castanares-Zapatero Pierre Franois Laterre | 2009 | Hepatobiliary & Pancreatic Diseases International2009,8,6: | 2 |
| 4 | Electrophretic morphology of gamma globulins in cerebrospinal fluid of multiple sclerosis and other diseases of the nervous system 显示文摘 | Laterre EC Callewaert A Hereans JF | 1970 | Neurology1970,20,: | 1 |
| 5 | Efficacy and safety of recombinant human activaled protein C for severe sepsis 显示文摘 | Bernard GR Vincent JL Laterre PF | 2001 | N Engl J Med2001,344,10: | 1 |
| 6 | CURB-65, PSI, and APACHE Ⅱ to assess mortality risk in patients with severe sepsis and community acquired pneumonia in PROWESS 显示文摘 | Richards G Levy H Laterre PF | 2011 | J Intensive Care Med2011,26,1: | 1 |
| 7 | Drotrecoginalfa (acti- vated) for adults with severe sepsis and a low risk of death 显示文摘 | Abraham E Laterre PF Garg R | 2010 | New Engl J Med2010,353,13: | 1 |
| 8 | A pilot-controlled study of a polymyxin B-immobilized hemoperfusion cartridge in patients with severe sepsis secondary to intra-abdominal infection显示文摘 | Vincent JL Laterre PF Cohen J | 2005 | Shock2005,23,5: | 1 |
| 9 | Efficacy and safety of recombinant human activated protein C for severe sepsis 显示文摘 | Bernm'd GR Vincent JL Laterre PF | 2001 | N Engl J Med2001,344,10: | 1 |
| 10 | Efficacy and safety of recombinant human activated protein C for severe sepsis显示文摘 | Bernard GR Vincent JL Laterre PF | 2001 | N Engl J Med2001,344,10: | 1 |
| 11 | Electrocardiographic changes after head trauma 显示文摘 | Wittebole X Hantson P Laterre PF | 2005 | J Electrocardiol2005,1,: | 1 |
| 12 | A clinical evaluation committee assessment of recombinant human tissue factor pathway inhibitor (tifacogin) in patients with severe community-acquired pneumonia 显示文摘 | Laterre PF Opal SM Abraham E | 2009 | Crit Care2009,13,2: | 1 |
| 13 | Efficacy and safety of recombinant human activated protein C for severe sepsis 显示文摘 | Bernard GR Vincent JL Laterre PF | 2001 | NEJM2001,344,10: | 1 |
| 14 | Efficacy and safety of recombinant human activated protein C for severe sepsis显示文摘 | Bernard GR Vincent JL Laterre PF | 2001 | N Engl J Med2001,344,: | 1 |
| 15 | Compartmentalization of the inflammatory response during acute pancreatitis: correlation with local and systemic complications 显示文摘 | Dugernier TL Laterre PF Wittebole X | 2003 | Am J Respir Crit Care Med2003,168,2: | 1 |
| 16 | Efficacy and safety of recombinant human activated protein Cfor severe sepsis 显示文摘 | Gordon R Vincent JL Laterre PF | 2001 | New Eng J Med2001,344,10: | 1 |
| 17 | Efficacy and safety of recombinant human activated protein C for severe sepsis显示文摘 | Bernard GR Vincent JL Laterre PF | 2001 | New Engl J Med2001,344,10: | 1 |
| 18 | Recombinant tissue factor pathway inhibitor in severe community-acquired pneumonia: a randomized trial显示文摘 | Wunderink RG Laterre PF Francois B | 2011 | Am J Respir Crit Care Med2011,183,11: | 1 |
| 19 | Toll-like receptor 4 modulation as a strategy to treat sepsis 显示文摘 | Wittebole X Castanares-Zapatero D Laterre PF | 2010 | Mediators Inflamm2010,2010,56: | 1 |
| 20 | Adult liver transplantation:UCL experience显示文摘 | Lerut J Laterre PF Roggen F | 1999 | Acta Gastroenlerol Belg1999,62,3: | 1 |